• Applied Microscopy
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• v.15 no.2
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• pp.19-30
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• 1985

Morphogenesis of rat spleen was studied by light and electron microscope from the fetal stage till the newborn or adult stages. The results indicate as follows: at the 14th day of gestation rat spleen, as an early form, consists of intercellular spaces and mesenchymal cells. And at this stage the spleen is in a premature state, then it appears its adult condition in structures after the 7th postnatal day. Erythropoiesis is shown to be an active process in rat spleen beginning about the 18th day of gestation, and once established the process continues at least till the 7th postnatal day. At the 20th day of gestation, there are splenic nodules, trabeculae, venous sinus, and granular leucocytes such as neutrophils and basophils in rat spleen. Lymphocytes appeared to be well differentiated at the 7th postnatal day and were present till the adult stage. While degenerating erythrocytes are phagocytosed by macrophages. In conclusion, rat spleen started to be appeared from the 14th day of gestation and erythropoiesis in rat spleen was carried out for about 10 days between prenatal and postnatal stage. Erythrophagocytosis was accomplished by macrophages and it is suggested that the proper functions of rat spleen set off from the 7 th postnatal day when its structures are similar to the adult's.

• Development and Reproduction
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• v.22 no.1
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• pp.65-72
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• 2018

Cyclic AMP-response element binding protein zhangfei (CREBZF), a member of ATF/CREB (activating transcription factor/ cAMP response element binding protein) family, regulates numerous cellular functions and development of cells by interacting transcription factors. This study discovered the expression pattern of CREBZF in seminiferous tubule of testes during the postnatal development of mice. In testis, CREBZF mRNA expression was the highest among other organs. Immunofluorescence analyses showed that the CREBZF was specifically expressed on spermatocyte but not in spermatogonia and Sertoli cells in seminiferous epithelium of mouse testis. Semi-quantitative polymerase chain reaction (PCR) analysis showed that CREBZF transcript level was significantly elevated during postnatal development of mouse testis. Confocal imaging analysis indicated that the protein expression of CREBZF in seminiferous tubule remained low until postnatal day (PD) 14, and was dramatically increased in PD 21. Interestingly, only one type of the spermatocyte expressed CREBZF specifically among SCP3-positive spermatocytes. Taken together, these results suggest that CREBZF may be novel putative marker of the spermatocyte and regulate meiosis during postnatal development of mice.

• Toxicological Research
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• v.3 no.1
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• pp.55-63
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• 1987

A Peri-and Postnatal Study was Carried out to examine the effects of rHuIFN-${\alpha}A$, produced by gene-manipulated E. coli, on offsprings of Wistar rats. The substance was administered intraperitoneally to dams at dose levels of $1{\times}10^5$, $4{\times}10^5$ and $1.2{\times}10^6$ I.U/kg/day during the period from day 17 of gestation to day 21 after delivery. All the pregnant dams were allowed to deliver naturally, and the postnatal development of the offsprings was observed. No noticeable toxic effects and pathological changes on dams were observed, and no detectable variations in postnatal development of offsprings occured.

• Applied Microscopy
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• v.24 no.4
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• pp.32-40
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• 1994

This study was undertaken to study the morphological changes of rat synapses during early postnatal periods. Neonatal rats were grouped by 1st, 2nd, 3rd, 4th and 6th postnatal weeks, and we observed the ultrastructural pattern of the synapses in the external plexiform layer of olfactory bulbs by electron microscopy. The results were as follows; 1. The numbers of synapses, lengths of synaptic thickenings and amounts of synaptic vesicles were markedly increased in the external plexiform layer during four postnatal weeks. 2. There was a tendency of increasing the proportion of the asymmetric synapse and the curved synapses during maturation. From the above results, it is suggested that the size of synapse is increasing during maturation, and at the same time the asymmetric synapses are formed from the symmetric type and the curved synapses are from the plane type.

• Applied Microscopy
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• v.27 no.4
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• pp.347-355
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• 1997

These studies were performed to observe the morphological changes of synapses in the visual cortex of rat during early postnatal development. Specimens of the visual cortex were taken from rats (Sprague Dawley) at 1, 3, 7, 14 and 21 days of age, and prepared for silver impregnation and electron microscopy. The number of synapse and the length of postsynaptic thickening were increased progressively with age, especially 14 and 21 days. The number of dendritic spine was increased conspicuously on postnatal days 14-21. And asymmetic, curved and axo-spinous synapses were increased markedly at the same ages. The present findings suggest that spurt of synaptogenesis in the rat visual cortex occurs during early postnatal development, especially in second to 3rd week period and asymmetric and/or curved axo-spinous synapse is a matured form of synapse with advanced age.

• Women's Health Nursing
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• v.12 no.3
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• pp.204-209
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• 2006

Purpose: The Edinbergh Postnatal Depression Scale (EPDS) has seen widespread use in epidemiological and clinical studies. The objective of this research was to translate and to test the reliability and validity of the 10-item EDPS in Korea. Methods: Subjects were 145 women who were 6 to 10 weeks post delivery. To test reliability, the internal consistency was assessed by Cronbach's alpha coefficient. Validity testing was performed using convergent validity by Pearson's correlation. Data was gathered at 3 hospitals during Oct. 2005 after obtaining an informed consent. Result: The mean age of the subjects was 29.9 years. and the mean parity was 1.46 times. The mean EPDS score was 18.4. Reliability analysis showed a satisfactory result (Cronbach's alpha coefficient=.84). There were significant positive correlations between EPDS and Mills postnatal depression and anxiety check list scores as expected(r=.69, p<.001) and thus supported convergent validity. Conclusion: The study findings showed that the Korean version of the EPDS-10 is a reliable and valid instrument that can be used for measuring postnatal depression in Korea.

• Clinical and Experimental Pediatrics
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• v.65 no.1
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• pp.1-9
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• 2022

With advancements in neonatal care and nutrition, the postnatal growth of preterm infants has improved; however, it remains an issue. Accurate assessments of growth using a standardized reference are needed to interpret the intrauterine and postnatal growth patterns of preterm infants. Growth in the earlier periods of life can contribute to later outcomes, and the refinement of postnatal growth failure is needed to optimize outcomes. Catch-up growth occurs mainly before discharge and until 24 months of age, and very low birth weight infants in Korea achieve retarded growth later in life. Knowing an infant's perinatal history, reducing morbidity rates during admission, and performing regular monitoring after discharge are required. Preterm infants with a lower birth weight or who were small for gestational age are at increased risk of poor neurodevelopmental outcomes. Furthermore, poor postnatal growth is predictive of adverse neurodevelopmental outcomes. Careful monitoring and early intervention will contribute to better development outcomes and national public health improvements.

• Korean Journal of Health Education and Promotion
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• v.32 no.3
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• pp.85-96
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• 2015

Objectives: This study aims to identify the influencing factors of using postnatal care among illiteracy women who live in the Democratic Republic of Congo. Methods: Household survey was done from February 1 to 8, 2013 in the Kwango district of Democratic Republic of Congo, and 400 childbearing women who has under 5 years old children and pregnant women was randomly selected and answered through the interview with a questionnaire. For analysis the data, ${\chi}^2$ test and logistic regression analysis were used. Results: Woman who can read, write and mathematical calculation was 195 (47.4%) of total 411 answers and 161 (39.2%) used postnatal care for their latest pregnancy. Age at first marriage (${\chi}^2=18.481$, p<.001), religions (${\chi}^2=11.165$, p=.011), languages (${\chi}^2=35.586$, p<.001), the experience of children death (${\chi}^2=16.507$, p<.001), antenatal care over 4 times (${\chi}^2=15.315$, p<.001), postnatal care (${\chi}^2=15.558$, p<.001) is significantly different from literacy level. Among illiterate women group, who are protestant (OR=.330), using Lingala (OR=.128), took elementary education (OR=.223) and farmer (OR=.040), used less postnatal care. Conclusions: For increasing usage of postnatal care among illiterate women, new approach method should be considered such as a visual communication method and a community health workers' training program for giving an outreach service to pregnant women care.

• Clinical and Experimental Pediatrics
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• v.57 no.4
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• pp.171-177
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• 2014

Purpose: Eosinophilia is common in premature infants, and its incidence increases with a shorter gestation period. We investigated the clinical significance of eosinophilia in premature infants born at <34 weeks gestation. Methods: We analyzed the medical records of premature infants born at <34 weeks gestation who were admitted to the neonatal intensive care unit at Ewha Womans University Mokdong Hospital between January 2003 and September 2010. Eosinophilia was defined as an eosinophil percentage of >3% of the total leukocytes. Perinatal parameters and clinical parameters were also analyzed. Results: Of the 261 infants born at <34 weeks gestation, 22.4% demonstrated eosinophilia at birth. The eosinophil percentage peaked in the fourth postnatal week at 7.5%. The incidence of severe eosinophilia increased after birth up to the fourth postnatal week when 8.8% of all patients had severe eosinophilia. Severity of eosinophilia was positively correlated with a lower gestational age, birth weight, and Apgar score. Respiratory distress syndrome, bronchopulmonary dysplasia, nephrocalcinosis, intraventricular hemorrhage, and sepsis were associated with a higher eosinophil percentage. The eosinophil percentage was significantly higher in infants with bronchopulmonary dysplasia from the first postnatal week and the percentage was the highest in the fourth postnatal week, with the maximal difference being 4.1% (P<0.001). Conclusion: Eosinophilia is common in premature infants and reaches peak incidence and severity in the fourth postnatal week. The eosinophil percentage was significantly higher in bronchopulmonary dysplasia patients from the first postnatal week. Severe eosinophilia was significantly associated with the incidence of bronchopulmonary dysplasia even after adjusting for other variables.

• Journal of dental hygiene science
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• v.12 no.5
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• pp.486-492
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• 2012

Immunostaing intensity of Dynamin II protein in ameloblast during mouse tooth development showed a significant increase of 48% at the postnatal day 3 and a significant increase of 50% at the postnatal day 5 as compared with the postnatal day 1, but showed a significant decrease of 16% at the postnatal day 7 and a significant decrease of 12% at the postnatal day 10 as compared with the postnatal day 1. From the above results, Dynamin II had relevance to secretion of amelogenin, ameloblastin, enamelin and matrix metalloproteinase-20 proteins for enamel formation in ameloblast. Dynamin II may be involved in the transport of vesicles containing proteins for enamel formation through the acceleration of vesicular formation and may be had a good possibility of secretory regulation of proteins for enamel formation in ameloblast. Therefore, Dynamin II have potential for being used in the field of gene theraphy for periodontal disease and in the regeneration for enamel and dentin tissues lost to dental caries.