• Parasites, Hosts and Diseases
• /
• 제61권3호
• /
• pp.231-239
• /
• 2023

Toxoplasma gondii is an intracellular parasitic organism affecting all warm-blooded vertebrates. Due to the unavailability of commercialized human T. gondii vaccine, many studies have been reported investigating the protective efficacy of pre-clinical T. gondii vaccines expressing diverse antigens. Careful antigen selection and implementing multifarious immunization strategies could enhance protection against toxoplasmosis in animal models. Although none of the available vaccines could remove the tissue-dwelling parasites from the host organism, findings from these pre-clinical toxoplasmosis vaccine studies highlighted their developmental potential and provided insights into rational vaccine design. We herein explored the progress of T. gondii vaccine development using DNA, protein subunit, and virus-like particle vaccine platforms. Specifically, we summarized the findings from the pre-clinical toxoplasmosis vaccine studies involving T. gondii challenge infection in mice published in the past 5 years.

• 디지털산업정보학회논문지
• /
• 제8권4호
• /
• pp.99-105
• /
• 2012

Recently, there are many user selection algorithms in multi user multiple-input multiple-output (MU-MIMO) systems. One of well-known user selection methods is Semi orthogonal user selection (SUS). It is an algorithm maximizing channel capacity. However, it is applicable only when user's antenna is one. We propose a generalized user selection algorithm regardless of the number of user's antennas. In the proposed scheme, Base station (Bs) selects the first user who has the highest determinant of channel and generates a user group that correlation with first user's channel is less than allowance of correlation. Then, each determinant of channels made up of first user's channel and a user's channel in the generated group is calculated and BS selects the next user who has the highest determinant of that. BS selects following users by repeating above procedure. In this paper, we get better performance because of selecting users who have the highest determinant of channel as well as allowance of correlation optimally calculated through matrix operations.

• 국제학술발표논문집
• /
• The 2th International Conference on Construction Engineering and Project Management
• /
• pp.662-671
• /
• 2007

Since variety of construction projects with their individual specifications could be handled through different procurement systems, selection of the most appropriate project delivery system is a vital step towards more efficient project execution. The appropriate selection of project delivery system may also ensure more competent management of the project. Its impacts are not only limited to the first stages of the project, as it could also influence pre-construction, construction and operational phases of the project. Among different approaches exerted for this purpose, none has taken uncertainty into account, despite the fact that during first stages of the project most of the selection factors are still uncertain and not clearly defined. This paper, hence, aims to provide a fuzzy insight into the project delivery system selection. Through this approach more tangible model of the evaluation process may be presented. Proposed fuzzy method is indeed a multi criteria decision making model, based on the group of criteria, assigned for the evaluation procedure. A case study is also conducted, based on the opinion of an invented group of the experts.

• 한국주거학회논문집
• /
• 제19권3호
• /
• pp.31-38
• /
• 2008

Recently, Seoul residential real estate market showed a big change, especially in 2007. The residential property price in Seoul had been mainly affected by 5 provideces: Kangnam-gu, Seocho-gu, Songpa-gu, Gangdong-gu and Yangchun-gu, but these providences started to show the decrease in price while the other providences ironically showed the opposite direction. Therefore, this project was derived from this phenomenon recognition and the necessity as the new market trend requires. The pre-research was carried out with the point of social-population academic view, but this project provides the analysis on the new market trend by simplifying the complex valuation indexes, originated from the pre-research. In result, the aspects of the change could be categorized into time-manner classification and territorial-manner classification, in cope with the change in the satisfaction degree on the residential environment and the selection tendency of the residential property. Based on the the moving-preferred area criteria, the territorial classification was categorized into 3 areas: 5 providences, which showed the initial decrease in real estate price (area 1), the other Kangnam area (area 2), and Kangbuk area (area 3). The result illustrated the reasonable change in the satisfaction degree on the residential environment and the selection tendency of the residential property. This project was able to reach the following conclusion : Firstly, the housing development planning should be devised by the residential environment, including the view and the natural environment, not by the area. Secondly, the housing development planning in the other Kangnam area (area 2) and Kangbuk area (area 3) should embrace the business function, not the housing development only. Last, the housing development planning in Kangbuk area (area 3) should be able to enhance education and culture function and be connected by various transportation system. This project analyzes the change in the satisfaction degree on the residential environment and the selection tendency of the residential property. Thereafter, this project has the purpose of providing the aid in understanding of the basis of housing development information.

• The Journal of Asian Finance, Economics and Business
• /
• 제7권1호
• /
• pp.279-290
• /
• 2020

Informal networks between individuals are widely seen as important in East Asian business systems. However, while the performance implications of guanxi in China have been extensively studied, much less is known on how informal networks may influence business outcomes in other East Asian countries. We examine informal networks in inter-organizational research collaborations in South Korea by studying the role of pre-existing social ties and relational orientation in new product development (NPD) collaborations and university-industry research (UIR) collaborations. We conduct an interview-based, in-depth case analysis of five NPD collaborations and five UIR collaborations. Pre-existing social ties and relational orientation are prevalent in both types of research collaborations. However, they have different consequences for collaboration outcomes. Pre-existing social ties strongly vary in their types and strength, and negatively affect collaboration outcomes unless they result in the selection of competent and motivated partners. Relational orientation manifests itself in a task-related and social exchange between collaboration partners, which contributes to outcomes such as knowledge acquisition and business performance. Korean collaboration managers should rely only on pre-existing social ties that are well-aligned with task-related requirements when initiating and conducting research collaborations. However, the creation of strong relationships between collaboration team members of partnering organizations should be encouraged.

• Asia pacific journal of information systems
• /
• 제16권3호
• /
• pp.67-93
• /
• 2006

Some consumers prefer online and others prefer offline. What makes them prefer online or offline? There has been a lack of theoretical development to adequately explain consumers' channel switching behavior between traditional physical stores and new virtual stores. Through consumers' purchase decision processes, this study examined the reasons why consumers changed channels depending on purchase process stages. Consumer's purchase decision process could be divided into three stages: pre-purchase stage, purchase stage, and post-purchase stage. We used the intention of channel selection as a surrogate dependent variable of channel selection. And some constructs, that is, channel function, channel benefits, customer relationship benefits, and perceived behavioral control, were selected as independent variables. In buying look-and-feel products, it was identified that consumers preferred virtual stores to physical stores at pre-purchase stage. To put it concretely, all constructs except channel benefits were more influenced to consumers at virtual stores. This result implied that information searching function, which is a main function at pre-purchase stage, was better supported by virtual stores than physical stores. In purchase stage, consumers preferred physical stores to virtual stores. Specially, all constructs influenced much more to consumers at physical stores. This result implied that although escrow service and trusted third parties were introduced, consumers felt that financial risk, performance risk, social risk, etc. still remained highly online. Finally, consumers did not prefer any channel at post-purchase stage. But three independent variables, i.e. channel function, channel benefits, and customer relationship benefits, were significantly preferred at physical stores rather than virtual stores at post-purchase stage. So we concluded that physical stores were a little more preferred to virtual stores at post-purchase stage. Through this study, it was identified that most consumers might switch channels according to purchase process stages. So, first of all, sales representatives should decide that what benefits should be given them through virtual stores at the pre-purchase stage and through physical stores at the purchase and post-purchase stages, and then devise collaborative channel strategies.

• BMB Reports
• /
• 제54권3호
• /
• pp.176-181
• /
• 2021

Bcl-x, a member of the Bcl-2 family, plays a key role in apoptosis. Alternative splicing of Bcl-x pre-mRNA through alternative 5' splice-site selection produces an anti-apoptotic mRNA isoform that includes exon 2b and a pro-apoptotic Bcl-x mRNA isoform that excludes exon 2b. Here we used Bcl-x minigene and identified SRSF2 and SRSF6 as two regulatory factors of 5' splice-site selection of Bcl-x pre-mRNA. We selected binding clusters closer to 5' splice-sites from multiple potential binding sites of SRSF2 and SRSF6 to perform loss of functions analysis through site-directed mutagenesis. Our results demonstrated that these mutations did not abolish regulatory functions of SRSF2 or SRSF6, indicating that a single binding motif or a cluster was not a functional target of these proteins in Bcl-x pre-mRNA splicing. Random deletion mutagenesis did not disrupt the role of SRSF2 and SRSF6. Importantly, mutagenesis of 5' splice-site to a conserved or a weaker score demonstrated that the weaker strength of the target 5' splice-site or higher strength of the other 5' splice-site strength limited the role of SRSF2 and SRSF6 in 5' splice-site activation.

• Management Science and Financial Engineering
• /
• 제16권2호
• /
• pp.53-65
• /
• 2010

Despite the overall success of neighbor-based CF methods, there are some fundamental questions about neighbor selection and prediction mechanism including arbitrary similarity, over-fitting interpolation weights, no trust consideration between neighbours, etc. This paper proposes a simple method to compute absolute interpolation weights based on similarity values. In order to supplement the method, two schemes are additionally devised for high-quality neighbour selection and trust metrics based on co-ratings. The former requires that one or more neighbour's similarity should be better than a pre-specified level which is higher than the minimum level. The latter gives higher trust to neighbours that have more co-ratings. Experimental results show that the proposed method outperforms the pure IBCF by about 8% improvement. Furthermore, it can be easily combined with other predictors for achieving better prediction quality.

• 한국과학교육학회지
• /
• 제31권6호
• /
• pp.887-900
• /
• 2011

생물교사는 자신의 글과 말을 활용하여 지식을 논리적인 과학적 설명의 형태로 변환하여 학생들을 지도한다. 그러므로 생물 예비교사들이 과학적 설명을 구성하는 능력을 확인할 수 있는 개방형 검사가 요구 될 것이다. 하지만 채점자간 일치도, 늦은 피드백과 같은 개방형 검사가 가진 문제로 선택형 검사가 대체 될 수 있을 것이다. 이 연구는 생물 예비교사들의 과학적 진화 설명 구성 능력을 확인함과 동시에 선택형 진화 개념 검사가 개방형 검사 결과를 어느 정도 예측하는지 두 가지를 조사하였다. 생물 예비교사 124명이 참여하였으며 20문항의 진화 개념 선택형 검사도구와 3문항의 실제 사례를 활용한 개방형 검사 문항을 모든 참여자에게 투입하였다. 연구 결과 생물 예비 교사는 선택형 검사 도구에 더 높은 능력을 보였으며 최상위(0 ~ 25%)의 참여자를 제외하고 선택형 검사 도구는 개방형 검사 도구 검사 결과를 예측하지 못하였다. 진화 설명의 일관성, 오개념이 포함되지 않은 순수성, 과학적 설명의 양을 측정한 결과, 선택형 검사 결과는 최상위 집단을 제외하고 다른 집단을 구분하지 못하였다. 또한 이 결과들은 생물 교사들이 과학적 설명의 구성 능력이 지식의 양에 비하여 상대적으로 낮은 것을 확인할 수 있었으며 일부 예비교사들은 오개념과 과학적 개념을 혼합하는 등의 세련되지 못한 과학적 설명을 가지고 있었다. 이 결과는 생물 예비교사들의 개념 평가는 선택형보다 개방형이 더 많은 정보를 제공할 수 있음을 보여주며, 생물 예비교사들을 위한 교사양성 프로그램은 과학적 설명 능력의 신장에 더욱 더 초점을 맞출 것을 제언한다.

• 한국소음진동공학회논문집
• /
• 제21권3호
• /
• pp.220-226
• /
• 2011

This paper presents the novel work for source localization of serial multiple impacts in a plate sructure. It is difficult to identify the source of serial multiple impacts with the current source localization techenology(SLT) because of the overlapping of dispersive wave induced by multiple impacts and the reflaction from the edge of the plate. In this paper, the new method is suggested for source localization. The method is developed based on the SLT with pre-signal processing such as some limitation for the selection of three sensors, the frequency range for TFA and impact time interval. Results from numerical simulation and experiment in isotropic plate structure are presented, which show the capability of the proposed method.