• Journal of Hospice and Palliative Care
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• 제19권2호
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• pp.170-179
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• 2016

목적: 암환자의 자가간호행위, 자기효능감, 외상 후 성장, 그리고 삶의 질의 정도를 평가하고, 질병관련특성에 따른 차이를 파악하여 이들의 정도가 낮은 환자군의 질병관련특성을 발견하여, 이를 증진시킬 교육과 프로그램의 적용 등 심리사회적 개입이 필요한 환자군에 대한 자료를 제공하고자 한다. 방법: 암환자 총 107명을 대상으로 자가간호행위, 자기효능감, 외상 후 성장, 심리, 사회관계적 삶의 질에 관한 설문조사 하였고, 진단병기, 진단 후 경과기간, 치료현황의 질병관련특성에 따라 그룹으로 나누어 이에 대해 평가하였다. 결과: 자가간호행위는 총 65점 중 평균점수 49.96점, 자기효능감은 총 50점 중 평균점수 37.78점으로 나타났다. 자가간호행위는 하위요인 중 투약의 항목에서는 진단 후 기간이 1년 이상 2년 미만의 환자집단에 비해 1년 미만의 환자집단에서, 추적관찰중 집단 및 전이집단에 비해서 현재치료중 집단이 높은 점수를 나타냈다. 외상 후 성장은 총 80점 중 평균점수 56.17점이 나왔고, 진단 후 경과기간 1년 이상 2년 미만의 환자집단이 1년 미만의 환자집단에 비해서 점수가 유의하게 높았으며, 하위요인으로는 자기지각의 변화가 차이를 보였다. 추적관찰 중인 집단이 현재치료 중 집단보다 점수가 유의하게 높았으며, 하위요인으로 대인관계의 깊이증가와 영적, 종교적 관심증가에서 차이를 보였다. 삶의 질은 총 40점 중 평균점수 25.79점이였으며, 질병관련특성에 따라 차이를 보이지 않았다. 결론: 진단 후 경과기간이 짧을수록 자가간호행위 높은 점수를 나타냈고, 외상 후 성장은 암 진단 후 경과기간이 1년 이후 2년 미만이 가장 높은 것으로 나타났다. 이를 토대로, 진단 후 1년 이내에 자가간호행위와 자기효능감 증진을 도모하는 것이 이를 유지하는 데에 도움을 줄 수 있을 것이다. 또한 암 진단 후 2년 시점에서 외상 후 성장을 위한 외적 자원의 투입이 필요하다.

• 대한디지털의료영상학회논문지
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• 제16권1호
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• pp.13-19
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• 2014

Purpose: FLAIR image is beneficial for the diagnosis of various bran diseases including ischemic CVS, brain tumors and infections. However the border between the legion of brain metastasis and surrounding edema may not be clear. Therefore, this study aims to investigate the practical benefits of delayed imaging by comparing the image from a patient with brain metastasis before a contrast enhancement and the image 10 minutes after a contrast enhancement. Materials and methods: Of the 92 people who underwent MRI brain metastases in suspected patients 13 people in three patients there is no video to target the 37 people confirmed cases, and motion artifacts brain metastases in our hospital June-December 2013, 18 people measurement position except for the three incorrect patient (male: 11 people, female: 7 people, average age: 60 years) in the target, test equipment, 3.0T MR System (ACHIEVA Release, Philips, I was 8ChannelSENSE Head Coil use Best, and the Netherlands). TR 11000 ms, TE 125 ms, TI2800 ms, Slice Thickness 5 mm, gap 5 mm, is a Slice number 21, the parameters of the 3D FFE, T2 FLAIR variable that was used to test, TR 8.1 ms, TE 3.7 ms, Slice number 240 I set to. The experiment was conducted by acquiring the FLAIR prior to contrast enhancement (heretofore referred to as Pre FLAIR), and acquiring the 3D FFE CE five minutes after the contrast enhancement, and recomposing the images in an axial plane of S/T 3mm, G 0mm (heretofore referred to as MPR TRA CE). Using the FLAIR 10 minutes after the contrast enhancement (heretofore referred to as Post FLAIR) and Pi-View, a retrospective study was conducted. Using MRIcro on the image of a patient confirmed for his diagnosis, the images before and after the contrast media, as well as the CNR and SNR of the MPR TRA CE images of the lesion and the site absent of lesion were compared and analyzed using a one-way analysis of variance. Results: CNR for Pre FLAIR and Post FLAIR were 34.35 and 60.13, respectively, with MPR TRA CE at 23.77 showing no significant difference (p<0.050). Post-experiment analysis shows a difference between Pre FLAIR and Post FLAIR in terms of CNR (p<0.050), but no difference in CNR between Post FLAIR and MPR TRA CE (p>0.050), indicating that the contrast media had an effect only on Pre FLAIR and Post FLAIR. The SNR for the normal site Pre FLAIR was 106.43, and for the lesion site 140.79. Post FLAIR for the normal site was 107.79, and for the lesion site 167.91. MPR TRA CE for the normal site was 140.23 and for the lesion site 183.19, showing significant difference (p<0.050), and post-experiment analysis shows that there was a difference in SNR only on the lesion sites for Pre FLAIR and Post FLAIR (p<0.050). There was no difference in SNR between the normal site and lesion site for Post FLAIR and MPR TRA CE, indicating no effect from the contrast media (p>0.050). Conclusions: This experiment shows that Post FLAIR has a higher contrast than Pre FLAIR, and a higher SNR for lesions, It was not not statistically significant and MPR TRA CE but CNR came out high. Inspection of post-contrast which is used in a high magnetic field is frequently used images of 3D T1 but, since the signal of the contrast medium and the blood flow is included, this method can be diagnostic accuracy is reduced, it is believed that when used in combination with Post FLAIR, and that can provide video information added to the diagnosis of brain metastases.

• 성인간호학회지
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• 제18권5호
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• pp.691-698
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• 2006

Purpose: This research was conducted to evaluate, analyze, and determine the limitation of the anesthesia that is used in there covery room in order to provide the foundation for developing the effectiveness of it. Method: There covery records of this study were collected from 41 hospitals in Seoul, Kyung Kii-Do, and Inchon province. The post anesthetic recovery records consisted of the evaluation of type, evaluative items, frequency, time, score and $SaO_2$. These records were collected from September to December of 2005. Results: The most commonly used post anesthetic evaluation tool was Alderete Score, which was used in 73% of hospitals. The second was Aldrete Score with $SaO_2$(17%). Also, 5% of the hospitals used the modified AS form. There were 2.5% of the hospitals applying the adult and child in the evaluation separately. Also, the last 2.5% of the hospitals did not use AS but measured BP, pulse, respiration, temperature, and $SaO_2$ with observing nausea, vomiting, urinary retention, backache, laryngitis, shock, and neurologic assessment. Conclusion: It is necessary to develop a post-anesthetic recovery evaluation tool including the application of $SaO_2$, so that the early-diagnosis of hypoxia can be possible. In addition, it is necessary to develop a post- anesthetic recovery evaluating method that can distinguish a difference between adults and children.

• Advances in pediatric surgery
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• 제15권1호
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• pp.38-43
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• 2009

With the widespread use of the obstetrical ultrasound, identification of a fetal suprarenal mass becomes more common. Most of these masses prove to be congenital neuroblastomas (CNB) postnatally. However, the diagnosis is often confused with other benign lesions and the post-natal management remains controversial. The medical records of 13 patients that underwent primary surgical excision for an antenatally detected adrenal CNB, between January 1995 and April 2009, were reviewed retrospectively. The clinical, radiological, surgical, and pathological data on the suprarenal mass were collected. Staging evaluation was performed after histological confirmation of the CNB. Most of the CNBs were stage I (N=11), with 1 stage IV and 1 stage IV-S. Four patients (3 stage I and 1 stage IV-S) had N-myc gene amplification. The stage I patients were cured by surgery alone, and stage IV patients underwent 9 cycles of adjuvant chemotherapy and currently have no evidence of disease after 39 months of follow-up. The patient with stage IV-S is currently receiving chemotherapy. There were no post-operative complications. For early diagnosis and treatment, surgical excision should be considered as the primary therapy for an adrenal CNB detected before birth. The surgery can be safely performed during the neonatal period and provides a cure in most cases. Surgical diagnosis and treatment of CNB is recommended in neonatal period.

• 대한한방내과학회지
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• 제20권1호
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• pp.244-260
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• 1999

This study was to investigate diagnosis of shoulder pain on cerebrovascular attack patients and treatment effects by using physical treatment and orienatal diagnosis aparatus, as oriental diagnosis equipments, these were used thermography, maegzin and yangdorag machine. as physical treatment equipments, these were used Hot pack, TENS (Transcutaneous electrical nerve stimulation), ICT(Interferential current therapy) the results were followed 1. In Sex and Age distribution on cerebrovascular attack patients with shoulder pain, male(51.7%)had many than female(48.3%) and 60s were the top, next 70s 50s 40s. 2. In the reason of cerebrovascular attack and the type of motor paresis, cerebrovascular infarction(73.3%) had many than hemorrhage(26.7%) 3. In hospitalizied period of cerebrovascular attack patients with shoulder pain, the period from 11 to 60 days had almost occupied. 4. Oriental medical diagnositic propriety of shoulder pain by using maegzin and yangdorag machine were not recognized. 5. In measuring passive range of motion of pre and post treatment, improvement effect on Hot pack was not showed, but effects on TENS, ICT were showed. 6. In measuring temperature of painful shouler joint of pre and post treatment by using thermography, the effect of Hot pack was not recognized but the effects of TENS, ICT were recognized.

• Journal of Korean Dental Science
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• 제8권1호
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• pp.1-9
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• 2015

Purpose: To evaluate the effectiveness of temporomandibular joint (TMJ) disorder follow-up and determine the factors that affect the TMJ bone scan hot spot numerical value (bone scan value), and to compare this value to the diagnosis of patients with temporomandibular joint disorders (TMD), their treatment options, and the resolution of their symptoms. Materials and Methods: A retrospective cohort study was performed on 24 patients (four males, 20 females) who received TMD treatment in the Section of Dentistry, Seoul National University Bundang Hospital (Seongnam, Korea) from 2007 to 2014. An analysis of the significance test and correlation between TMD diagnosis, treatment options, a baseline the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) questionnaire, treatment before and after the clinical examination and subjective progress, and TMJ bone scan value change were completed by using SPSS version 12.0. Result: Although only 14 patients had bony factors that caused TMD, the average pre-treatment bone scan value of the all patients was $4.29{\pm}0.31$, which is higher than the finding for osteoarthritis (3.88), and reduced post-treatment bone scan value was found to be without a statistically significant difference (P=0.056). After the treatments, clinical symptoms in 18 patients disappeared, and six patients did not require additional treatment, although they still displayed subjective symptoms. It was observed that the higher the pre-treatment bone scan value, nonspecific physical symptoms, chronic pain index, characteristic pain intensity, disability score, were, the lower the post-treatment bone scan value was. And this reduced post-treatment bone scan value tendency was not shown with the pre-treatment depression index, but there was not a statistical difference. Conclusion: The post-treatment TMJ bone scan value tended to be insignificantly reduced in the 24 patients whose clinical symptoms were improved (P=0.056). Moreover, the TMJ bone scan value showed no relation to the TMD type or its related symptoms.

• Journal of Oral Medicine and Pain
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• 제16권1호
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• pp.103-111
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• 1991

This study was performed to observe the effect of micro-wave diathermy and ultrasonic-wave diathermy on the craniomandibular disorder patients. 19 patients were classified into 12 acute and 7 chronic groups according to the duration of 6 months. They were treated with micro-wave diathermy and ultrasonic-wave diathermy for 2 weeks and pain, maximum comfortable opening, active range of motion were checked before and after therapy. Electromyographic activities of temporal and masseter muscles were also measured at physiologic rest position, clenching and mastication before and after therapy. The obtained results were as follows : 1. After treatment, pain were reduced and active range of motion and maximum comfortable opening were increased. 2. Temporoal and masseter muscle activities of post-treatment in rest position, clenching and mastication were lower than those of pre-treatment. 3. In rest position, temporal and masseter muscle activities of pre-treatment on affected sides were higher than those on unaffected sides, but there were no differences in muscle activities between affected ad unaffected sides on clenching and mastication in pre and post-treatment respectively. 4. There were no significant differences in active range of motion, pain and maximum comfortable opening between acute and chronic groups in pre and post-treatment but there were significant differences between pre-treatment and post-treatment in acute and chronic groups respectively. 5. Muscle activities of masseter and temporal muscles in acute and chronic patients were reduced in rest position after treatment.

• Nuclear Medicine and Molecular Imaging
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• 제40권6호
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• pp.316-321
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• 2006

목적: 동정맥 혈관기형은 혈역학적 변화를 일으켜 생명에 위험을 줄 수 있으므로, 사지의 선천성 혈관기형 환자에서 동정맥 혈관기형과 비동정맥 혈관기형을 정확히 감별진단 하는 것이 중요하다. 이 연구에서는 혈관조영술과 비교하여 경동맥 폐관류 신티그라피(transarterial lung perfusion scintigraphy, TLPS)가 선천성 혈관기형 중 상하지에 위치하는 동정맥 혈관기형의 진단과 치료 효과 평가에 유용한 지를 알아보았다. 대상 및 방법: 색전술/경화요법 전에 처음 TLPS를 시행 받은 57명(나이: $21{\pm}13$세, 남:여 = 26:31)이 연구대상이 되었다. 병변의 위치는 상지가 9명이었고 하지가 48명이었다. TLPS에서 폐의 시간 방사능 곡선을 이용하여 혈액 단락량을 구하였다. 모든 환자들에서 혈관조영술을 시행하여 혈관기형의 해부학적 및 혈역학적 평가를 하였다. 혈관조영술로 동전맥 혈관기형이 진단된 환자들은 치료 후 TLPS를 추적 시행하였다. 결과: 혈관조영술상 16명은 동정맥 혈관기형(상지 8명, 하지 8명), 나머지 41명은 비동정맥 혈관기형(상지 1명, 하지 40명)으로 진단되었다. 동정맥 혈관기형 환자들의 치료 전 평균 혈액 단락량은 비동정맥혈관기형 환자들에 비하여 유의하게 높았다($66.4{\pm}25.8%\;vs.\;2.8{\pm}4.3%$, p<0.0001). TLPS의 치료 전 상하지 동정맥 혈관기형을 진단하는 예민도와 특이도, 정확도는 각각 93.8% (15/16), 100% (41/41), 98.2% (56/57)이었다(혈액 단락량 기준 역치 = 20%). 동정맥 혈관기형 환자 16명은 추적 TLPS를 시행하였고 이 중 13명은 치료 평가에서 혈관조영술과 일치하는 결과를 보여주었다(81.3%). 색전술/경화요법 시행 후 TLPS 혈액 단락량은 유의하게 감소하였다($69.5{\pm}24.0%\;vs.\;41.0{\pm}34.7%$, p = 0.01). 결론: TLPS는 상하지동정맥 혈관기형에서 혈액 단락량의 반정량적인 정보를 제공해주며 혈관 조영술과 높은 검사결과 일치도를 보여주었다. 그러므로, TLPS는 상하지 동정맥 혈관기형의 진단과 치료 평가에 유용하다.

• 대한예방한의학회지
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• 제6권1호
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• pp.51-95
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• 2002

1. As a point at issue of occidental medicine examination, followings have been indicated, 1) Occidental medical examination is performed by mainly test and instrument and therefore, role of doctors could be excluded and it could be diagnosed only for target disease and 2) in Korea, it could not be conducted in public medical system and therefore improvement effect of public health promotion could not be made due to increase of total medical expenses and infirmity of post management. These points are substantial limit of paradigm resided in occidental medicine and also problem caused by unique characteristics of medical system of Korea. In Korea, result of occidental medical examination show increased health risk from aged thirties and major diagnosed diseases are circulatory disease or chronic disease such as hepatic, hyperlipemic, hypertensional disease and diabetes, etc. Accounting that those chronic disease make a role as major public health risk, it is difficult that medical examination by only occidental medicine make effect on public health promotion. 2. Characteristics of oriental medicine examination could be summarized as diagnosis (information acquisition based on the facts) and demonstration (speculation based on acquired information) and in addition, quadruple diagnosis, as a medical examination method, include test as well as basic examination. Accounting on oriental medical examination, principally it is performed by independent herbalist and therefore, herbalist could acquire systemic result during first medical examination. Based on the theory of inner-outer examination, oriental medical examination has a principle of universe theory, systemic analysis of quadruple diagnosis, demonstration & reasoning. In addition, root of oriental medical examination could be found in pre-disease theory, a principal theory of oriental medicine. Pre-disease service could prove the advantage of oriental medicine in medical examination activities and therefore, it is needed that content of oriental medical examination should be actualized in current medical system. 3. In this study, oriental medical examination program, comprised of pulse-diagnosis, contrast muscular taking and medical consultation of herbalist is progressed communally with occidental medical examination. As pre-examination, questionary was given of general characteristics, health promoting life style, physical constitution and subjective symptom of musculoskeletal system. In addition, post-examination notification was given to subjects about health promoting control, physical constitution regimen and management of musculoskeletal system. During this study program, verification was conducted for input of acquired information and difference of each information after analysis and in addition, performed was analysis of factor influencing health promoting life style and musculoskeletal subjective symptom and evaluation of relationship of physical constitution and health promoting life study. In addition, it was verified of difference between musculoskeletal subjective symptom and result of muscle contrast picture evaluation. 4. Evaluation of oriental medical examination model is divided into 2 categories of oriental medical examination-consultation and result evaluation -post management. Oriental medical examination-consultation demands establishment of examination system, standardization of examination and establishment of examination form and in addition, it should be admitted as enlarged examination assists systemic quadruple diagnosis of herbalist not a key of oriental medical examination. In addition, information acquisition for research purpose should be performed according to the systemic research plan based on the separation of questionary for examination purpose and research purpose. For evaluation of the result, it was concluded that needed are result evaluation meets oriental medical system and post-notification system, informing health management information, based on examination result. 5. Accounting on satisfaction for oriental medical examination model, affirmative reply was much higher (66%) than negative (8.64%). Satisfaction of each area was in order of consultation of herbalist, systemic muscle contrast taking, pulse examination, post-notification and questionary fill-up and dissatisfaction was in order of post-notification, questionary fill-up, consultation of herbalist, systemic muscle contrast taking and pulse measurement. Satisfaction for collaborative examination of occidental and oriental medicine was over 60% and over 75% hope oriental examination would be included in later medical examination program. Based on this result, collaborative examination including occidental and oriental medicine could increase satisfaction of subjects for medical examination program.

• BMB Reports
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• 제51권11호
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• pp.563-571
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• 2018

Colorectal cancer (CRC), the third most common cancer in the world, has no specific biomarkers that facilitate its diagnosis and subsequent treatment. The miRNAs, small single-stranded RNAs that repress the mRNA translation and trigger the mRNA degradation, show aberrant levels in the CRC, by which these molecules have been related with the initiation, progression, and drug-resistance of this cancer type. Numerous studies show the microRNAs influence the cellular mechanisms related to the cell cycle, differentiation, apoptosis, and migration of the cancer cells through the post-transcriptionally regulated gene expression. Specific patterns of the upregulated and down-regulated miRNA have been associated with the CRC diagnosis, prognosis, and therapeutic response. Concretely, the downregulated miRNAs represent attractive candidates, not only for the CRC diagnosis, but for the targeted therapies via the tumor-suppressing microRNA replacement. This review shows a general overview of the potential uses of the miRNAs in the CRC diagnosis, prognosis, and treatment with a special focus on the downregulated ones.