• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.10.1-10.11
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• 2018

Although early studies suggested that bladder cancer (BCa) is more prevalent in men than in women, muscle-invasive rates are higher in women than in men, suggesting that sex hormones might play important roles in different stages of BCa progression. In this work, we found that estrogen receptor beta ($ER{\beta}$) could increase BCa cell proliferation and invasion via alteration of miR-92a-mediated DAB2IP (DOC-2/DAB2 interacting protein) signals and that blocking miR-92a expression with an inhibitor could partially reverse $ER{\beta}$-enhanced BCa cell growth and invasion. Further mechanism dissection found that $ER{\beta}$ could increase miR-92a expression at the transcriptional level via binding to the estrogen-response-element (ERE) on the 5' promoter region of its host gene C13orf25. The $ER{\beta}$ up-regulated miR-92a could decrease DAB2IP tumor suppressor expression via binding to the miR-92a binding site located on the DAB2IP 3' UTR. Preclinical studies using an in vivo mouse model also confirmed that targeting this newly identified $ER{\beta}$/miR-92a/DAB2IP signal pathway with small molecules could suppress BCa progression. Together, these results might aid in the development of new therapies via targeting of this $ER{\beta}$-mediated signal pathway to better suppress BCa progression.

• Steel and Composite Structures
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• v.23 no.4
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• pp.473-481
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• 2017

Steel plate shear wall (SPSW) system has been increasingly used for lateral loads resisting system since 1980s when the utilization of post-buckling strength of SPSW was realized. The structural response of SPSWs largely depends on the behavior of the surrounded beams. The beams are normally required to behave in the elastic region when the SPSW fully buckled and formed the tension field action. However, most modern design codes do not specify how this requirement can be achieved. This paper presents theoretical investigation and design procedures of manually calculating the plastic flexural capacity of the beams of SPSWs and can be considered as an extension to the previous work by Qu and Bruneau (2011). The reduction in the plastic flexural capacity of beam was considered to account for the presence of shear stress that was altered towards flanges at the boundary region, which can be explained by Saint-Venant's principle. The reduction in beam web was introduced and modified based on the research by Qu and Bruneau (2011), while the shear stress in the web in this research is excluded due to the boundary effect. The plastic flexural capacity of the beams is given by the superposition of the contributions from the flanges and the web. The developed equations are capable of predicting the plastic moment of the beams subjected to combined shear force, axial force, bending moment, and tension fields induced by yielded infill panels. Good agreement was found between the theoretical results and the data from previous research for flexural capacity of beams.

• Tribology and Lubricants
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• v.35 no.1
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• pp.1-8
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• 2019

Demand for plastic gears are increasing in many industries due to their low production cost, light weight, applicability without lubricant, corrosion resistance and high resilience. Despite these benefits, utilizing plastic gears is limited due to their poor material properties. In this work, DLC coating was applied to improve the tribological properties of polyamide66 gear. 0 V, 40 V, and 70 V of negative bias voltages were selected as a deposition parameter in DC magnetron sputtering system. Pin-on-disk experiment was performed in order to investigate the wear characteristics of the gears. The results of the pin-on-disk experiment showed that DLC coated polyamide66 with 40 V of negative bias voltage had the lowest friction coefficient value (0.134) and DLC coated PA66 with 0 V of negative bias voltage showed the best wear resistance ($9.83{\times}10^{-10}mm^3/N{\cdot}mm$) among all the specimens. Based on these results, durability tests were conducted for DLC coated polyamide66 gears with 0 V of negative bias voltage. The tests showed that the temperature of the uncoated polyamide66 gear increased to about $37^{\circ}C$ while the DLC coated gear saturated at about $25^{\circ}C$. Also, the power transmission efficiency of the DLC coated gear increased by about 6% compared to those without coating. Weight loss of the polyamide66 gears were reduced by about 73%.

• Steel and Composite Structures
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• v.31 no.3
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• pp.319-327
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• 2019

This paper describes an experimental study of steel beam-column connections with or without expanded beam flanges with different geometries. The objectives of this study are to elucidate the cyclic behavior of these connections, identify the location of the plastic hinge zone, and provide useful test data for future numerical simulations. Five connection specimens are designed and tested under cyclic load. The test setup consists of a beam and a column connected together by a connection with or without expanded beam flanges. A constant axial force is applied to the column and a time varying point load is applied to the free end of the beam, inducing shear and moment in the connection. Because the only effect to be studied in the present work is the expanded beam flange, the sizes of the beam and column as well as the magnitude of the axial force in the column are kept constant. However, the length, width and shape of the expanded beam flanges are varied. The responses of these connections in terms of their hysteretic behavior, failure modes, stiffness degradation and strain variations are experimentally obtained and discussed. The test results show that while the influence of the expanded beam flanges on hysteretic behavior, stiffness degradation and energy dissipation capacity of the connection is relatively minor, the size of the expanded beam flanges does affect the location of the plastic hinge zone and strain variations in these beam-column joints. Furthermore, in terms of ductility, moment and rotational capacities, all five connections behave well. No weld fracture or premature failure occurs before the formation of a plastic hinge in the beam.

• Applied Microscopy
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• v.45 no.2
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• pp.37-43
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• 2015

In present work, work-hardening behavior of TiCu-based bulk metallic glass composite with B2 particles has been studied by systemic structural and mechanical investigations. After yield, pronounced work-hardening of the alloy was clearly exhibited, which was mainly related to the martensitic transformation as well as the deformation twinning in B2 particles during deformation. At the early plastic deformation stage (work-hardening stage), the stress-induced martensitic transformation from B2 phase to B19' phase and deformation-induced twinning of B19' phase was preferentially occurred in the around interface areas between B2 phase and amorphous matrix by stress concentration. The higher hardness value was observed in vicinity of interface within the B2 particles which are probably connected with martensitic transformation and deformation twinning. This reveals that the work-hardening phenomenon of this bulk metallic glass composite is a result of the hardening of B2 particles embedded in amorphous matrix.

• Archives of Plastic Surgery
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• v.38 no.4
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• pp.438-444
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• 2011

Purpose: Adipose-derived stromal cells (ASCs) are readily harvested from lipoaspirated tissue or subcutaneous adipose tissue fragments. The stromal vascular fraction (SVF) is a heterogeneous set of cell populations that surround and support adipose tissue, which includes the stromal cells, ASCs, that have the ability to differentiate into cells of several lineages and contains cells from the microvasculature. The mechanisms that drive the ASCs into the osteoblast lineage are still not clear, but the process has been more extensively studied in bone marrow stromal cells. The purpose of this study was to investigate the osteogenic capacity of adipose derived SVF cells and evaluate bone formation following implantation of SVF cells into the bone defect of human phalanx. Methods: Case 1 a 43-year-old male was wounded while using a press machine. After first operation, segmental bone defects of the left 3rd and 4th middle phalanx occurred. At first we injected the SVF cells combined with demineralized bone matrix (DBM) to defected 4th middle phalangeal bone lesion. We used P (L/DL)LA [Poly (70L-lactide-co-30DL-lactide) Co Polymer P (L/DL)LA] as a scaffold. Next, we implanted the SVF cells combined with DBM to repair left 3rd middle phalangeal bone defect in sequence. Case 2 was a 25-year-old man with crushing hand injury. Three months after the previous surgery, we implanted the SVF cells combined with DBM to restore right 3rd middle phalangeal bone defect by syringe injection. Radiographic images were taken at follow-up hospital visits and evaluated radiographically by means of computerized analysis of digital images. Results: The phalangeal bone defect was treated with autologous SVF cells isolated and applied in a single operative procedure in combination with DBM. The SVF cells were supported in place with mechanical fixation with a resorbable macroporous sheets acting as a soft tissue barrier. The radiographic appearance of the defect revealed a restoration to average bone density and stable position of pharyngeal bone. Densitometric evaluations for digital X-ray revealed improved bone densities in two cases with pharyngeal bone defects, that is, 65.2% for 4th finger of the case 1, 60.5% for 3rd finger of the case 1 and 60.1% for the case 2. Conclusion: This study demonstrated that adipose derived stromal vascular fraction cells have osteogenic potential in two clinical case studies. Thus, these reports show that cells from the SVF cells have potential in many areas of clinical cell therapy and regenerative medicine, albeit a lot of work is yet to be done.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 1997.04a
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• pp.133-143
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• 1997

In this paper, some of the critical factors in Necking-In process are investigated using a numerical analysis. The optimal processing parameters are established and applied to the actual processes. FEM analysis is carried out based on elastic-plastic work hardening model using ABAQUS/Standard. The results obtained from the commercially available code ABAQUS/Standard are compared with the experimental data and shows a good agreement with experimental data. The purpose of this paper is to search for the relations among the roller angle, feed length, and working force. Stress, strain distribution, displacement and increase in the length of the workpiece are also investigated.

• Proceedings of the Materials Research Society of Korea Conference
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• 1995.11a
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• pp.3-3
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• 1995

Plastic IC encapsulation utilizing lead on chip(LOC) die attach technique allows higher device density per unit package area, and faster current speed and easter leadframe design. Nevertheless, since the top surface of the chip is directly attached to the area of the leadframe with a double-sided adhesive tape in the LOC package, it tends to be easily damaged by the leadframe, leading to limitation in its utilization. In this work, it is detailed how the damage of the chip surface occurs, and it is influenced and improved by the LOC construct.

• 제어로봇시스템학회:학술대회논문집
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• 1989.10a
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• pp.206-210
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• 1989

In automobile glass fitting the stud is welded on the window seating panel in order to insert the plastic molding onto the stud. Since this type of process is in general manually done, almost 50% of the output turns out to be failure resulted from work inefficiency and weld inferiority. Therefore, it is required to improve this process for the productivity elevation through the application of the robot.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.04a
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• pp.910-920
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• 1997

In this paper, some of the critical factors in Necking-In process are investigated using a numerical analysis. The optimal processing parameters are established and applied to the actual processes. FEM analysis is carried out based on elastic-plastic work hardening model using ABAQUS / Standard. The results obtained form the commercially available code ABAQUS / standard are compared with the experimental data and shows a good agreement with experimental data. The purpose of this paper is to search for the relations among the roller angel, feed length, and working force. Stress, strain distribution, displacement and increase in the length of the workpiece are also investigated.