• Title/Summary/Keyword: Pressure down

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Comparisons of Renoprotective Activities between White Ginseng Radix and Rootlet in Spontaneously Hypertensive Rats with Diabetes

  • Chung, Sung-Hyun;Ko, Sung-Kwon;Park, Se-Ho
    • The Korean Journal of Physiology and Pharmacology
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    • v.6 no.1
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    • pp.57-61
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    • 2002
  • The renoprotective activities of white ginseng radix and rootlet were compared in spontaneously hypertensive rat (SHR) with diabetes. During oral administration of white ginseng radix (Ginseng Radix Alba, GRA) and white ginseng rootlet (Ginseng Radix Palva, GRP) for four weeks, arterial blood pressure and blood glucose levels were determined at every 10 days. In both GRA- and GRP-treatment groups, arterial blood pressures started to go down after 10 days of administration and maintained throughout the study period. After four weeks administrations of GRA and GRP, diastolic blood pressures were significantly decreased with 17% and 9%, respectively. GRA treatment also decreased blood glucose levels after 10 days of administration when compared with diabetic SHR group. At the end of the experiment, serum creatinine (Scr) and blood urea nitrogen (BUN) were not significantly different between the groups, except 62% higher value of BUN in diabetic SHR group when compared with SHR group. In the diabetic SHR group, the excretion of urinary albumin was increased significantly when compared with SHR. The level of urinary albumin in GRA treated group was markedly reduced when compared with diabetic SHR group $(67.8{\pm}4.7\;vs.\;131.3{\pm}13.5\;mg/24\;h).$ To examine the effects of ginseng radices on an overt diabetic nephropathy, index of kidney hypertrophy and transforming growth $factor-{\beta}1\;(TGF-{\beta}1)$ protein levels were evaluated. The glomerular and tubular cells stained positive for $TGF-{\beta}1$ seemed to be more abundant in diabetic SHR than in those with SHR, and GRA treated rats showed somewhat less $TGF-{\beta}1$ protein in glomerular and tubular cells when compared with diabetic SHR. Our results suggest that GRA might be a useful antihypertensive and antidiabetic agent with renoprotective effect.

Wind Tunnel Test on the Aerodynamic Characteristics of a PARWIG Craft (PARWIG선의 공력특성에 관한 풍동실험)

  • H.H. Chun;J.H. Chang;K.J. Paik;M.S. Shin
    • Journal of the Society of Naval Architects of Korea
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    • v.37 no.3
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    • pp.57-68
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    • 2000
  • The Power Augmented Ram(PAR) effect, which blows the down stream of the propellers into the underside of the wings and hence increases the pressure between the lower surface of the wings and the sea surface, is known significantly to enhance the performance of the WIG concept by reducing the take-off and landing speeds. The aerodynamic characteristics of a 20 passenger PARWIG are investigated by wind tunnel tests with the 1/20 scale model. The efflux of the forward mounted propellers are simulated by jet flows with a blower and duct system. The lift, drag, and pitch moment of the model with various ground clearances, angles of attack and flap angles are measured for the various jet velocities, jet nozzle angles, horizontal and vertical positions of the nozzle, and the nozzle diameters. The aerodynamic characteristics of the PARWIG due to these parametric changes are compared and pertinent discussions are included. It is shown that the proper use of the PAR can increase the lift coefficient of as much as up to 4.

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A NUMERICAL STUDY ON THERMAL DESIGN OF A LARGE-AREA HOT PLATE FOR THERMAL NANOIMPRINT LITHOGRAPHY (나노임프린트 장비용 대면적 열판 열설계를 위한 수치 연구)

  • Park, G.J.;Lee, J.J.;Kwak, H.S.
    • Journal of computational fluids engineering
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    • v.21 no.2
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    • pp.90-98
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    • 2016
  • A numerical study is conducted on thermal performance of a large-area hot plate specially designed as a heating and cooling tool for thermal nanoimprint lithography process. The hot plate has a dimension of $240mm{\times}240mm{\times}20mm$, in which a series of cartridge heaters and cooling holes are installed. The material is stainless steel selected for enduring the high molding pressure. A numerical model based on the ANSYS Fluent is employed to predict the thermal behavior of the hot plate both in heating and cooling phases. The PID thermal control of the device is modeled by adding user defined functions. The results of numerical computation demonstrate that the use of cartridge heaters provides sufficient heat-up performance and the active liquid cooling in the cooling holes provides the required cool-down performance. However, a crucial technical issue is raised that the proposed design poses a large temperature non-uniformity in the steady heating phase and in the transient cooling phase. As a remedy, a new hot plate in which heat pipes are installed in the cooling holes is considered. The numerical results show that the installation of heat pipes could enhance the temperature uniformity both in the heating and cooling phases.

The Development and Application of Sound Quality Index for the Improving Luxury Sound Quality of Road Vehicle Power Window System (차량 윈도우 리프트 음질 고급감 향상을 위한 음질 지수 제작 및 개선에의 응용)

  • Kim, Seonghyeon;Park, Dong Chul;Jo, Hyeonho;Sung, Weonchan;Kang, Yeon June
    • Transactions of the Korean Society for Noise and Vibration Engineering
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    • v.24 no.2
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    • pp.108-116
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    • 2014
  • With the increasing the importance of emotional quality of vehicle, the sound quality of systems with electric motor components has become increasingly important. Electric motors are used for windows, seats, sun roof, mirrors, steering columns, windshield wiper and climate control blowers, etc. In this paper, a study was conducted to identify sound quality factors that contribute to customer's satisfaction and preference of the window lift system. Jury test for subjective evaluation was carried out and sound quality index was developed. Averaged sound pressure level and sharpness were significant factors when glass moves down. Also, maximum loudness at stop section and averaged loudness were significant factor when glass moves up. Next, noise source identification was carried out using beam forming method during glass transferred section and impulsive noise at stop section. Several improvement methods were applied using the source identification result. And finally, the degree of sound quality improvement was judged using sound quality index.

Easy Reproducible Tie-over Dressing using Silastic$^{(R)}$ Drainage (실라스틱(Silastic$^{(R)}$) 배액관을 이용한 간편한 봉합고정 드레싱)

  • Kim, Peter Chan Woo;Park, Sang-Soon;Lee, Yong-Jig;Shim, Jeong-Su;Park, Dae-Hwan
    • Archives of Plastic Surgery
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    • v.37 no.3
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    • pp.313-316
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    • 2010
  • Purpose: Tie-over dressing is widely used to secure skin grafting on face, body, or extremities. It can be a rather complicated task and is not easy to make compressive dressing again if performed in a conventional method. So, we hereby introduce an easy reproducible tie over dressing method. Methods: After completing the skin graft, Cut the silastic drainage longitudinally in half and spread to the grafted skin margin. Drainage is fixed by using the stapes or sutures. A fluffy gauze bolus dressing is placed over a furacin impregnated gauze and wrapped around. After suturing the distal margin of silastics with opposite side using the silk thread either 5 - 0 or 3 - 0, knot of suturing, which is pressed down against the dressing while the threads are tightened, is made into center of each sides. Results: It can make dressing again after observing the grafted skin, and it can also make pressure on the grafted area evenly until the grafted skin is taken. Conclusion: This dressing method makes the surgeons and patients comfortable. To surgeons, it provides more rapid and easier way to do dressing, and to patients, it eliminates pain caused by redressing.

Experimental Study to Examine Wear Characteristics and Determine the Wear Coefficient of Ductile Cast Iron (DCI) Roll (Ductile Cast Iron (DCI) 롤의 마모 특성 고찰 및 마모계수 도출을 위한 실험적 연구)

  • Byon, Sang-Min
    • Tribology and Lubricants
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    • v.33 no.3
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    • pp.98-105
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    • 2017
  • A pin-on-disk test is performed to measure the wear volume of a ductile cast iron (DCI) roll when it wears down using a high carbon steel and two alloy steels at different sliding velocities between the roll and the material (steel). Normal pressure is set as constant and test temperatures are 400, 500 and $600^{\circ}C$. In addition, thermal softening behavior of the DCI roll is examined using a high-temperature micro-hardness tester and the surface hardness variation of the DCI roll is expressed in terms of temperature and heating time. Based on experimental data, a wear coefficient used in Archard's wear model for each material is obtained. The wear volume is clearly observed when the test temperature is $400^{\circ}C$ and sliding velocity varies. However, it is not measured at temperatures of $500^{\circ}C$ and $600^{\circ}C$ even with variations in sliding velocity. From the optical photographs of the pin and disk, the abrasive wear is observed at $400^{\circ}C$ clearly, but no at $500^{\circ}C$ and $600^{\circ}C$. At higher temperatures, the pin surface is not smooth and has many tiny caves distributed on it. It is found that wear volume is dependent on the carbon contents rather than alloy contents. Results also reveal that the variations of wear coefficients are almost linearly proportional to the carbon contents of the material.

Emergency Treatment and Nursing Activities of Severe Trauma Patients according to Elapsed Time and Vital Signs (중증외상환자의 치료경과 시간과 활력징후에 따른 응급처치 및 간호활동)

  • Kim, Myung Hee;Park, Jung Ha;Kim, Myung Hee;Koo, Ji Ehun
    • Journal of Korean Biological Nursing Science
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    • v.16 no.3
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    • pp.182-191
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    • 2014
  • Purpose: The aim of this study was to identify necessary emergency treatment and nursing activities for severe trauma patients according to elapsed time and vital signs. Methods: A survey was conducted with 121 patients over 15 points ISS on EMR from June 1, 2011 to May 31, 2012. Collected data were analyzed with descriptive statistics, applying McNemar's test using SPSS 12.0. Results: Almost all of the subjects were men and the mean age was 46.9. Run-time for primary diagnosis, treatment decision, and leaving for the hospital room was 0.19, 4.36, and 4.21 hours, respectively, and stayover time was 9 hours. Regardless of vital signs, emergency treatments involving ambu-bagging, intubation, ventilator, and central vein catheterization insertion were offered within an hour. Central venous pressure, Foley catheter/Levin tube preparation and maintenance were performed in cases of unstable vital sign patients within an hour. Unrelated to vital signs, nursing activities for consciousness assessment, skin assesment and wound care, bed sore/fall down assesment and care, intravenous injection insertion and maintenance were conducted for all severe trauma patients within an hour. Foley catheter/Levin tube drainage care was performed for patients who had unstable vital signs within an hour. Conclusion: Emergency treatment and nursing activities for severe trauma patients were specific according to elapsed time and vital signs.

The Effect of refrigerant pass & distribution in aluminum parallel flow heat exchanger (알루미늄 평행류 열교환기에서 냉매패스와 분배량 변화의 영향)

  • Kim, Jeong-Sik;Kim, Nae-Hyun;Kim, Kwang-Hee
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.10 no.12
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    • pp.3546-3552
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    • 2009
  • In this study, an analysis code was created for a 190*650*25-mm (W*H*D) parallel-flow evaporator, and research was done on how to increase the heat transfer rate of aluminum PF heat exchanger for application in IDU. After varying the R410A refrigerant up-down flow to two and three passes and the distribution ratio to 1:1:1 and 1:2:2, it was determined that the two-pass flow has a 30% higher partial heat transfer rate and a 25% lower heat transfer coefficient compared to the three-pass flow. As for the distribution ratios of the three-pass flow, 1:1:1 was found to have a lower refrigerant pressure loss than 1:2:2 distribution. It was assumed, though, that the refrigerant distribution had a uniform flow and that its value was thus overestimated in the actual case of maldistribution in each pass.

The Shape Optimization of a Torque Converter Lock-up Clutch Using the B-Spline and Finite Element Mesh Smoothing (B-Spline 및 유한요소 유연화법 활용 자동차 록업클러치의 형상최적화)

  • Hyun, Seok-Jeong;Kim, Cheol;Son, Jong-Ho;Shim, Se-Hyun;Jang, Jae-Duk;Joo, In-Sik
    • Transactions of the Korean Society of Automotive Engineers
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    • v.12 no.3
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    • pp.101-108
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    • 2004
  • A FEM-based efficient method is developed for the shape optimization of 2-D structures. The combined SLP and Simplex method are coupled with finite element analysis. Selected set of master nodes on the design boundaries are employed as design variables and assigned to move towards their normal directions. The other nodes along the design boundaries are grouped into the master node. By interpolating the repositioned master nodes, the B-spline curves are formed so that the rest mid-nodes efficiently settle down on the B-spline curves. Mesh smoothing scheme is also applied for the nodes on the design boundary to maintain most finite elements in good quality. Finally, a numerical implementation of optimum design of an automobile torque converter piston subjected to pressure and centrifugal loads is presented. The results shows additional weight up to 13% may be saved after the shape optimization.

The Effect of Adaptation to Sound Intensity on the Neural Metabolism in Auditory Pathway: Small Animal PET Study (소동물 [F-18]FDG 양전자단층촬영 기법을 이용한 청각신경에서의 소리크기에 대한 적응효과 연구)

  • Jang, Dong-Pyo
    • Journal of Biomedical Engineering Research
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    • v.32 no.1
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    • pp.55-60
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    • 2011
  • Although sound intensity is considered as one of important factors in auditory processing, its neural mechanism in auditory neurons with limited dynamic range of firing rates is still unclear. In this study, we examined the effect of sound intensity adaptation on the change of glucose metabolism in a rat brain using [F-18] micro positron emission tomography (PET) neuroimaging technique. In the experiment, broadband white noise sound was given for 30 minutes after the [F-18]FDG injection in order to explore the functional adaptation of rat brain into the sound intensity levels. Nine rats were scanned with four different sound intensity levels: 40 dB, 60 dB, 80 dB, 100 dB sound pressure level (SPL) for four weeks. When glucose uptake during the adaptation of a high intensity sound level (100 dB SPL) was compared with that during adaptation to a low intensity level (40 dB SPL) in the experiment, the former induced a greater uptake at bilateral cochlear nucleus, superior olivary complexes and inferior colliculi in the auditory pathway. Expectedly, the metabolic activity in those areas linearly increased as the sound intensity level increased. In contrast, significant decrease interestingly occurred in the bilateral auditory cortices: The activities of auditory cortex proportionally decreased with higher sound intensities. It may reflect that the auditory cortex actively down-regulates neural activities when the sound gets louder.