Browse > Article
http://dx.doi.org/10.7314/APJCP.2014.15.16.6485

Recently Emerging Signaling Landscape of Ataxia-Telangiectasia Mutated (ATM) Kinase  

Farooqi, Ammad Ahmad (Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College)
Attar, Rukset (Department of Obstetrics and Gynecology, Yeditepe University Faculty of Medicine)
Arslan, Belkis Atasever (Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Uskudar University)
Romero, Mirna Azalea (Laboratorio de Farmacologia, Unidad Academica de Medicina, Universidad Autonoma de Guerrero)
ul Haq, Muhammad Fahim (Department of Biochemistry, RLMC)
Qadir, Muhammad Imran (Institute of Molecular Biology and Biotechnology, BZU)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.16, 2014 , pp. 6485-6488 More about this Journal
Abstract
Research over the years has progressively and sequentially provided near complete resolution of regulators of the DNA repair pathways which are so important for cancer prevention. Ataxia-telangiectasia mutated kinase (ATM), a high-molecular-weight PI3K-family kinase has emerged as a master regulator of DNA damage signaling and extensive cross-talk between ATM and downstream proteins forms an interlaced signaling network. There is rapidly growing scientific evidence emphasizing newly emerging paradigms in ATM biology. In this review, we provide latest information regarding how oxidative stress induced activation of ATM can be utilized as a therapeutic target in different cancer cell lines and in xenografted mice. Moreover, crosstalk between autophagy and ATM is also discussed with focus on how autophagy inhibition induces apoptosis in cancer cells.
Keywords
Ataxia-telangiectasia mutated kinase; signalling landscape; cancer therapy;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Bais MV, Ozdener GB, Sonenshein GE, et al (2014). Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways. Oncogene, [Epub ahead of print].
2 Borodkina A, Shatrova A, Abushik P, et al (2014). Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells. Aging (Albany NY), 6, 481-95.
3 Carvalho S, Vitor AC, Sridhara SC, et al (2014). SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint. Elife (Cambridge), 3, e02482.
4 Colis L, Peltonen K, Sirajuddin P, et al (2014). DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response. Oncotarget, 5, 4361-9.
5 Dixit D, Ghildiyal R, Anto NP, et al (2014). Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism. Cell Death Dis, 5, e1212.   DOI
6 Han D, Li SJ, Zhu YT, Liu L, Li MX (2013). LKB1/AMPK/ mTOR signaling pathway in non-small-cell lung cancer. Asian Pac J Cancer Prev, 14, 4033-9.   과학기술학회마을   DOI
7 Lee JH, Guo Z, Myler LR, et al (2014). Direct activation of ATM by resveratrol under oxidizing conditions. PLoS One, 9, e97969.   DOI
8 Lee SH, Cheng H, Yuan Y, et al (2014). Regulation of ionizing radiation-induced adhesion of breast cancer cells to fibronectin by Alpha5beta1 integrin. Radiat Res, 181, 650-8.   DOI
9 Lim CB, Fu PY, Ky N, et al (2014). NF-kappaB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death. BMC Complement Altern Med, 12, 93.
10 Lin CS, Wang YC, Huang JL, Hung CC, Chen JY (2012). Autophagy and reactive oxygen species modulate cytotoxicity induced by suppression of ATM kinase activity in head and neck cancer cells. Oral Oncol, 48, 1152-8.   DOI
11 Liu H, Zhou L, Shi S, et al (2014). Oligosaccharide G19 inhibits U-87 MG human glioma cells growth in vitro and in vivo by targeting epidermal growth factor (EGF) and activating p53/p21 signaling. Glycobiology, 24, 748-65.   DOI
12 Liu L, Yim H, Choi JH, et al (2014). ATM kinase promotes both caspase-8 and caspase-9 activation during TNF-$\alpha$-induced apoptosis of HeLa cells. FEBS Lett, 588, 929-35.   DOI
13 Pandey S, Chandravati (2012). Autophagy in cervical cancer: an emerging therapeutic target. Asian Pac J Cancer Prev, 13, 4867-71.   과학기술학회마을   DOI   ScienceOn
14 Luo GX, Cai J, Lin JZ, et al (2012). Autophagy inhibition promotes gambogic acid-induced suppression of growth and apoptosis in glioblastoma cells. Asian Pac J Cancer Prev, 13, 6211-6.   과학기술학회마을   DOI
15 Luo X, Suzuki M, Ghandhi SA, et al (2014). ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1- sCLU) expression that protects cells against senescence. PLoS One, 9, e99983.   DOI
16 Malbert-Colas L, Ponnuswamy A, Olivares-Illana V, et al (2014). HDMX Folds the Nascent p53 mRNA following Activation by the ATM Kinase. Mol Cell, 54, 500-11.   DOI
17 Pirildar S, Sutlupinar N, Atasever B, et al (2010). Chemical constituents of the different parts of colchicum baytopiorum (Liliaceae) and their cytotoxic activities on K562 and HL60 cell-lines. Pharm Biol, 48, 32-9.   DOI
18 Sasca D, Hahnel PS, Szybinski J, et al (2014). SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia. Blood, 124, 121-33.   DOI
19 Shi M, Zhang T, Sun L, et al (2013). Calpain, Atg5 and Bak play important roles in the crosstalk between apoptosis and autophagy induced by influx of extracellular calcium. Apoptosis, 18, 435-51.   DOI
20 Sun CC, Xu HM, Yuan Y, et al (2014). Riccardin D, a macrocyclic bisbibenzy, inhibits human breast cancer growth through the suppression of telomerase activity. Basic Clin Pharmacol Toxicol, [Epub ahead of print].
21 Wu SH, Wu TY, Hsiao YT, et al (2014). Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways. Am J Chin Med, 42, 729-42.   DOI
22 Toulany M, Mihatsch J, Holler M, Chaachouay H, Rodemann HP. Cisplatin-mediated radiosensitization of non-small cell lung cancer cells is stimulated by ATM inhibition. Radiother Oncol, 111, 228-36.
23 Tripathi DN, Chowdhury R, Trudel LJ, et al (2013). Reactive nitrogen species regulate autophagy through ATM-AMPKTSC2- mediated suppression of mTORC1. Proc Natl Acad Sci USA, 110, E2950-7.   DOI
24 Wang FZ, Fei HR, Cui YJ, et al (2014). The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Apoptosis, 19, 1389-98.   DOI
25 Yan Y, Hein AL, Greer PM, et al (2014). A novel function of HER2/Neu in the activation of G2/M checkpoint in response to $\gamma$-irradiation. Oncogene, [Epub ahead of print].
26 Yang C, Hao J, Kong D, et al (2014). ATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint. Carcinogenesis, [Epub ahead of print].
27 Yao G, Qi M, Ji X, et al (2014). ATM-p53 pathway causes G2/M arrest, but represses apoptosis in pseudolaric acid B-treated HeLa cells. Arch Biochem Biophys, 558, 51-60.   DOI
28 Yousefi S, Perozzo R, Schmid I, et al (2006). Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol, 8, 1124-32.   DOI   ScienceOn
29 Zhang HQ, He B, Fang N, et al (2013). Autophagy inhibition sensitizes cisplatin cytotoxicity in human gastric cancer cell line SGC7901. Asian Pac J Cancer Prev, 14, 4685-8.   과학기술학회마을   DOI
30 Zhang JW, Zhang SS, Song JR, et al (2014). Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. Biochem Pharmacol, 90(3), 265-75.   DOI
31 Zhao L, Chen H, Zhan YQ, et al (2014). Serine 249 phosphorylation by ATM protein kinase regulates hepatocyte nuclear factor-$1{\alpha}$ transactivation. Biochim Biophys Acta, 1839(7), 604-20.   DOI
32 Zhao Z, Yin JQ, Wu MS, et al (2014). Dihydromyricetin activates AMP-activated protein kinase and P38MAPK exerting antitumor potential in osteosarcoma. Cancer Prev Res (Phila), [Epub ahead of print].
33 Zou Y, Wang Q, Li B, Xie B, Wang W (2014). Temozolomide induces autophagy via ATM-AMPK-ULK1 pathways in glioma. Mol Med Rep, 10, 411-6.
34 Marino G, Niso-Santano M, Baehrecke EH, Kroemer G (2014). Self-consumption: the interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol, 15, 81-94.   DOI