• 한국어병학회지
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• 제32권1호
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• pp.29-35
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• 2019

2015년부터 2017년까지 우리나라 넙치 양식장에서 발생하는 폐사피해를 표본조사를 통해 모니터링 하였다. 표본어가는 전국의 수산질병관리원과 지속적으로 거래하고 있으며 현장방문을 통해 설문이 가능한 양식어가 중 층화구조분석을 통해 선정 하였다. 수산질병관리사 조사요원의 직접적인 현장방문을 통한 설문 조사를 수행하여 객관적으로 양식현황 및 폐사 현황을 파악하였다. 조사기간 중 24.78%/2015년, 30.19%/2016년 그리고 21.59%/2017년의 누적 폐사율을 나타내었고, 감염성 질병에 의한 폐사는 스쿠티카증(2015-2017년 평균 누적 폐사율: 56.7%)과 바이러스성출혈성 패혈증 감염(추정)(2015-2017년 평균 누적 폐사율: 8.9%)에 의한 피해가 높은 것으로 나타났으며, 제주에서는 여윔증(2016-2017년 평균 누적 폐사율: 10.3%)에 의한 피해가 높게 나타났다.

• 한국ITS학회 논문지
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• 제21권1호
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• pp.209-220
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• 2022

최근 다양한 사회 경제 이슈가 사회적인 화두로 떠오르고 있으며, 지역 경제 상황을 빠르게 판단하고 정책을 수립하기 위한 경기종합지수의 중요성이 대두되고 있다. 이에 따라 해외 연구자들은 지역 경제활동과 밀접하게 연관된 실시간성 교통 빅데이터를 이용하여 빠른 경제 상황 진단과 맞춤형 정책 방향의 수립을 고려하고 있다. 본 연구의 주요 목적은 울산광역시를 기종점으로 하는 TCS 데이터를 여객·화물통행, 단거리·장거리통행으로 구분하고, 각각의 통행량을 이용하여 지역경기진단이 가능한 경기종합지수들을 선정한 후 각 지수들의 경기변동 특징인 선행, 동행, 후행성을 교차 상관함수(Cross-Correlation Functions) 분석을 통하여 정의하는데 있다. 연구 결과로부터 TCS 교통량의 추이와 상관관계가 높은 경기 종합지수들은 서비스업 생산지수, 도매 및 소매업, 숙박 및 음식점업 등으로 나타났다. 이 중 화물, 여객, 단거리 목적 통행은 도매 및 소매업, 숙박 및 음식점업에 대해 선행성을 가지는 것으로 도출되었다.

• Pediatric Infection and Vaccine
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• 제9권2호
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• pp.201-207
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• 2002

목 적 : 집단 생활을 하는 영유아에서 흔히 이환될 수 있는 세기관지염, 폐렴 등의 급성 하기도 감염증의 원인 바이러스를 규명하고 그 임상상을 분석하여 환자 진료에 도움을 주고자 하기 위함이다. 방 법 : 2001년 4월말에서 5월초에 걸쳐 모 해외 입양 기관에서 집단 생활을 하면서 호흡기 감염 증상을 보였던 영유아 30명 중 세기관지염 및 폐렴으로 입원 치료한 13명의 비인두 분비물을 채취한 후 서울대학교병원 바이러스 연구소에 의뢰하여 respiratory syncytial virus(이하 RSV), adenovirus, parainfluenza virus에 대한 배양 검사를 시행하였다. 결 과 : 1) 검사한 13명 중 4명에서 바이러스가 검출되어 바이러스 검출율은 30.7%였다. 이 중 RSV 단독 감염은 2명(15.4%), adenovirus 단독 감염 1명(7.7 %), RSV와 adenovirus 중복 감염이 1명(7.7%)였으며 parainfluenza virus는 없었다. 2) 원인 바이러스가 밝혀진 환아 4명은 모두 폐렴으로 진단되었다. 3) 환아의 연령 분포는 0~3개월이 9명, 4~12개월이 1명, 13~24개월이 2명이었으며, 25개월 이상이 1명이었다. 4) 입원 당시 주 증상은 발열(69%), 기침(100%), 빈 호흡(54%), 흉곽 함몰(69%), 수포음(85%), 천명음(15%)이었다. 5) 백혈구 수는 3명(23%), C-반응 단백은 6명(46 %)에서 10 이상으로 증가되었으며, 흉부 방사선 소견상 9명(69%)에서 폐 침윤을 보였다. 결 론 : 비록 대상 환아 중 30.7%에서만 호흡기 바이러스가 검출되었지만, 집단 생활을 하는 영유아에서 바이러스성 하기도 감염의 유행이 있었던 것으로 생각되며, 효율적인 치료법이 없는 현 시점에서는 병의 전염경로를 차단하는 격리 등의 예방 조치가 필요하다고 사료된다.

• 한국산학기술학회논문지
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• 제11권1호
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• pp.335-340
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• 2010

신종 및 재출현 전염병이 지속적으로 유행하고 해외 전염병의 국내유입 가능성이 증대됨에 따라 국립검역소의 검역관리 사업의 효율성 평가는 매우 중요하다. 본 연구는 평가 구성요소 사이의 상대적 중요도, 즉 가중치(weight) 부여에 있어서 과학적 타당성을 인정받고 있는 계층분석절차(Analytical Hierarchy Process; AHP) 기법에 의한 이원비교방법을 사용하여 설정하였다. AHP기법은 복잡한 다기준 의사결정문제(multi-criteria decision making problem)를 계층화하여 단순화 체계화시킴으로써 그 영향도를 계량화하는데 탁월한 기법이라는 평가를 받고 있다. 평가지표별 가중치는 기관평가 영역이 0.2, 서비스 및 프로그램 영역이 0.8로 분석되었으며, 서비스 및 프로그램 영역내에서 검역 업무가 0.45로 가장 높게 나타났다. 대영역(기관평가영역, 서비스 및 프로그램평가 영역), 중영역(투입, 과정, 결과, 검역업무, 검사업무, 위생관리업무, 병원체조사감시업무, 전염병예방홍보 교육업무)으로 구분하여 최종적으로 평가지표로 선정된 지표는 실제 국립검역소 사업에 적용하였으며, 이에 대한 최소한의 평가지표를 최종 선정하여 향후 국립검역소 사업평가 체계를 보다 체계화 하였다.

• Clinical and Experimental Pediatrics
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• 제53권5호
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• pp.639-643
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• 2010

Purpose: Hand-foot-mouth disease (HFMD) is a common viral illness in children, which is usually mild and self-limiting. However, in recent epidemics of HFMD in Asia, enterovirus 71 (EV71) has been recognized as a causative agent with severe neurological symptoms with or without cardiopulmonary involvement. HFMD was epidemic in Korea in the spring of 2009. Severe cases with complications including death have been reported. The clinical characteristics in children with neurologic manifestations of EV71 were studied in Ewha Womans University Mokdong Hospital. Methods: Examinations for EV71 were performed from the stools, respiratory secretion or CSF of children who presented neurologic symptoms associated with HFMD by realtime PCR. Clinical and radiologic data of the patients were collected and analyzed. Results: EV71 was isolated from the stool of 16 patients but not from respiratory secretion or CSF. Among the 16 patients, meningitis (n=10) was the most common manifestation, followed by Guillain-Barre syndrome (n=3), meningoencephalitis (n=2), poliomyelitis-like paralytic disease (n=1), and myoclonus (n=1). Gene analysis showed that most of them were caused by EV71 subgenotype C4a, which was prevalent in China in 2008. Conclusion: Because EV71 causes severe complications and death in children, a surveillance system to predict upcoming outbreaks should be established and maintained and adequate public health measures are needed to control disease.

• 대한간호학회지
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• 제4권1호
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• pp.107-120
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• 1974

Necessity and purpose of this study: In a large number of countries it has been founded that children′s domestic accidents are at great risk year by year In the United States, they publish detailed accident statistics at regular intervals. In Korea. there have been just a few studies on Accidents-At-Home of preschool children. But it can not be said that there have been any systematic statistics about this area. and any study accounting for the relations of home accidents and preschool: children in detail, Therefore, the purpose of this thesis was focused on the inquire of these relations so as to make a little contribution to Korean preschool children′s health and security measures. So, the detail-purposes are to study following questions and to testify following hypothesis. Prob. 1. What the types of accidents of Preschool children, where the place accidents occurred\ulcorner Prob. 2. What the cause of accidents and, the main factors of the cause\ulcorner Prob. 3. How about the number of their children. the disparity of age among their children and mother′s age in each case of accidents\ulcorner hypothesis 1. There will be differences in the density of protection of parents according to the number of their children. hypothesis 2, There will be differences in accident-types and first-aid methods according to parents socio-economic background. Method; This study employed the interviewing survey method, in which 130 preschool children ware random.sampled, who visit hospital to have medical care. These children (from 1 to 6 years olds) were selected at the emergency room of five hospitals in Seoul (Hosp: Severance, Woosok, Medical Center, Hanyang Medical College Hospital and Seoul Medical Col1age Hospital during study-period (from Aug. to Oct, 1973). Four head nurses in above Hospitals were employed as accident members for this study. Concerning research analysis, the method of hypothesis verifying is used. Conclusion: As two American experts on this subject. Dr, Raymond Neuter and Mr. Ross Mc Garland have drawn attention to "minor epidemics of accidents" that could be avoided by fairly simple measures. preschool children′s accidents could be avoided by parents fair attentions. In other words, one of the most common causes of preschool children′s accidents derived from their parent′s inattention. Therefore, one important task on this subject is to instruct the parents fairly about the children′s accidents. Many accidents could be avoided by the exorcist of a little self-discipline. Also, as much the prevention of accidents is important, as the first-aid Is Important and necessary at the case of the accidents. So, the methods of proper first-aid treatment must be emphasized, and must be taught in school, especially in girls school. And there could be other means available for prevention of accidents. Firstly, the public authorities can take legal measures. More stringent safety standards can be made enforceable by law. Building materials and equipment for domestic us: ought to meat minimum safety criteria at all times. Next the public itself has to understand the seriousness of the problem, and here the dissemination of information is of great importance. All mass media should be brought into play to promote greater public awareness of the question. At last, it will be needed to obtain more detailed epidemiological data through additional surveys and statistics after this study.

• Genomics & Informatics
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• 제14권3호
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• pp.96-103
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• 2016

The influenza A (H1N1) virus, also known as swine flu is a leading cause of morbidity and mortality since 2009. There is a need to explore novel anti-viral drugs for overcoming the epidemics. Traditionally, different plant extracts of garlic, ginger, kalmegh, ajwain, green tea, turmeric, menthe, tulsi, etc. have been used as hopeful source of prevention and treatment of human influenza. The H1N1 virus contains an important glycoprotein, known as neuraminidase (NA) that is mainly responsible for initiation of viral infection and is essential for the life cycle of H1N1. It is responsible for sialic acid cleavage from glycans of the infected cell. We employed amino acid sequence of H1N1 NA to predict the tertiary structure using Phyre2 server and validated using ProCheck, ProSA, ProQ, and ERRAT server. Further, the modelled structure was docked with thirteen natural compounds of plant origin using AutoDock4.2. Most of the natural compounds showed effective inhibitory activity against H1N1 NA in binding condition. This study also highlights interaction of these natural inhibitors with amino residues of NA protein. Furthermore, among 13 natural compounds, theaflavin, found in green tea, was observed to inhibit H1N1 NA proteins strongly supported by lowest docking energy. Hence, it may be of interest to consider theaflavin for further in vitro and in vivo evaluation.

• Healthcare Informatics Research
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• 제24권4호
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• pp.300-308
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• 2018

Objectives: Prompt detection is a cornerstone in the control and prevention of infectious diseases. The Integrated Disease Surveillance Project of India identifies outbreaks, but it does not exactly predict outbreaks. This study was conducted to assess temporal correlation between Google Trends and Integrated Disease Surveillance Programme (IDSP) data and to determine the feasibility of using Google Trends for the prediction of outbreaks or epidemics. Methods: The Google search queries related to malaria, dengue fever, chikungunya, and enteric fever for Chandigarh union territory and Haryana state of India in 2016 were extracted and compared with presumptive form data of the IDSP. Spearman correlation and scatter plots were used to depict the statistical relationship between the two datasets. Time trend plots were constructed to assess the correlation between Google search trends and disease notification under the IDSP. Results: Temporal correlation was observed between the IDSP reporting and Google search trends. Time series analysis of the Google Trends showed strong correlation with the IDSP data with a lag of -2 to -3 weeks for chikungunya and dengue fever in Chandigarh (r > 0.80) and Haryana (r > 0.70). Malaria and enteric fever showed a lag period of -2 to -3 weeks with moderate correlation. Conclusions: Similar results were obtained when applying the results of previous studies to specific diseases, and it is considered that many other diseases should be studied at the national and sub-national levels.

• 한국동물위생학회지
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• 제45권2호
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• pp.133-137
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• 2022

Lumpy skin disease (LSD) is a severe cross-border infectious disease that causes fever, skin and visceral nodules in cattle. LSD is caused by the lumpy skin disease virus (LSDV), a dsDNA virus that belongs to the genus Capripoxvirus. Although LSD has been found only in Southern Africa traditionally, in the last decade it is spreading very quickly through the Middle East and into Eastern Europe and China. It usually affects cattle and water buffalos being transmitted by blood-feeding insects. As it causes a huge economic impact, LSD is a notifiable disease by World Organisation for Animal Health, and managed as the legal infectious disease class I in Korea. Therefore, the purpose of this study was to confirm the existence of LSDV antigens or antibodies in Korean livestock. We collected 1,200 blood samples from cattle (Korean native and dairy cattle) and Korean water deer in 4 major provinces of the country, then tested the existence of LSDV antigen and antibody. None (0.0%) of the 1,200 blood samples were positive for both antigen and antibody of LSDV. To the best of our knowledge, this is the first study that examines the prevalence of LSDV in Korea. Our study aims to report the LSDV occurrence situation obtained by surveillance in Korea and provide information that may help prevention of LSD epidemics.

• 한국농공학회논문집
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• 제53권1호
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• pp.29-36
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• 2011

HPAI (High pathogenic avian influenza) which is a disease legally designated as an epidemic generally shows rapid spread of disease resulting in high mortality rate as well as severe economic damages. Because Korea is contiguous with China and southeast Asia where HPAI have occurred frequently, there is a high risk for HPAI outbreak. A prompt treatment against epidemics is most important for prevention of disease spread. The spread of HPAI should be considered by both direct and indirect contact as well as various spread factors including airborne spread. There are high risk of rapid propagation of HPAI flowing through the air because of collective farms mostly in Korea. Field experiments for the mechanism of disease spread have limitations such as unstable weather condition and difficulties in maintaining experimental conditions. In this study, therefore, computational fluid dynamics which has been actively used for mass transfer modeling were adapted. Korea has complex terrains and many livestock farms are located in the mountain regions. GIS numerical map was used to estimate spreads of virus attached aerosol by means of designing three dimensional complicated geometry including farm location, road network, related facilities. This can be used as back data in order to take preventive measures against HPAI occurrence and spread.