• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5605-5611
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• 2012

Background: In the last two decades, pioneering research on anti-tumour activity of saffron has shed light on the role of crocetin, picrocrocin and safranal, as broad spectrum anti-neoplastic agents. However, the exact mechanisms have yet to be elucidated. Identification and characterization of the targets of bioactive constituents will play an imperative role in demystifying the complex anti-neoplastic machinery. Methods: In the quest of potential target identification, a dual virtual screening approach utilizing two inverse screening systems, one predicated on idTarget and the other on PharmMapper was here employed. A set of target proteins associated with multiple forms of cancer and ranked by Fit Score and Binding energy were obtained from the two independent inverse screening platforms. The validity of the results was checked by meticulously analyzing the post-docking binding pose of the picrocrocin with Hsp90 alpha in AutoDock. Results: The docking pose reveals that electrostatic and hydrogen bonds play the key role in inter-molecular interactions in ligand binding. Picrocrocin binds to the Hsp90 alpha with a definite orientation appropriate for nucleophilic attacks by several electrical residues inside the Hsp90-alpha ATPase catalytic site. Conclusion: This study reveals functional information about the anti-tumor mechanism of saffron bioactive constituents. Also, a tractable set of anti-neoplastic targets for saffron has been generated in this study which can be further authenticated by in vivo and in vitro experiments.

• Archives of design research
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• v.12 no.3
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• pp.43-52
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• 1999

For Bauhaus, the vaious typography experiments developed around the printing workshops, and it was only in the later Weimar Period that L. Moooly-Nagy, who came to be in charge of the rxinting workshops, approached it from the functional way of thinking and demanded print type reforms Using this as the basis, a new form of typograph called "typophoto" was developed by combining images and characters together using photography techniques and Bauhaus Unification Chaacter producyion. Harbert Bayer, striving at molds based on the ideologies of L. Moody-Nagy, prepared the framework for modern informational advertisements by producing a variety of advertisements based on several law of psychology and physiology. Bayer's successor, Joost Schmidt focused on lettering based on functionalism and typographic training and practice, while pioneering in the new area of display design wiwh efficient usage of space for exhibitions a1d dsplays. Thus, despite being carried doWl by the same leader in the sane era, the series of typographic experiments undertaken by the artists Bauhaus present guidelines to the direction modern visual communication must take through creativity and insight into the upcoming future that is not contained within the boundaries of traditions and customs.and customs.

• Journal of Ocean Engineering and Technology
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• v.25 no.2
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• pp.134-144
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• 2011

In this paper, the global study trends for material behaviors are investigated regarding the static and dynamic hardenings and final fractures of marine structural steels. In particular, after reviewing all of the papers published at the 4th and 5th ICCGS (International Conference on Collision and Grounding of Ship), the used hardening and fracture properties are summarized, explicitly presenting the material properties. Although some studies have attempted to employ new plasticity and fracture models, it is obvious that most still employed an ideal hardening rule such as perfect plastic or linear hardening and a simple shear fracture criterion with an assumed value of failure strain. HSE (2001) presented pioneering study results regarding the temperature dependency of material strain hardening at various levels of temperature, but did not show strain rate hardening at intermediate or high strain rate ranges. Nemat-Nasser and Guo (2003) carried out fully coupled tests for DH-36 steel: strain hardening, strain rate hardening, and temperature hardening and softening at multiple steps of strain rates and temperatures. The main goal of this paper is to provide the theoretical background for strain and strain rate hardening. In addition, it presents the procedure and methodology needed to derive the material constants for the static hardening constitutive equations of Ludwik, Hollomon, Swift, and Ramberg-Osgood and for the dynamic hardening constitutive equations of power from Cowper-Symonds and Johnson-Cook.

• Journal of the Korean Society of Costume
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• v.61 no.1
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• pp.69-83
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• 2011

This study applied cartoon-like simple and implicit symbol of Keith Haring works to tubular jacquard knit, designed woman casual knit wear with fun, explicit and activities using fluorescent yarns with explicit features. This study aimed to propose the directions for new market pioneering that meets the emotional requirements of modern people by raising the level of utilization and expression area of knit fashion, and to present the constructive directions for high value-added knit wear by designing highly effective knit wear. Methods of this study examined the lifetime and artistic background of Keith Haring and collected his works through searching of internet, scholastic publications or thesis. Formative types and colors of works collected were analyzed and classified according to characteristic standards of Haring and characteristic formativeness and color of works were extracted. The result of this study is as shown below: First, the feature of his works can be summarized into motif that has symbolic and implicit cartoon-like lines including narratives as well as enormous number of works. Such feature is very suitable for variation and recombination in realization of design and has unlimited potentials for development. Second, image colors can be extracted such as black and white, original color and fluorescent paints, which reflects the intention of artist who put focus on communication with the public. Such color feature is very suitable for design motif that has explicitness of reflecting the intention of artist through use of special fluorescent yarn. Third, I made it as reversible wear that has effects of increasing or decreasing the explicitness according to color area ratio using the feature of textures allowing use of both sides as well as form stability of tubular jacquard. Fourth, by adjusting the thickness of fabric with controlling of ply in fabric using poly yarn and wool union yarn, I could obtain good results of study in terms of technique that can express various materials with embossed dynamic effects of unevenness on flat surface.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.12 no.2
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• pp.152-157
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• 2001

Background : Electrolarynx, Esophageal voice, and Silicone voice prosthesis with tracheoesophageal(T-E) fistula have been used as vocal rehabilitating methods for the post-laryngectomized patients. Prosthetic rehabilitation of voice after total laryngectomy has gained wide acceptance and has become a common practice in many clinics since the pioneering works of Singer and Blom In 1979. Since the introduction of tracheo-esophageal puncture and application of Blom Singer$\circledR$ voice prosthesis in 1980, several reliable voice prostheses have been developed and are successfully being used. Objectives : Even though quality of voice produced by Silicone voice prosthesis with T-E fistula is superior to other modalities, it still has some disadvantages. We devised a new cannulatyped silicone voice prosthesis. Methods : 1) Devising a new prototype of cannula-typed silicone voice prosthesis. 2) Application of the prototype using canine animal model(laryngectormized dog) and fitting trial on human patient whose previously inserted Silicone voice prosthesis is not functioning due to presumed fungal infection. Discussion : Final form of prototype was made after several times of major and minor modifications. Insertion of the newly developed Cannula-typed Silicone voice prosthesis on canine animal model and human trial were done without any difficulty. There were no serious leakage of saliva or food during swallowing. Conclusion : The newly developed Cannula-typed Silicone voice prosthesis(So-Mang$\circledR$) and the modified replacement method will further improve the results of post-laryngectomized prosthetic voice rehabilitation. Long-term animal study and human trial are planned in the near future.

• Journal for History of Mathematics
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• v.23 no.2
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• pp.1-21
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• 2010

The first Korean mathematical science journal was published by Yu, Il- Sun in 1905 and the name of this journal is "Mathematical Science magazine". This monthly journal was published for 2 years. But in the existing literature, there is no information about it. We discovered its existence and studied its contents. From the historical materials, pioneering contributions of Yu, Il-Sun to mathematics were provided. In this article, the first issue of this journal was fully analyzed. We could see his affection and enthusiasm for the journal that he started. More mathematical search efforts on finding historical math materials should be continued. More efforts should be made on finding historical math literatures. Related researches will be done. Those works will be worth to be shared in ICME-12 and ICM 2014.

• Korean Institute of Interior Design Journal
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• v.27 no.1
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• pp.109-116
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• 2018

Prairie style houses in first stages of Frank Lloyd Wright's architecture activity pay a leading role in the process of house modernization as reflecting social and economic circumstances of the time based on traditional house style of the States. Wright's first work after retiring from L. Sullivan's office, Winslow house in 1983 is pioneering work predicting prairie house. This is because this house has only one modern architecture language of Wright and follow no style prevailing of the time. So, a researcher analyse Winslow house within the framework of functional thinking and new formative value creation in the modernization process of western house. Through this, The goal of this study is to find out modern characteristics and the meaning of Winslow house in modernization process prior to the 1900s. Firstly, the followings are modern characteristics of Winslow house. First, Winslow house has original planning breaking from custom based on modern functional and reasonable thoughts, and has practical space reflecting resident's inner demand. Second, Winslow house has modern new plastic value through original exterior breaking from custom and integrated shape of inner-outer space and structure. Secondly, the followings are the meaning of Winslow house in modernization process prior to the 1900s. First, Wright intend to suggest directions of residence modernization through Winslow house before designing Prairie style houses in earnest. Second, mixing of modern vocabulary and eclecticism show a sign of residence modernization process on the time. Third, inner-outer flowing space, opening space concept of Winslow house has innovative meanings predicting spacial characteristics of modern architecture.

• Journal of Fashion Business
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• v.11 no.5
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• pp.90-99
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• 2007

Arts is the expression of reasoning and conscious life of human and arouse human the concept of existence, utmost emotion and excellent thoughts. Also it makes humans life very abundant. I make it come first to get rid of the art thirst on the opposite sight of technical one for hair as on part of humans body. Next purpose is that to confirm the esthetic value of 'hair arts' by solidify the academic ground of beauty arts through creating 'hair arts' works and learning and make the direction for the beauty industry and education of the next generation. In this study I investigated the Greek myth(the background and develop)and the hair styles of ancient Greek Goddesses. On the basis of that symbols I elaborated hair formative works made of metal and studied, analyzed and displayed that. Work No.1 'Aphrodite' is the sculpture showing the win of love which animated. I formed it very active and vigorous. Next 'Birth of Venus', No.2, involves fineness and freshness. 'Fear of Medusa', the third piece, displays the very second when medusa was executed as a beautiful and active scene not a scary one. And lastly in 'Lovely Medusa' Medusa finally find the stability and it was expressed her beautiful and shining hair. So this study conducted based on the concept of practical hair and have made efforts to be close to theoretical manufacturing research needed at making hair arts works and academic one needed at organic design composition for pioneering new field, 'art hair.' I hope these 'hair arts' works make creativity of the practise hair alive. It will be very thankful to me if this study can help even though slightly for splendid beauty arts to make its status firm as a one part of arts, and there are following studies.

• Journal of Korea Society of Industrial Information Systems
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• v.19 no.1
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• pp.99-109
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• 2014

This study illustrates and compares the platform strategy of Apple and Samsung, which have been operating their own App stores, by using the $IISI^n$ model. Apple, the first mover of the platform, has employed closed strategy for quality control of the platform and customer loyalty. On the other hand, Samsung has employed open strategy for increasing the platform network effects. The result of this study showed that the platform strategy "Openness", which is a free entry of participants, and "Sharing" of created value, are important along with the excellent platform environment. As a pioneering study of the platform strategy for the co-creation, this research contributes to both theory and practice.

• The Journal of the Korea Contents Association
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• v.7 no.4
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• pp.141-149
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• 2007

In this study, the use of abstraction has been considered, focusing on the abstract metaphoric expressions presented in Animatrix and it has a purpose as the case study in the use of abstraction as a unique element of animation in which imaginative ideas and stimuli are significantly important and the pioneering works of abstract animations were produced in the early 20th century. The abstract metaphors expressed in The Second Renaissance Part1 & Part2 and Matriculated among the episodes of Animatrix, the animation produced in the omnibus form directed by Wachowski Brothers and great Master in the world, can be analyzed into Anima of Abstraction abstractively expressing organic vital power, Extensity of Abstraction which 4D space is realized possibly recognizing the human emotions as well as 3D space, and Conceptualization of Abstraction directly presenting the human mentality and imaginary world.