• 셀메드
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• 제13권14호
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• pp.14.1-14.9
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• 2023

Administration of Scopolamine can be considered a psychopharmacological model of Alzheimer's disease (AD). We made an animal model of Alzheimer's disease (AD) by administering Scopolamine to Blab/c mice. In this study, we investigated the effects of Resplex Alpha on memory impairment and cognitive function in mice in a mouse animal model of Scopolamine-induced memory impairment. Through Y-mazed and passive avoidance behavioral assays, we observed that Resplex Alpha recovered Scopolamine-induced short-term memory and cognitive functions. The results of our study imply that Resplex Alpha may be beneficial in the prevention of Alzheimer's disease (AD).

• 동의신경정신과학회지
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• 제20권2호
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• pp.1-17
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• 2009

Objectives : Alzheimer's disease(AD) is the most common form of dementia, which is characterized by progressive deterioration of memory and higher cortical functions that ultimately results in total degradation of intellectual and mental activities. Nokyongdaebo-tang(Lurongdabutang) has been usually used for the treatment for the deficiency syndrome dementia and amnesia. This experiment was designed to investigate the effect of the Nokyongdaebo-tang(Lurongdabutang) hot water extract on pathological AD model. Methods : The effects of the Nokyongdaebo-tang(Lurongdabutang) hot water extract on cultured spinal cord cells induced by ${\beta}$-amyloid were investigated. The effects of the Nokyongdaebo-tan(Lurongdabutang) hot water extract on the memory deficit mice induced by scopolamine were investigated. Results : 1. ${\beta}$-amyloid treatment on cultured spinal cord cells increased both GFAP-staining intensity of astrocytes and caspase 3 immunoreactivity on cultured cells. Then, Nokyongdaebo-tang(Lurongdabutang) treatment reduced the labeling intensity for both GFAP and caspase 3 proteins in culture cells. 2. Scopolamine treatment into mice increased levels of GFAP-positive astrocytes and caspase 3-labeled cells of the hippocampal subfields dentate hilar region, CA3 and CA1 area. In vivo administration of Nokyongdaebo-tang(Lurongdabutang) attenuated labeling intensity for those two proteins in the same hippocampal areas. Similar effects were observed by the treatment of galanthamine, an inhibitor of acetylcholinesterase. Conclusions : This experiment shows that the Nokyongdaebo-tang(Lurongdabutang) may play a protective role in damaged neural tissues. Since neuronal damage seen in degenerative brains such as AD are largely unknown, the current data may provide possible insight into therapeutic strategies for AD treatments. Nokyongdaebo-tang(Lurongdabutang) might be effective for the prevention and treatment of AD.

• 동의생리병리학회지
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• 제20권5호
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• pp.1200-1210
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• 2006

This experiment was designed to investigate the effect of the CMT and MCMT hot water extract & ultra-fine powder on microglia and memory deficit model. The effects of the CMT and MCMT hot water extract on expression of IL-l${\beta}$, IL-6, TNF-${\alpha}$, NOS-II, COX-2, IL-10, TGF-${\beta}$1 mRNA and production of IL-lP, IL-6, TNF-a, NO, ROS in BV2 microglial cell line treated by lipopolysacchaide(LPS) ; serum glucose, uric acid, AChE activity of the memory deficit mice induced by scopolamine , behavior of the memory deficit mice induced by scopolamine and were investigated, respectively. The CMT and MCMT hot water extract suppressed the expression of IL-1${\beta}$, IL-6, TNF-${\alpha}$, NOS-II, COX-2 mRNA, production of IL-l${\beta}$, IL-6, TNF-${\alpha}$, NO, ROS and increased the expression of IL-10, TGF-${\beta}$l mRNA in BV2 microglial cell line treated by LPS. The MCMT hot water extract & ultra-fine powder increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit mice induced by scopolamine. The CMT and MCMT hotwater extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. According to the above result, it is suggested that the CMT and MCMT hot water extract & ultra-fine powder might be usefully applied for prevention and treatment of dementia.

• 동의생리병리학회지
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• 제20권4호
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• pp.997-1008
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• 2006

This experiment was designed to investigate the effect of the CMT and PCMT hot water extract & ultra-fine powder on microglia and memory deficit model. The effects of the CMT and PCMT hot water extract on expression of $IL-l{\beta},\;IL-6,\;TNF-{\alpha}$, NOS-II, COX-2, IL-10, $TGF-{\beta}1$ mRNA and production of $IL-l{\beta},\;IL-6,\;TNF-{\alpha}$, NO, ROS in BV2 microglial cell line treated by lipopolysacchaide(LPS) , serum glucose, uric acid, AChE activity of the memory deficit mice induced by scopolamine , behavior of the memory deficit mice induced by scopolamine and were investigated, respectively. The CMT and PCMT hot water extract suppressed the expression of $IL-l{\beta},\;IL-6,\;TNF-{\alpha}$, NOS-11, COX-2 mRNA, production of $IL-l{\beta},\;IL-6,\;TNF-{\alpha}$, NO, ROS and increased the expression of IL-10, $TGF-{\beta}1$ mRNA in BV2 microglial cell line treated by LPS. The PCMT hot water extract & ultra-fine powder increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit mice induced by scopolamine. The CMT and PCMT hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. According to the above result, it is suggested that the CMT and PCMT hot water extract & ultra-fine powder might be usefully applied for prevention and treatment of dementia.

• 융합정보논문지
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• 제9권8호
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• pp.248-253
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• 2019

노인성 치매의 전 임상단계인 경도인지장애(MCI)를 조기 진단하고, 조기 개입한다면, 치매의 발병률을 줄일 수 있다. 본 연구는 우리나라 지역사회 노인의 MCI 예측 모형을 개발하고 노년기 인지장애의 예방을 위한 기초자료를 제공하였다. 연구대상은 2012년 Korean Longitudinal Survey of Aging(KLoSA)에 참여한 65세 이상 지역사회 노인 3,240명(남성 1,502명, 여성 1,738명)이다. 결과변수는 MCI유병으로 정의하였고, 설명변수는 성, 연령, 혼인상태, 교육수준, 소득수준, 흡연, 음주, 주1회 이상의 정기적인 운동, 월평균 사회활동 참여시간, 주관적 건강, 고혈압, 당뇨병을 포함하였다. 예측모형의 개발은 Restricted Boltzmann Machine(RBM) 인공신경망을 이용하였다. RMB 인공신경망을 이용하여 우리나라 지역사회 노인의 MCI 예측 모형을 구축한 결과, 유의미한 요인은 연령, 성별, 최종학력, 주관적 건강, 혼인상태, 소득수준, 흡연, 규칙적 운동이었다. 이 결과를 기초로 MCI 고위험군의 특성을 고려한 맞춤형 치매 예방 프로그램의 개발이 요구된다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 춘계학술대회
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• pp.308-311
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• 2021

본 논문은 가상현실을 기반으로 한 고령자용 치매 예방 기능성 게임 개발에 대해 기술한다. 게임의 개발에는 Unity 3D 엔진을 사용하였고, 가상현실 공간인 낚시터를 구현하였다. 게임의 대상자가 가상현실과는 상대적으로 친숙하지 않은 고령자인 점을 감안하여 VH HMD 장비에 쉽게 적응할 수 있도록 게임 내에서 플레이어의 움직임이 없도록 하였고, 조작에 있어서 어려움을 줄이기 위해 조작 버튼 개수를 최소화하였으며, 직관적인 게임 구성으로 거부감과 피로감을 줄였다. 또한, 게임 완료 후 별점을 부과하는 시스템으로 성취감을 주어 즐겁고 꾸준히 참여하도록 유도하였다. 개발된 게임은 전체적으로 메인, 인터페이스, 스테이지, 별점, TTS, 튜토리얼, 엔딩크레딧 등으로 이루어져 있다. 각 카테고리별 스테이지를 3단계로 나누어 하나의 통합 환경에서 구현하였고 VR HMD를 이용해 가상현실 내에서 기억력, 주의력, 판단력을 증진시킬 수 있는 게임을 진행할 수 있도록 되어 있다.

• Perspectives in Nursing Science
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• 제11권1호
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• pp.10-17
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• 2014

Purpose: The aim of this study was to analyze health promotion programs utilizing forests by reviewing regional healthcare program plans in Korea. Methods: We analyzed 227 regional healthcare program plans from 2011 to 2014; seven health promotion programs of the 16 major healthcare programs were prescribed by public health law. Results: Our analysis revealed that only 35 health promotion programs from 29 sites were utilizing forests. Furthermore, of 21 known categories of health promotion programs, only nine incorporated the use of forests. Atopy-asthma healthcare programs were the most common forest health promotion programs, which also included specialized disease management programs (e.g., for atopy prevention and healing, patients with metabolic syndrome or cancer) and specialized mental health management programs (e.g., for addiction or dementia prevention). Others included programs on the development of forest roads or industrial development using forest products. Conclusion: Health programs using forests in Korea are still very limited and primarily comprise atopy-asthma prevention/management, health behavioral change, and mental health programs. This study provided useful information for developing health policies and forest health promotion programs further in Korea.

• 한국보건간호학회지
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• 제11권2호
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• pp.57-72
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• 1997

The objectives of this study are : 1) To understand self-care ability, living habits, utilization patterns of medical facililties for the elderly in Puk-Cheju county which has the highest percent age of senior citizens among Cheju rural community: 2) To identify factors which influence living quality and long life for the eldely 3) To develop health care service with a view to guaranteering living quality The eldely population of Puk-Cheju county was $10.8\%$ in 1995. It will be increasing and is projeted $23.0\%$ by 2030. The result indicated that utilizations rate by out-patient were 5.89 claims and utilizations rate by in-patient were 0.17 claims per person. The highest disease among respondents were disease of musculoskeletal system and connective tissue. A total of 310 elderlys were responded to analyze self-care ability and health behavior. The most important factors of long life were to have peaceful mind$(50.0\%)$. The common disease of acute and chronic disease was musculoskeletal system disease. $66.8\%$ of respondents went to hospital and local clinic when they got sick. The most needed health care service was home visiting service among public health center, representing $31.4\%$. The repondent's self-care ability and self-efficacy were relatively superiority. A total of 92 elderlys were conducted the intelligence test for the rate of dementia and their average age was 74.3. The result of Minimental State Scale indicated that 25% of respondents were suspected to be dementia. The followings are recommendations based on the survey result. 1) Concidering every conditions of self-care ability and health status for elderly. It is important to embody appopriate health care service. 2) Considering concrete method, it is necessary to establish health service, which match health status and self-care ability, and various planning for sepecial facilities for the elderly. 3) It is desiable to make actual programs for the elderly in each community level. 4) It must be develop the better use of volunteers and programs for prevention of dementia. Finally, Concerning the orgarnization of public health center, community health center need to be reorganized for health service for the elderly. It is important to develop and operate health promotion for the elderly, and it is necessary to form the foundation for the support of facilities equipments. This contribute to promote health status for the rural elderly.

• 사물인터넷융복합논문지
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• 제8권5호
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• pp.119-125
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• 2022

최근 고령화로 인한 치매환자의 증가로 그들의 배회행동과 실종예방을 위한 대책이 시급하다. 이러한 문제를 해결하기 위해 다양한 인증 방법과 위치 탐지 기법들이 소개되고 있으나 개인인증의 보안성 문제와 실내·외를 전반적으로 확인할 수 있는 시스템은 찾아보기 어려웠다. 본 연구에서는 프라이빗 블록체인 환경에서 손목 밴드 형태의 웨어러블 디바이스를 활용해 개인인증, 기본적 건강 상태 파악 및 실내·외의 전반적인 위치를 파악할 수 있는 시스템을 제안하고자 한다. 이 시스템에서 개인인증은 위변조가 어렵고 개인식별성이 높은 ECG를, 실내는 저전력, 비접촉 및 자동 송수신 방식으로 사용이 용이한 블루투스 비콘을, 실외는 GPS 위성의 의사거리 오차를 보정한 DGPS를 활용하여 치매환자의 위치를 파악함으로써 배회행동 및 이상징후를 탐지하고자 한다. 이를 통해 재가나 요양시설 등에서 생활하는 치매환자의 배회행동 및 이상징후 시 신속한 대처와 실종예방에 기여하고자 한다.

• 한국컴퓨터정보학회논문지
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• 제25권11호
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• pp.179-185
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• 2020

본 연구에서 우리는 COVID-19의 사망에 대한 영향요인과 혈액변수의 타당도를 제안하였다. 이 연구를 위하여 질병관리본부 중앙방역대책본부에서 제공하는 2020년 4월 30일까지 격리해제되었거나 사망한 COVID-19확진자 5628명의 임상역학정보를 활용하였으며, 자료는 R 3.4.1을 사용하여 분석하였다. 분석결과, 사망에 대한 위험요인으로 치매(HR 7.03), 많은 나이(HR 5.39), 높은 림프구(HR 4.66), 암(HR 4.27), 호흡곤란(HR 3.25), 만성폐쇄성 폐질환(HR 3.22), 의식변화(HR 3.13), 심장질환(HR 2.24), 높은 혈소판(HR 2.14), 비정상 이완기 혈압(HR 2.02), 열(HR 1.69)이 확인되었다. 사망에 대한 혈액검사의 타당도는 림프구, 헤모글로빈, 헤마토크리트, 혈소판, 백혈구 순으로 정확도가 높았다. 그러므로 COVID-19 환자를 치료할 때 사망의 위험요인으로 확인된 초기 임상적 특징 및 기저질환, 혈액검사의 소견을 고려하여 보다 효율적인 관리가 가능하도록 해야 할 것이다.