• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2107-2117
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• 2015

Thyroid cancer is the most common endocrine neoplasia. The medullary thyroid carcinoma (MTC) is one of the most aggressive forms of thyroid malignancy,accounting for up to 10% of all types of this disease. The mode of inheritance of MTC is autosomal dominantly and gain of function mutations in the RET proto-oncogene are well known to contribute to its development. MTC occurs as hereditary (25%) and sporadic (75%) forms. Hereditary MTC has syndromic (multiple endocrine neoplasia type 2A, B; MEN2A, MEN2B) and non-syndromic (Familial MTC, FMTC) types. Over the last two decades, elucidation of the genetic basis of tumorigenesis has provided useful screening tools for affected families. Advances in genetic screening of the RET have enabled early detection of hereditary MTCs and prophylactic thyroidectomy for relatives who may not show any symptom sof the disease. In this review we emphasize the main RET mutations in syndromic and non syndromic forms of MTC, and focus on the importance of RET genetic screening for early diagnosis and management of MTC patients, based on American Thyroid Association guidelines and genotype-phenotype correlation.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6485-6488
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• 2014

Research over the years has progressively and sequentially provided near complete resolution of regulators of the DNA repair pathways which are so important for cancer prevention. Ataxia-telangiectasia mutated kinase (ATM), a high-molecular-weight PI3K-family kinase has emerged as a master regulator of DNA damage signaling and extensive cross-talk between ATM and downstream proteins forms an interlaced signaling network. There is rapidly growing scientific evidence emphasizing newly emerging paradigms in ATM biology. In this review, we provide latest information regarding how oxidative stress induced activation of ATM can be utilized as a therapeutic target in different cancer cell lines and in xenografted mice. Moreover, crosstalk between autophagy and ATM is also discussed with focus on how autophagy inhibition induces apoptosis in cancer cells.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1565-1570
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• 2013

Relationships between diet and health have attracted attention for centuries; but links between diet and cancer have been a focus only in recent decades. The consumption of diet-containing carcinogens, including polycyclic aromatic hydrocarbons and heterocyclic amines is most closely correlated with increasing cancer risk. Epidemiological evidence strongly suggests that consumption of dietary phytochemicals found in vegetables and fruit can decrease cancer incidence. Among the various vegetables, broccoli and other cruciferous species appear most closely associated with reduced cancer risk in organs such as the colorectum, lung, prostate and breast. The protecting effects against cancer risk have been attributed, at least partly, due to their comparatively high amounts of glucosinolates, which differentiate them from other vegetables. Glucosinolates, a class of sulphur-containing glycosides, present at substantial amounts in cruciferous vegetables, and their breakdown products such as the isothiocyanates, are believed to be responsible for their health benefits. However, the underlying mechanisms responsible for the chemopreventive effect of these compounds are likely to be manifold, possibly concerning very complex interactions, and thus difficult to fully understand. Therefore, this article provides a brief overview about the mechanism of such compounds involved in modulation of carcinogen metabolising enzyme systems.

• 교육시설 논문지
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• 제23권1호
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• pp.33-42
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• 2016

The majority of school accidents occur due to negligence caused by the student. And there are many accidents caused by inadequate facilities and poor. In order to improve the facilities, a lot of improvement in student life facilities will be preceded conscious about the sense of safety, than the budget. If schools member have a risk recognition through safety training and ongoing attention of all experience-oriented, the occurrence of accidents is significantly reduced. it is needed continuous attentions and careful efforts to improve school facilities. The results were as follows. First, check for accident prevention and the improvement of the school facilities should be made immediately. Second, we need to redefine the standards facilities for school safety accident prevention. Third, the management program is needed to prevented school accident. Fourth, the Hazard identification and risk assessment training is needed.

• 성인간호학회지
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• 제25권3호
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• pp.263-274
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• 2013

Purpose: Clinical nurses are at high risk of incurring hospital violence during their working life. Hospital violence and its outcomes have an impact on the job satisfaction, the recruitment and retention of nurses as well as the quality of care delivered to patients. The purpose of this study was to identify coping styles toward hospital violence in clinical nurses using Q-methodology. Methods: Q-methodology, which analyzes the subjectivity of each type of attitude, and coping styles was used. The 40 selected Q-statements from each of 35 participants were classified into the shape of a normal distribution using a 9-point scale. The collected data were analyzed using the pc-QUANAL program. Results: The results revealed four discrete groups of clinical nurses toward hospital violence: take strong action and promote the recurrence prevention, appear psychosomatic symptoms, investigate the cause and focus on prevention, and request hospital assistance and keep up my duty. Conclusion: The findings indicate that development of nursing intervention program based on the four types could beneficially contribute to the violence prevention in hospital.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7401-7407
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• 2015

Cervical cancer continues to be a serious public health problem in the developing world, including China. Because of its large population with geographical and socioeconomic inequities, China has a high burden of cervical cancer and important disparities among different regions. In this review, we first present an overview of the cervical cancer incidence and mortality over time, and focus on diversity and disparity in access to care for various subpopulations across geographical regions and socioeconomic strata in China. Then, we describe population-based cervical cancer screening in China, and in particular implementation of the National Cervical Cancer Screening Program in Rural Areas (NACCSPRA) and the challenges that this program faces. These include low screening coverage, shortage of qualified health care personnel and limited funds. To improve prevention of cervical cancer and obtain better cancer outcomes, the Chinese government needs to urgently consider the following key factors: reducing disparities in health care access, collecting accurate and broadly representative data in cancer registries, expanding target population size and increasing allocation of government funding for training of personnel, improving health education for women, enhancing quality control of screening services and improving a system to increase follow up for women with positive results.

• 대한안전경영과학회지
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• 제15권2호
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• pp.39-45
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• 2013

Occupational injury rate of Korea recently slides slightly downward after stagnating around 0.7%'s for more than 10 years. To accelerate this trend, injury prevention for small enterprises is crucially important because vast majority of injuries take place in small enterprises. Considering huge number of small enterprises, we need to focus our efforts to type of riskier industries. By analysing detailed injury data, we select type of industries which need our concentrated prevention efforts. Several preventive measures are recommended, after we made literature survey of case studies for small enterprises. The result identifies riskier type of industries including transportation machinery manufacturing industry type(B), woods & veneer manufacturing industry, etc. Safety of machinery, new enterprises less than 2 years in service and new employees serving less than 6 months are in need for focused prevention efforts. To cope with these vulnerable spots, recommended preventive measures include strengthening of machinery safety standards, early assistance for safety to new enterprises, mandatory safety education before employment, etc.

• 농업과학연구
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• 제43권3호
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• pp.320-329
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• 2016

Salmonella is one of the most important food-borne zoonotic pathogens, causing acute or chronic digestive diseases such as enteritis. The acute form of enteritis is common in young pigs of 2 - 4 months of age. The main symptoms include high fever ($41-42^{\circ}C$), loss of appetite, and increased mortality within 2 - 4 days of onset of the disease. It is often the cause of increasing mortality, decreasing growth rate and reducing feed efficiency of piglets. In the case of chronic enteritis in pigs, the main symptom is weight loss due to the continuing severe diarrhea. Salmonella enterica serovar Typhimurium and Salmonella enterica serovar Choleraesuis are typical pig adapted serotypes, which cause one of four major syndromes: enteric fever, enterocolitis/diarrhea, bacteremia and chronic asymptomatic carriage. These syndromes cause a huge economic burden to swine industry by reducing production. Therefore, it is necessary that swine industries should strive to decrease Salmonellosis in pigs in order to reduce economic losses. There are several measures, such as vaccination to prevent salmonellosis, that are implemented differently from country to country. For the treatment of Salmonella, ongoing antibiotic treatment is needed. However constant doses of antibiotics can be a problem because of antibiotic resistance. Therefore, the focus should be made more on prevention than treatment. In this review, we addressed the basic information about Salmonella, route of infection, clinical symptoms, and prevention of Salmonellosis.

• Corrosion Science and Technology
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• 제16권2호
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• pp.85-89
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• 2017

One of the most challenging issues in the oil and gas industry is corrosion assessment and management in subsea structures or equipment. At present, almost all steel pipelines are sensitive to corrosion in harsh working environments, particularly in salty water and sulphur ingress media. Nowadays, the most commonly practiced solution for a damaged steel pipe is to entirely remove the pipe, to remove only a localized damaged section and then replace it with a new one, or to cover it with a steel patch through welding, respectively. Numerous literatures have shown that fiber-reinforced polymer-based composites can be effectively used for steel pipe repairs. Considerable research has also been carried out on the repair of corroded and gouged pipes incorporated with hybrid natural fiber-reinforced composite wraps. Currently, further research in the field should focus on enhanced use of the lesser and highly explored hybrid-biocomposite material for the development in corrosion prevention. A hybrid-biocomposite material from renewable resource based derivatives is cost-effective, abundantly available, biodegradable, and an environmentally benign alternative for corrosion prevention. The aim of this article is to provide a comprehensive review and to bridge the gap by developing a new hybrid-biocomposite with superhydrophobic surfaces.

• 보건교육건강증진학회지
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• 제22권3호
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• pp.13-28
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• 2005

Objectives: The purpose of this paper is to describe the role for public education in mental health promotion, prevention of mental illness and treatment of mental disorders in Canada. Results: A brief history of the changing nature of the way we treat mental disorders in Canada argues for an increasingly critical role for public education. Furthermore, the new understanding of the role of social determinants in prevention of mental illness again necessitates a vital role for public education as the shift in focus moves from exclusively individual-focused health care treatments to creating supportive environments. The roles for mental health public education then become: advocacy for the social determinants of health approach, better understanding of the nature of mental health problems, useful information for self-management, and more knowledge about appropriate treatments. A brief discussion of the structure of the response in Canada provides an overview of national and provincial responsibilities in mental health care with a case study highlighting one community's response to addressing mental disorders. Conclusion : Finally, challenges regarding the most effective educators and the issue of professional expertise embedded in the status quo are discussed.