• 한국조경학회지
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• 제24권4호
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• pp.39-58
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• 1997

This study aims to find out differences between designer's design guidelines and user's actual behavior about play facilities of children playground in multifamily housing site by using the method of Post-Occupancy Evaluation. Korea National Housing Cooperation developed the 18 play facilities and constructed them into children' playground of Bun-dong and Junggae-dong housing site in Seoul. The results are as follows: First, user's behaviors which differed from designer's guidelines were influenced by mechanical and technical problems rather than design. Second, users adjusted their brahvior to play facilities which have a little operational problems. Third. users tried to make dangrous activity instead of designer's guidelines based on the safety. It infers that users want to make creative activities from play facilities. Fourth. designers should have developed play facilities for infants and youth. Fifth. users liked to play more complicated play facilities rather than single facility.

• Archives of Pharmacal Research
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• 제8권4호
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• pp.197-203
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• 1985

It was attempted to observe the effect of garlic on the hepatic glutathione s-transferase and glutathione peroxidase activity in this study. Glutathione s-transferase (EC 2.5.1.18) are thought to play a physiological role in initiating the detoxication of potential alkylating agents, inclnding pharmacologically active compounds. Glutathione peroxidase (EC 1. 11. 1. 9) might play an important role in the protection of cellular structures against oxidative challenge. The activities of glutathione s-transferase and glutathione peroxidase in rat liver were increased by the treatment of garlic juice. Allicin fraction, heat-treated allicin fraction and garlic butanol fraction markedly inhibited glutathione s-transferase activity in vitro, whereas glutathione peroxidase activity was significantly increased in heat-treated allicin fraction and garlic butanol fraction.

• 한국생활과학회지
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• 제16권4호
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• pp.855-875
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• 2007

The purpose of this study is to suggest a guideline for outdoor play settings in child care centers. From March to July, 2005, data were collected from 223 directors at child care centers through a structured questionnaire, field measurement survey and non-participatory observation in seventeen child care centers in Seoul and Daejeon. The statistical methods for analysing data were frequency, percentage, mean, $X^2$ and F-test. The results showed as follows: 1)the existing outdoor playground area in child care centers should be expanded more than $4\;m^2$ per child. 2) Outdoor play facilities should be equipped with two structured play sets, a play facility for unstructured play and an adventure facility to make child's various activities possible and to promote child development. 3)flooring materials for outdoor playground should be required to use more than three kinds such as solid coverings (cf. asphalt, standard concrete), wood, lawn, soil or sands. 4)to let children enjoy various activities, outdoor playground area should be composed of various play facilities like indoor play gyms and should be independent but have good connections between play facilities depending on characteristics of play activities. 5)Play spaces of outdoor playground should be composed of physical play space, unstructured and dramatized play space, rest space, space for nature and adventure space. In addition, appropriate play equipments should be provided in respective play space.

• 한국생활과학회지
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• 제19권5호
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• pp.775-794
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• 2010

This study is to provided a basic model to encourage environment and outdoor play programs. The study was based on the analyses of actual activities performed in two child care centers in Daejeon area and the way in which the programs for outdoor play were related to the environment of the centers. Data were collected through 'The Daily Report of the Outdoor Play Programs: Plan and Evaluation' paper conducted at each center performed from 2007 to 2009. Following Mockwha Choi et al., (2007), the play observed and described by teachers was analyzed to classify play areas and play activities within each area. The places, equipment and, playthings using in each play period were also examined as well as the limitation and inspiration caused by the environment. The results of the study are as follows: 1) Empty and unfilled space tended to generate more types of non-structural play and role-pretend play 2)Adventurous play was rarely observed. More thoughtfully designed physical environments need to be provided for children to experience challenge and adventure through physical activities 3) Outdoor play environment should be suitable for the overall developments of infants and toddlers depending on their activities. A child care specialist should support the design such environment 4) Naturally, the programs of outdoor play will not be identical for all child care centers. Rather, they should go along with the programmatic characters and environmental attributes of each center. Therefore the awareness of teachers and parents as to the importance of must realize of outdoor play should be further increased.

• 로봇학회논문지
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• 제17권4호
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• pp.447-454
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• 2022

This paper presents the psychomotorik-based play activities executed by the social robot at home which helps children's social and emotional development. Based on the theory and practice of the psychomotorik therapy, the play activities were implemented in the close collaboration between psychmotorik experts, service designers and robotics engineers. The designed play activities are classified into four categories depending on the main areas of child development. The robotic system that can express verbal and nonverbal behaviors was developed in order to play games with children and but also to make children have continuous interest during the play activities with it. Finally, the psychomotorik-based play service scenario and interactive robot system were validated by the expert group from the domain of child psychotherapy. The evaluation results showed that the play service and the robot system were appropriately developed for children from the experts point of view.

• 한국초등수학교육학회지
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• 제10권1호
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• pp.67-87
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• 2006

본 연구는 초등학교에서 이루어지는 수행평가 실시에서의 문제점을 인식하고 자기평가, 동료평가 및 관찰평가의 실천을 통하여 평가에 따르는 시간적인 제약을 줄이고, 평가의 결과를 교수 학습계획에 반영시킴으로써 평가를 통한 초등수학과 교수 학습의 개선에 대한 시사점을 찾아보고자 이루어졌다. 이러한 목적을 달성하기 위하여 연구자는 초등학교 2학년 1개 반 학생 40명을 대상으로 자기평가, 동료평가를 실시하고 '재미있는 놀이를 하여 봅시다' 차시의 운영과정에서 관찰평가를 한 학기동안 적용하였으며 평가의 적용과정에서 얻어진 학생들의 자기평가결과물(수학일지, 자기평가지, 평가의 과정에서의 대화내용)과 관찰평가 결과물(체크리스트, 놀이 활동 결과물, 놀이의 과정에서의 대화내용)을 분석해 보았다.

• IMMUNE NETWORK
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• 제21권3호
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• pp.21.1-21.22
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• 2021

Myeloid-derived suppressor cells (MDSCs) have strong immunosuppressive activity and are morphologically similar to conventional monocytes and granulocytes. The development and classification of these cells have, however, been controversial. The activation network of MDSCs is relatively complex, and their mechanism of action is poorly understood, creating an avenue for further research. In recent years, MDSCs have been found to play an important role in immune regulation and in effectively inhibiting the activity of effector lymphocytes. Under certain conditions, particularly in the case of tissue damage or inflammation, MDSCs play a leading role in the immune response of the central nervous system. In cancer, however, this can lead to tumor immune evasion and the development of related diseases. Under cancerous conditions, tumors often alter bone marrow formation, thus affecting progenitor cell differentiation, and ultimately, MDSC accumulation. MDSCs are important contributors to tumor progression and play a key role in promoting tumor growth and metastasis, and even reduce the efficacy of immunotherapy. Currently, a number of studies have demonstrated that MDSCs play a key regulatory role in many clinical diseases. In light of these studies, this review discusses the origin of MDSCs, the mechanisms underlying their activation, their role in a variety of clinical diseases, and their function in immune response regulation.

• 한국생활과학회지
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• 제15권2호
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• pp.209-225
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• 2006

The purpose of this study is to research the actual condition of environment and management of outdoor play at child care centers in Seoul, and to present a planning guideline for outdoor play environment. For this purpose, data were collected by a structured questionnaire and subjects were 164 directors of child care centers located in Seoul. The contents of the questionnaire were composed of general facts about the respondent and facility, environmental condition, managerial condition, and director's understanding about outdoor play. The data were then analyzed using the frequency, percentage, mean and crosstab. The major results have shown the following: 1) Most child care centers in Seoul had some space for outdoor play. 62% of them used front yard and 11 % a rooftop. 2) The space usually included fixed play instruments such as slide and complex unit structures, sand play area, and open area. It also had many natural elements as shrubs and earth. 3) 78% of the centers had a schedule for outdoor play. The schedule operates flexibly according to each center's own day schedule. Generally, a time for outdoor play was 21 to 30 minutes. 4) The directors of child care centers thought highly of outdoor play for it contributes to the balanced development of children. They answered that equipments and spaces, program devices, and teacher's understanding are some of the important factors for active outdoor play. 5) Most of them wanted wood-working area (construction activity area), water play area, and cages.

• 약학회지
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• 제32권1호
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• pp.40-49
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• 1988

There is evidence that brain norepinephrine may play a role in experimentally induced seizures in animals. Thus the present experiments were undertaken in an attempt to explore the role of brain norepinephrine in anticonvulsant activity of clonazepam. 6-Hydroxydopamine was given to newborn rats and PTZ-induced seizures were tested $70{\sim}90$ days after birth and the rats were killed for determination of brain norepinephrine 8 days after the seizure test. Depletion of norepinephrine in the rat brain significantly potentiated the PTZ-induced convulsions and antagonized the effect of clonazepam on clonic seizures, tonic seizures and the number of seizures, but the latency to the seizure and the mortality has not been altered. However the 6-hydroxydopamine-induced antagonism of anticonvulsant action was surmountable by increasing the dose of clonazepam. These results show that brain norepinephrine may play an important role in seizure susceptability as well as in the anticonvulsant activity of clonazepam in rats.

• 아동학회지
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• 제26권4호
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• pp.71-84
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• 2005

Eighty-eight 5-year-old subjects were tested by the Torrance Tests of Creative Thinking, and randomly assigned to experimental(n=44) or control(n=44) groups. Developed in collaboration with kindergarten teachers, physical activity projects were based on themes from "life and health" and "life as expression" of the kindergarten curriculum. The resulting program consisting of 24 activities was applied to the experimental group for 24 sessions. Data were analyzed by mean, standard deviation, and repeated measures ANOVA. Effectiveness of the physical activity program for enhancing creativity was shown by a significant increase in mean creativity scores of the experimental group and in the sub-scores of fluency, originality, abstraction of title, elaboration, and resistance to an impetuous ending.