• The Korean Journal of Physiology and Pharmacology
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• 제21권4호
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• pp.397-405
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• 2017

MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and induced cell death in a concentration-dependent manner. At a moderate concentration (${\sim}20{\mu}M$), MDL-12330A mainly induced apoptotic death whereas at concentrations greater than $20{\mu}M$, it increased non-apoptotic cell death. The induction of apoptosis was at least partially regulated by CHOP-mediated DR5 upregulation, as detected by immunoblotting and gene interference assays. More importantly, low concentrations of MDL-12330A effectively enhanced recombinant human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (rhTRAIL)-induced apoptosis and clonogenicity in these gastric cancer cells. This study demonstrates a possible role of MDL-12330A as a potential sensitizer to TRAIL, and suggests a novel therapeutic strategy targeting gastric cancer cells.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권6호
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• pp.2546-2566
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• 2016

This paper investigates an efficient transmission scheme for the remote wireless sensors to receive information which is rarely discussed in the integrated remote wireless sensor and multibeam satellite networks (IWSMSNs). The networks can be employed to exchange sensing information for emergency scenario, ocean scenario, and so on, which are isolated from available terrestrial networks. As the efficient transmission link is important to the IWSMSNs, we propose a hybrid full frequency (HFF) precoding by taking advantage of frequency reuse and multiple-input multiple-output (MIMO) precoding. Considering energy efficiency and sinks fairness are crucial to transmission link, thus the HFF precoding problems are formulated as transmit power minimization (TPM) and max-min fair (MMF) received signal to interference plus noise ratio (SINR) problems, which can be transformed to indefinite quadratic optimization programs. Then this paper presents a semi-definite programming (SDP) algorithm to solve the problems for the IWSMSNs. The promising potential of HFF for the real IWSMSNs is demonstrated through simulations.

• 신재생에너지
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• 제7권3호
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• pp.92-100
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• 2011

With the increased demand of clean energy and global warming measures, the renewable energy development has been increased recently. The TCP (Tidal Current Power) is one of the ocean renewable energy sources. Having the high tidal energy source in Korea, there are many potential TCP sites with strong current speed. The rotor, which initially converts the energy, is a very important component because it affects the efficiency of the entire system. The rotor performance is determined by various design parameters including number of blades, shape, sectional size, diameters and etc. However, the interactions between devices also contribute significantly to the energy production. The rotor performance considering the interaction needs to be investigated to predict the exact power in the farm. This paper introduces the optimum design of TCP turbine and the performance of devices considering the interference between rotors.

• 한국정보통신학회논문지
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• 제16권4호
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• pp.686-691
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• 2012

UWB(Ultra-WideBand)는 대역별로 배타적 주파수 이용 권한이 부여되는 방식을 탈피하여 매우 넓은 주파수 대역을 활용하면서도 기존에 해당 주파수를 사용하고 있는 다른 서비스에 주파수 간섭을 일으키지 않는 기술 방식이면서 동시에 수백 Mbps 이상의 데이터 전송률을 실현 할 수 있는 기술로 무궁무진한 발전 가능성을 가진 기술이라 할 수 있다. 이에, 본 논문에서는 UWB의 기술 일반에 대한 이해와 더불어 기술 동향에 대해 연구하고, UWB 통신에 사용되는 안테나를 분석하고 무선 영상 송수신용 단말기에 적용 가능한 UWB용 소형 안테나를 설계 및 구현하였다.

• Journal of Power Electronics
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• 제14권2호
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• pp.203-216
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• 2014

In the conventional dc-dc converter, a pair of additional diode and the adjacent passive component capacitor/inductor can be added to the circuit with an X-shape connection, which generates a family of new topologies. The novel circuits, also called diode-assisted dc-dc converter, enhance the voltage boost/buck capability and have a great potential for high step-up/step-down power conversions. This paper mainly investigates and compares conventional dc-dc converter and diode-assisted dc-dc converter in wide range power conversion from the aspects of silicon devices, passive components requirements, electro-magnetic interference (EMI) and efficiency. Then, a comprehensive comparison example of a high step-up power conversion system was carried out. The two kinds of boost dc-dc converters operate under the same operation conditions. Mathematical analysis and experiment results verify that diode-assisted dc-dc converters are very promising for simultaneous high efficiency and high step-up/step-down power conversion in distributed power supply systems.

• 로봇학회논문지
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• 제7권1호
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• pp.35-44
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• 2012

This paper presents a method to optimize motion planning for industrial manipulators with redundancy. For optimal motion planning, first of all, particular inverse kinematic solution is needed to improve efficiency for manipulators with redundancy working in various environments. In this paper, we propose three kinds of methods for solving inverse kinematics problems; numerical and combined approach. Also, we introduce methods for optimal motion planning using potential function considering the order of priority. For efficient movement in industrial settings, this paper presents methods to plan motions by considering colliding obstacles, joint limits, and interference between whole arms. To confirm improved performance of robot applying the proposed algorithms, we use two kinds of robots with redundancy. One is a single arm robot with 7DOF and another is a dual arm robot with 15DOF which consists of left arm, right arm with each 7DOF, and a torso part with 1DOF. The proposed algorithms are verified through several numerical examples as well as by real implementation in robot controllers.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 추계학술대회 논문집 전기기기 및 에너지변환시스템부문
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• pp.220-222
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• 2007

With the wide spread of direct current (DC) electric railroads in Korea, the stray currents or leakage currents from negative return rails become a pending problem to the safety of nearby underground infrastructures. The most widely used mitigation method for this interference is the stray current drainage method, which connects the underground metallic structures to the rails with diodes (polarized drainage) or thyristor (forced drainage). Although this method inherently possesses some drawbacks, its cost effectiveness and efficiency to protect the interfered structures has been the main reason for the wide adoption. In this paper, we show the field test results for the application of stray current drainage system to a city gas pipeline paralleling a depot area of a metropolitan rapid transit system. The process for optimal positioning is briefly illustrated. The effectiveness of constant voltage, constant current, and constant potential drainage schemes was also described.

• 한국실내디자인학회논문집
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• 제23권5호
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• pp.3-13
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• 2014

Typology in Contemporary Architecture wants to escape from the classical typology that has the problems about specific program of structuralism, typical repeatation of customary form. As visible and non-visible things are appeared in contemporary architecture through the analysis of the inner system involving development process of changing itself, typology of contemporary is utilized at a tool of form generation in the process of architect. And it notes that the structural properties of the building system. The form of contemporary architecture has the new connecting strucure not reduced to existing ones. It carries out generative access as a device in order to solve the complexity of society. From this perspective, we analyze the process of projects of contemporary architects that can be typological strategy not representation of post geometric form but a tool of form generation in architectural process. As a result, we can find four characteristics of typology as a tool of form generation; 'interference and mix of program', 'continous slabs', 'rearrangement through relationship setting', 'transformation of multi-layers'. These are expanding to the process that reflect history and context or infer from morphology. Therefore, typology as architectural process of form generation overcomes morphological typology of classical typology and suggests that the different architectural approach having potential possibility.

• 한국연소학회지
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• 제12권4호
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• pp.1-7
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• 2007

Carbon monoxide (CO) is not only an important intermediate species in chemical reaction mechanisms of hydrocarbon fuel combustion, but also a crucial pollutant species emitted from automotive engines. To better understand the physical processes impacting CO emissions, the development of laser-based measurement techniques that can visualize in-cylinder CO distributions is desirable. Among these techniques, Laser-Induced Fluorescence (LIF) is a sensitive and species-selective detection technique capable of good spatial resolution. However, some technical matters such as deep UV excitation, severe pressure dependency of the LIF signal, and potential interference from other species have been major challenges for CO LIF application. This study is focused on investigating the feasibility of CO two-photon LIF in a direct-injection diesel engine operating at typical pressure and temperature conditions with commercial grade diesel fuel. Spectroscopic analysis shows that the CO fluorescence signal can be separated from $C_2$ Swan band or broadband fluorescence from PAHs when the signal is collected near 483 nm. The signal-to-noise ratio of CO LIF deteriorate rapidly as pressure is increased, following $P^{-1.49}$ which matches the theoretical signal pressure dependency.

• Smart Structures and Systems
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• 제6권4호
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• pp.405-421
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• 2010

This paper proposes a method for early warning of hazard for pipelines. Many pipelines transport dangerous contents so that any damage incurred might lead to catastrophic consequences. However, most of these damages are usually a result of surrounding third-party activities, mainly the constructions. In order to prevent accidents and disasters, detection of potential hazards from third-party activities is indispensable. This paper focuses on recognizing the running of construction machines because they indicate the activity of the constructions. Acoustic information is applied for the recognition and a novel pipeline monitoring approach is proposed. Principal Component Analysis (PCA) is applied. The obtained Eigenvalues are regarded as the special signature and thus used for building feature vectors. One-class Support Vector Machine (SVM) is used for the classifier. The denoising ability of PCA can make it robust to noise interference, while the powerful classifying ability of SVM can provide good recognition results. Some related issues such as standardization are also studied and discussed. On-site experiments are conducted and results prove the effectiveness of the proposed early warning method. Thus the possible hazards can be prevented and the integrity of pipelines can be ensured.