• The Korean Journal of Physiology and Pharmacology
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• v.21 no.1
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• pp.65-74
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• 2017

Here we investigated the central processing mechanisms of mechanical allodynia and found a direct excitatory link with low-threshold input to nociceptive neurons. Experiments were performed on male Sprague-Dawley rats weighing 230-280 g. Subcutaneous injection of interleukin 1 beta ($IL-1{\beta}$) ($1ng/10{\mu}L$) was used to produce mechanical allodynia and thermal hyperalgesia. Intracisternal administration of bicuculline, a gamma aminobutyric acid A ($GABA_A$) receptor antagonist, produced mechanical allodynia in the orofacial area under normal conditions. However, intracisternal administration of bicuculline (50 ng) produced a paradoxical anti-allodynic effect under inflammatory pain conditions. Pretreatment with resiniferatoxin (RTX), which depletes capsaicin receptor protein in primary afferent fibers, did not alter the paradoxical anti-allodynic effects produced by the intracisternal injection of bicuculline. Intracisternal injection of bumetanide, an Na-K-Cl cotransporter (NKCC 1) inhibitor, reversed the $IL-1{\beta}$-induced mechanical allodynia. In the control group, application of GABA ($100{\mu}M$) or muscimol ($3{\mu}M$) led to membrane hyperpolarization in gramicidin perforated current clamp mode. However, in some neurons, application of GABA or muscimol led to membrane depolarization in the $IL-1{\beta}$-treated rats. These results suggest that some large myelinated $A{\beta}$ fibers gain access to the nociceptive system and elicit pain sensation via $GABA_A$ receptors under inflammatory pain conditions.

• The Journal of the Korea Contents Association
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• v.18 no.5
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• pp.330-342
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• 2018

The purpose of this study was to investigate effects of abuse, neglect, and excessive interference of parents on adolescent aggression in the longitudinal context and examine the moderating effect of playing computer game theoretically guided by the flow theory. 2,351 adolescents from the Korean Children & Youth Panel Survey was analyzed using Linear Mixed Effects Regression procedures. Primary findings are as follows: (1) adolescents with higher level of abuse or excessive interference showed higher level of aggression. (2) the aggression level of adolescents with higher level of abuse or excessive interference consistently decreased over time. (3) the link between abuse and aggression was significantly moderated by playing computer game. In conclusion, the negative effect of the abuse on adolescent aggression could be significantly decreased by playing computer game.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.6 no.8
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• pp.1241-1250
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• 2002

The communication between Ship and Land have bad communication environment and high cost comparing with land situation. In case of data communication for I-mail, the primary used speed is from 4800 bps to 9600bps. even this low speed user has difficulty to use data communication because of high cost. and this kind of data communication software is all imported from foreign country. In this paper we designed and implemented this communication server and client using Inmarsat A/B/miniM/M4/GAN(F77) by benchmarking of foreign product like Netverk, Marinet, Amosmail. the focus of this product is like next 1) communication cost down 2) Link between Ship Application and Land Office Application 3) Convenient of usage in Ship 4) perfect management of message to from ship.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.4
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• pp.724-730
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• 2017

SpaceWire invented for spacecrafts has Time-Code defined for time synchronization over SpaceWire network. A Time-Code suffers transmission delay of 14[bit-period] and jitter up to 10[bit-period] whenever it passes through a SpaceWire link, which is the primary cause of time synchronization error. This work presents a simple method to improve the time synchronization which uses two extended Time-Codes. Nodes on a SpaceWire network can find how much delay and jitter a received Time-Code has suffered while it passes through the network, and they can correct time synchronization error with this information. The proposed method was validated in a simulation environment developed based on OMNeT++. The simulation result showed that time synchronization error less than a few bit-periods can be achieved. The proposed method is cost effective and suitable for small-scale SpaceWire network systems.

• Journal of Power Electronics
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• v.17 no.1
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• pp.56-66
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• 2017

Fast and accurate fault detection is the primary step and one of the most important tasks in fault tolerant converters. In this paper, a fast and simple method is proposed to detect and diagnosis the faulty cell in a cascaded H-bridge multilevel inverter under a short circuit fault. In this method, the reference voltage is calculated using switching control pulses and DC-Link voltages. The comparison result of the output voltage and the reference voltage is used in conjunction with active cell pulses to detect the faulty cell. To achieve this goal, the cell which is active when the Fault signal turns to "0" is detected as the faulty cell. Furthermore, consideration of generating the active cell pulses is completely described. Since the main advantage of this method is its simplicity, it can be easily implemented in a programmable digital device. Experimental results obtained with an 11-level inverter prototype confirm the effectiveness of the proposed fault detection technique. In addition, they show that the diagnosis method is unaffected by variations of the modulation index.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.4A
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• pp.371-376
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• 2008

In this paper, we explain the unified inter-cell interference avoidance and cancellation in OFDM mobile cellular systems. Interference avoidance is used for cell-interior or two-cell-edge users, and interference cancellation is applied to three-cell-edge users. The performance of the unified scheme is evaluated by simplified system simulation. Link simulation results are used in the interpretation of system simulation output. We compare three schemes which are "no interference management," "only interference avoidance," "both avoidance and cancellation." Primary performance measures are the data rate of the 5th percentile user and the mean data rate. Simulation results show that interference management schemes greatly improve the cell edge performance, but slightly reduce the mean data rate. Use of both avoidance and cancelaltion is better than that of only avoidance in terms of the cell edge throughput and the mean data rate.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.13 no.2
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• pp.265-282
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• 2002

The purpose of this study is to investigate the principles of school library media center program and to finds out present level and future outlook of the program implementation in primary and middle school. The fundamental objective of school is learning and school library functions as a link to support this objective. Therefore quality of education must always be linked to the library media programs. A questionaire which consists of 13 questions covering school library media center operation was designed to final out how learning-teaching media program is being practiced in Korea. Based on this study, it is concluded that there is significant difference between present practice level and desired future-oriented practice. It is hoped that this study will help planners in formulating school library policy to achieve educational goal of the school.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6347-6352
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• 2015

Background: Breast malignancies are one of the leading causes of deaths in females worldwide. There are a number of risk factors associated with breast cancer but in Karachi Pakistan there are insufficient data available. Materials and Methods: A case control study was conducted on females in age group between 30-80 years. This study was accomplished by retrospective data collection in Aga Khan University Hospital Karachi, Pakistan. A total of 108 females with primary malignancy of breast were included along with 108 matched controls. Relationship of various factors with disease was studied using logistic regression to calculate odds ratios with 95 % confidence intervals. Results: A total of 14 variables were analyzed and based on and 7 were found to be risk factors: old age, family history of breast cancer, family history of other carcinomas, personal history of breast carcinoma, early age of menarche, older age of mother at first delivery and lower number of children. Five factors, parity, breast feeding, history of oral contraceptive pills intake, past history of oophorectomy and hysterectomy showed protective associations. One variable, use of hormonal replacement therapy, showed a controversial link and one other, marital status, was not significant in this study. Conclusions: It is concluded that most of the well-known risk factors for breast cancer are also associated with the disease in the female population of Karachi, Pakistan. High risk patients should be the focus with the help of this study so that screening can be more effective for early diagnosis before clinically evident breast malignancy.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1783-1789
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• 2014

Background: The EMSY gene encodes a BRCA2-binding partner protein that represses the DNA repair function of BRCA2 in non-hereditary breast cancer. Although amplification of EMSY gene has been proposed to have prognostic value in breast cancer, no data have been available concerning EMSY tissue expression patterns and its associations with clinicopathological features. Materials and Methods: In the current study, we examined the expression and localization pattern of EMSY protein by immunohistochemistry and assessed its prognostic value in a well-characterized series of 116 unselected breast carcinomas with a mean follow up of 47 months using tissue microarray technique. Results: Immunohistochemical expression of EMSY protein was detected in 76% of primary breast tumors, localized in nuclear (18%), cytoplasmic (35%) or both cytoplasmic and nuclear sites (23%). Univariate analysis revealed a significant positive association between EMSY expression and lymph node metastasis (p value=0.045) and larger tumor size (p value=0.027), as well as a non-significant relation with increased risk of recurrence (p value=0.088), whereas no association with patients' survival (log rank test, p value=0.482), tumor grade or type was observed. Conclusions: Herein, we demonstrated for the first time the immunostaining pattern of EMSY protein in breast tumors. Our data imply that EMSY protein may have impact on clinicipathological parameters and could be considered as a potential target for breast cancer treatment.

• Journal of Korea Port Economic Association
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• v.23 no.3
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• pp.103-126
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• 2007

As a result of the development of heavy and chemical industries during the Economic Development Plan, Korean shipbuilding industry expanded its capacity rapidly and became a strategic export industry. The 1973 Arab oil crisis and the subsequent doubling of oil prices greatly reduced world demand for tankers and the market was crashed as numberous orders for tankers were cancelled in Japan and Europe. Under these circumstances, Korean Shipping industry also experienced a decrease in overseas demand for shipbuilding. The Korean government established the 'planned shipbuilding' scheme. The primary purpose of the scheme was to develop the shipbuilding industry, to link the industry to the shipping industry and to develop both industries together. However, Japanese shipping established goals linking with macro-national economic policy, such as saving foreign currencies and freight of importing goods, also assisting reconstruction and development of shipbuilding industry. To accomplish these goals, Japanese government used several policy tools such as financial assistance, law, guidance.