• Genomics & Informatics
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• v.21 no.1
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• pp.6.1-6.8
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• 2023

Glaucoma is the second leading cause of irreversible blindness, and primary open-angle glaucoma (POAG) is the most common type. Due to inadequate diagnosis, treatment is often not administered until symptoms occur. Hence, approaches enabling earlier prediction or diagnosis of POAG are necessary. We aimed to identify novel drugs for glaucoma through bioinformatics and network analysis. Data from 36 samples, obtained from the trabecular meshwork of healthy individuals and patients with POAG, were acquired from a dataset. Next, differentially expressed genes (DEGs) were identified to construct a protein-protein interaction (PPI) network. In both stages, the genes were enriched by studying the critical biological processes and pathways related to POAG. Finally, a drug-gene network was constructed, and novel drugs for POAG treatment were proposed. Genes with p < 0.01 and |log fold change| > 0.3 (1,350 genes) were considered DEGs and utilized to construct a PPI network. Enrichment analysis yielded several key pathways that were upregulated or downregulated. For example, extracellular matrix organization, the immune system, neutrophil degranulation, and cytokine signaling were upregulated among immune pathways, while signal transduction, the immune system, extracellular matrix organization, and receptor tyrosine kinase signaling were downregulated. Finally, novel drugs including metformin hydrochloride, ixazomib citrate, and cisplatin warrant further analysis of their potential roles in POAG treatment. The candidate drugs identified in this computational analysis require in vitro and in vivo validation to confirm their effectiveness in POAG treatment. This may pave the way for understanding life-threatening disorders such as cancer.

• Child Health Nursing Research
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• v.30 no.3
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• pp.187-198
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• 2024

Purpose: This study aimed to implement a child abuse prevention program and evaluate its effectiveness based on the Nursing Model of Resilience and Coping Skills Training Model for unmarried mothers during pregnancy and puerperium. Methods: This study had a prospective single-case, AB design with four repeated self-questionnaire measures and three observational measures. Seven unmarried mothers were provided with 10 sessions child abuse prevention program through individual visits from 32 to 34 weeks of pregnancy to six weeks after childbirth. The questionnaire was composed related to resilience, maternal stress, maternal attitude, parent-child interaction, child abuse potential. The observation was measured by video recording (total 16 times) the interaction of parent-child during feeding and analyzing it by three experts. Data were analyzed by Wilcoxon signed-rank test and Friedman's test. Results: Maternal attitude and parent-child interaction were statistically significantly improved after intervention compared to before intervention. However, maternal stress decreased after intervention compared to before intervention, but it was not statistically significant. Additionally, resilience and child abuse potential were not statistically significant. This program is partially effective in preventing child abuse by promoting parenting attitudes and parent-child interactions. Conclusion: This study focused on individual resilience and applied systematic intervention as coping skills training to prevent child abuse. This study is meaningful in that interventions were conducted through individual visits to unmarried mothers at high risk of child abuse, and the program was applied, including pregnancy and postpartum periods, to prevent child abuse early.

• Journal of the Korean Association of Geographic Information Studies
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• v.17 no.4
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• pp.167-178
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• 2014

As large-scale housing sites are being developed rapidly in Sejong City, which was launched in 2012 for resolving the adverse effects of overconcentration in the capital area, promoting balanced development of the country, and reinforcing national competitiveness, changes in spatial structure are expected in the surrounding areas. For setting the directions of urban planning, it is essential to understand changes in spatial structure. This study purposed to measure changes in the spatial structure of neighboring areas resulting from the construction of Sejong City by approaching from the aspect of spatial interaction. In the analysis, we calculated population potential for future spatial interaction using the accessibility model, and interpreted quantitatively and qualitatively the outcomes of spatial interaction among neighboring areas before and after the construction of Sejong City using population potential as an indicator. According to the results of the analysis, the impact range of the population potential of the subject areas had been shrinking continuously since 1995, and in 2013 population potential dispersed as the population concentrated on and around Cheonan City. Although Sejong City, as a new area of population potential, was not found to play the role of a pivotal point for the surrounding areas, it is probably because the analysis was made just after people began to move to Sejong City. Accordingly, along with the effort of Sejong City to reach the planned population, it is necessary to keep monitoring changes in related factors and changes in the spatial structure of the surrounding cities resulting from the growth of population.

• Journal of applied mathematics & informatics
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• v.26 no.1_2
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• pp.45-60
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• 2008

Here we consider the evaluation of the the dynamic component of the second order force due to wave diffraction by a circular cylinder analytically and numerically. The cylinder is fixed, vertical, surface piercing in water of finite uniform depth. The formulation of the wave-structure interaction is based on the assumption of a homogeneous, ideal, incompressible, and inviscid fluid. The nonlinearity in the wave-structure interaction problem arises from the free surface boundary conditions, namely, dynamic and kinematic free surface boundary conditions. We expand the velocity potential and free surface elevation functions in terms of a small parameter and then consider the second order diffraction problem. After deriving the pressure using Bernoulli's equation, we obtain the analytical expression for the dynamic component of the second order force on the cylinder by integrating the pressure over the wetted surface. The computation of the dynamic force component requires only the first order velocity potential. Numerical results for the dynamic force component are presented.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.17-25
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• 2003

Determining the binding sites in protein-nucleic acid complexes is essential to the complete understanding of protein-nucleic acid interactions and to the development of new drugs. We have developed a set of algorithms for analyzing protein-nucleic acid interactions and for predicting potential binding sites in protein-nucleic acid complexes. The algorithms were used to analyze the hydrogen-bonding interactions in protein-RNA and protein-DNA complexes. The analysis was done both at the atomic and residue level, and discovered several interesting interaction patterns and differences between the two types of nucleic acids. The interaction patterns were used for predicting potential binding sites in new protein-RNA complexes.

• Journal of Microbiology and Biotechnology
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• v.16 no.1
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• pp.109-117
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• 2006

The Rev binding to Rev Responsive Element (RRE) of HIV-1 mRNA plays an important role in the HIV-I viral replication cycle. The disruption of the Rev-RRE interaction has been studied extensively in order to develop a potential antiviral drug. In order to provide the basis for a more promising approach to develop a Rev-RRE binding inhibitor against HIV-I infection, it is necessary to understand the binding modes of the aminoglycoside antibiotics to RRE. In the present study, the binding mode of a modified antibiotic, a neamine conjugated with pyrene and arginine (NCPA), to RRE has been studied by the methods of $T_m$ measurement and spectroscopic analysis of RRE with or without antibiotics. The results confirmed that NCPA competes with Rev in binding to RRE.

• Bulletin of the Korean Chemical Society
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• v.32 no.8
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• pp.2722-2726
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• 2011

Plasticized poly(vinyl chloride), PVCs, with different membrane compositions tested for use in the construction of an ion-selective sensor for the determination dibucaine. A prepared membrane with dioctyl phthalate-PVC and ion-pair of N-(1-naphthyl)ethylenediamine dihydrochloride-tetraphenyl borate had a good potential to acts as a potentiometric sensor for the analysis of dibucaine. A linear relationship was obtained between potential and logC varying between $1.0{\times}10^{-6}$ and $1.0{\times}10^{-2}$ M dibucaine with a good repeatability and reproducibility. The sensor was applied for the determination of the drug in pharmaceuticals and biological fluids such as plasma and urine samples with satisfactory results. The drug electrode has also been used to study the interaction of bovine serum albumin (BSA) with dibucaine. The saturated quantities of dibucaine binding were 13.04, 5.30 and 9.70 mol/mol in 0.01, 0.02 and 0.1% of protein, respectively.

• Journal of the Korean Chemical Society
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• v.34 no.4
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• pp.325-330
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• 1990

The solubilities of caffeine in supercritical ammonia were measured at various temperatures and pressures to represent the relationship between the solubility and the density of ammonia at desired temperature and pressure by means of a simple equation. Using the equation, the interaction virial coefficient between ammonia and caffeine has been determined to give the parameters of Lennard-Jones potential function for the system. Furthermore, there are comparisons and discussions of the interaction virial coefficients and Lennard-Jones potential functions determined by the same techniques from the solubility data of naphthalene in supercritical ammonia and of caffeine and naphthalene in supercritical carbon dioxide from existing data sources others.

• Biomolecules & Therapeutics
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• v.19 no.2
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• pp.155-173
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• 2011

Humans have and hold 100 trillion intestinal bacteria that are essential for health. For millions of years human-microorganisms interaction has co-evolved, and maintained close symbiotic relationship. Gut bacteria contributes to human health and metabolism, and humans provides the optimum nutrition-rich environment for bacteria. What is the mechanism of the host distinguishing the intestinal bacteria as its cohabiting partner and what kind of benefits does the gut microbiota provide the human are the fundamental questions to be asked and solved in order to make human life a higher quality. This review explains the physiological relationship and mutualism between the host and gut microorganism, and highlights the potential therapeutic approach for treating diseases, maintaining and improving health based on these correlations.

• Structural Engineering and Mechanics
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• v.65 no.4
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• pp.359-368
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• 2018

Dynamic analysis of complex and large structures may be costly from a numerical point of view. For coupled vibroacoustic finite element models, the importance of reducing the size becomes obvious because the fluid degrees of freedom must be added to the structural ones. In this paper, a component mode synthesis method is proposed for large vibroacoustic interaction problems. This method couples fluid subdomains and dynamical substructuring of Craig and Bampton type. The acoustic formulation is written in terms of the velocity potential, which implies several advantages: coupled algebraic systems remain symmetric, and a potential formulation allows a direct extension of Craig and Bampton's method to acoustics. Those properties make the proposed method easy to implement in an existing finite element code because the local numerical treatment of substructures and fluid subdomains is undifferentiated. Test cases are then presented for axisymmetric geometries. Numerical results tend to prove the validity and the efficiency of the proposed method.