• 대한방사성의약품학회지
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• 제7권2호
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• pp.153-159
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• 2021

This article provides an efficient ¹⁸F-labeling protocol based on a rapid condensation reaction between 2-cyanobenzothiazole (CBT) and N-terminal cysteine-containing biomolecules. The ¹⁸F-labeled CBT (¹⁸F-1) was prepared by radiofluorination of the tosylated precursor 4 with 18-crown-6/K+/[¹⁸F]F- complex. Using the purified ¹⁸F-1, ¹⁸F-labeled peptide (¹⁸F-7) and protein (¹⁸F-8) could be synthesized efficiently under mild conditions. This strategy would provide a convenient approach for rapid and site-specific ¹⁸F-labeling of various peptides and proteins for in vivo imaging and biomedical applications.

• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2005년도 공동학술대회 논문집
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• pp.93-101
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• 2005

본 연구에서는 지진 예지 연구를 위하여 한반도에서 발생한 MMI 진도가 VIII 보다 큰 역사 지진들의 전진들에 대하여 지진활동도의 변화를 분석하였다. 한반도에서의 강진에 대하여 13년의 전진기간과 진앙을 중심으로 위도 $1.1^{\circ}$, 경도 $1.1^{\circ}$ 크기의 사각형 모양의 전진범위를 가정했을 경우 가장 안정적인 전진들의 b값을 도출할 수 있었다. 이 전진기간과 전진범위에 의해 결정된 11개의 MMI 진도 VIII 이상의 강진의 전체 전진들에 대한 b값은 전체 역사지진의 b값인 0.36에 비해 확연히 작은 0.27로 결정되었다. 또한 강진 발생을 앞두고 작은 b값을 가지는 지진들이 강진의 진앙 근처에서 집중적으로 발생하였다. 본 연구를 통해 십 수 년 동안의 b값의 변화를 자세히 관찰함으로써 강진의 예지가 가능하다는 것이 확인되었다.

• 지구물리
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• 제8권3호
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• pp.115-121
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• 2005

본 연구에서는 지진 예지 연구를 위하여 한반도에서 발생한 MMI 진도가 VIII 보다 큰 역사 지진들의 전진들에 대하여 지진활동도의 변화를 분석하였다. 한반도에서의 강진에 대하여 13년의 전진기간과 진앙을 중심으로 위도 1.1o, 경도 1.1o 크기의 사각형 모양의 전진범위를 가정했을 경우 가장 안정적인 전진들의 b값을 도출할 수 있었다. 이 전진기간과 전진범위에 의해 결정된 11개의 MMI 진도 VIII 이상의 강진의 전체 전진들에 대한 b값은 전체 역사지진의 b값인 0.36에 비해 확연히 작은 0.27로 결정되었다. 또한 강진 발생을 앞두고 작은 b값을 가지는 지진들이 강진의 진앙 근처에서 집중적으로 발생하였다. 본 연구를 통해 십 수 년 동안의 b값의 변화를 자세히 관찰함으로써 강진의 예지가 가능하다는 것이 확인되었다.

• Journal of Microbiology and Biotechnology
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• 제26권2호
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• pp.233-240
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• 2016

FK506, a widely used immunosuppressant, is a 23-membered polyketide macrolide that is produced by several Streptomyces species. FK506 high-yielding strain Streptomyces sp. RM7011 was developed from the discovered Streptomyces sp. KCCM 11116P by random mutagenesis in our previous study. The results of transcript expression analysis showed that the transcription levels of tcsA, B, C, and D were increased in Streptomyces sp. RM7011 by 2.1-, 3.1-, 3.3-, and 4.1-fold, respectively, compared with Streptomyces sp. KCCM 11116P. The overexpression of tcsABCD g enes in Streptomyces sp. RM7011 gave rise to approximately 2.5-fold (238.1 μg/ml) increase in the level of FK506 production compared with that of Streptomyces sp. RM7011. When vinyl pentanoate was added into the culture broth of Streptomyces sp. RM7011, the level of FK506 production was approximately 2.2-fold (207.7 μg/ml) higher than that of the unsupplemented fermentation. Furthermore, supplementing the culture broth of Streptomyces sp. RM7011 expressing tcsABCD genes with vinyl pentanoate resulted in an additional 1.7-fold improvement in the FK506 titer (498.1 μg/ml) compared with that observed under non-supplemented condition. Overall, the level of FK506 production was increased approximately 5.2-fold by engineering the supply of allylmalonyl-CoA in the high-yielding strain Streptomyces sp. RM7011, using a combination of overexpressing tcsABCD genes and adding vinyl pentanoate, as compared with Streptomyces sp. RM7011 (95.3 μg/ml). Moreover, among the three precursors analyzed, pentanoate was the most effective precursor, supporting the highest titer of FK506 in the FK506 high-yielding strain Streptomyces sp. RM7011.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2012년도 춘계학술발표대회
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• pp.65-65
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• 2012

Copper zinc tin sulfide ($Cu_2ZnSnS_4$, CZTS) is a very promising material as a low cost absorber alternative to other chalcopyrite-type semiconductors based on Ga or In because of the abundant and economical elements. In addition, CZTS has a band-gap energy of 1.4~1.5eV and large absorption coefficient over ${\sim}10^4cm^{-1}$, which is similar to those of $Cu(In,Ga)Se_2$(CIGS) regarded as one of the most successful absorber materials for high efficient solar cell. Most previous works on the fabrication of CZTS thin films were based on the vacuum deposition such as thermal evaporation and RF magnetron sputtering. Although the vacuum deposition has been widely adopted, it is quite expensive and complicated. In this regard, the solution processes such as sol-gel method, nanocrystal dispersion and hybrid slurry method have been developed for easy and cost-effective fabrication of CZTS film. Among these methods, the hybrid slurry method is favorable to make high crystalline and dense absorber layer. However, this method has the demerit using the toxic and explosive hydrazine solvent, which has severe limitation for common use. With these considerations, it is highly desirable to develop a robust, easily scalable and relatively safe solution-based process for the fabrication of a high quality CZTS absorber layer. Here, we demonstrate the fabrication of a high quality CZTS absorber layer with a thickness of 1.5~2.0 ${\mu}m$ and micrometer-scaled grains using two different non-vacuum approaches. The first solution-processing approach includes air-stable non-toxic solvent-based inks in which the commercially available precursor nanoparticles are dispersed in ethanol. Our readily achievable air-stable precursor ink, without the involvement of complex particle synthesis, high toxic solvents, or organic additives, facilitates a convenient method to fabricate a high quality CZTS absorber layer with uniform surface composition and across the film depth when annealed at $530^{\circ}C$. The conversion efficiency and fill factor for the non-toxic ink based solar cells are 5.14% and 52.8%, respectively. The other method is based on the nanocrystal dispersions that are a key ingredient in the deposition of thermally annealed absorber layers. We report a facile synthetic method to produce phase-pure CZTS nanocrystals capped with less toxic and more easily removable ligands. The resulting CZTS nanoparticle dispersion enables us to fabricate uniform, crack-free absorber layer onto Mo-coated soda-lime glass at $500^{\circ}C$, which exhibits a robust and reproducible photovoltaic response. Our simple and less-toxic approach for the fabrication of CZTS layer, reported here, will be the first step in realizing the low-cost solution-processed CZTS solar cell with high efficiency.

• Bulletin of the Korean Chemical Society
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• 제21권9호
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• pp.867-874
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• 2000

Two new azobenzene crown ether calix[4]arenes, 10 and 11, were synthesized by two pathways. In the first pathway,two ethoxy nitrobenzene groups were attached to t-butylcalix[4]arenes in a 1,3 position. Subsequent reduction ofthe nitrobenzene group s by metallic zinc in an alkaline solution afforded 10 and 11 in8% and 12%,respectively. In the second pathway,an azobenzene containing two glycolic units was prepared prior connect-ing to t-butylcalix[4]arenes. The yields from the second approach (5%, 8% for 10 and 11, respectively) were lower than those from the former approach. Single crystals of 10 suitable for X-ray crystallography was ob-tained by recrystallization in methanol.Both the X-ray structure and the 1H-NMR spectrum of 10 indicated that the stereoisomer of the azobenzene moiety was trans and the calixarene platform was in cone conformation. 1H NMR spectroscopy suggested that 10 underwent an observable cis-trans isomerization in CDCl3 under room light and upon UV irradiation with cis:trans ratios of 33:67 and 36:64,respectively. Compound 6 which was the precursor of 11showed fluxional behavior and was found to have mixed conformations ofcone and partial cone with a ratio of 47:53 at -30 $^{\circ}C.$ 1H NMR spectrum of 11 suggested that 11 was initially isolated as cis azobenzene with calix[4]arene in cone conformation and underwent conformational interconversion through calix[4]arene annulas in a similar fashion to 6 upon exposing to light. The complexation studies of 10 with picrate salts of Na+ and K+ using 1H NMR spectroscopysuggested that Na+ preferred to bind the cis form of 10 while K+ preferred to bind the trans form. The stereoisomer of the azobenzene unit in 11 changed partially from cis to trans upon complexing with K+.

• 한국항행학회논문지
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• 제28권2호
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• pp.185-192
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• 2024

항공산업은 기술적인 혁신을 통해 안전성을 향상했으며, 항공 당국의 안전 규제와 감독을 통해 비행안전을 강화해 왔다. 항공산업의 안전 접근 방식이 항공기 시스템 전체에 대한 체계적인 접근 방식으로 발전함으로써 항공사는 새로운 안전 관리시스템을 구축하게 되었다. 항공기의 기술적 결함이나 비정상적인 데이터는 사고로 이어질 수 있는 전조 징후가 될 수 있으며, 이러한 징후를 조기에 식별하고 대처함으로써 사고 발생의 위험을 감소시킬 수 있다. 따라서 비정상적인 전조 징후의 관리는 데이터 기반 의사결정을 촉진하고, 항공사의 운영 효율성 및 안전수준을 강화하는 데 있어 필수적인 요소이다. 본 연구에서는 항공기 착륙 시에 활주로 이탈로 이어질 수 있는 크랩랜딩 이벤트의 패턴과 원인 분석을 위한 사전적 분석 단계에서 QAR (quick access recorder) 비행 데이터 통계 분석 모델을 제시하여 착륙 이벤트의 전조 징후와 원인을 식별 및 제거하는 안전관리의 효율성을 제고하고자 한다.

• 한국세라믹학회지
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• 제53권3호
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• pp.317-324
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• 2016

Continued miniaturization and increasingly exact requirements for thin film deposition in the semiconductor industry is driving the search for new effective, efficient, selective precursors and processes. The requirements of defect-free, conformal films, and precise thickness control have focused attention on atomic layer deposition (ALD). ALD precursors so far have been developed through a trial-and-error experimental approach, leveraging the expertise and tribal knowledge of individual research groups. Precursors can show significant variation in performance, depending on specific choice of co-reactant, deposition stage, and processing conditions. The chemical design space for reactive thin film precursors is enormous and there is urgent need for the development of computational approaches to help identify new ligand-metal architectures and functional co-reactants that deliver the required surface activity for next-generation thin-film deposition processes. In this paper we discuss quantum mechanical simulation (e.g. density functional theory, DFT) applied to ALD precursor reactivity and state-of-the-art automated screening approaches to assist experimental efforts leading toward optimized precursors for next-generation ALD processes.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
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• pp.125.2-125.2
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• 2016

Semiconductor nanowires are essential building blocks for various nanotechnologies including energy conversion, optoelectronics, and thermoelectric devices. Bottom-up synthetic approach utilizing metal catalyst and vapor phase precursor molecules (i.e., vapor - liquid - solid (VLS) method) is widely employed to grow semiconductor nanowires. Al has received attention as growth catalyst since it is free from contamination issue of Si nanowire leading to the deterioration of electrical properties. Al-catalyzed Si nanowire growth, however, unlike Au-Si system, has relatively narrow window for stable growth, showing highly tapered sidewall structure at high temperature condition. Although surface chemistry is generally known for its role on the crystal growth, it is still unclear how surface adsorbates such as hydrogen atoms and the nanowire sidewall morphology interrelate in VLS growth. Here, we use real-time in situ infrared spectroscopy to confirm the presence of surface hydrogen atoms chemisorbed on Si nanowire sidewalls grown from Al catalyst and demonstrate they are necessary to prevent unwanted tapering of nanowire. We analyze the surface coverage of hydrogen atoms quantitatively via comparison of Si-H vibration modes measured during growth with those obtained from postgrowth measurement. Our findings suggest that the surface adsorbed hydrogen plays a critical role in preventing nanowire sidewall tapering and provide new insights for the role of surface chemistry in VLS growth.

• 대한교통학회지
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• 제23권8호
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• pp.147-152
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• 2005

본 연구에서는 구간의 교통상황을 보다 정확하게 관측할 수 있는 기법 중의 하나인 차량자동인식기법(AVI, Automatic Vehicle Identification)의 성능 요구사항 (performance requirements)을 분석할 수 있는 기법을 처음으로 제시하였다. 미시적 교통시뮬레이터인 Paramics를 이용하여 개별차량의 재인식(re-identification)을 통한 AVI 성능요구사항 분석을 몬테카를로 시뮬레이션을 적용하여 구현하였다. 본 연구에서 제안한 기법은 목표로 설정한 통행시간의 정확도를 달성하기 위한 매칭률(matching rate)과 오매칭률(mis-matching rate)의 조합을 찾고, 나아가 이에 부합하는 AVI 기술을 선정하는데 사용될 수 있다. 본 연구에서 제안한 기법은 AVI를 통한 정확하고 신뢰성 있는 교통정보의 수집 및 가공을 위한 의사결정지원 수단으로 유용하게 사용될 것으로 기대된다.