• 융합보안논문지
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• 제16권3_1호
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• pp.27-35
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• 2016

미국이 추진하고 있는 제3차 국방과학기술 상쇄전략에 대하여 그 출현 배경, 상쇄전략에 의하여 추진되는 국방과학기술 분야, 그리고 시사점을 분석하였다. 중국과 소련은 지난 수년간 군사력 현대화를 추진하여 왔으며, 미국과 국방과학기술의 여러 분야에서 수준 격차를 줄여 왔다. 미국은 과거에 누렸던 압도적인 국방과학기술의 우세성이 더 이상 보장받을 수 없다고 판단하고, 경쟁국가와 국방과학기술의 간격을 다시 벌릴 수 있는 제3차 상쇄전략을 추진하게 되었다. 핵심적으로 구상하고 있는 국방과학기술 분야는 인공지능을 응용한 학습기계 기술, 인간과 기계의 협동, 인간과 기계의 전투팀 구성, 로봇, 자율무기 등이다. 제3차 상쇄전략은 상대방 국가가 확보하기 어려운 분야이여야 하고, 중국과 군비경쟁으로 발전되지 말아야 하며, 우방국들과 갈등도 발생하지 않도록 관리되어야 할 것이다. 민간영역의 신기술이 국방영역으로 순조롭게 유입되도록 미 국방획득체계의 개선도 과제이다. 한국도 국방과학기술 분야에 대하여 스마트한 연구개발 전략 수립이 필요하다. 한국은 장차 미국의 3차 상쇄전략 기술 분야 중에서 상호 협력할 수 있는 국방과학기술을 검토하는 것도 요구된다.

• 정보학연구
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• 제10권4호
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• pp.69-83
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• 2007

As a hospital environment is reconstructed from supplier-centered values to consumer-centered ones for the existence in the rapidly changing medical market, it can be said that not only must old slogans such as unconditional restructuring, remodelling, etc. be reconsidered, but a new strategy for the development and renovation of a hospital must be urgently required. Accordingly, development of customer-oriented practical strategies is needed and it appears possible to develop marketing and manage contacts, as a practical management strategy, for raising satisfaction of internal and external customers. The ultimate goal of such strategy development may be to ensure consistent potential development by maintenance of existing customers and securing new customers through a strategy of satisfying both existing and new customers. It appears that the competition in the medial will be keener in the future by human resources, members of an organization, Under these circumstances, and in relation to appearance of a new type of occupation of a coordinator, if a hospital could offer appropriate service which can meet the demand of the customers by efficiently utilizing the limited resources through efficient management of contacts between the customers and personnel, the competitive power of a hospital would be much stronger. Therefore, it is necessary to seek customer-impressing management by utilizing a coordinator as a more specialized intermediary as well as many-sided contact management through positive introduction of an expert coordinator system for internal and external customer contact management. It is expected that a hospital can secure a competitive advantage in the market through strategy development supported by an expert coordinator and increasing competitive power by means of practice of a developed creative strategy.

• 국제초고층학회논문집
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• 제3권2호
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• pp.155-165
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• 2014

This study measured and compared the variation of ventilation rate and fan energy consumption according to various control strategies after installing wireless sensor-based pilot ventilation system in order to verify the applicability of demand-controlled ventilation (DCV) strategy that was efficient ventilation control strategy for underground parking lot. The underground parking lot pilot ventilation system controlled the ventilation rate by directly or indirectly tracking the traffic load in real-time after sensing data, using vehicle detection sensors and carbon monoxide (CO) and carbon dioxide ($CO_2$) sensor. The ventilation system has operated for 9 hours per a day. It responded real-time data every 10 minutes, providing ventilation rate in conformance with the input traffic load or contaminant level at that time. A ventilation rate of pilot ventilation system can be controlled at 8 levels. The reason is that a ventilation unit consists of 8 high-speed nozzle jet fans. This study proposed vehicle detection sensor based demand-controlled ventilation (VDS-DCV) strategy that would accurately trace direct traffic load and CO sensor based demand-controlled ventilation (CO-DCV) strategy that would indirectly estimate traffic load through the concentration of contaminants. In order to apply DCV strategy based on real-time traffic load, the minimum required ventilation rate per a single vehicle was applied. It was derived through the design ventilation rate and total parking capacity in the underground parking lot. This is because current ventilation standard established per unit floor area or unit volume of the space made it difficult to apply DCV strategy according to the real-time variation of traffic load. According to the results in this study, two DCV strategies in the underground parking lot are considered to be a good alternative approach that satisfies both energy saving and healthy indoor environment in comparison with the conventional control strategies.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.427-436
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• 2012

Targeted therapy has been a very promising strategy of drug development research. Many molecular mechanims of diseases have been known to be regulated by abundance of proteins, such as receptors and hormones. Chemoprevention for treatment and prevention of diseases are continuously developed. Pre-clinical and clinical studies in chemoprevention field yielded many valuable data in preventing the onset of disease and suppressing the progress of their growth, making chemoprevention a challenging and a very rational strategy in future researches. Natural products being rich of flavonoids are those fruits belong to the genus citrus. Ethanolic extract of Citrus reticulata and Citrus aurantiifolia peels showed anticarcinogenic, antiproliferative, co-chemotherapeutic and estrogenic effects. Several examples of citrus flavonoids that are potential as chemotherapeutic agents are tangeretin, nobiletin, hesperetin, hesperidin, naringenin, and naringin. Those flavonoids have been shown to possess inhibition activity on certain cancer cells' growth through various mechanisms. Moreover, citrus flavonoids also perform promising effect in combination with several chemotherapeutic agents against the growth of cancer cells. Some mechanisms involved in those activities are through cell cycle modulation, antiangiogenic effect, and apoptosis induction.Previous studies showed that tangeretin suppressed the growth of T47D breast cancer cells by inhibiting ERK phosphorylation. While in combination with tamoxifen, doxorubicin, and 5-FU, respectively, it was proven to be synergist on several cancer cells. Hesperidin and naringenin increased cytotoxicitity of doxorubicin on MCF-7 cells and HeLa cells. Besides, citrus flavonoids also performed estrogenic effect in vivo. One example is hesperidin having the ability to decrease the concentration of serum and hepatic lipid and reduce osteoporosis of ovariectomized rats. Those studies showed the great potential of citrus fruits as natural product to be developed as not only the source of co-chemotherapeutic agents, but also phyto-estrogens. Therefore, further study needs to be conducted to explore the potential of citrus fruits in overcoming cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10847-10853
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• 2015

Background: Lapatinib, a dual tyrosine kinase inhibitor that interrupts the epidermal growth factor receptor (EGFR) and HER2/neu pathways, has been indicated to have significant efficacy in treating HER2-positive breast cancer. However, acquired drug resistance has become a very serious clinical problem that hampers the use of this agent. In this study, we aimed to screen small molecule drugs that might reverse lapatinib-resistance of breast cancer by exploring differentially expressed genes (DEGs) via a bioinformatics method. Materials and Methods: We downloaded the gene expression profile of BT474-J4 (acquired lapatinib-resistant) and BT474 (lapatinib-sensitive) cell lines from the Gene Expression Omnibus (GEO) database and selected differentially expressed genes (DEGs) using dChip software. Then, gene ontology and pathway enrichment analyses were performed with the DAVID database. Finally, a connectivity map was utilized for predicting potential chemicals that reverse lapatinib-resistance. Results: A total of 1, 657 DEGs were obtained. These DEGs were enriched in 10 pathways, including cell cycling, regulation of actin cytoskeleton and focal adhesion associate examples. In addition, several small molecules were screened as the potential therapeutic agents capable of overcoming lapatinib-resistance. Conclusions: The results of our analysis provided a novel strategy for investigating the mechanism of lapatinib-resistance and identifying potential small molecule drugs for breast cancer treatment.

• 한국태양에너지학회 논문집
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• 제36권1호
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• pp.39-47
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• 2016

Geographic information system (GIS) based renewable energy resource map including potential analysis can play a crucial role not only to develop the national plan for renewable energy deployment but also to make strategic investment decision in the private sector. Korea Institute of Energy Research (KIER) has been developing domestic maps about several resources such as solar, wind, hydro, biomass, and geothermal, as well as conducting research on methodologies for potential analysis. Furthermore, the institute is trying to transfer related technologies and know-how to foreign countries, recently. In this context, the main purpose of this study is to introduce the business model of renewable energy resource map. From the value chain analysis, we focus on the government-side market in foreign countries, such as the development of the national level renewable energy resource map and the support of the national renewable energy plan. For about 180 countries, we segment the customers according to the consideration of economic capacity, renewable energy resource capacity, existence of renewable resource map, current portion of renewable energy facility capacity, and renewable energy policies, and we conclude that the target customers are non-Organization for Economic Co-operation and Development (non-OECD) countries or some OECD countries, their per capita GDP are under the average among OECD countries, that do not have renewable resource map yet. We segment the target customers into four groups, and suggest different strategies for market positioning and financing strategy based on Strengths, Weaknesses, Opportunities, Threats (SWOT) analysis. This study can help to develop the business strategy about the development of renewable energy resource map in foreign countries.

• 한국안전학회지
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• 제34권1호
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• pp.62-69
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• 2019

Korean shipbuilding companies have taken many efforts for safety over the years by developing Health, Safety & Environment (HSE) Management Systems, Procedures, Training, and studying Programs for prevention of incidents. As a result, the shipbuilding industry has succeeded in reducing overall injury rates. Nevertheless, the industry also noticed that incident rates are still not at zero and more importantly, serious injuries and fatalities are still occurring. One factor that may be attributing to this is the lack of managing potential severity during incident investigations, most incident investigations are implemented based on the actual result. Generally, each shipbuilding company develops their customized incident investigation programs and these are also commonly being focused on actual result. This study aimed to develop a shift in strategy toward safety to classify the criteria of potential severity from any incidents and manage that to prevent any recurrence or causing any serious injuries or fatalities in the shipbuilding industry. Several global energy companies have already developed potential severity management tools and applied them in their incident investigations. In order to verify the necessity of improvement for current systems, a case study and comparative analysis between a domestic shipbuilding company and several global energy companies from foreign countries was implemented and comparison of two incident investigation cases from specific offshore projects was conducted to measure the value of a potential severity system. Also, a checklist was established from the data of fatalities and serious injuries in recent 5 years that occurred in Korea shipbuilding industry and a proposal to verify high potential incidents in the incident investigation process and comparative analysis between the assessment by appling proposed checklist and the assessment from a global energy company by using their own system was implemented. As a measure to prevent any incidents, it is required to focus on potential severity assessment during the incident investigation rather than to only control actual result. Hence, this study aims to propose a realistic plan which enables to improve the existing practices of incident investigation and control in the shipbuilding industry.

• 생태와환경
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• 제52권4호
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• pp.340-347
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• 2019

The red swamp crayfish (Procambarus clarkia) originated from the North America distribute widely as invasive species throughout the world including Europe, Asia, Africa, North America and South America. The red swamp crayfish is also an invasive species in South Korea. We aimed to characterize the occurrence and distribution pattern of the red swamp crayfish, and evaluate the potential distribution of this species in South Korea. In South Korea, the red swamp crayfish was firstly reported in Seoul in 1996, and recently its occurrence is frequently reported at streams or reservoirs at different regions, showing the expansion of its distribution area. The red swamp crayfish has high potential to occur in the nationwide scale in South Korea because of their biological adaptation, effects of climate change, changes of their habitat condition, and various types of human activities. Finally, our results revealed the necessary to conduct an extensive field survey, to keep up a monitoring program for the occurrence of alien species, and to implement a strategy to prevent the dispersal of alien species in the natural ecosystems.

• Journal of Preventive Medicine and Public Health
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• 제44권5호
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• pp.201-209
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• 2011

Objectives: This study examined the use of health impact assessment (HIA) as a tool for intersectoral collaboration using the case of an HIA project conducted in Gwang Myeong City, Korea. Methods: A typical procedure for rapid HIA was used. In the screening step, the Aegi-Neung Waterside Park Plan was chosen as the target of the HIA. In the scoping step, the specific methods and tools to assess potential health impacts were chosen. A participatory workshop was held in the assessment step. Various interest groups, including the Department of Parks and Greenspace, the Department of Culture and Sports, the Department of Environment and Cleansing, civil societies, and residents, discussed previously reviewed literature on the potential health impacts of the Aegi-Neung Waterside Park Plan. Results: Potential health impacts and inequality issues were elicited from the workshop, and measures to maximize positive health impacts and minimize negative health impacts were recommended. The priorities among the recommendations were decided by voting. A report on the HIA was submitted to the Department of Parks and Greenspace for their consideration. Conclusions: Although this study examined only one case, it shows the potential usefulness of HIA as a tool for enhancing intersectoral collaboration. Some strategies to formally implement HIA are discussed.

• Journal of Power Electronics
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• 제14권2호
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• pp.315-323
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• 2014

An optimized space vector pulse width modulation (SVPWM) method with common mode voltage elimination and neutral point potential balancing is proposed for an open-end winding induction motor. The motor is fed from both of the ends with two neutral point clamped (NPC) three-level inverters. In order to eliminate the common mode voltage of the motor ends and balance the neutral point potential of the DC link, only zero common mode voltage vectors are used and a balancing control factor is gained from calculation in the strategy. In order to improve the harmonic characteristics of the output voltages and currents, the balancing control factor is regulated properly and the theoretical analysis is provided. Simulation and experimental results show that by adopting the proposed method, the common mode voltage can be completely eliminated, the neutral point potential can be accurately balanced and the harmonic performance for the output voltages and currents can be effectively improved.