• Biomedical Science Letters
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• v.3 no.1
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• pp.49-54
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• 1997

Meanwhile Pityrosporum species as well as Candida species in yeast phase are not pathogenic, Pityrosporum in mycelial phase is pathogenic. Pityrosporum species can be isolated not only from tinea versicolor patients but also from ninety (90) percent of healthy persons. Minimal inhibitory concentration (MIC) of ketoconazole against Pityrosporum spp. was 0.05~0.8$\mu\textrm{g}$ ml$^{-1}$and the MIC of ketoconazole was the lowest. Of itraconazole, selenium sulfide, sodium thiosulfate and ketoconazole had the lowest MIC against P. orbiculare. The P. orbiculare strains isolated from healthy persons were inhibited by lower MIC than those isolated from tinea versicolor patients. P. ovale strains were inhibited by lower MIC at MIC$_{50}$ and MIC$_{90}$ of oral and topical antifungal agents than p. orbiculare.

• Korean Journal of Pharmacognosy
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• v.34 no.4 s.135
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• pp.303-307
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• 2003

For the purpose of searching for the new antifungal agent from the plant origin, we have examined twenty seven species of medicinal plants for the antifungal activity against Candida albicans and Pityrosporum ovale. The whole MeOH extract of each plant material and the n-hexane and EtOAc fractions were evaluated individually for the antifungal activity. Among the test materials, the fractions from the root bark of Zanthoxylum schinifolium, Zanthoxylum piperitum and Citrus unshiu showed significant antifungal activities in a dose dependent manner against Pityrosporum ovale and Candida albicans, respectively.

• KSBB Journal
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• v.25 no.2
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• pp.173-178
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• 2010

Antifungal effect of Ginkgo biloba leaves extracts conducted for Pityrosporum ovale. Antifungal effect verified by diffusion test, optical density test and colony counting test under various concentration. Extract of ginkgo biloba leaves performed with 40% ethanol and 60% water solution at $60^{\circ}C$ and major components analyzed by HPLC. The concentrated extract have bilobalide and ginkgolide A and ginkgolide B and their concentration were 153.0 mg/L, 8403.5 mg/L and 2723.0 mg/L respectively. Ginkgo biloba leaves extracts gave 99.1% of antifungal effect for Pityrosporum ovale examined by colony counting method.

• Journal of Food Hygiene and Safety
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• v.18 no.3
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• pp.113-117
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• 2003

In order to develop a antimicrobial agent, bamboo oil was extracted by high temperature suction from dired bamboo truk and then antimictobial activities against Trichophyton and Pityrosporum are investigated. 1. Bamboo oil showed the strongest antimicrobial effect on Trichophyton mentagrophytes > Epidermophyton floccusum > Trichophyton rubrun. Bamboo oil showed the strongest antimicrobial activity on Trichophyton mentagrophytes. 2. Bamboo oil showed the strongest antimicrobial effect on Pityroporum ovale 75 > Pityrosporum ovale 77. Bamboo oil showe the strongest antimicrobial activity on Pityroporum ovale 75.3 Antimicrobial effect in 50%-ethanol extracts of bamboo oil are similar to 100%-bamboo oil.

• Journal of Evidence-Based Herbal Medicine
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• v.2 no.2
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• pp.1-7
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• 2009

Pulsatillae Radix, the root of Pulsatilla koreana Nakai (Ranunculaceae), has been traditionally used as a remedy for leukorrhea and amoebic dysentery by taking internally‘ and as an antimicrobial for external use. We carried out this study to examine the anti-dandruff effect of 70% Ethanol-Extract of Pulsatillae Radix (EPX) compared with 1 % zinc pyrithione used commercially as anti-dandruff. The EPX showed significant antimicrobial activity against Pityrosporum ovale, major cause of dandruff, and also showed significant anti-dandruff and itch-improvement effect of head skin.

• YAKHAK HOEJI
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• v.17 no.1
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• pp.13-16
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• 1973

The three alkaloids with antimicrobial activity against Pityrosporum ovale and Trichophytom mentagrophytes were isolated from Veratrum grandiflorum and idnetified as jervine, its glucoside, and veratramine.

• Biomolecules & Therapeutics
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• v.20 no.1
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• pp.118-124
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• 2012

This study was conducted to evaluate the effect of Grateloupia elliptica, a seaweed native to Jeju Island, Korea, on the prevention of hair loss. When immortalized rat vibrissa dermal papilla cells were treated with extract of G. elliptica, the proliferation of dermal papilla cells significantly increased. In addition, the G. elliptica extract significantly inhibited the activity of $5{\alpha}$-reductase, which converts testosterone to dihydrotestosterone (DHT), a main cause of androgenetic alopecia. On the other hand, the G. elliptica extract promoted $PGE_2$ production in HaCaT cells in a dose-dependent manner. The G. elliptica extract exhibited particularly high inhibitory effect on LPS-stimulated IL-12, IL-6, and TNF-${\alpha}$ production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells. The G. elliptica extract also showed inhibitory activity against Pityrosporum ovale, a main cause of dandruff. These results suggest that G. elliptica extract has the potential to treat alopecia via the proliferation of dermal papilla, $5{\alpha}$-reductase inhibition, increase of $PGE_2$ production, decrease of LPS-stimulated pro-inflammatory cytokines and inhibitory activity against Pityrosporum ovale.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2007.11a
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• pp.339.2-339.2
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• 2007

See Full Text

• Journal of the Society of Cosmetic Scientists of Korea
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• v.24 no.1
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• pp.100-112
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• 1998

향 비듬 샴푸에 대한 비중이 증가되는 현 샴푸시장에서 향 비듬력을 측정할 수 있는 간단한 in vitro 실험법의 요구가 증대되고 있다. 기존의 향 비듬력의 측정을 위하여 사용되고 있는 방법으로는 Pityrosporum ovale에 대한 MIC test와 halo test가 널리 쓰이고 있으나, Pityrosporum 배지의 자체 탁도 때문에 균의 성장 여부를 육안으로 관찰하기 어렵고, 종이 디스크와 두피와의 차이에 의하여 실제 사용과 효과가 다르다는 단점이 있었다. 저자들은 임상 실험을 거치기 전 간단히 향 비듬력을 측정할 수 있는 in vitro 방법으로 skin disk diffusion method를 개발하였다. SDDM에서는 종이 디스크 대신 기니픽의 피부 조직을 사용하고, 향 비듬 제제의 처리 후 세척 단계를 포함시켜 실제 사용과의 차이를 줄였다. SDDM의 유용성을 확인하기 위하여 향 비듬 제제로 2.0% ketoconazole, 분산된 상태의 zinc pyrithion, 분자화 기술로 활성을 높인 ZPT에 대해 기존의 in vitro 시험법과 함께 향 비듬력을 측정하였다. 결과는 SDDM 시험에서만 20% ketoconazole 제제와 분자화된 0.5% ZPT제제의 억제대가 비슷한 것으로 나타나 임상 시험에서 두 제제 모두 비듬에 대해 개선 효과가 있었으며 향 비듬 효과에 차이가 없다는 결과와 일치하였다. 본 시험의 결과로 SDDM이 향 비듬 샴푸와 같은 wash-off 제품의 효능 측정에 간단하고 효과적인 적절한 in vitro 시험법으로 생각되어 SDDM 시험과 임상 시험결과를 소개한다.

• YAKHAK HOEJI
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• v.17 no.3
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• pp.137-140
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• 1973

Antimicrogbial activity of Veratrum alkaloids against Pityrosporum ovale. Trichopyton mentagrophytes, and Saccharomyces cerevisiae were investgated. Of the alkaloids tested, only jervaeratrum alkaloids exhibited antimicrobial activity. The most basic structural requirement for activity of jerveratrum alkaloids is mainly due to the introduction of an oxygen in ring C regardless of the difference in structural types. Glucoside is more active than alkamine, suggesting the assistance in the trasport processes.