• 한국ITS학회:학술대회논문집
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• 한국ITS학회 2004년도 제3회 정기총회 및 추계학술대회
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• pp.192-197
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• 2004

• Communications for Statistical Applications and Methods
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• 제29권5호
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• pp.547-559
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• 2022

For a chi-squared test, which is a statistical method used to test the independence of a contingency table of two factors, the expected frequency of each cell must be greater than 5. The percentage of cells with an expected frequency below 5 must be less than 20% of all cells. However, there are many cases in which the regional expected frequency is below 5 in general small area studies. Even in large-scale surveys, it is difficult to forecast the expected frequency to be greater than 5 when there is small area estimation with subgroup analysis. Another statistical method to test independence is to use the Bayes factor, but since there is a high ratio of data dependency due to the nature of the Bayesian approach, the low expected frequency tends to decrease the precision of the test results. To overcome these limitations, we will borrow information from areas with similar characteristics and pool the data statistically to propose a pooled Bayes test of independence in target areas. Jo et al. (2021) suggested hierarchical Bayesian pooling models for small area estimation of categorical data, and we will introduce the pooled Bayes factors calculated by expanding their restricted pooling model. We applied the pooled Bayes factors using bone mineral density and body mass index data from the Third National Health and Nutrition Examination Survey conducted in the United States and compared them with chi-squared tests often used in tests of independence.

• 산업경영시스템학회지
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• 제45권4호
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• pp.53-60
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• 2022

In a group-testing method, instead of testing a sample, for example, blood individually, a batch of samples are pooled and tested simultaneously. If the pooled test is positive (or defective), each sample is tested individually. However, if negative (or good), the test is terminated at one pooled test because all samples in the batch are negative. This paper considers a queueing system with a two-stage group-testing policy. Samples arrive at the system according to a Poisson process. The system has a single server which starts a two-stage group test in a batch whenever the number of samples in the system reaches exactly a predetermined size. In the first stage, samples are pooled and tested simultaneously. If the pooled test is negative, the test is terminated. However, if positive, the samples are divided into two equally sized subgroups and each subgroup is applied to a group test in the second stage, respectively. The server performs pooled tests and individual tests sequentially. The testing time of a sample and a batch follow general distributions, respectively. In this paper, we derive the steady-state probability generating function of the system size at an arbitrary time, applying a bulk queuing model. In addition, we present queuing performance metrics such as the offered load, output rate, allowable input rate, and mean waiting time. In numerical examples with various prevalence rates, we show that the second-stage group-testing system can be more efficient than a one-stage group-testing system or an individual-testing system in terms of the allowable input rates and the waiting time. The two-stage group-testing system considered in this paper is very simple, so it is expected to be applicable in the field of COVID-19.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2002년도 학술대회지
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• pp.490-493
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• 2002

건설 전단계에서 통합적인 관리를 위해서는 건설 전단계에 걸친 관리가 이루어져야 하고, 이러한 프로세스가 원활히 이루어지기 위해서는 자재의 원활한 조달이 이루어져야 한다. 현재 국내${\cdot}$외에서는 공급사슬관리를 위한 도구로서 인터넷을 활용한 통합조달과 자재의 분류체계를 통한 인터넷활용 방안에 대하여 연구${\cdot}$개발중이다. 본 연구의 목적은 건설자재 중 전기설비자재인 케이블덕트관의 공장제작과정과, 공정과정 흐름을 모델링하여 각 단계에서 발생되는 낭비요소들을 파악하여 개선점을 제시하는데 있다.

• Journal of Pharmaceutical Investigation
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• 제30권3호
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• pp.191-199
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• 2000

Genomics is providing targets faster than we can validate them and combinatorial chemistry is providing new chemical entities faster than we can screen them. Historically, the drug discovery cascade has been established as a sequential process initiated with a potency screening against a selected biological target. In this sequential process, pharmacokinetics was often regarded as a low-throughput activity. Typically, limited pharmacokinetics studies would be conducted prior to acceptance of a compound for safety evaluation and, as a result, compounds often failed to reach a clinical testing due to unfavorable pharmacokinetic characteristics. A new paradigm in drug discovery has emerged in which the entire sample collection is rapidly screened using robotized high-throughput assays at the outset of the program. Higher-throughput pharmacokinetics (HTPK) is being achieved through introduction of new techniques, including automation for sample preparation and new experimental approaches. A number of in vitro and in vivo methods are being developed for the HTPK. In vitro studies, in which many cell lines are used to screen absorption and metabolism, are generally faster than in vivo screening, and, in this sense, in vitro screening is often considered as a real HTPK. Despite the elegance of the in vitro models, however, in vivo screenings are always essential for the final confirmation. Among these in vivo methods, cassette dosing technique, is believed the methods that is applicable in the screening of pharmacokinetics of many compounds at a time. The widespread use of liquid chromatography (LC) interfaced to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) allowed the feasibility of the cassette dosing technique. Another approach to increase the throughput of in vivo screening of pharmacokinetics is to reduce the number of sample analysis. Two common approaches are used for this purpose. First, samples from identical study designs but that contain different drug candidate can be pooled to produce single set of samples, thus, reducing sample to be analyzed. Second, for a single test compound, serial plasma samples can be pooled to produce a single composite sample for analysis. In this review, we validated the issue whether the second method can be applied to practical screening of in vivo pharmacokinetics using data from seven of our previous bioequivalence studies. For a given drug, equally spaced serial plasma samples were pooled to achieve a 'Pooled Concentration' for the drug. An area under the plasma drug concentration-time curve (AUC) was then calculated theoretically using the pooled concentration and the predicted AUC value was statistically compared with the traditionally calculated AUC value. The comparison revealed that the sample pooling method generated reasonably accurate AUC values when compared with those obtained by the traditional approach. It is especially noteworthy that the accuracy was obtained by the analysis of only one sample instead of analyses of a number of samples that necessitates a significant man-power and time. Thus, we propose the sample pooling method as an alternative to in vivo pharmacokinetic approach in the selection potential lead(s) from combinatorial libraries.

• Investigative Magnetic Resonance Imaging
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• 제19권1호
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• pp.37-46
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• 2015

Purpose: This report compared the diagnostic effectiveness between ultrasmall superparamagnetic iron oxide (USPIO) and gadolinium (Gd) based magnetic resonance imaging (MRI) for differentiation of axillary status in breast cancer patients. Materials and Methods: The present authors performed a meta-analysis of previous studies that compared USPIO or Gd based MRI with histological diagnosis after surgery or biopsy. We searched PubMed, EMBASE, Cochrane Library, ScienceDirect, SpringerLink, Ovid databases and references of articles to identify studies reporting data until December 2013. Pooled sensitivity and specificity were calculated for every study; summary receiver operating characteristic and subgroup analysis was done. Analyses of study quality and heterogeneity were also assessed. Results: There were 14 publications that met the criteria for inclusion in our meta-analysis. USPIO based MRI showed 0.83 (95% CI: 0.75-0.89) and 0.97 (95% CI: 0.94-0.98) for pooled sensitivity and specificity, respectively. Gd based MRI represented pooled sensitivity and specificity of 0.61 (95% CI: 0.55-0.67) and 0.90 (95% CI: 0.87-0.92) for each. Overall weighted area under the curve for USPIO and Gd based MRI were 0.9563 and 0.9051, respectively. Conclusion: USPIO based MRI had a tendency toward high pooled sensitivity and specificity in detection of axillary metastases for breast cancer. This result may mean that USPIO based MRI could be used as complementary modality to differentiate axillary status more precisely, and assist in the decision-making process regarding possible invasive procedures, such as sentinel node biopsy.

• 무역학회지
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• 제41권3호
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• pp.177-198
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• 2016

중국은 1979년부터 본격적으로 시장경제체제를 도입함으로써 급격한 경제성장을 이루었는데, 본고는 저임금과 중국정부의 적극적인 외자유치정책을 활용하기 위해 밀려들어온 외국인투자에 어떤 요인들이 영향을 미쳤는지를 검토하기 위해 1979년부터 2013년까지의 패널데이터를 이용해서 각 성·시의 고유한 특성까지 활용하는 실증분석을 시도한다. 실증분석을 위해 본고는 확률효과모형, 고정효과모형, Pooled OLS, 그리고 확률계수모형을 사용하는데, Pooled OLS와 확률계수모형의 결과는 본 연구의 분석결과와 비교를 위해서 제시된다. Hausman' test 결과 Random Effect Model보다는 Fixed Effect Model이 더 효율적인 분석결과를 제시하는 것으로 나타나 이를 근거로 중국정부에 대한 정책적 시사점을 제시한다. 분석결과는 FDI유입에 각 성·시의 지역소득수준, 자본량, 통신비는 긍정적인 영향을 미치고 고속도로는 부정적인 영향을 미치는 것으로 나타난다.

• 한국산업보건학회지
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• 제11권1호
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• pp.48-55
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• 2001

The purpose of this study was to evaluate the analytical accuracy and precision of microwave oven digestion/atomi absorption spectrophotometry (AAS) for analyzing airborne chromium collected on mixed cellulose ester membrane (M filter from the work environment, and to compare the accuracy and the precision with those of the National Institute for Occupational Safety and Health (NIOSH) Method #7024 hot plate digestion/AAS method. For this study, field air sample pairs were collected from a electroplating process, and spiked samples in a laboratory were prepared and using these samples. Two digestion methods were comp; and evaluated in terms of recovery rate and bias as indices of accuracy and coefficient of variation as a index of precision. The results and conclusions are as follows. In spiked samples, the accuracies (% mean recoveries) of hot plate/AAS and microwave oven/AAS method were 97.19%, 97.1%, respectively, and the precisions (pooled respectively, and the precisions (pooled coefficient of variance, $CV_{pooled}$) 6.93% and 3.88%, respectively. The biases of hot plate ani microwave oven methods were 4.56 - 14.7% and 2.22 - 7.42% respectively. There was no statistically significant difference between hot plate and microwave oven methods recovery rates of spiked samples (p>0,05). Also, no statistically significant difference was shown among the concentrations of air samples determined by two method (p>0.05). In conclusion, microwave oven/AAS method h excellent accuracy and precision, and advantages such as time-saving and simple procedure in comparison with the classical NIOSH method. Therefore, this method can be use widely to analyze airborne chromium collected on MCE filter from the work environments.

• 아태비즈니스연구
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• 제10권4호
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• pp.87-118
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• 2019

The purpose of this study is to examine the effects of person-job fit, which consists of educational fit and skill fit, on employees' intrinsic job satisfaction. To the end, the 10-year balanced panel data of the Korean Labor and Income Panel Study(KLIPS) by the Korea Labor Institute (KLI) for 2008-2017 are utilized. This study analyzes 12,730 observations by 1,273 employees by using fixed effect model, random effect model, and pooled OLS estimation method. The empirical results are as follows: First, it is founded that educational fit and skill fit seem affect job satisfaction positively. Second, the negative effects of over-education are clear and the negative effects of under-education are unclear, while the effects of over-skilled and under-skilled are insignificant statistically. Third, the results imply that the size of effect of over-education on intrinsic job satisfaction is larger than that of the effect of over-skilled. Forth, it is shown that the use of fixed effect model is more effective and trustworthy than that of random effect model and pooled OLS estimation method, implying that the effect size of coefficients which are estimated by pooled OLS method and random effect model are likely over-estimated. The empirical results above imply that firms and employees should focus on solving over-education issue before all in order to enhance employees' job satisfaction and it is needed to monitor regularly whether systemic job assignment process is done based on the employees' educational attainment and skill level and to provide more chances for job re-allocation and job rotation.

• 한국컴퓨터정보학회논문지
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• 제22권10호
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• pp.145-150
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• 2017

This study aims to analyze panel data using OECD Health data of 34 years to examine how significant the inequality of income is to the inequality of health. The data was from OECD's pooled Health data of 32 countries from 1980 to 2013. The process of determining analysis model was as follows; First, through the descriptive statistics, we examined averages and standard deviation of variables. Second, Lagrange multiplier test has done. Third, through the F-test, we compared Least squares method and Fixed effect model. Lastly, by Hausman test, we determined proper model and examined effective factor using the model. As a result, rather than Pooled OLS Model, Fixed Effect Model was shown as effective in order to consider the characteristics of individual in the panel. The results are as follows: First, as relative poverty rate(${\beta}=-19.264$, p<.01) grows, people's life expectancy decreases. Second, as the rate of smoking(${\beta}=-.125$, p<.05) and the rate of unemployment (${\beta}=-.081$, p<.01) grows, people's life expectancy decreases. Third, as health expenditure(${\beta}=.414$, p<.01) shares more amount of GDP and as the number of hospital beds(${\beta}=-.190$, p<.05) grows, people's life expectancy increases.