• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.12
• /
• pp.7543-7550
• /
• 2013

Objective: To evaluate associations between tea consumption, alcohol drinking and physical activity and breast cancer risk among Chinese females. Methods: Three English databases (PubMed, ScienceDirect and Wiley) and three Chinese databases (CNKI, WanFang and VIP) were independently searched by 2 reviewers up to December 2012, complemented by manual searches. The quality of included studies was assessed with the Newcastle-Ottawa Scale items. Random-effects models were used to estimate the pooled odds ratios (ORs) and 95% confidence intervals (CIs). Potential publication bias was estimated through Egger's and Begg's tests. Heterogeneity between studies was evaluated with $I^2$ statistics. Results: Thirty-nine studies involving 13,204 breast cancer cases and 87,248 controls were identified. Compared with non-drinkers, regular tea drinkers had decreased risk (OR=0.79, 95%CIs: 0.65-0.95; $I^2$=84.9%; N=16). An inverse association was also found between regular physical activity and breast cancer risk (OR=0.73, 95%CIs: 0.63-0.85; $I^2$=77.3%; N=15). However, there was no significant association between alcohol drinking and breast cancer risk (OR=0.85, 95%CIs: 0.72-1.02; $I^2$=63.8%; N=26). Most of the results from the subgroup analysis were consistent with the main results. Conclusion: Tea consumption and physical activity are significantly associated with a decreased risk of breast cancer in Chinese females. However, alcohol drinking may not be associated with any elevation of risk.

• Journal of The Korean Society of Integrative Medicine
• /
• v.8 no.4
• /
• pp.253-263
• /
• 2020

Purpose : The purpose of this study was conducted to compare the fear of falling, self-efficacy and fall prevention behavior according to the fall experience of the elderly. Methods : The subjects of this study were 162 elderly in B metropolitan city. The data collection period was from September 10th to November 30th of 2018. The collected data was processed using SPSS 21.0 and was analyzed using descriptive statistics, t-test, ANOVA, Scheffe's test. Results : The mean scores for fear of falling according to the fall experience and no fall experience of the elderly were 2.28±0.63 and 1.84±0.64 respectively and the results showed that fear of falling (t=4.26, p<.001) and self-efficacy of falling (t=3.88, p<.001) were significantly different between the two groups, but the mean scores for fall prevention behavior according to the fall experience and no fall experience of the elderly were 1.63±0.20 and 1.67±0.17 respectively and there was no significantly different in fall prevention behavior (t=-1.16, p=.25). Fear of falling according to the fall experience was significantly different by age (F=3.25, p<.05) and physical activity related to daily life (F=13.22, p<.001). Self-efficacy according to the fall experience was significantly different by age (F=3.03, p<.05), income per month (F=3.74, p<.05) and physical activity related to daily life (F=11.99, p<.001). But fall prevention behavior was no significantly different of general characteristics. Fear of falling according to the no fall experience was significantly different by age (F=3.37, p<.05), marriage status (F=3.37, p<.05), education level (F=5.15, p<.01), income per month (F=3.58, p<.05) and physical activity related to daily life (F=15.71, p<.001). Self-efficacy according to the no fall experience was significantly different by sex (t=2.32, p<.05), age (F=5.20, p<.01), marriage status (F=5.04, p<.01), education level (F=6.55, p<.001), income per month (F=5.99, p<.001) and physical activity related to daily life (F=18.86, p<.001). Fall prevention behavior was significantly different by marriage status (F=3.51, p<.05). Conclusion : The results of this study suggest the following : it is necessary to develop a program that can lower the fear of falling in the elderly and to increase the self-efficacy of falling, and to develop an education program that can improve the elderly's practice of fall prevention behavior regardless of the fall experience and to verify its effectiveness.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.11
• /
• pp.4429-4436
• /
• 2014

Background: Although the nutritional may exert effect on the breast cancer risk, it is not clear whether the role diet is the same in sedentary and physically active women. The aim of this study was to evaluate the association between fruit, vegetable and carbohydrate intake and the risk of breast cancer among Polish women considering their physical activity level. Materials and Methods: A case-control study was conducted that included 858 women with histological confirmed breast cancer and 1,085 controls, free of any cancer diagnosis, aged 28-78 years. The study was based on a self-administered questionnaire to ascertain physical activity, dietary intake, sociodemographic characteristics, reproductive factors, family history of breast cancer, current weight and high, and other lifestyle factors. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in unconditional logistic regression analyses including a broad range of potential confounders. Results: With comparison of the highest vs lowest quartile of intake, strong significant associations were observed for total vegetables (OR=0.37, 95%CI=0.20-0.69 P for trend <0.01 and OR=0.53, 95%CI=0.29-0.96, P for trend <0.02), and total fruits (OR=0.47, 95%CI=0.25-0.87, P for trend <0.05 and OR=0.47, 95%CI=0.24-0.90, P for trend <0.02) among women characterized by the lowest and the highest quartile of physical activity. No associations were observed for total carbohydrate intake. Additional analysis showed a positive association for sweets and desert intake among women in the lowest quartile of physical activity (OR=3.49, 95%CI=1.67-7.30, P for trend <0.009) for extreme quartiles of intake comparing to the referent group. Conclusions: The results suggest that a higher consumption of vegetable and fruit may be associated with a decreased risk of breast cancer, especially among women who were low or most physically active throughout their lifetimes. These findings do not support an association between diet high in carbohydrate and breast cancer. However, a higher intake of sweets and deserts may by associated with an increased risk of breast cancer among women who were less physically active.

• Physical Therapy Korea
• /
• v.28 no.1
• /
• pp.84-91
• /
• 2021

Background: A hip fracture may occur spontaneously prior to the hip impact, due to the muscle pulling force exceeding the strength of the femur. Objects: We conducted falling experiments with humans to measure the activity of the hip muscles, and to examine how this was affected by the fall type. Methods: Eighteen individuals fell and landed sideways on a mat, by mimicking video-captured real-life older adults' falls. Falling trials were acquired with three fall directions: forward, backward, or sideways, and with three knee positions at the time of hip impact, where the landing side knee was free of constraint, or contacted the mat or the contralateral knee. During falls, the activities of the iliopsoas (Ilio), gluteus medius (Gmed), gluteus maximus (Gmax) and adductor longus (ADDL) muscles were recorded. Outcome variables included the time to onset, activity at the time of hip impact, and timing of the peak activity with respect to the time of hip impact. Results: For Ilio, Gmed, Gmax, and ADDL, respectively, EMG onset averaged 292, 304, 350, and 248 ms after fall initiation. Timing of the peak activity averaged 106, 96, 84, and 180 ms prior to the hip impact, and activity at the time of hip impact averaged 72.3, 45.2, 64.3, and 63.4% of the peak activity. Furthermore, the outcome variables were associated with fall direction and/or knee position in all but the iliopsoas muscle. Conclusion: Our results provide insights on the hip muscle activation during a fall, which may help to understand the potential injury mechanism of the spontaneous hip fracture.

• Journal of the Korean Society of School Health
• /
• v.37 no.1
• /
• pp.12-21
• /
• 2024

Purpose: This study aimed to provide basic data for future infectious disease prevention educational programs targeting preschoolers by verifying the effects of the 2023 Home-visiting Infectious Disease Prevention Class Project for Preschoolers. Methods: The study is a descriptive survey that analyzed educational satisfaction of kindergarten teachers and the activity reports of visiting teachers. The effectiveness of the education on the children's side was evaluated with a quasi-experimental approach using pre- and post-test design. Data collection was conducted from September 6 to November 10, 2023. The data from 96 kindergarten teachers, 100 activity reports written by visiting teachers, 56 children in the experimental group, and 50 children in the control group were analyzed. Results: As a result of analyzing the satisfaction survey results of the kindergarten teachers and the activity reports submitted by the visiting teachers, all questions received a very positive evaluation with 4 or more out of 5 points. In addition, the children in the experimental group showed statistically significant positive changes both in hand-washing accuracy and their awareness of immunity. Conclusion: The Home-visiting Infectious Disease Prevention Class Project for Preschoolers is of great educational significance and is expected to be a useful educational intervention that can improve infection prevention behaviors and show practical preventive effects in preschoolers so that they can be prepared for various infectious diseases in the future.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.7
• /
• pp.3275-3279
• /
• 2012

Recently, population-based studies of type 2 diabetes patients have provided evidence that metformin treatment is associated with a reduced cancer incidence and mortality, but its mode of action remains unclear. Here we report effects of metformin on hepatocellular carcinoma (HCC) Hep-G2 cells and details of molecular mechanisms of metformin activity. Our research indicates that metformin displays anticancer activity against HCC through inhibition of the mTOR translational pathway in an AMPK-independent manner, leading to G1 arrest in the cell-cycle and subsequent cell apoptosis through the mitochondrion-dependent pathway. Furthermore, we showed that metformin strongly attenuated colony formation and dramatically inhibited Hep-G2 tumor growth in vivo. In conclusion, our studies suggested that metformin might have potential as a cytotoxic drug in the prevention and treatment of HCC.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.4
• /
• pp.1331-1336
• /
• 2015

Natural glycoproteins can induce apoptosis of tumor cells and exert anti-tumor activity by immunomodulatory functions, cytotoxic and anti-inflammation effects, and inhibition of endothelial growth factor. Given their prospects as novel agents, sources of natural antitumor glycoproteins have attracted attention and new research directions in glycoprotein biology are gradually shifting to the direction of cancer treatment and prevention of neoplastic disease. In this review, we summarize the latest findings with regard to the tumor suppressor signature of glycoproteins and underlying regulatory mechanisms.

• Food Science and Biotechnology
• /
• v.16 no.5
• /
• pp.828-831
• /
• 2007

We evaluated the effects of heat treatment on various properties of onion extracts (Allium cepa). Onion was heated at various temperatures ($110-150^{\circ}C$) for various times (1-5 hr), and the total polyphenol, flavonoid, and free sugar contents, and antioxidant activity were investigated. With increased heating temperatures and exposure times, the total contents of polyphenols and flavonoids, as well as antioxidant activity increased. The highest total polyphenol content (189.80 mg/100g) occurred after heating for 2 hr at $140^{\circ}C$. The highest total flavonoid content (252.51 mg/100g) occurred after heating for 3 hr at $150^{\circ}C$. The antioxidant activity assessed using the DPPH method was highest, at 2.1 mg/mL ($IC_{50}$ value), after heating for 2 hr at $150^{\circ}C$. Correlations between antioxidant activity and the total polyphenol, total flavonoid, and fructose contents were highly significant (all p<0.01). The optimal heating time and temperature were 2 hr and $130^{\circ}C$.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.4
• /
• pp.1739-1744
• /
• 2016

We report herein an in vitro anticancer evaluation of a series of seven curcumin analogues (3a-g). The National Cancer Institute (NCI US) Protocol was followed and all the compounds were evaluated for their anticancer activity on nine different panels (leukemia, non small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer) represented by 60 NCI human cancer cell lines. All the compounds showed significant anticancer activity in one dose assay (drug concentration $10{\mu}M$) and hence were evaluated further in five dose assays (0.01, 0.1, 1, 10 and $100{\mu}M$) and three dose related parameters $GI_{50}$, TGI and $LC_{50}$ were calculated for each (3a-g) in micro molar drug concentrations (${\mu}M$). The compound 3d (NSC 757927) showed maximum mean percent growth inhibition (PGI) of 112.2%, while compound 3g (NSC 763374) showed less mean PGI of 40.1% in the one dose assay. The maximum anticancer activity was observed with the SR (leukemia) cell line with a $GI_{50}$ of $0.03{\mu}M$. The calculated average sensitivity of all cell lines of a particular subpanel toward the test agent showed that all the curcumin analogues showed maximum activity on leukemia cell lines with $GI_{50}$ values between 0.23 and $2.67{\mu}M$.

• Journal of Korean Academy of Nursing
• /
• v.43 no.3
• /
• pp.331-340
• /
• 2013

Purpose: The purpose of this study was to investigate the effects of the lifestyle modification coaching program on self efficacy, lifestyle and physiologic indexes related to the recurrence of stroke in patients with stroke. Methods: Sixty-one patients with stroke registered with a stroke center participated in this study. Of the participants, 32 were assigned to the experimental group and 29 to the control group. Self efficacy, alcohol drinking, smoking, physical activity, BMI (body mass index), WHR (waist-hip ratio), blood lipid level, and blood pressure were measured both for the baseline, as well as after intervention. The lifestyle modification coaching program consisted of an 8-week telecoaching session following face-to-face education. The control group received only the face-to-face education. Results: There were significant differences in physical activities, WHR, blood pressure within and between groups after intervention. The lifestyle modification coaching program had significant influences on blood pressure even after gender, age, and physical activity had been adjusted. Conclusion: The results of the study indicate that lifestyle modification coaching program is effective for physical activity, abdominal obesity and blood pressure. Therefore it can be used by nurses in hospitals and communities as one of the secondary stroke prevention programs for patients with stroke.