• Molecules and Cells
• /
• 제27권2호
• /
• pp.143-148
• /
• 2009

EBV-transformed lymphoblastoid cell lines (LCLs) are used as a resource for human genetic, immunological, and pharmacogenomic studies. We investigated the biological activity of 20 LCL strains during continuous long-term subculture up to a passage number of 160. Out of 20 LCL strains, 17 proliferated up to a passage number of 160, at which point LCLs are generally considered as "immortalized". The other three LCL strains lost the ability to proliferate at an average passage number of 41, during which these LCLs may have undergone cellular crisis. These non-immortal LCL strains exhibited no telomerase activity, decreased EBV gene expression, and a lower copy number of the EBV genome and mitochondrial DNA when compared with immortal LCLs. Thus, this study suggests that sustained EBV viral activity as well as telomerase activity may be required for complete LCL immortalization.

• 한국전문물리치료학회지
• /
• 제30권1호
• /
• pp.78-85
• /
• 2023

Background: Despite fall prevention strategies suggested by researchers, falls are still a major health concern in older adults. Understanding factors that differentiate successful versus unsuccessful balance recovery may help improve the prevention strategies. Objects: The purpose of this review was to identify biomechanical factors that differentiate successful versus unsuccessful balance recovery in the event of a fall. Methods: The literature was searched through Google Scholar and PubMed. The following keywords were used: 'falls,' 'protective response,' 'protective strategy,' 'automated postural response,' 'slips,' 'trips,' 'stepping strategy,' 'muscle activity,' 'balance recovery,' 'successful balance recovery,' and 'failed balance recovery.' Results: A total of 64 articles were found and reviewed. Most of studies included in this review suggested that kinematics during a fall was important to recover balance successfully. To be successful, appropriate movements were required, which governed by several things depending on the direction and characteristics of the fall. Studies also suggested that lower limb muscle activity and joint moments were important for successful balance recovery. Other factors associated with successful balance recovery included fall direction, age, appropriate protective strategy, overall health, comorbidity, gait speed, sex and anticipation of the fall. Conclusion: This review discusses biomechanical factors related to successful versus unsuccessful balance recovery to help understand falls. Our review should help guide future research, or improve prevention strategies in the area of fall and injuries in older adults.

• 보건교육건강증진학회지
• /
• 제31권4호
• /
• pp.73-92
• /
• 2014

Objectives: To provide basic data needed to develop national physical activity policy, this study was examined to identify the relationship among physical inactivity, physical activity, and chronic diseases. Methods: I have reviewed articles and research reports in relation to physical activity, health, and chronic disease published in national and international since 2005 through PubMed, RISS, and KISS. Results: physical activity should be the priority of public health for the prevention and management of chronic diseases as following reasons. 1) Prevalence of physical inactivity has been continuously increased. 2) There were strong evidences that sufficient physical activity could prevent and treat dozens of chronic diseases. Conclusions: Both central and local governments need to make the amount of physical activity to be increased by providing information and establishing a physical activity-friendly environment. Also, the local public health centers and the primary medical institutions are institutionally needed to counsel and prescribe every patient's exercise program at every visit.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권14호
• /
• pp.5817-5822
• /
• 2015

The developing countries have higher mortality rates for breast cancer. A reason for this is presentation at advanced stages due to low levels of public awareness. Activities are arranged by health authorities of developing countries to increase the knowledge of women but their effectiveness has not been evaluated in detail. A multiple choice questionnaire with questions about socio-demographic profile and questions about breast cancer knowledge was designed in local language Urdu, to evaluate the knowledge of the participants before and after an audio visual educational activity in Lahore, Pakistan. Scores of 0-2, 3-5 and 6-8 were ranked as poor, fair and good, respectively. Among 146 participants these scores were achieved by 1%, 55% and 45% before activity and 0%, 16% and 84% after the activity. Overall 66% of participants increased their knowledge score. Younger age, higher education, reliance on television as source of information and being a housewife were associated with better impact of the awareness activity. For the six knowledge related questions 3%, 5%, 11%, 23%, 33% and 44% more participants gave correct answers after the activity. However 6% and 7% fewer participants answered correctly for 2 questions related to the cause and the best prevention for breast cancer. The study indicated that awareness activities are effective to increase the knowledge of women and better impact is associated with higher education and younger age of women. The component analysis showed that the questions and related presentations using medical terms have a negative impact and should not therefore be used. Analysis of activity therefore leads to identification of deficiencies which can be remedied in future.

• 시큐리티연구
• /
• 제17호
• /
• pp.301-316
• /
• 2008

우리들 대부분은 어렸을 적 없었던 동화 가운데 “아기돼지 삼형제”이야기를 기억하고 있을 것이다. 늑대의 공격으로부터 아기돼지 삼형제를 구한 것은 막내 돼지의 벽돌집이었다는 것을 알 수 있다. 이 이야기가 경호 경비 관련자에게 시사하는 바는 "잘 설계된 물리적 환경이 범죄의 예방에 얼마나 중요한가"라는 것이다. 범죄 방지를 위한 지역 경찰의 능력은 치안수요에 비해 턱없이 부족하여 국민이 범죄에 대한 두려움을 해소시키지 못하였으며, 급기야는 공권력의 불신으로 이어져 심각한 사회위기 요인으로 작용하게 되었다. 사회에서 보는 것처럼 범죄대응체계와 방범체계를 비웃기라도 하듯이 순식간에 범행을 마치고 경찰이 출동하여 현장에 도착하기 전에 도주하는 경향이 보여 정부의 치안력 한계를 느끼게 하는 한다. 환경설계를 통한 범죄예방(CPTED: Crime Prevention Through Environmental Design)기법의 도입을 통해 범죄예방의 효율성의 기하는 한편 체계적인 범죄예방 프로그램과 가장 적합한 모델을 선정하여 활용하는데 과제를 안고 있으며, 지역 사회 범죄활동에 대해 경호활동의 중요성을 인식하고, 다양한 지역사회의 치안활동을 분석하여 이에 대한 전략으로 경호활동의 참여를 통한 접근에 초점을 맞추며, 현재까지 빈번하게 발생하고 있는 크고 작은 지역사회 범죄예방책으로 CPTED기법을 경찰과 민간경호경비업체에 적용하여 유효적절한 모델을 설정하고 지능화되고 흉포화 하는 범죄에 대응하고 예방하는 지표를 삼고자 하는 데에 이 연구의 궁극적인 목적이 있다.

• 시큐리티연구
• /
• 제1호
• /
• pp.175-208
• /
• 1997

I study the actual condition and the problem of the crime prevention system of two seoul police station. that is operated on the unit of police box, and present the new improvement. Stragic and active is the new crime prevention system that introduces a concept of community oriented policing, the tendency of a developed country police. I present a medium - sized police station where 250${\sim}$300 policemen work. It consist of a patrol division, a community division and a administration support division. The chief of police bears the responsibility only for crime prevention service by concentrating on pure Patrol - centered crime prevention activity and community relation activity. Next I present a police inspector system. The most important on this paper is the community policing officer system that a policeman bears responsibility on district apart from a patrol division and support a police service related community. To be operated these systems effectively, these need to be regulated according to a police distinct, a police purpose and it's demand. Also a scale, function, authority of a existing. Police station must be regulated and the police training must be carried out.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권24호
• /
• pp.10543-10555
• /
• 2015

Breast cancer primary prevention is a high research priority due to the high psychological and economic costs. The disease is a multistep process and several risk factors have been recognized. Over the past three decades numerous studies have investigated the association of lifestyle with breast cancer, showing independent effects of various factors. We report here a summary of the present state of knowledge on the role of lifestyle patterns, such as physical activity, diet, smoking, hormone therapy, and experience of psychological stress in the modulation of breast cancer in women, and discuss commonly accepted biological mechanisms hypothesized as responsible for the associations. The findings indicate that regular physical activity of moderate to vigorous intensity is probably linked with the decreased breast cancer risk among postmenopausal females and suggestive for a decrease of the risk in premenopausal women. In contrast, the consumption of high-fat diet, alcohol intake, and use of combined estrogen and synthetic progestagen hormonal therapy may increase the risk. Epidemiological findings dealing with a role of smoking and experience of psychological stress are conflicting.

• 재활간호학회지
• /
• 제16권1호
• /
• pp.55-62
• /
• 2013

Purpose: The purpose of this study was to identify the factors affected with nurses' prevention activity against hospital fall. Methods: The data were collected from 325 nurses at C University Hospital in G City by using the structured questionnaires from February 21, 2011 to March 12, 2011. The data were analyzed by stepwise multiple regression. Results: The main factor associated with prevention activity against hospital fall was the attitude towards hospital fall (${\beta}$=.26, p<.001), the next one was the educational level (${\beta}$=.16, p=.002), and the last one was the frequency of fall prevention education (${\beta}$=.14, p=.009). The all factors could explain 11.1% of the variance in the nurses' prevention activities against hospital fall. Conclusion: Hospital managers need to make hospital culture to enhance the nurse's positive attitude about hospital fall prevention. In addition, educators need to develop educational programs including hospital fall prevention through academic curriculum and continuing education.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권12호
• /
• pp.6033-6038
• /
• 2012

This study was designed to identify beliefs about physical activity in cancer patients. Semi- structured interviews were conducted with 20 patients under treatment, who were invited to identify perceived barriers for not adopting a physically active lifestyle and to express their beliefs about physical activity. Content analyses revealed five main categories of beliefs including four types of barriers: (a) barriers related to the side effects of treatment; (b) barriers related to a lack of perceived physical abilities; (c) barriers related to a lack of interest for physical activity; (d) beliefs about the negative effects of physical activity, and (e) beliefs about the positive effects of physical activity. These findings extend the existing literature by indicating how stereotypes may play a role in explaining sedentary lifestyles in cancer patients.

• Clinical and Experimental Pediatrics
• /
• 제52권12호
• /
• pp.1321-1326
• /
• 2009

Prevalence of obesity in Korean children and adolescents has dramatically increased since the last 10-20 years. It is important to initiate prevention efforts early in childhood because prevalence of obesity in adolescence is the strongest predictor of its prevalence in adulthood. Intrauterine life, infancy, and preschool years may comprise the critical periods that are essential for the long-term regulation of energy balance therefore, obesity-prevention strategies should be initiated in utero and continued throughout childhood and adolescence. Families with high-risk children should be provided early education about maintaining normal weight. Encouraging physical activity and, especially, avoiding inactivity, are key challenges in the prevention of future obesity. Schools should be primarily involved in educating parents to discourage their children from excessively watching TV or playing computer games and eating unhealthy snacks and food. The involvement of medical practitioners is also important, especially, in the case of obese parents, obesity prevention strategies should be promoted from the first visit of pregnant women to the physicians. Health professionals can also be involved in obesity prevention because they are ideally equipped to identify young children at risk of obesity. Community and nation-wide efforts to increase awareness and promote environments that encourage physical activity and healthy nutrition are required.