• KSBB Journal
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• v.20 no.3
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• pp.244-249
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• 2005

Chiral separation of racemic ibuprofen was achieved on a Kromasil KR100-5CHI-TBB column. Some chromatographic parameters (resolution, number of theoretical plates, HETP, capacity factor) are calculated under different separation conditions such as change of mobile phase compositions (hexane / t-BME : 85 / 15, 75 / 15, 65 / 35, 55 /45) as well as acetic acid concentrations for adjusting pH (0.1 to 1 $v/v\%$). Flow rate versus number of theoretical plates and HETP were compared to evaluate column efficiency. To determine the adsorption isotherms, PIM (Pulsed Input Method) was carried out. At concentrations of racemic ibuprofen between 0.1 and 0.3 mg/ml, S- and R-ibuprofen have the same retention time of 4.48 and 5.81 min. Ibuprofen isotherms show a linear form under concentrations of 0.3 mg/ml with eluent (hexane / t-BME = 55 / 45).

• The Korean Journal of Rheology
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• v.9 no.3
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• pp.124-131
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• 1997

스테인레스 강(SUS 316L) 분말과 왁스계 결합제를 혼합하여 제조한 분말사출재의 유변학적 특성을 낮은 전단율에서 측정하기 위해 동심원반식 점성측정기를 이용하여 실험을 실시하였다. 측정기 벽면에서 발생하는 벽면 슬립(Slip)을 확인하고 벽면 슬립을 보정하기 위하여 두가지의 원반 간격에서 측정된 실험 자료를 이용하여 벽면 슬립을 보정하는 방법을 채택하였다. 실험 중, 측정 전단율범위를 제한하는 Thixotropy 현상을 발견학고 이에대한 원인분석을 위한 실험을 진행한 결과 과도한 전단응력에 의해서 분말사출재로부터 분리되어 나온 슬립층이 내부로 빠르게 흡수되어 들어가지 못하고 잔류하면서 Thixotropy 현상을 발 생시키는 것으로 판단되었다. Thixotropy 현상이 발생하지 않는 범위를 조사한후, 제한된 범위내에서 분말사출재의 유변학적 특성을 측정하였다. 측정된 자료는 항복응력을 지니는 유체의 특성을 표현하는 Bingham 식의 변형식에 잘 근사 되었으며, 슬립속도를 실험결과로 부터 계산한 결과 전단응력에 따라 선형적인 관계를 가지고 있는 점과 항복응력의 존재를 정성적으로 보여주는 결과를 얻었다.

• Transactions of Materials Processing
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• v.16 no.1 s.91
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• pp.61-66
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• 2007

Powder injection molding(PIM) is widely used for many parts in the field of automotives, electronics and medical industries, due to the capability of net shaping for complex 3-D geometry. Powder injection mold design for the dental scaler tip, a component of medical appliance, was presented. In comparison with conventional machining process, powder injection molding has many advantages, specially in price and dimensional stability, for molding dental scaler tip which has complex geometry. Both product design and mold design for dental scaler tip were presented. A PIM feedstock was made of stainless series(17-4PH, 316L, 440C) powder and a wax based binder. The 'rapid mold' concept was applied to manufacture the various forms and materials of dental scaler tip including vibration characteristics.

• Journal of Powder Materials
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• v.9 no.4
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• pp.251-260
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• 2002

In the viscosity measurement of PIM feedstock, slip correction methods require a number of experiments and produce a high level of error. In this study, a rotational rheometer with a parallel-discs configuration having different surface roughness was tried to minimize the effect of the slip phenomenon. Disc surface was prepared in 3 different roughness conditions - a smooth and 2 roughened surfaces. Results with the roughened surfaces were compared with the results obtained with a slip correction method. Relationship between powder characteristics such as size and shape and a surface roughness of the disc was examined for feedstock of 4 different powders with a same binder. As results, the effect of the slip phenomenon could be sufficiently minimized on the roughened surface in most cases. However, the effect of the slip phenomenon could not be sufficiently minimized for feedstock of a round-particular-shape powder and in the case of very narrow gap size.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.05a
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• pp.270-274
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• 2005

The capability of net shaping for complex 3-D geometry, powder injection molding(PIM) is widely used for parts in the field of automotives, electronics and medical industry. Powder injection mold design for dental scaler tip, a component of medical appliance, was presented. In comparison with conventional machining process, powder injection molding has many advantages, specially in price and dimensional stability, for molding dental scaler tip. Product design and mold design for dental scaler tip was presented. Short shot experiment with scaler tip PIM mold and several defect (flash etc.) during injection molding process was discussed.

• Journal of Powder Materials
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• v.18 no.3
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• pp.262-268
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• 2011

In order to investigate the microstructure and mechanical properties of WC-10 wt% Co insert tool alloy fabricated by PIM (Powder Injection Molding) process, the feedstock of WC-10 wt% and wax used as a kind of binder were mixed together by two blade mixer. After injection molding, the debinding process was carried out by two-steps. First, solvent extraction, in which the binder was eliminated by putting the specimen into normal hexane for 24 hrs at $60^{\circ}C$, and subsequently thermal debinding which was conducted at $260^{\circ}C$ and $480^{\circ}C$ for 6 hrs in the mixed gas of $H_2/N_2$, respectively. Meantime, in order to compensate the decarburization due to hydrogen, 1.2~1.8% of carbon was added to ensure the integrity of the phase. Finally, the specimens were sintered in vacuum under different temperatures, and the relative density of 99.8% and hardness of 2100 Hv can be achieved when sintered at $1380^{\circ}C$, even the TRS is lower than the conventional sintering process.

• Genomics & Informatics
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• v.21 no.1
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• pp.8.1-8.19
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• 2023

Cancer of the stomach is the second most frequent cancer-related death worldwide. The survival rate of patients with gastric cancer (GC) remains fragile. There is a requirement to discover biomarkers for prognosis approaches. Helicobacter pylori in the stomach is closely associated with the progression of GC. We identified the genes associated with poor/favorable prognosis in H. pylori-induced GC. Multivariate statistical analysis was applied on the Gene Expression Omnibus (GEO) dataset GSE54397 to identify differentially expressed miRNAs (DEMs) in gastric tissues with H. pylori-induced cancer compared with the H. pylori-positive with non-cancerous tissue. A protein interaction map (PIM) was built and subjected to DEMs targets. The enriched pathways and biological processes within the PIM were identified based on substantial clusters. Thereafter, the most critical genes in the PIM were illustrated, and their prognostic impact in GC was investigated. Considering p-value less than 0.01 and |Log2 fold change| as >1, five microRNAs demonstrated significant changes among the two groups. Gene functional analysis revealed that the ubiquitination system, neddylation pathway, and ciliary process are primarily involved in H. pylori-induced GC. Survival analysis illustrated that the overexpression of DOCK4, GNAS, CTGF, TGF-b1, ESR1, SELE, TIMP3, SMARCE1, and TXNIP was associated with poor prognosis, while increased MRPS5 expression was related to a favorable prognosis in GC patients. DOCK4, GNAS, CTGF, TGF-b1, ESR1, SELE, TIMP3, SMARCE1, TXNIP, and MRPS5 may be considered prognostic biomarkers for H. pylori-induced GC. However, experimental validation is necessary in the future.

• Journal of Korea Game Society
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• v.4 no.4
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• pp.3-9
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• 2004

Expansion of internet and construction of high speed network which require multimedia services like MMORPG are exceeding the infra-structure. In this work, CBT is analyzed by focusing on the multicast routing protoco and the algorithm which is transformable to Anycast scheme from CBT scheme is suggested to adapt game traffic. Anycast routing scheme is suitable to distribute high density traffic. Simulation model was set per a number of group and group member, which enabled to reflect real environments. Performance evaluation of routing based on the characteristics of end-to-end delay of CBT and Anycast was mainly focused, The result showed that Anycast method was improved up 8.7%, 25.5%, 34.0%, 38.6% and 51.8%, 56.6% comparing with PIM-DM and CBT routing when packet site was 128, 512 and 1K byte respectively. From the simulation, CBT/Anycast routing scheme can be presented as a flexible and solid solution for the MMORPG traffic to improve the delay characteristics of game packets.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.430-434
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• 2010

OECD등 국제기구와 현재 국회에 계류 중인 물 관리기본법 제정(안)등에서 물 이용자에 대한 수익자 부담 원칙을 요구하고 있어, 농업용수의 대부분을 관리하고 있는 한국농어촌공사 관리지역의 농업용수 이용료(구 조합비) 면제에 대한 문제점이 제기되고 일부 전문가들 사이에서도 농업용수 이용료 부과의 필요성이 지속적으로 제기되고 있는 실정이다. 이러한 시점에서 과거 농업용수 이용료(구 조합비) 부과 및 면제의 역사를 살펴보고, 농업용수 및 농업 농촌의 특성을 고려한 농업용수 이용에 따른 수익자 부담원칙에 대하여 검토하였다. 농업용수 이용료는 1908년 수리조합이 시작된 이후 1999년까지 조합비 형태로 부과하다가 2000년 농업용 수관련 3개 기관이 공사로 통합하면서 면제가 되었고, 지난 10년 동안 외부(OECD 등)의 요구뿐만 아니라 내부적으로도 농업용수관리 비용증가로 인한 이용료 부과가 필요하다는 주장이 제기되었다. 한편 이용료 부과시 농업인 경제적 부담증가, 농업용수관리 정책의 혼선, 농업인 반발로 인한 사회문제화, 이용료 징수의 실효성 및 실익성에 대한 문제가 발생될 수 있다. 따라서 농업용수이용에 대하여 단순히 수익자 부담원칙 준수를 요구만 할 것이 아니라 면제에 대한 역사적, 사회경제적인 배경과 농업 농촌의 특성을 이해하고 국내외적으로 대두되는 수익자 부담원칙에 대하여 어떻게 합리적인 방법과 사회적인 합의를 이끌어 낼 것인가 장기적인 연구와 검토가 필요하다. 또한 비용부담측면만이 아니라 농업인의 물 관리 참여(PIM, Participatory Irrigation Management)등을 통한 수익자부담 원칙 달성 및 비용절감을 유도할 수 있는 제 3의 방안을 찾아야 한다.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2009.05a
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• pp.60-63
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• 2009

Manufacturing technologies of micro spur gear and micro mold by micro PIM were studied with stainless steel feedstock. For molding of gears, micro mold with gear cavity of 1.2 mm in diameter was produced by wire EDM. The proper injection pressure was selected to 70bar by observation and measuring of shapes and shrinkage of gears before/after sintering. For fabrication of micro mold, a tiny polymer gear was produced by injection into the mold. Then, 316L feedstock was again injected/compressed on the polymer gear and debinded together with polymer gear followed by sintering. As a result, another metal mold with gear cavity reduced to about 20% was fabricated and through repetition of this process chain, micro gear mold with cavity about below 800 um was finally obtained. In reduction of size by injection/compression molding, height of gear tooth was shrunk more and the effort for decrease of roughness of micro cavity were carried out ultrasonic polishing and as a result, the roughness in cavity decreased from 3-4 um to about 200 nm.