• Proceedings of the Korean Society of Applied Pharmacology
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• 2008.04a
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• pp.119-142
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• 2008

Zizyphi Spinosi Semen (ZSS) has been widely used for the treatment of anxiety and insomnia in Korea and China. This experiment was performed to know whether sanjoinine A, one of major alkaloid compounds of ZSS has anxiolytic and hypnotic effects through the GABAergic systems. Our results showed that administration of sanjoinine A increased open arm entries and spent time in open arm in the elevated plus-maze and increased head dips in hole board test. Different from traditional anxiolytic, diazepam, sanjoinine A itself did not decrease locomotor activity and strength level in mice. Furthermore, Sanjoinine A (0.5-2.0 mg/kg) prolonged sleeping time and reduced sleeping latency induced by pentobarbital in a dose-dependent manner similar to muscimol, a $GABA_A$ receptor agonist. Sanjoinine A (0.25-1.0 mg/kg) also increased sleeping rate and sleeping time in the combined administration at the sub-hypnotic dose of pentobarbital and showed synergic effects with muscimol in potentiating sleeping onset and enhancing sleeping time induced by pentobarbital. However, sanjoinine A itself did not induce sleeping at the higher dose. In addition, both of sanjoinine A and pentobarbital increased chloride influx in primary cultured cerebellar granule cells. Sanjoinine A decreased the $GABA_A$ receptor ${\alpha}$-subunit expression and increased ${\gamma}$-subunit expression, and had no effects on abundance of ${\beta}$-subunit in primary cultured cerebellar granule cells, showing different expression of subunits from pentobarbital. In conclusion, sanjoinine A shows anxiolytic-like effects and augments pentabarbital-induced sleeping behaviors through the modification of GABAergic systems. [This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (The Regional Research Universities Program/Center for Healthcare Technology Development)].

• Journal of Communications and Networks
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• v.11 no.2
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• pp.122-133
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• 2009

As wireless spectrum resources become more scarce while some portions of frequency bands suffer from low utilization, the design of cognitive radio (CR) has recently been urged, which allows opportunistic usage of licensed bands for secondary users without interference with primary users. Spectrum sensing is fundamental for a secondary user to find a specific available spectrum hole. Cooperative spectrum sensing is more accurate and more widely used since it obtains helpful reports from nodes in different locations. However, if some nodes are compromised and report false sensing data to the fusion center on purpose, the accuracy of decisions made by the fusion center can be heavily impaired. Weighted sequential probability ratio test (WSPRT), based on a credit evaluation system to restrict damage caused by malicious nodes, was proposed to address such a spectrum sensing data falsification (SSDF) attack at the price of introducing four times more sampling numbers. In this paper, we propose two new schemes, named enhanced weighted sequential probability ratio test (EWSPRT) and enhanced weighted sequential zero/one test (EWSZOT), which are robust against SSDF attack. By incorporating a new weight module and a new test module, both schemes have much less sampling numbers than WSPRT. Simulation results show that when holding comparable error rates, the numbers of EWSPRT and EWSZOT are 40% and 75% lower than WSPRT, respectively. We also provide theoretical analysis models to support the performance improvement estimates of the new schemes.

• Proceedings of the KSME Conference
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• 2001.06d
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• pp.858-863
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• 2001

In this paper, the test and result of flow and combustion for 21AFR lean fuel models are described. The necessity to develop the low emission combustor has been issued from the concern on the increase of green house and the destruction of ozone layer. To evaluate the flow and combustion performance of new designed 21AFR lean modules, the hydraulic tests in stereo lithographic airflows models, the low pressure combustion tests in three injectors model for weak extinction and ignition and the high pressure combustion tests in single sector for NOx, SAE and efficiency are performed. The low pressure tests reveal that the governing parameters in weak extinction and ignition at atmospheric condition are prefilmer length, swirl flow rotation direction, secondary swirl angle and flow split. As a results of combustion test at high pressure, the efficiency and smoke level are satisfied with performance targets, but EINOx of 17.8 is higher than target value of 13.1. The high pressure tests show that the main parameters influenced on NOx are primary swirl angle, swirl flow rotation direction, heatshield exit angle and liner mixing hole location.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.8
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• pp.1132-1137
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• 2002

In this paper, the test results of the combustion for 2 IAFR lean fuel models are described. The need for the low emission combustor has been issued from the concern on the increase of green house and the destruction of ozone layer. To evaluate the flow and combustion performance of newly designed 21AFR lean modules, the hydraulic tests in stereolithographic airflows models, the low pressure combustion tests in three injectors model for weak extinction and ignition and the high pressure combustion tests in single sector for NOx, SAE and efficiency are performed. The low pressure tests reveal that the governing parameters in weak extinction and ignition at atmospheric condition are prefilmer length, swirl flow rotation direction, secondary swirl angle and flow split. As a result of combustion test at high pressure, the efficiency and smoke level are satisfied with performance targets, but EINOx of 17.8 is higher than target value of 13.1 The high pressure tests show that the main parameters influenced on NOx are primary swirl angle, swirl flow rotation direction, heatshield exit angle and liner mixing hole location.

• Proceedings of the Korean Geotechical Society Conference
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• 2005.10a
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• pp.198-209
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• 2005

Overbreak or underbreak is one of the most important factors in evaluation the results of a tunnel blasting. Overbreak, which depends on the quality of rock, the type and quantity of explosives, and the method and condition of drilling, has been a target of challenge to many blasting engineers as it is connected with economic directly. Drilling is generally known as a primary one of overbreak producing factors. So, This study presented the practical solution to reduce overbreak, which was caused by drilling, through the analyses of how to make a drilling process accurate and how to evaluate the effect of each drilling method. Thus, this solution would give a quantitative analysis of overbreak and provide the information of how to reduce the quantity of overbreak. Moreover, for verifying this solution, we applied it to a tunnel project and then have found out that the quantity of overbreak decreased to approximately 10-40% compared with the previous way of overbreak control.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.1
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• pp.277-283
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• 1995

For the development of low NO$_{x}$ gas burners aimed for absorption chiller/heater unit, three proto type burners of different capacity (265000, 498000, and 664000 kcal/h) have been manufactured through a combustion method of step-by-step air injection. In order to characterize the overall features of the flame and the properties of the emission gas, the temperature of the flame and the concentration of NO$_{x}$ and CO were determined. The main factors in the design of burners (the area of primary air injection, the diameter of secondary air injection hole, fuel nozzle diameter) were observed to increase linearly with the scale-up of burner capacity. The flame temperature profiles of the burners were observed to be almost similar, irrespective of their capacity. However, as their capacity increased, the flame temperature slightly increased and the hot region of the flames moved to ward the flame tip along with the expansion to the direction of radius. From the proto type units, the amount of their NO$_{x}$ emission was determined to be around 25 - 30 vppm(3% )$_{2}$) and the CO emission was less than 19 vppm (3% $O_{2}$).TEX>).

• The Bulletin of The Korean Astronomical Society
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• v.42 no.2
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• pp.64.2-64.2
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• 2017

The Population III (Pop III) stars are thought to be massive. If massive Pop III stars form binary system and they experience mass transfer via the Roche lobe overflow, this may significantly change the properties of the system. For example, mass transfer in such system may shorten the period of the system, forming short period binary black hole (BBH) system, which is the most promising candidate for recently detected gravitational wave radiation sources. Also, there is an expectation that due to the stripped envelope of donor star by mass transfer, this system can play a significant role in the cosmic reionization by emitting more UV photons. However, this outcome highly depends on the initial properties of the system. We perform grid calculation on Pop III binary models with various initial primary masses (20 ~ 100 solar mass), initial separations, and initial mass ratios (q = 0.5 ~ 0.9). We find that 1) in most cases binary models show no increase in the number of ionizing photons and 2) formation of short period BBH system via mass transfer is highly unlikely.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.534-537
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• 2008

In recent years, the dissimilar metal, Alloy 82/182 welds used to connect stainless steel piping and low alloy steel or carbon steel components in nuclear reactor piping system have experienced cracking due to primary water stress corrosion(PWSCC). It is well known that one reason of the cracking is the residual stress by the weld. But, it is difficult to estimate exactly weld residual stress due to many parameters of welding. In this paper, the analysis of 3 FEM models made by ABAQUS Code is performed to estimate exactly the weld residual stress on the dissimilar metal weld. 3 FEM models are Butt model, Repair model and Overlay model and are the plane.strain 2D model. The thermal analysis and the stress analysis are performed on each model and the residual stresses on each model were calculated and compared respectively. Also, the specimen of Butt model was made and the residual stresses were measured by X-Ray method and Hole Drilling Technique. These results were compared with the FEM result of Butt model.

• Advances in Traditional Medicine
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• v.6 no.1
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• pp.21-26
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• 2006

The ethanolic extract of Fleurya interrupta Gaud, (Urticaceae) was tested for its possible neuropharmacological effects on experimental animals, For the primary neuropharmacological screening of this plant, the ethanolic extract of its aerial parts was subjected to preliminary evaluation for acute toxicity, antinociceptive activity and central nervous system (CNS) activities. At the doses of 125 and 250 mg/kg, the extract significantly (P < 0.01 and P < 0. 001) and dose-dependently increased the frequency of acetic acid induced writhing in mice. In the pentobarbitone induced sleeping time test, the extract at the above dose levels, significantly and dose-dependently decreased the pentobarbitone induced sleeping time (P < 0.001) and increased the time for onset of sleep (P < 0.001) in mice. In the open field and hole cross tests, test animals showed an increase in their movement in the both tests from the 2nd observation period (30 min) and persisted throughout the entire experimental period (240 min). These results of the extract may attribute a stimulating action on the CNS. On the basis of these findings, it can be assumed that the extract exerts its stimulating effect on the CNS in mice by interfering with the cortical function or increasing the effect of some CNS stimulating neurotransmitters.

• Journal of Korea Foundry Society
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• v.32 no.1
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• pp.24-31
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• 2012

In this study, semi-solid thin plate of A 356 aluminum alloy was fabricated by using slope plate apparatus and vacuum pressurization. Slope plate was used to produce semi-solid material with spheroidal microstructures. After molten metal was poured into the slope plate connected to the pouring hole of die, semi-solid material flowed into the die cavity by vacuum degree. The primary crystals of the cast metal became spheroidal. In order to increase the working pressure, gas pressurization of U shape was designed for fabrication of thin plate. For 3 bar of gas pressure and 60 mmHg of vacuum degree, thin plate was fabricated without defects on surface.