• Computers and Concrete
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• v.25 no.5
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• pp.427-432
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• 2020

In this research, the buckling analysis of sandwich beam with composite reinforced by graphene platelets (GPLs) in two face sheets is investigated. Three type various porosity patterns including uniform, symmetric and asymmetric are considered through the thickness direction of the core. Also, the top and bottom face sheets layers are considered composite reinforced by GPLs/CNTs based on Halpin-Tsai micromechanics model and extended mixture rule, respectively. Based on various shear deformation theories such as Euler-Bernoulli, Timoshenko and Reddy beam theories, the governing equations of equilibrium using minimum total potential energy are obtained. It is seen that the critical buckling load decreases with an increase in the porous coefficient, because the stiffness of sandwich beam reduces. Also, it is shown that the critical buckling load for asymmetric distribution is lower than the other cases. It can see that the effect of graphene platelets on the critical buckling load is higher than carbon nanotubes. Moreover, it is seen that the difference between carbon nanotubes and graphene platelets for Reddy and Euler-Bernoulli beam theories is most and least, respectively.

• Biomolecules & Therapeutics
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• v.22 no.3
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• pp.254-259
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• 2014

The pentacyclic triterpenoid ursolic acid (UA) and its isomer oleanolic acid (OA) are ubiquitous in food and plant medicine, and thus are easily exposed to the population through natural contact or intentional use. Although they have diverse health benefits, reported cardiovascular protective activity is contentious. In this study, the effect of UA and OA on platelet aggregation was examined on the basis that alteration of platelet activity is a potential process contributing to cardiovascular events. Treatment of UA enhanced platelet aggregation induced by thrombin or ADP, which was concentration-dependent in a range of $5-50{\mu}M$. Quite comparable results were obtained with OA, in which OA-treated platelets also exhibited an exaggerated response to either thrombin or ADP. UA treatment potentiated aggregation of whole blood, while OA failed to increase aggregation by thrombin. UA and OA did not affect plasma coagulation assessed by measuring prothrombin time and activated partial thromboplastin time. These results indicate that both UA and OA are capable of making platelets susceptible to aggregatory stimuli, and platelets rather than clotting factors are the primary target of them in proaggregatory activity. These compounds need to be used with caution, especially in the population with a predisposition to cardiovascular events.

• Steel and Composite Structures
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• v.35 no.2
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• pp.249-260
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• 2020

The main purpose of this research work is to investigate the free vibration of conical shell structures reinforced by graphene platelets (GPLs) and the elastic properties of the nanocomposite are obtained by employing Halpin-Tsai micromechanics model. To this end, a shell model is developed based on Donnell's theory. To solve the problem, the analytical Galerkin method is employed together with beam mode shapes as weighting functions. Due to importance of boundary conditions upon mechanical behavior of nanostructures, the analysis is carried out for different boundary conditions. The effects of boundary conditions, semi vertex angle, porosity distribution and graphene platelets on the response of conical shell structures are explored. The correctness of the obtained results is checked via comparing with existing data in the literature and good agreement is eventuated. The effectiveness and the accuracy of the present approach have been demonstrated and it is shown that the Donnell's shell theory is efficient, robust and accurate in terms of nanocomposite problems.

• Steel and Composite Structures
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• v.35 no.2
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• pp.295-306
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• 2020

This paper deals with free vibration analysis of non-uniform column resting on elastic foundations and subjected to follower force at its free end. The internal pores and graphene platelets (GPLs) are distributed in the matrix according to different patterns. The model is proposed with material parameters varying in the thickness of column to achieve graded distributions in both porosity and nanofillers. The elastic modulus of the nanocomposite is obtained by using Halpin-Tsai micromechanics model. The differential quadrature method as an efficient and accurate numerical approach is used to discretize the governing equations and to implement the boundary conditions. It is observed that the maximum vibration frequency obtained in the case of symmetric porosity and GPL distribution, while the minimum vibration frequency is obtained using uniform porosity distribution. Results show that for better understanding of mechanical behavior of nanocomposite column, it is crucial to consider porosities inside the material structure.

• International Journal of Advanced Culture Technology
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• v.6 no.4
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• pp.109-115
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• 2018

Garlic is a medicinal plant used throughout the world for its anti-inflammatory, antioxidant, and antiplatelet activities. Chitosan is a natural polysaccharide obtained from chitin, and derivatives of chitosan have been shown to inhibit platelet aggregation and adhesion. We hypothesized that fermented preparations of these products may possess stronger antiplatelet effects than the non-fermented forms owing to the increased bioavailability of the bioactive compounds produced during fermentation. Therefore, we compared these compounds via in vitro and ex vivo platelet aggregation assays by using standard light transmission aggregometry and ex vivo granule secretions from rat platelets. We found that fermented preparations exerted more potent and significant inhibition of platelet aggregation both in vitro and ex vivo. Likewise, ATP release from dense granules of platelets was also significantly inhibited in fermented preparation-treated rat platelets compared to that in non-fermented preparation-treated ones. We concluded that fermented preparations exerted more potent effects on platelet function both in vitro and ex vivo, possibly as a result of the increased bioavailability of active compounds produced during fermentation. We therefore suggest that fermented products may be potent therapeutics against platelet-related CVDs and can be used as antiplatelet and antithrombotic agents.

• Steel and Composite Structures
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• v.33 no.2
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• pp.195-208
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• 2019

Based on a four-variable shear deformation shell theory, the free vibration analysis of functionally graded graphene platelet-reinforced composite (FGGPRC) doubly-curved shallow shells with different boundary conditions is investigated in this work. The doubly-curved shells are composed of multi nanocomposite layers that are reinforced with graphene platelets. The graphene platelets are uniformly distributed in each individual layer. While, the volume faction of the graphene is graded from layer to other in accordance with a novel distribution law. Based on the suggested distribution law, four types of FGGPRC doubly-curved shells are studied. The present shells are assumed to be rested on elastic foundations. The material properties of each layer are calculated using a micromechanical model. Four equations of motion are deduced utilizing Hamilton's principle and then converted to an eigenvalue problem employing an analytical method. The obtained results are checked by introducing some comparison examples. A detailed parametric investigation is performed to illustrate the influences of the distribution type of volume fraction, shell curvatures, elastic foundation stiffness and boundary conditions on the vibration of FGGPRC doubly-curved shells.

• Clinical and Experimental Pediatrics
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• v.65 no.4
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• pp.182-187
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• 2022

We frequently encounter newborn infants with thrombocytosis in the neonatal intensive care unit. However, neonatal thrombocytosis is not yet fully understood. Thrombocytosis is more frequently identified in newborns and young infants, notably more often in those younger than 2 years than in older children or adults. The production of megakaryocytes (megakaryopoiesis) and platelets (thrombopoiesis) is mainly regulated by thrombopoietin (TPO). Increased TPO levels during infection or inflammation can stimulate megakaryopoiesis, resulting in thrombopoiesis. TPO concentrations are higher in newborn infants than in adults. Levels increase after birth, peak on the second day after birth, and start decreasing at 1 month of age. Initial platelet counts at birth increase with gestational age. Thus, preterm infants have lower initial platelet counts at birth than late-preterm or term infants. Postnatal thrombocytosis is more frequently observed in preterm infants than in term infants. A high TPO concentration and low TPO receptor expression on platelets leading to elevated plasma-free TPO, increased sensitivity of megakaryocyte precursor cells to TPO, a decreased red blood cell count, and immaturity of platelet regulation are speculated to induce thrombocytosis in preterm infants. Thrombocytosis in newborn infants is considered a reactive process (secondary thrombocytosis) following infection, acute/chronic inflammation, or anemia. Thrombocytosis in newborn infants is benign, resolves spontaneously, and, unlike in adults, is rarely associated with hemorrhagic and thromboembolic complications.

• Steel and Composite Structures
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• v.46 no.5
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• pp.649-658
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• 2023

Although some scholars have studied the thermal post-buckling of graphene platelets strengthened metal foams (GPLRMFs) plates, they have not considered the influence of initial geometrical imperfection. Inspired by this fact, the present paper studies the thermal post-buckling characteristics of GPLRMFs plates with initial geometrical imperfection. Three kinds of graphene platelets (GPLs) distribution patterns including three patterns have been considered. The governing equations are derived according to the first-order plate theory and solved with the help of the Galerkin method. According to the comparison with published paper, the accuracy and correctness of the present research are verified. In the end, the effects of material properties and initial geometrical imperfection on the thermal post-buckling response of the GPLRMFs plates are examined. It can be found that the presence of initial geometrical imperfection reduces the thermal post-buckling strength. In addition, the present study indicates that GPL-A pattern is best way to improve thermal post-buckling strength for GPLRMFs plates, and the presence of foams can improve the thermal post-buckling strength of GPLRMFs plates, the Foam- II and Foam- I patterns have the lowest and highest thermal post-buckling strength. Our research can provide guidance for the thermal stability analysis of GPLRMFs plates.

• Advances in nano research
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• v.15 no.4
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• pp.367-384
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• 2023

Natural frequency behavior of graphene platelets reinforced composite (GPL-RC) joined truncated conical-cylindrical- conical shells resting on Winkler-type elastic foundation is presented in this paper for the first time. The rule of mixture and the modified Halpin-Tsai approach are applied to achieve the mechanical properties of the structure. Four different graphene platelets patterns are considered along the thickness of the structure such as GPLA, GPLO, GPLX, GPLUD. Finite element procedure according to Rayleigh-Ritz formulation has been used to solve 2D-axisymmetric elasticity equations. Application of 2D axisymmetric elasticity theory allows thickness stretching unlike simple shell theories, and this gives more accurate results, especially for thick shells. An efficient parametric investigation is also presented to show the effects of various geometric variables, three different boundary conditions, stiffness of elastic foundation, dispersion pattern and weight fraction of GPLs nanofillers on the natural frequencies of the joined shell. Results show that GPLO and BC3 provide the most rigidity that cause the most natural frequencies among different BCs and GPL patterns. Also, by increasing the weigh fraction of nanofillers, the natural frequencies will increase up to 200%.

• Biomedical Science Letters
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• v.29 no.3
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• pp.184-189
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• 2023

Normal activation of platelets and their aggregation are crucial during hemostasis process. It appears excessive or abnormal aggregation of platelets may bring about cardiovascular diseases like stroke, atherosclerosis, and thrombosis. For this reason, finding a substance that can regulate platelet aggregation or suppress aggregation will aid in the prevention and treatment of cardiovascular diseases. Artemisinin, a compound derived from Artemisia or Scopolia plants, has shown potential in various areas such as anticancer and Alzheimer's disease research. However, the specific role and mechanisms by which artemisinin influences platelet activation and thrombus formation are not yet fully understood. This study investigated the effects of artemisinin on platelet activation and thrombus formation. This study examined the effect of artemisinin on regulation of U46619-induced platelet aggregation, granule secretion. In addition, the effects of artemisinin on phosphorylation of PI3K/Akt and MAPK pathway involved in platelet aggregation was studied. As a result, artemisinin significantly downregulated of PI3K/Akt and MAPK pathway. In addition, artemisinin significantly reduced granule secretion, and platelet aggregation was inhibited by artemisinin. Therefore, we suggest that artemisinin is an anti-platelet substance that regulates PI3K/Akt and MAPK pathway and is valuable as a therapeutic and preventive agent for platelet-derived cardiovascular disease.