• Polymer(Korea)
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• v.32 no.4
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• pp.328-333
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• 2008

The osmotic delivery systems are based on osmosis. The transverse diffusion of water through a porous membrane from a medium with a low osmotic pressure to a medium with a high osmotic pressure. Nifedipine tablet dosage forms of Procardia $XL^{(R)}$(Pfizer) and $Adalat^{(R)}$(Bayer) are commercialized systems of this type that push-pull osmotic tablet operates successfully in delivering water-insoluble drugs. We prepared osmotic pellet system by fluidized bed coating method, and model-drug used nifedipine. The osmotic pellet system was composed of the core material. the swelling and osmotic pressure layer, the drug coating layer, and the porous membrane. This work is performed to investigate the effect of different factors, such as composition and thickness of membrane. The osmotic pellet has been successfully prepared by fluidized bed coating technology. The drug release behavior depended on the increase of CA ratio and thickness in porous membrane. The morphology of the osmotic pellet before and after the dissolution test were observed by SEM. In conclusion, we found that the drug release of osmotic pellet depended on the composition and coating thickness of porous membrane.

• Polymer(Korea)
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• v.31 no.4
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• pp.329-334
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• 2007

Osmotic pellet system, which is one of the oral drug delivery systems, has been developed to improve manufacturing process, reduce product cost and other problems of osmotic tablet systems. Osmotic pellet is consisted of water swellable seed layer, drug layer, and membrane layer. Among them, the membrane layer plays an important role in a control of the drug release. In this work, we examined the effect of ratio for Eudragit RL and RS on the drug release behavior. Osmotic pellet with nifedipine as a model drug was easily obtained in a good yield by fluidized bed coater. Osmotic pellet showed round morphology with a range of size $1300{\sim}1500\;{\mu}m$. In the experiment of nifedipine release, the release amount increased with the increase of the ratio of Eudragit. This is due to the fact that Eudragit RL contains more hydrophilic quaternary ammonium group than Eudragit RS. Additionally, the release amount was retarded with increasing the membrane thickness. There are no differences in the release amount measured at the different pH 1.2, 6.5, 6.8, and 7.2. In conclusion, it was found that the drug release from osmotic pellets depended on the composition ratio and coating thickness of membrane layer.

• Polymer(Korea)
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• v.29 no.5
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• pp.468-474
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• 2005

PLGA and PCL copolymers initiated by carbitol as drug carriers were synthesized by ring-opening polymerization of L-lactide (LA), glycolide (GA), and $\varepsilon-caprolactone(\varepsilon-CL)$. Implantable wafers were simply fabricated by direct compression method after physical mixing of copolymers and bovine serum albumin-fluorescein isothiocyanate (BSA-FITC) as a model protein drug. The release amounts of BSA-FITC from wafers were determined by fluorescence intensity using the fluorescence spectrophotometer. Also, the release behavior of BSA-FITC on wafers was controlled by adding the additives such as collagen, small intestinal submucosa (SIS), poly(vinyl pyrrolidone) (PVP), and poly(thylene glycol) (PEG). The wafer prepared by PLGA and PCL exhibited slow release within $10\%$ for 30 days. But, those prepared by a variety of additives exhibited the controlled BSA release patterns with a dependence on the additive contents. furthermore, the wafers containing natural materials such as collagen and SIS showed more zero-order release profile than that with synthetic materials such as PVP and PEG. It was confirmed that the release of BSA from implantable wafers could be easily controlled by adding natural additives.

• Journal of Ocean Engineering and Technology
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• v.27 no.5
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• pp.99-104
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• 2013

Recently, various nanoparticles have been used for filler in polymer matrices. The particles of nano size are whether high or not cross-link density in polymer affects the thermal and mechanical properties of one. The properties change as a result of chemical reactions between the nanoparticles and the surface of the polymer. There are two models for nanocomposites: "repulsive interaction" and "attractive interaction" between the nanoparticles and matrix. In this study, the variation in the curing mechanism was examined when nano-size $TiO_2$ was dispersed into an epoxy (Bisphenol A, YD-128) with different curing agents. The results of this study showed that the exothermic temperature and Tg in the case of the nanoparticles used (Jeffamine) (D-180) at room temperature were reduced by an increase in the $TiO_2$ contents because of the "repulsive interaction" between the nanoparticles and the matrix. The tensile strengths were increased by increasing amounts of $TiO_2$ until 3 wt% because of a dispersion strengthening effect caused by the nanoparticles, because of the repulsive interaction. However, such tensile properties decreased at 5 wt% of $TiO_2$, because the $TiO_2$ was agglomerated in the epoxy. In contrast, in the case of the nanoparticles that used NMA and BDMA, the exothermic temperature and Tg tended to rise with increasing amounts of $TiO_2$ as a result of the "attractive interaction." This was because the same amounts of $TiO_2$ were well dispersed in the epoxy. The tensile strength decreased with an increase in the $TiO_2$ contents. In the general attractive interaction model, however, the cross-link density was higher, and tensile strength tended to increase. Therefore, for the nanoparticles that used NMA, it was difficult to conclude that the result was caused by the "attractive model."

• Proceedings of the Korea Society for Energy Engineering kosee Conference
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• 2008.04a
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• pp.101-108
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• 2008

Polymer electrolyte membrane (PEM) fuel cells are promising power generation devices which are ideal for residential and automobile applications, thanks to their fast transient characteristics. However, liquid water produced in PEM fuel cells should be properly managed to enhance the performances and durabilities of the cells. In this study, a visualization experiment was conducted to investigate the flow behavior of water droplets in cathode channels. The visualization experiment was done with four different model flow channels which were made by varying the material (Acrylic and Teflon) and the channel width (1 mm and 2 mm). Acrylic is hydrophilic (contact angle is about $80^{\circ}$) while Teflon is hydrophobic (contact angle is about $120^{\circ}$). A computational fluid dynamics (CFD) analysis was also performed to compare the observed and the simulated two-phase water/air flow characteristics in cathode channels. The computational models were made to be consistent with the geometries and surface properties of the model flow channels. Both the experimental and numerical results showed that the Teflon cathode channel with 1 mm width has the best water management performance among four model flow channels considered. A close correlation was found between the experimental visualization results and the numerical CFD simulation results.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.133-136
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• 2008

The cost of repairing the deterioration of concrete structures due to corrosion of the reinforcement steel has been the prominent figure in the maintenacne of the reinforced-concrete infrastructures. As an alternative material to steel reinforcement, the use of Glass Fiber Reinforced Polymer (GFRP) bar in concrete is being actively studied for the high resistance of chemical environment and high strength to weight ratio properties of GFRP. However, there remain various aspects of GFRP properties that still need to be studied before the standard design criteria can be established. One of the imminent issues is the bond between GFRP and concrete. In this study, the bond-behavior of GFRP bars in concrete is investigated via the pullout test with varying parameters: surface condition of GFRP bars and concrete compression strength. And the local bond-stress model of GFRP rabars with applying monotonc load was also derived from the present test.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.40 no.2
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• pp.197-208
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• 2020

This paper evaluated the optimum Carbon Fiber Reinforced Polymer (CFRP) using a circular concrete bridge pier subjected to dynamic loading. A three-dimensional finite element model was simulated using finite element program, ABAQUS. Concrete Damage Plasticity (CDP) option and plastic properties of the materials were incorporated to model the non-linearity of the structure. The analyses parameters were changed in length-to-height ratio and width-to-span ratio where columns were subjected to dynamic loading. Numerical analysis was conducted, and the seismic performance of the structures were evaluated by analyzing the ductility behavior of the structure. Results showed that the use of CFRP enhances the structural performance of column and revealed that the increase in length-to-height ratio plays vital role of improving the performance of the structure than the change in width-to-span ratio.

• Steel and Composite Structures
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• v.26 no.3
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• pp.347-360
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• 2018

The aim of this paper is to evaluate the accuracy and reliability of the available bond-slip laws which are being used for the numerical modeling of Fiber Reinforced Polymer (FRP)/concrete interfaces. For this purpose, a set of Reinforced Concrete (RC) beams retrofitted with external FRP were modeled using the 3D nonlinear Finite Element (FE) approach. All considered RC beams have been previously tested and the corresponding experimental data are available in the literature. The failure modes of these beams are concrete crushing, steel yielding and FRP debonding. Through comparison of the numerical and experimental results, the effectiveness of each FRP/concrete bond-slip model for the prediction of the structural behavior of externally retrofitted RC beams is assessed. The sensitivity of the numerical results against different modeling considerations of the concrete constitutive behavior and bond-slip laws has also been evaluated. The results show that the maximum allowable stress of FRP/concrete interface has an important role in the accurate prediction of the FRP debonding failure.

• Journal of Pharmaceutical Investigation
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• v.31 no.1
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• pp.1-5
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• 2001

The aggregation behavior of nystatin (NYS) in the presence of pluronic F127, triblock copolymer of poly (ethylene oxide) (PEO) and poly (propylene oxide) (PPO), was measured and correlated with hemolytic activity. Antifungal activity was also studied using Saccharomyces cerevisiae as a model strain. The critical aggregation concentrations (CAC) of the drug were 50.1, 108.0, 134.2, 154.3, and $217.9\;{\mu}M$ at 0.1%, 0.5%, 1.0%, 1.5%, and 2.0% pluronic F127 solution, respectively. The levels of NYS required to start lysis of erythrocytes were about 80, 100, 125, 150, and $200\;{\mu}M$ at 0.1%, 0.5%, 1.0%, 1.5%, and 2.0% pluronic F127 solution, respectively. It was $50\;{\mu}M$ in the absence of the polymer. Minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of NYS-pluronic F127 lyophilizate were same at $3\;{\mu}g/ml$, while MIC and MFC of pure NYS are $3\;{\mu}g/ml$ and $12\;{\mu}g/ml$, respectively. By modulating the aggregation behavior of NYS, pluronic F127 was able to reduce the toxicity of the drug without compromising the MIC and MFC.

• Computers and Concrete
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• v.16 no.5
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• pp.759-774
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• 2015

This study simulates the flexural behavior of ultra-high-performance fiber-reinforced concrete (UHPFRC) beams reinforced with steel and glass fiber-reinforced polymer (GFRP) rebars. For this, micromechanics-based modeling was first carried out on the basis of single fiber pullout models considering inclination angle. Two different tension-softening curves (TSCs) with the assumptions of 2-dimensional (2-D) and 3-dimensional (3-D) random fiber orientations were obtained from the micromechanics-based modeling, and linear elastic compressive and tensile models before the occurrence of cracks were obtained from the mechanical tests and rule of mixture. Finite element analysis incorporating smeared crack model was used due to the multiple cracking behaviors of structural UHPFRC beams, and the characteristic length of two times the element width (or two times the average crack spacing at the peak load) was suggested as a result of parametric study. Analytical results showed that the assumption of 2-D random fiber orientation is appropriate to a non-reinforced UHPFRC beam, whereas the assumption of 3-D random fiber orientation is suitable for UHPFRC beams reinforced with steel and GFRP rebars due to disorder of fiber alignment from the internal reinforcements. The micromechanics-based finite element analysis also well predicted the serviceability deflections of UHPFRC beams with GFRP rebars and hybrid reinforcements.