• BMB Reports
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• 제37권6호
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• pp.648-656
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• 2004

This paper deals with the development of a predictive probabilistic model, a composite dependency-reflecting model (CDRM), which was designed to detect core promoter regions and transcription start sites (TSS) in vertebrate genomic DNA sequences, an issue of some importance for genome annotation. The model actually represents a combination of first-, second-, third- and much higher order or long-range dependencies obtained using the expanded maximal dependency decomposition (EMDD) procedure, which iteratively decomposes data sets into subsets on the basis of dependency degree and patterns inherent in the target promoter region to be modeled. In addition, decomposed subsets are modeled by using a first-order Markov model, allowing the predictive model to reflect dependency between adjacent positions explicitly. In this way, the CDRM allows for potentially complex dependencies between positions in the core promoter region. Such complex dependencies may be closely related to the biological and structural contexts since promoter elements are present in various combinations separated by various distances in the sequence. Thus, CDRM may be appropriate for recognizing core promoter regions and TSSs in vertebrate genomic contig. To demonstrate the effectiveness of our algorithm, we tested it using standardized data and real core promoters, and compared it with some current representative promoter-finding algorithms. The developed algorithm showed better accuracy in terms of specificity and sensitivity than the promoter-finding ones used in performance comparison.

• Communications for Statistical Applications and Methods
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• 제24권1호
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• pp.67-80
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• 2017

Over the last few decades, ensemble forecasts based on global climate models have become an important part of climate forecast due to the ability to reduce uncertainty in prediction. Moreover in ensemble forecast, assessing the prediction uncertainty is as important as estimating the optimal weights, and this is achieved through a probabilistic forecast which is based on the predictive distribution of future climate. The Bayesian model averaging has received much attention as a tool of probabilistic forecasting due to its simplicity and superior prediction. In this paper, we propose a new Bayesian model averaging method for probabilistic ensemble forecasting. The proposed method combines a deterministic ensemble forecast based on a multivariate regression approach with Bayesian model averaging. We demonstrate that the proposed method is better in prediction than the standard Bayesian model averaging approach by analyzing monthly average precipitations and temperatures for ten cities in Korea.

• 대한인간공학회지
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• 제5권2호
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• pp.11-15
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• 1986

In this paper, we consider the validity of a human probabilistic learning model applied to the perdiction of errors associated with the absolute identification of tones. It is shown that the probabilistic learning model describes the human error process adequately. The model parameters are estimated by two methods which are the method of maximum likelihood, and the method of mement. The MLE version of the model has the better predictive power but the ME version is more readily obtainable and may be more practical.

• 한국건설관리학회논문집
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• 제17권5호
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• pp.13-21
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• 2016

주수급자 역할을 하는 건설기업의 부실화는 발주자에게 공사계약 미이행에 따른 피해를 초래할 수 있고, 전문건설업체 및 자재공급업체의 재무건전성에 악영향을 줄 수 있다. 건설업은 프로젝트를 수주하고 진도에 따라 기성을 받는 현금흐름의 재무적 특성이 존재하고, 사업 진행 중의 부실화는 투입한 자금의 손실로 이어질 수 있으므로 건설업체의 부실화 예측은 중요하다. 국내 건설업체의 부실화 예측은 90년도 초 미국에서 개발된 KMV (Kealhofer McQuown and Vasicek)사의 KMV모형으로 수행되는 경우도 있지만, 이 모형은 일반적인 기업 및 은행의 신용위험 평가에 개발되어져 건설기업 예측력에는 부족함이 있다. 또한, KMV값의 부도확률 예측력에 대해서는 분석대상의 기업수 및 데이터의 부족으로 의문점이 지속적으로 제기되고 있다. 따라서 이러한 의문점을 해결하기 위해 기존 부도예측확률모형에 베이지안 확률적 접근법(Bayesian Probabilistic Approach)을 접목하고자 한다. 베이즈 통계학의 사전확률(Prior Probability)만 적절하게 예측가능하다면 적은 정보라도 증거에 대한 조건부 획득으로 신뢰성 있는 사후확률(Posterior Probability)을 예측할 수 있기 때문이다. 이에 본 연구에서는 기존 부도예측확률모형에 베이지안 확률적 접근법을 활용하여 예상부도확률(Expected Default Frequency, EDF)을 측정하고, 기존 모형의 예상부도확률과 비교하여 정확성을 예측하고자 한다.

• Asian-Australasian Journal of Animal Sciences
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• 제32권2호
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• pp.274-281
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• 2019

Objective: The objective of this study was to estimate the risk of Campylobacter jejuni (C. jejuni) infection from various jerky products in Korea. Methods: For the exposure assessment, the prevalence and predictive models of C. jejuni in the jerky and the temperature and time of the distribution and storage were investigated. In addition, the consumption amounts and frequencies of the products were also investigated. The data for C. jejuni for the prevalence, distribution temperature, distribution time, consumption amount, and consumption frequency were fitted with the @RISK fitting program to obtain appropriate probabilistic distributions. Subsequently, the dose-response models for Campylobacter were researched in the literature. Eventually, the distributions, predictive model, and dose-response model were used to make a simulation model with @RISK to estimate the risk of C. jejuni foodborne illness from the intake of jerky. Results: Among 275 jerky samples, there were no C. jejuni positive samples, and thus, the initial contamination level was statistically predicted with the RiskUniform distribution [RiskUniform (-2, 0.48)]. To describe the changes in the C. jejuni cell counts during distribution and storage, the developed predictive models with the Weibull model (primary model) and polynomial model (secondary model) were utilized. The appropriate probabilistic distribution was the BetaGeneral distribution, and it showed that the average jerky consumption was 51.83 g/d with a frequency of 0.61%. The developed simulation model from this data series and the dose-response model (Beta Poisson model) showed that the risk of C. jejuni foodborne illness per day per person from jerky consumption was $1.56{\times}10^{-12}$. Conclusion: This result suggests that the risk of C. jejuni in jerky could be considered low in Korea.

• 한국축산식품학회지
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• 제39권4호
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• pp.565-575
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• 2019

This study evaluated Campylobacter jejuni risk in ground meat products. The C. jejuni prevalence in ground meat products was investigated. To develop the predictive model, survival data of C. jejuni were collected at $4^{\circ}C-30^{\circ}C$ during storage, and the data were fitted using the Weibull model. In addition, the storage temperature and time of ground meat products were investigated during distribution. The consumption amount and frequency of ground meat products were investigated by interviewing 1,500 adults. The prevalence, temperature, time, and consumption data were analyzed by @RISK to generate probabilistic distributions. In 224 samples of ground meat products, there were no C. jejuni-contaminated samples. A scenario with a series of probabilistic distributions, a predictive model and a dose-response model was prepared to calculate the probability of illness, and it showed that the probability of foodborne illness caused by C. jejuni per person per day from ground meat products was $5.68{\times}10^{-10}$, which can be considered low risk.

• 한국축산식품학회지
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• 제32권1호
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• pp.62-67
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• 2012

This study calculated kinetic parameters of Escherichia coli O157:H7 and developed a probabilistic model to estimate growth probabilities of E. coli O157:H7 on polyethylene cutting boards as a function of temperature and time. The surfaces of polyethylene coupons ($3{\times}5$ cm) were inoculated with E. coli O157:H7 NCCP11142 at 4 Log $CFU/cm^2$. The coupons were stored at 13 to $35^{\circ}C$ for 12 h, and cell counts of E. coli O157:H7 were enumerated on McConkey II with sorbitol agar every 2 h. Kinetic parameters (maximum specific growth rate, Log $CFU/cm^2/h$; lag phase duration, h; lower asymptote, Log $CFU/cm^2$; upper asymptote, Log $CFU/cm^2$) were calculated with the modified Gompertz model. Of 56 combinations (temperature${\times}$time), the combinations that had ${\geq}$0.5 Log $CFU/cm^2$ of bacterial growth were designated with the value of 1, and the combinations that had increases of <0.5 Log $CFU/cm^2$ were given the value 0. These growth response data were fitted to the logistic regression to develop the model predicting probabilities of E. coli O157:H7 growth. Specific growth rate and growth data showed that E. coli O157:H7 cells were grown at $28-35^{\circ}C$, but there were no obvious growth of the pathogen below $25^{\circ}C$. Moreover, the developed probabilistic model showed acceptable performance to calculate growth probability of E. coli O157:H7. Therefore, the results should be useful in determining upper limits of working temperature and time, inhibiting E. coli O157:H7 growth on polyethylene cutting board.

• 한국식품위생안전성학회지
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• 제33권3호
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• pp.157-161
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• 2018

본 연구에서는 육제품의 다양한 조건(포장, 저장온도, 염농도, 아질산염농도)에서의 식중독세균의 생장을 예측하는소프트웨어를 예측미생물학에 대한 지식이 부족한 비전문가도 손쉽게 이용할 수 있도록 개발하였다. 육제품에서의 식중독세균예측소프트웨어(FAME: Foodborne bacteria Animal product Modeling Equipment)는 Javascript와 HTML을 이용하여 개발하였으며, 육제품에 대한 카이네틱모델과 확률모델을 포함하고있다. FAME에서는 검증(validation) 기능을 포함하고 있으며, FAME에 탑재 되어있는 예측모델의 수식을 자유롭게 수정할 수 있도록 고안 하였다. FAME에는 포장조건, 온도, 염농도, 아질산염농도 조합에 따라 실험한 데이터를 카이네틱모델(5,400 데이터)과 확률모델(345,600 데이터)에 탑재하였다. 사용자가 FAME을 이용하여 육제품의 제조 조건을 소프트웨어에 입력하면, 시간에 따른 식중독세균의 생장패턴과 생장확률이 즉시 계산 되어진다. 따라서 예측 미생물학에 대한 전문 지식이 없는 비전문가라고 하더라도 FAME을 이용하여 직접 실험을 하지 않고도 육제품에서의 식중독세균의 생장을 쉽고 빠르게 예측할 수 있어, 육가공분야에서 매우 유용하게 사용되어 질 수 있을 것으로 판단된다.

• 한국안전학회지
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• 제18권2호
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• pp.104-118
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• 2003

It has been criticized that conventional human reliability analysis (HRA) methodologies for probabilistic safety assessment (PSA) have been focused on the quantification of human error probability (HEP) without detailed analysis of human cognitive processes such as situation assessment or decision-making which are crticial to successful response to emergency situations. This paper introduces a new human reliability analysis (HRA) methodology, AGAPE-ET (A guidance And Procedure for Human Error Analysis for Emergency Tasks), focused on the qualitative error analysis of emergency tasks from the viewpoint of the performance of human cognitive function. The AGAPE-ET method is based on the simplified cognitive model and a taxonomy of influencing factors. By each cognitive function, error causes or error-likely situations have been identified considering the characteristics of the performance of each cognitive function and influencing mechanism of PIFs on the cognitive function. Then, overall human error analysis process is designed considering the cognitive demand of the required task. The application to an emergency task shows that the proposed method is useful to identify task vulnerabilities associated with the performance of emergency tasks.

• Earthquakes and Structures
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• 제14권3호
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• pp.203-214
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• 2018

Predictive demand and collapse fragility functions are two essential components of the probabilistic seismic demand analysis that are commonly developed based on statistics with enormous, costly and time consuming data gathering. Although this approach might be justified for research purposes, it is not appealing for practical applications because of its computational cost. Thus, in this paper, Bayesian regression-based demand and collapse models are proposed to eliminate the need of time-consuming analyses. The demand model developed in the form of linear equation predicts overall maximum inter-story drift of the lowto mid-rise regular steel moment resisting frames (SMRFs), while the collapse model mathematically expressed by lognormal cumulative distribution function provides collapse occurrence probability for a given spectral acceleration at the fundamental period of the structure. Next, as an application, the proposed demand and collapse functions are implemented in a seismic fragility analysis to develop fragility and consequently seismic demand curves of three example buildings. The accuracy provided by utilization of the proposed models, with considering computation reduction, are compared with those directly obtained from Incremental Dynamic analysis, which is a computer-intensive procedure.