• 대한족부족관절학회지
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• 제5권1호
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• pp.28-34
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• 2001

Study design: Clinical results were retrospectively analyzed in 11 patients with fractures of talar neck who were treated in our department from Jan. 1994 to Dec. 1999. Objective: The purpose of this study is to evaluate the short-term results and to assess the prognostic factors of talar neck fractures. Material and Method: 11 cases with fractures of talar neck were reviewed retrospectively with minimum 1 year follow-up. There were 8 men & 3 women, and the average age was 25. The most common cause was traffic accident. According to the modified Hawkins classification, type I was in 4 cases, type II in 5, type III in 2, and type IV was none. All type I fractures were treated conservatively, and others were treated operatively. Results: According to Hawkins criteria, there was excellent result in 7 cases(64%), good in 2(18%), and fair in 2(18%). Post-traumatic arthritis occurred in 2 cases, but there was no avascular necrosis. Conclusion: Careful selection of method of treatment and urgent management are important prognostic factors in talar neck fractures. The longer follow-up in more cases is necessary to evaluate the long-term clinical results and complications more accurately.

• 한국안전학회지
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• 제27권6호
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• pp.192-204
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• 2012

For a severe accident of nuclear power plant, an approach to estimation of the radiological source term using a severe accident code(MELCOR) has been proposed. Although the MELCOR code has a capability to estimate the radiological source term, it has been hardly utilized for the radiological consequence analysis mainly due to a lack of understanding on the relevant function employed in MELCOR and severe accident phenomena. In order to estimate the severe accident source term to be linked with the radiological consequence analysis, this study proposes 4-step procedure: (1) selection of plant condition leading to a severe accident(i.e., accident sequence), (2) analysis of the relevant severe accident code, (3) investigation of the code analysis results and post-processing, and (4) generation of radiological source term information for the consequence analysis. The feasibility study of the present approach to an early containment failure sequence caused by a fast station blackout(SBO) of a reference plant (OPR-1000), showed that while the MELCOR code has an integrated capability for severe accident and source term analysis, it has a large degree of uncertainty in quantifying the radiological source term. Key insights obtained from the present study were: (1) key parameters employed in a typical code for the consequence analysis(i.e., MACCS) could be generated by MELCOR code; (2) the MELOCR code simulation for an assessment of the selected accident sequence has a large degree of uncertainty in determining the accident scenario and severe accident phenomena; and (3) the generation of source term information for the consequence analysis relies on an expert opinion in both areas of severe accident analysis and consequence analysis. Nevertheless, the MELCOR code had a great advantage in estimating the radiological source term such as reflection of the current state of art in the area of severe accident and radiological source term.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2006년도 International Symposium on GPS/GNSS Vol.2
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• pp.33-37
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• 2006

Since 1993, the civil aviation community through RTCA (Radio Technical Commission for Aeronautics) and the ICAO (International Civil Air Navigation Organization) have been working on the definition of GNSS augmentation systems that will provide improved levels of accuracy and integrity. These augmentation systems have been classified into three distinct groups: Aircraft Based Augmentation Systems (ABAS), Space Based Augmentation Systems (SBAS) and Ground Based Augmentation Systems (GBAS). The last one is an implemented system to support Air Navigation in CAT-I approaching operation. It consists of three primary subsystems: the GNSS Satellite subsystem that produces the ranging signals and navigation messages; the GBAS ground subsystem, which uses two or more GNSS receivers. It collects pseudo ranges for all GNSS satellites in view and computes and broadcasts differential corrections and integrity-related information; the Aircraft subsystem. Within the area of coverage of the ground station, aircraft subsystems may use the broadcast corrections to compute their own measurements in line with the differential principle. After selection of the desired FAS for the landing runway, the differentially corrected position is used to generate navigation guidance signals. Those are lateral and vertical deviations as well as distance to the threshold crossing point of the selected FAS and integrity flags. The Department of Applied Science in Naples has create for its study a virtual GBAS Ground station. Starting from three GPS double frequency receivers, we collect data of 24h measures session and in post processing we generate the GC (GBAS Correction). For this goal we use the software Pegasus V4.1 developed from EUROCONTROL. Generating the GC we have the possibility to study and monitor GBAS performance and integrity starting from a virtual functional architecture. The latter allows us to collect data without the necessity to found us authorization for the access to restricted area in airport where there is one GBAS installation.

• Journal of Information Processing Systems
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• 제14권3호
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• pp.751-770
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• 2018

Web applications are indispensable in the software industry and continuously evolve either meeting a newer criteria and/or including new functionalities. However, despite assuring quality via testing, what hinders a straightforward development is the presence of defects. Several factors contribute to defects and are often minimized at high expense in terms of man-hours. Thus, detection of fault proneness in early phases of software development is important. Therefore, a fault prediction model for identifying fault-prone classes in a web application is highly desired. In this work, we compare 14 machine learning techniques to analyse the relationship between object oriented metrics and fault prediction in web applications. The study is carried out using various releases of Apache Click and Apache Rave datasets. En-route to the predictive analysis, the input basis set for each release is first optimized using filter based correlation feature selection (CFS) method. It is found that the LCOM3, WMC, NPM and DAM metrics are the most significant predictors. The statistical analysis of these metrics also finds good conformity with the CFS evaluation and affirms the role of these metrics in the defect prediction of web applications. The overall predictive ability of different fault prediction models is first ranked using Friedman technique and then statistically compared using Nemenyi post-hoc analysis. The results not only upholds the predictive capability of machine learning models for faulty classes using web applications, but also finds that ensemble algorithms are most appropriate for defect prediction in Apache datasets. Further, we also derive a consensus between the metrics selected by the CFS technique and the statistical analysis of the datasets.

• The Journal of Korean Physical Therapy
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• 제23권1호
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• pp.37-43
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• 2011

Purpose: We studied the changes in motor response time and stop signal response time following visuomotor skill learning of a stop signal task in young healthy subjects. This study also was designed to determine what an effective practice is for different stop signals in the stop signal task (SST). Methods: Forty-five right-handed normal volunteers without a history of neurological dysfunction were recruited. They all gave written informed consent. In all subjects, motor reaction time (RT) and stop signal reaction time (SSRT) were measured for the stop signal task. Tasks were classified into three categories: predictable-stop signal task (P-SST) practice group random-stop signal task (R-SST) practice group control group. Results: Motor reaction time in the P-SST was significantly reduced when comparing pre- and post-tests (p<0.05). Stop signal reaction times in the P-SST and the R-SST were significantly reduced following motor skill learning (p<0.05). Also, the reaction time of the R-SST was shorter than that of the P-SST. Conclusion: These findings indicate that practice of an SST improves motor performance and stop function for some stop signals in the SST. P-SST practice was effective in the stop function of regular movement because of faster of the motor prediction and preparation but the R-SST was effective in the stop function of movements because of faster motor selection.

• 동의생리병리학회지
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• 제34권3호
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• pp.117-125
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• 2020

The purpose of this review is to confirm whether Soyo-san (Xiaoyao-san) and its modifications is effective on alleviating clinical symptoms in chronic fatigue syndrome (CFS) patients. We collected clinical trials (randomized controlled trial, quasi-randomized controlled trial, controlled clinical trial) to investigate the effects of Soyo-san and its modifications on general symptoms, fatigue, depression and anxiety in CFS patients. The databases used for data retrieval were Pubmed, Central Cochrane, Embase, CNKI, CQVIP, Wanfang, CiNii, OASIS, RISS, and Koreamed. We performed selection/exclusion process from the found studies to conform with prespecified criteria, and assessed the final included trials according to the Cochrane risk of bias tool. The included studies were classified based on the interventions in experimental and control group. Eight randomized controlled trials and one controlled clinical trial (total 921 participants) were eligible and their results were synthesized in the meta analysis. The synthesis showed a considerable effect of Soyo-san and its modifications on improvement of general symptoms (relative risk 0.27 [95% CI 0.19 to 0.39], Z=7.03, P<0.00001; I2=0%) and fatigue severity (SMD -1.20 [95% CI -1.46 to -0.93], Z=8.78, P<0.00001; I2=52%) in CFS patients, while Effect on depression and anxiety were inconclusive. We found that Soyo-san and its modifications were effective for improvement of general symptoms and fatigue severity in CFS post-treatment.

• Molecules and Cells
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• 제40권2호
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• pp.151-161
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• 2017

Proper synaptic function in neural circuits requires precise pairings between correct pre- and post-synaptic partners. Errors in this process may underlie development of neuropsychiatric disorders, such as autism spectrum disorder (ASD). Development of ASD can be influenced by genetic factors, including copy number variations (CNVs). In this study, we focused on a CNV occurring at the 16p11.2 locus in the human genome and investigated potential defects in synaptic connectivity caused by reduced activities of genes located in this region at Drosophila larval neuromuscular junctions, a well-established model synapse with stereotypic synaptic structures. A mutation of rolled, a Drosophila homolog of human mitogen-activated protein kinase 3 (MAPK3) at the 16p11.2 locus, caused ectopic innervation of axonal branches and their abnormal defasciculation. The specificity of these phenotypes was confirmed by expression of wild-type rolled in the mutant background. Albeit to a lesser extent, we also observed ectopic innervation patterns in mutants defective in Cdk2, Gq, and Gp93, all of which were expected to interact with Rolled MAPK3. A further genetic analysis in double heterozygous combinations revealed a synergistic interaction between rolled and Gp93. In addition, results from RT-qPCR analyses indicated consistently reduced rolled mRNA levels in Cdk2, Gq, and Gp93 mutants. Taken together, these data suggest a central role of MAPK3 in regulating the precise targeting of presynaptic axons to proper postsynaptic targets, a critical step that may be altered significantly in ASD.

• Journal of Korean Neurosurgical Society
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• 제30권sup1호
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• pp.61-67
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• 2001

Objectives : To demonstrate the preventive effect on post-operative spinal deformity of the laminoplasty compared with laminectomy for spinal cord tumor. Methods : Sixteen patients who underwent laminoplasty and 89 patients who underwent lamenectomy were reviewed retrospectively after removal of spinal cord tumors between February 1981 and December 1999. The mean follow-up period after laminoplasty and laminectomy were 29 months(range, 12-49 months) and 66 months(range, 6-120 months) respectively. Patients were observed neurologically and radiologically. Results : Postoperative kyphosis was observed 17 patients(19%) in the laminectomy group, but was not observed in the laminoplasty group. Postoperative slipping was observed 16 patients(18%) in the laminectomy group, but was not observed in the laminoplasty group. Complications such as postoperative scoliosis, rotation, and swan-neck deformity were observed in the laminectomy group, but were not observed in the laminoplasty group. Conclusions : Laminoplasty prevented postoperative spinal deformities after removal of spinal cord tumors, and afforded anatomic reconstruction of the vertebral arch. Additionally, appropriate patient selection maximizes the chance of optimal neurologic outcomes and minimizes complications. Laminoplasty appears to warrant further evaluation as an alternative to wide laminectomies for exposure of intraspinal tumors.

• Journal of Veterinary Science
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• 제22권4호
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• pp.58.1-58.13
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• 2021

Background: The morphometry of the acetabulum is one source of information that assists in the clinical diagnosis of the hip and influences the proper selection of a prosthesis, reducing post-operative complications such as those seen in total hip replacement (THR). However, acetabular parameters in small-breed dogs are rarely reported. Objectives: To investigate acetabular parameters using radiography and computed tomography (CT) in small-breed dogs with Maltese and Shih Tzu dogs used as model breeds. Methods: Standard calibrated, extended hip radiographs and CT images were obtained. Subsequently, acetabular width (AW) in various directions was measured using radiography and CT, whereas acetabular depth (AD) was obtained by CT. Acetabular index (AI) is a ratio calculated from AD and AW. Results: The values of AW and AD were much higher in Shih Tzu than in Maltese dogs. Male Shih Tzus showed higher values of these parameters than females, while sex-based differences in most of the parameters could not be detected in Maltese. Body weight, but not age, influenced AWs and ADs. While AWs and ADs were influenced by several factors, AI was comparable among the assessed factors and between Maltese and Shih Tzu dogs (p = 0.172; 31.42 ± 1.35 and 32.60 ± 1.80, respectively). Also, AI did not vary with breed, sex, or body size. Conclusions: The obtained radiographic and CT acetabular parameters could be useful as guidelines for evaluating the acetabulum of small-breed dogs in clinical practice.

• 한국임상약학회지
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• 제29권1호
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• pp.18-24
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• 2019

Background: Although a growing number of guidelines and clinical researches are available for immunosuppressive treatment of post-transplantation, there is no clinical practice guideline for the care of kidney transplant recipients in Korea. Selection of a researchable question is the most important step in conducting qualified guideline development. Thus, we aimed to formulate key questions for Korean guideline to aid clinical decision-making for immunosuppressive treatment. Methods: Based on previous published guidelines review, a first survey was constructed with 29 questions in the range of immunosuppressive treatments. The experts were asked to rate the clinical importance of the question using a 5-point Likert scale. The questions reached 60% or more from the first survey and additional new questions were included in the second survey. In analyzing the responses to items rated on the 9-point scale, consensus agreement on each question was defined as 75% or more of experts rating 7 to 9. Results: In the first survey, 50 experts were included. Among the 29 questions, 27 were derived to get 60% or more importance and 3 new questions were additionally identified. Through the second survey, 9 questions were selected that experts reached consensus on 75% and over of the options. Finally, we developed key questions using PICO (patient, intervention, comparison, and outcome) methodology. Conclusion: The experts reached a high level of consensus on many of key questions in the survey. Final key questions provide direction for developing clinical practice guideline in the immunosuppressive treatment of transplantation.