• The Journal of Korean Physical Therapy
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• v.28 no.3
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• pp.201-204
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• 2016

Purpose: The purpose of this study was to compare the immediate effects of alternative treatment methods in lowering the blood pressure and pulse of prehypertensive patients. Methods: A total of 48 prehypertensive patients were randomly divided into 4 groups of 12 patients and each group received a different intervention. The control group was made to rest, the heat pack (HP) group received heat pack treatment, the ultrasound (US) group received an ultrasound massage, and the myofascial release (MFR) group received myofascial release. The blood pressure and pulse rate were measured before and after intervention. Results: Following intervention, the patients of the MFR group showed a decrease in systolic pressure, diastolic pressure, and pulse rate. Although blood pressure was similar in all groups, a significant decrease in pulse rate was seen in the MFR group compared to others. Conclusion: The application of MFR was shown to be an effective method for lowering the blood pressure and pulse rate in prehypertensive patients.

• Journal of Preventive Medicine and Public Health
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• v.43 no.1
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• pp.18-25
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• 2010

Objectives: Prehypertension is associated with a higher risk of developing hypertension compared with normotension. Yet, factors predicting the development of hypertension among prehypertensive people are ill-understood. This prospective cohort study was performed to examine if serum gamma-glutamyltrasferase (GGT) within a normal range can predict the future risk of hypertension among prehypertensive adults. Methods: Study subjects were 293 prehypertensive persons >30-years-of-age who participated in a community-based health survey in 2003 and who were followed up in 2008. Sex-specific quartiles of baseline serum GGT were used to examine association with 5-year hypertension incidence. Results: Baseline serum GGT within normal range predicted the risk of developing hypertension for 5 years only in prehypertensive women. Adjusted relative risks were 1.0, 3.7, 3.6, and 6.0 according to quartiles of baseline serum GGT (P for trend <0.01). This pattern was similarly observed in non-drinkers. However, serum GGT was not associated with incident hypertension in men. Different from serum GGT, baseline serum alanine aminotransferase, another well-known liver enzyme, did not predict the risk of incident hypertension in both genders. Conclusions: Even though baseline serum GGT within normal range strongly predicted the future risk of hypertension, it was observed only in women, Although underlying mechanisms of this association are currently unclear, serum GGT can be used to select a high risk group of hypertension in prehypertensive women.

• Journal of Life Science
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• v.19 no.11
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• pp.1568-1574
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• 2009

The purpose of this study was to investigate whether group III muscle afferents play an important role eliciting abnormal blood pressure response mediated during passive muscle stretch in prehypertensive individuals. Eleven middle-aged prehypertensive men (average BP 133/80 mmHg) and nine middle-aged normotensive men (average BP 119/74 mmHg) participated in this study. After 1 min rest baseline data collection, the subject's foot was flexed (dorsiflexion) by an automated cybex for one minute. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), heart rate, stroke volume, cardiac output, and total peripheral resistance were continuously measured on a beat-by-beat basis from a finger via a Finapres device for 1 minute. To evaluate the role of mechanoreflex, a component of exercise pressor reflex, SBP, DBP, and MAP responses over the course of time were examined. The results showed that the pressor response mediated by the muscle mechanoreflex was faster in prehypertensive individuals compared to the normotensive individuals. The substantial pressor response was observed within mean 20 sec of the onset of passive stretch in prehypertension, while mean 45 sec in normotension (p<0.05). It is concluded that excessive pressor response produced during exercise in prehypertension may be due to the dysfunction of the mechano-receptors.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.300-300
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• 1994

$Na^{+}$,$K^{+}$-ATPase activity, $Na^{+}$-dependent phosphorylalion, and [$^3$〕ouabain binding in sarcolemma prepared from 4 week old spontaneously hypertensive rat(SHR) ventricles were compared to the same parameters in sarcolemma from age matched normotensive Wistar-Kyoto(WKY) rat ventricles to examine whether the reduced myocardial $Na^{+}$-pump activity in SHR is an inherited enzymatic defect or a second phenomenon due to sustained hypertension. The total body weights, ventricular weights, and blood pressures were the same for SHR and WKY. No significant differences in sarcolemmal protein content and protein recovery were noted between the two pups. Sarcolemma isolated from SHR ventricles showed sigificantly less $Na^{+}$,$K^{+}$-ATPase activity and number of phosphorylation sites when compared to snrcolemma 1mm the WKY ventricles. Equilibrium binding of [$^3H$〕ouabain and the turnovcr number of myocardial $Na^{+}$,$K^{+}$-ATPast however, wee the same for both groups. These results. indicate that the low affinity(${\alpha}$, or ${\alpha}_1$) isoform for ouabain is reduced in SHR compared to WKY but that the high affinity(${\alpha}$+, or ${\alpha}_2$) isoform is the same in ventricles of SHR and WKY. The reduced amount of at isoform of the $Na^{+}$,$K^{+}$-ATPasc in prehypertensive SHR ventricles may play some pole in the development of hypertension.

• Journal of Nutrition and Health
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• v.54 no.5
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• pp.459-473
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• 2021

Purpose: Although numerous systematic reviews or meta-analysis have reported the hypotensive effects of garlic, the application of these results in the area of functional food is limited. This is because the trials used various garlic preparations and patients with differing hypertensive intensities. To validate the use of garlic powder as a blood pressure lowering functional food, we performed the current meta-analysis, focusing on the study of prehypertensive subjects. Methods: Literature search was carried out using various database up to July 2020, including PubMed, Cochrane, ScienceDirect and Korean studies Information Service System, and each study was screened by pre-stated inclusion/exclusion criteria. We identified nine trials that met the eligibility, of which two studies with moderate or high risk of bias were excluded. Results: Meta-analysis of the seven studies revealed that an intake of garlic powder significantly lowered the systolic blood pressure (SBP) and diastolic blood pressure (DBP) by -6.0 mmHg (95% confidence interval [CI], -11.2, -0.8; p = 0.025) and -2.7 mmHg (95% CI, -5.3, -0.1; p = 0.046), respectively. Shapes of the funnel plot for both SBP and DBP seemed symmetrical, and the Egger's regression revealed no publication bias. Moreover, duration of the intervention period was inversely associated with the pooled effects of garlic powder on SBP (p = 0.019) and DBP (p = 0.019), and this result was supported by the subgroup-analysis. The daily dose of garlic powder, baseline value of each biomarker, and subject number, did not moderate the effects on SBP and DBP. Conclusion: Results of the present meta-analysis indicate that garlic powder supplements are superior to placebo for improving the BP in prehypertensive individuals.

• The Journal of the Society of Stroke on Korean Medicine
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• v.23 no.1
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• pp.25-40
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• 2022

■Objectives This study aimed to collect and analyze clinical studies on the significance of acupuncture in the treatment of hypertension among Korean patients. ■Methods Among Korean patients with a blood pressure (BP) of 120 mmHg or higher and a diastolic BP of 80 mmHg or higher, those, treated with acupuncture only, were included. A literature search was conducted through 'Embase', 'Medline', 'Science and Technology Information Integration Service (NDSL)', 'Traditional Korean Knowledge Portal (OASIS)', 'PubMed', and 'Scopus'. The search keywords were (hypertension OR 'blood pressure') AND acupuncture. The papers, published before the day of the search (02. January 2022), were included in this study. ■Results Among the 12 selected papers, seven involved randomized controlled trial (RCT), four before-and-after studies, and one case series. The number of RCTs has increased yearly. The treatment methods used in the studies included needle acupuncture in eight studies, auricular acupuncture in two, pharmacopuncture in one, and si-acupuncture in one. The average numbers of patients enrolled in RCTs, before-and-after studies, and case series were 21.1, 30, and 23 respectively. Six studies were conducted on prehypertensive patients, two on stage 1 hypertension patients, and four on stage 2 hypertension patients. The involved acupoints have been reported to be ST36 in eight papers, LI11 in four papers, and PC6 in three papers. The treatment period lasted for < 1 week in eight studies and 8 weeks in four studies. Acupuncture successfully lowered blood pressure in nine out of 12 studies ■Conclusions Acupuncture is a viable alternative treatment option for prehypertensive patients, who are not taking medications. Additionally, it is also useful in further lowering the BP of patients with stage 1 and stage 2 hypertension in the short term. Large-scale and long-term studies on acupuncture for hypertension should be conducted.

• Korean Journal of Human Ecology
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• v.21 no.1
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• pp.141-149
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• 2012

This study investigates the effects of wear training on blood pressure and blood lipid profiles. For the purpose of this research, 'wear training' refers to the alternating stimulation of temperature while using specific clothing under controlled situations ($18.8{\pm}0.2^{\circ}C$, $38{\pm}3%RH$). The participants alternated between two different garments producing a $1.5^{\circ}C$ difference in the innerest microclimate temperature over a period of 4 weeks. The experiments in this study were conducted in a comfortable environment after sufficient rest. The results were as follows. The systolic blood pressure and mean arterial pressure were lower in the post test than in the pre test (p<.05). The atherogenic index (AI) was also reduced and the LDL-C/HDL-C ratio increased (p<.05) in the post test. These results demonstrated that wear training positively affected improvement in vascular stiffness.

• Archives of Pharmacal Research
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• v.17 no.4
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• pp.226-230
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• 1994

The characteristics of voltage-dependent ^{45}Calcium$ uptake and norepinephrine release as factors controlling neural activities in the hypothalamus which is an important regulatory site for cardiovascular function wre studied. Two groups of animals : male spontaneously hyperterisive rat (SHR) and age-matched nomotensive wistar rat (NW) were used in this study. Animals at 4, 6 and 16 weeks of age were sacrificed by decapitiation and the hypothalamus was dissected out. Voltage-dependent calcium uptake and norepinephrine release were determined from hypothalamic synaptosomes either in low potassium (5 mM) or high potassium (41 mM) stimulatory conditions by using ^{45}Ca$ isotope and HPLC-ECD techniques. Degrees of voltage-dependent ^{45}Calcium$ uptake and norepinephrine release evoked by calcium uptake in the hypothalamus of prehypertensive phase (4 weeks old) of SHR were significantly smaller than those in NW of the same age. However, in the developmental phase (6 weeks old) and the established phase (16 weeks old) of hyperrtension in SHR, degrees of voltage-dependent ^{45}Calcium$ uptake and norepinephrine release were similar to those of age-matched normotensive wistae eats. These data imply that the deficit in hypothalamic norepinephrine release might be an important underlying factor for the development of hypertension in SHR.

• Journal of Korean Biological Nursing Science
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• v.10 no.2
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• pp.121-130
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• 2008

Purpose: This study was undertaken to identify stroke risk with risk factors and knowledge of stork in women with prehypertension. Methods: A total of 46 pre-hypertensive women in urban area aged 44.8 (SD 11.4) yr old in average were selected by a convenient sampling. Demographic data, risk factors, and knowledge of stroke were assessed through face to face interview. Stroke risk scores were calculated based on points given to age, systolic blood pressure, smoking, DM, and heart disease in Framingham stroke risk score. Data were analyzed by SPSS WIN 12.0 using descriptive statistics, two sample t-test, and Pearson's correlation coefficient. Results: The mean systolic blood pressure of participants was 133.11 mmHg, and HDL cholesterol was lower than the recommended level, although rest of physiologic risk factors were within normal. Of the participants, 82% did not do regular physical activity and 75% did not control fat intake persistently. Mean stroke risk points and knowledge scores were 4.48 and 29.15, respectively, which were significantly different between women with and without persistent controlling fat intake. Conclusion: Results indicate stroke prevention intervention for prehypertensive women should address comprehensively modifying lifestyle as well as physiologic factors, and information focusing on stroke risk factors and warning symptoms.

• Journal of Korean Public Health Nursing
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• v.20 no.1
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• pp.28-38
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• 2006

Purpose: To explore the level of health status and health promotion lifestyle, and the group differences in health promotion lifestyle among Seoul citizens who participated in free hypertension screening. Methods: This study was a cross sectional descriptive design. The administered questionnaire included the Health-Promoting Lifestyle Profile II (HPLP II), perceived health status scale, and demographic questions. Blood pressure was measured by researcher teams. Data were collected from July 2 to 6, 2004 in the waiting area of subway stations 7 in Seoul. The study subjects were 168 adults. Results: The average age of the respondents was 55.45 years and 38.7% of them perceived themselves as healthy, while 44% did not know their own blood pressure. Among the participants, 44.6% were classified as 'prehypertensive', and 36.9% as having high blood pressure. The mean score of health promotion lifestyle was 2.62 and the order of subcategories of health promotion lifestyle was interpersonal relationship, spiritual growth, nutrition, stress management, physical activities, and health responsibilities. The subcategories of health promotion lifestyle differed significantly by age, sex, job, and smoking. Conclusions: It is important to encourage adults to participate actively in health promotion. In addition, health promotion programs should be developed and implemented based on group differences.