• Genomics & Informatics
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• 제11권4호
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• pp.282-288
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• 2013

The molecular vibration-activity relationship in the receptor-ligand interaction of adenosine receptors was investigated by structure similarity, molecular vibration, and hierarchical clustering in a dataset of 46 ligands of adenosine receptors. The resulting dendrogram was compared with those of another kind of fingerprint or descriptor. The dendrogram result produced by corralled intensity of molecular vibrational frequency outperformed four other analyses in the current study of adenosine receptor agonism and antagonism. The tree that was produced by clustering analysis of molecular vibration patterns showed its potential for the functional classification of adenosine receptor ligands.

• Asian Journal of Innovation and Policy
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• 제10권1호
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• pp.90-107
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• 2021

This paper analyses how technological capabilities and entrepreneurship of technology-based start-ups affect their performance. In this paper, a multiple regression analysis was conducted on 248 technology-based start-ups. The effects of indicators of technological capacity like R&D intensity, R&D organization, technology competitiveness, patents, and certification were analyzed. Factors affecting sales were R&D intensity and technological competitiveness. Technology competitiveness and patents were the significant factors influencing product competitiveness. The factor that positively influenced organizational performance, customer performance, and achievement of start-up goals was technological competitiveness. The results of such an analysis should be designed to discover and foster long-term innovation potential, rather than relying on short-term financial performance.

• International Journal of Industrial Entomology and Biomaterials
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• 제48권1호
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• pp.19-24
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• 2024

For over five millennia, humans have benefited from the valuable byproducts of Bombyx mori silkworms nourished on mulberry leaves and a multitude of potential applications remains available due to the diverse array of silkworm varieties. In this work, we discuss the utilization of Daehwangjam (DHJ), golden silk (GS), and Juhwangjam (JHJ), distinctive colored silks found in Korea, as chemosensors. These novel silks emit fluorescence under external stimuli and show a diminishing fluorescence intensity when exposed to HCl vapor. The considerable surface-to-volume ratio of these cocoons allows for the identification of 5 ppm, 300 ppm, and 3000 ppm HCl vapors through decreased fluorescence intensity. The results show the suitability of natural DHJ, GS, and JHJ for applications in biosensing applications.

• 비파괴검사학회지
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• 제19권1호
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• pp.1-7
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• 1999

교류전위차법 (alternating current potential drop : ACPD)을 이용하여 이차원 표면균열을 갖고 있는 상자성체 (paramagnetic material)의 모드 I (opening mode) 응력확대계수($K_I$)를 실험적으로 평가하기 위하여 하중에 따른 교류전위차 변화(change in ACPD)를 연구하였다. 아울러 하중에 의한 전위차 변화의 원인 그리고 전위차 변화에 미치는 자속(magnetic flux) 탈자(demagnetization) 및 균열길이의 영향을 연구하였다. 상자성체의 교류전위차는 인장하중을 증가시킬수록 선형적으로 감소하였다. 전위차 감소의 원인은 균열선단 주위의 도전율(conductivity)이 인장하중의 증가에 따라 증가하고 이는 시험편의 저항과 내부 인덕턴스를 감소시키기 때문이다. 도전율의 변화는 균열선단 주변의 응력상태에 의존하기 때문에 일정 $K_I$ 변화에 따른 전위차 변화량은 균열길이에 의존하지 않는다. 하중에 의한 전위차변화량은 시험편 주위의 자속의 유무에 영향을 받지만 탈자의 유무에는 영향을 받지 않는다.

• 비파괴검사학회지
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• 제19권1호
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• pp.8-15
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• 1999

교류전위차법 (alternating current potential drop : ACPD)을 이용하여 이차원 표면균열을 갖고 있는 강자성체 (ferromagnetic material)와 상자성체 (paramagnetic material)의 모드 I (opening mode) 응력확대계수($K_I$)를 효과적으로 계측하는 방법을 개발하기 위하여 하중에 따른 교류전위차 변화(change in ACPD)에 미치는 자속(magnetic flux)의 영향을 연구하였다. 그리고 하중에 따른 전위차 변화에 미치는 탈자(demagnetization) 및 균열길이의 영향을 연구하였다. 기전력을 많이 유도할 수 있도록 설계된 계측계의 경우 하중에 따른 교류전위차 변화량은 크게 증가하였다. 아울러 교류전위차 변화와 응력확대계수 변화 사이의 관계는 탈자 등의 조치가 없어도 선형적이며, 탈자는 전위차 변화에 거의 영향을 미치지 않았다. 일정 $K_I$ 변화에 의한 전위차 변화량은 균열길이에 의존하지 않고 계측계에 의존한다. 교류전위차법을 이용하여 효과적으로 응력확대계수를 결정하는 방법은 기전력을 많이 유도할 수 있도륵 설계된 계측계를 사용하여 교류전위차 변화를 측정하는 것이다.

• Ocean Systems Engineering
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• 제10권2호
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• pp.181-199
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• 2020

Cyclone Heat Potential (CHP) is an essential parameter for accurate prediction of the intensity of tropical cyclones. The variability of the heat storage in the near-surface layers and the vertical stratification near the surface due to large fresh water inputs create challenges in predicting the intraseasonal and interannual evolution of monsoons and tropical cyclones in the Bay of Bengal. This paper for the first time presents the D26- referenced cyclone heat potential observed in the Bay of Bengal during the period 2012-17 based on the in-situ data collected from 5.5 million demanding offshore instrument-hours of operation in the Ocean Moored Buoy Network for Northern Indian Ocean (OMNI) buoy network by the National Institute of Ocean Technology. It is observed that the CHP in the Bay of Bengal varied from 0-220 kJ/㎠ during various seasons. From the moored buoy observations, a CHP of ~ 90 kJ/㎠ with the D26 isotherm of minimum 100m is favorable for the intensification of the post-monsoon tropical cyclones. The responses of the D26 thermal structure during major tropical cyclone events in the Bay of Bengal are also presented.

• Journal of Korean Neurosurgical Society
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• 제64권1호
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• pp.78-87
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• 2021

Objective : Intraoperative neurophysiological monitoring (IONM) has been widely used during spine surgery to reduce or prevent neurologic deficits, however, its application to the surgical management for cervical myelopathy remains controversial. This study aimed to assess the success rate of IONM in patients with cervical myelopathy and to investigate the factors associated with successful baseline monitoring and the effect of increasing the stimulation intensity by focusing on motor evoked potentials (MEPs). Methods : The data of 88 patients who underwent surgery for cervical myelopathy with IONM between January 2016 and June 2018 were retrospectively reviewed. The success rate of baseline MEP monitoring at the initial stimulation of 400 V was investigated. In unmonitorable cases, the stimulation intensity was increased to 999 V, and the success rate final MEP monitoring was reinvestigated. In addition, factors related to the success rate of baseline MEP monitoring were investigated using independent t-test, Wilcoxon rank-sum test, chi-squared test, and Fisher's exact probability test for statistical analysis. The factors included age, sex, body mass index, diabetes mellitus, smoking history, symptom duration, Torg-Pavlov ratio, space available for the cord (SAC), cord compression ratio (CCR), intramedullary increased signal intensity (SI) on magnetic resonance imaging, SI length, SI ratio, the Medical Research Council (MRC) grade, the preoperative modified Nurick grade and Japanese Orthopedic Association (JOA) score. Results : The overall success rate for reliable MEP response was 52.3% after increasing the stimulation intensity. No complications were observed to be associated with increased intensity. The factors related to the success rate of final MEP monitoring were found to be SAC (p<0.001), CCR (p<0.001), MRC grade (p<0.001), preoperative modified Nurick grade (p<0.001), and JOA score (p<0.001). The cut-off score for successful MEP monitoring was 5.67 mm for SAC, 47.33% for the CCR, 3 points for MRC grade, 2 points for the modified Nurick grade, and 12 points for the JOA score. Conclusion : Increasing the stimulation intensity could significantly improve the success rate of baseline MEP monitoring for unmonitorable cases at the initial stimulation in cervical myelopathy. In particular, the SAC, CCR, MRC grade, preoperative Nurick grade and JOA score may be considered as the more important related factors associated with the success rate of MEP monitoring. Therefore, the degree of preoperative neurological functional deficits and the presence of spinal cord compression on imaging could be used as new detailed criteria for the application of IONM in patients with cervical myelopathy.

• Restorative Dentistry and Endodontics
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• 제16권2호
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• pp.85-98
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• 1991

The aim of this study was to investigate the effect of low - power laser used in the medical field for various purposes to suppress pain responses evoked by noxious electrical or mechanical stimuli. After both inferior alveolar nerves and the left anterior digastric muscle of cats under general anesthesia were exposed, a recording electrode for the jaw opening reflex was inserted into the anterior digastric muscle. The right inferior alveolar nerve was dissected under a surgical microscope until the response of the functional single nerve could be evoked by the electrical stimulation of the dental pulp or oral mucosa. The electrical stimulus was applied with a rectangular pulse of 10 ms duration for measuring the threshold intensity of a single nerve fiber in the inferior alveolar nerve which responds to stimulation of dental pulp and oral mucosa. Then a pulse of 1 ms duration was applied for determination of conduction velocity. A noxious mechanical stimulus to the oral mucosa was applied by clamping the receptive field with an arterial clamp. The Ga-As diodide laser(wave length, 904 nm ; frequency, 1,000 Hz) was irradiated to the prepared tooth cavity, inferior alveolar nerve and oral mucosa as a pulse wave of 2 mW for 6 minutes. This was followed by a continuous wave of 15 mW for 3 minutes. The action potential of the nerve and EMG of the digastric muscle evoked by the noxious electrical stimulus and nerve response to noxious mechanical stimulus were compared at intervals of before, immediately after, and at 5, 10, 20, 40, 60 minutes after laser irradiation. The results were as follows: The conduction velocity of the intrapulpal $A{\delta}$- nerve fiber recorded from the inferior alveolar nerve before irradiation had a mean value of $6.68{\pm}2.07m/sec$. The laser irradiation did not affect the conduction velocity of the AS - nerve fiber and did not change the threshold intensity or amplitude of the action potential either. The EMG of the digastric muscle evoked by noxious electrical stimulation to the tooth was not changed by the laser irradiation, whether in latency, threshold intensity or amplitude. The laser irradiated to the receptive field of the oral mucosa which was subjected to noxious stimuli did not affect the amplitude of the action potential or the frequency either.

• 비파괴검사학회지
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• 제20권1호
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• pp.54-61
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• 2000

피로손상이 발생하는 초기단계는 결정립계나 석출물, 그리고 잔류응력과 같은 전위(dislocation)의 이동성에 영향을 미치는 변수에 의해 지배되는 것으로 널리 알려져 있으나, 물리적으로 손상의 발생을 탐지할 수 있는 단계는 미소균열의 발생단계라 할 수 있다. 미소균열은 microcrack으로 부르는 것이 일반적이지만 피로손상의 문제에서만은 short(or small) fatigue crack으로 통용되고 있다. 따라서 미소균열 보다는 소균열 또는 피로 단균열이 더 알맞은 용어일지도 모르는데, 그 크기가 수 ${\mu}m$에서 수 mm의 범위에 걸친 균열의 총칭이다. 이러한 크기라면 대략 통상적인 비파괴시험 방법으로 탐지할 수 있는 범위의 한계 부근에 있으므로 피로손상의 탐지와 관련된 비파괴평가의 역할과 관련하여 새삼스럽게 한번 짚고 넘어가는 것도 의미 있는 일이라 생각된다. 피로와 관련하여 보고된 비파괴평가에 관한 연구는 감히 그 숫자를 헤아릴 수 없이 많으나 그 대부분은 피로균열의 성장 및 전파에 관한 것으로, 피로 단균열과 관련한 연구는 상대적으로 적으며 특히 국내에서는 거의 찾아볼 수 없다. 그러나 피로 단균열의 탐지와 관련하여 지금까지 전세계적으로 보고된 연구 결과는 다수 있으므로 여기서는 주로 비파괴평가로 볼 수 있는 연구에 대해서만 살펴보기로 한다.

• Journal of Astronomy and Space Sciences
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• 제29권3호
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• pp.259-267
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• 2012

Polar cap potential has long been considered as an indicator for the amount of energy flowing in the magnetosphere-ionosphere system. Thus, the estimation of polar cap potential is important to understand the physical process of the magnetosphere. To estimate the polar cap potential in the Northern Hemisphere, merging electric field by Kan & Lee (1979) is adopted. Relationships between the PC index and calculated merging electric field ($E^*$) are examined during full-time and storm-time periods separately. For this purpose Dst, AL, and PC indices and solar wind data are utilized during the period from 1996-2003. From this linear relationship, polar cap potential (${\Phi}^*$) is estimated using the formula by Doyle & Burke (1983). The values are represented as $58.1{\pm}26.9$ kV for the full-time period and $123.7{\pm}84.1$ kV for a storm-time period separately. Considering that the average value of polar cap potential of Doyle & Burke (1983) is about 47 kV during moderately quiet intervals with the S3-2 measurements, these results are similar to such. The monthly averaged variation of Dst, AL, and PC indices are then compared. The Dst and AL indices show distinct characteristics with peaks during equinoctial season whereas the average PC index according to the month shows higher values in autumn than in spring. The monthly variations of the linear correlation coefficients between solar wind parameters and geomagnetic indices are also examined. The PC-AL linear correlation coefficient is highest, being 0.82 with peaks during the equinoctial season. As with the AL index, the PC index may also prove useful for predicting the intensity of an auroral substorm. Generally, the linear correlation coefficients are shown low in summer due to conductance differences and other factors. To assess the role of the PC index during the recovery phase of a storm, the relation between the cumulative PC index and the duration is examined. Although the correlation coefficient lowers with the storm size, it is clear that the average correlation coefficient is high. There is a tendency that duration of the recovery phase is longer as the PC index increases.