• Journal of Korean Neuropsychiatric Association
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• v.57 no.4
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• pp.276-286
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• 2018

Circadian rhythm is a periodic and continuous change in physiological, behavioral, and mental characteristics that occurs in most organisms on the Earth, because the Earth rotates in a 24-hour cycle. The circadian system regulates daily rhythms of physiology and behavior, such as the sleep/wake cycle, body temperature, hormonal secretion, and mood. The influence of circadian rhythm is very powerful, but limited research has addressed its effects. However, many recent studies have shown that circadian dysregulation may play an important role in the pathogenesis of bipolar disorder. This review study examined current and noteworthy studies, including the authors' own works, and proposes a possible clinical application of bipolar disorder based on evidence that circadian rhythm dysregulation in bipolar disorder may be a key pathogenetic mechanism.

• Korean Journal of Acupuncture
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• v.33 no.3
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• pp.95-101
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• 2016

Objectives : This study aims to overview the therapeutic mechanism of back-shu points in terms of sympathetic visceral motor nervous system. Methods : Studies about autonomic nervous system, and studies and ancient texts about back-shu points were reviewed. We interpreted possible mechanism of back-shu points considering similarities of anatomical and physiological characteristics of back-shu points and visceral motor nervous system. Results : Afferent signals for organ lesions that can develop the symptoms of autonomic neurological symptoms, pain, hyperalgesia through the skin segment. Through a physical examination of the myotome and dermatome, it is possible to diagnose segmental disorders. Treatment stimulation of the thick fibers of the disorder segment skin can reduce abnormal autonomic influence over the sympathetic reflex mechanism. In addition, if spinal muscles are relaxed, the pressure on the nerve roots could be reduced and consequently the hyperactivity of the sympathetic visceral motor signal would be suppressed. Conclusions : The back-shu points treatments work through the mechanism of the sympathetic nervous reflex. Moreover, segmental acupuncture can reduce tension of the spinal muscles, thereby improving pathological conditions of the sympathetic nervous system.

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.5
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• pp.305-314
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• 2018

This study was designed to understand the patho-physioloigcal mechanism of effects of Bojungikitangchunbang on Allergic Rhinitis. The mechanism was examined in three parts of concept of allergic rhinitis, composition of prescription, and concept of ascending and descending principle. And the relationship between the thoracic cavity and the abdominal cavity during respiration was also explored. The mechanism of Bojungikgitangchunbang on rhinitis treatment was systematically analyzed from the pathophysiological perspectives, and it was found to treat nose, spleen and lungs related to the ascending and descending principle. The water-dampness and edema causing allergic rhinitis are formed by disturbed ascending and descending mechanism when the Junggi goes down. The Bojungikgitangchunbang eliminates water-dampness and edema by ascending the troubled Junggi.

• Journal of the Korea Society of Computer and Information
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• v.22 no.7
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• pp.75-82
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• 2017

Correct prediction of emotion is essential for developing advanced health devices. For this purpose, neural network has been successfully used. However, interpretation of how a certain emotion is predicted through the emotion prediction neural network is very tough. When interpreting mechanism about how emotion is predicted by using the emotion prediction neural network can be developed, such mechanism can be effectively embedded into highly advanced health-care devices. In this sense, this study proposes a novel approach to interpreting how the emotion prediction neural network yields emotion. Our proposed mechanism is based on HRV (heart rate variability) measurements, which is based on calculating physiological data out of ECG (electrocardiogram) measurements. Experiment dataset with 23 qualified participants were used to obtain the seven HRV measurement such as Mean RR, SDNN, RMSSD, VLF, LF, HF, LF/HF. Then emotion prediction neural network was modelled by using the HRV dataset. By applying the proposed mechanism, a set of explicit mathematical functions could be derived, which are clearly and explicitly interpretable. The proposed mechanism was compared with conventional neural network to show validity.

• BMB Reports
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• v.53 no.9
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• pp.453-457
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• 2020

The right-handed double-helical structure of DNA (B-DNA), which follows the Watson-Crick model, is the canonical form of DNA existing in normal physiological settings. Even though an alternative left-handed structure of DNA (Z-DNA) was discovered in the late 1970s, Z-form nucleic acid has not received much attention from biologists, because it is extremely unstable under physiological conditions, has an ill-defined mechanism of its formation, and has obscure biological functions. The debate about the physiological relevance of Z-DNA was settled only after a class of proteins was found to potentially recognize the Z-form architecture of DNA. Interestingly, these Z-DNA binding proteins can bind not only the left-handed form of DNA but also the equivalent structure of RNA (Z-RNA). The Z-DNA/RNA binding proteins present from viruses to humans function as important regulators of biological processes. In particular, the proteins ADAR1 and ZBP1 are currently being extensively re-evaluated in the field to understand potential roles of the noncanonical Z-conformation of nucleic acids in host immune responses and human disease. Despite a growing body of evidence supporting the biological importance of Z-DNA/RNA, there remain many unanswered principal questions, such as when Z-form nucleic acids arise and how they signal to downstream pathways. Understanding Z-DNA/RNA and the sensors in different pathophysiological conditions will widen our view on the regulation of immune responses and open a new door of opportunity to develop novel types of immunomodulatory therapeutic possibilities.

• Journal of the Korean Society of Industry Convergence
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• v.7 no.3
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• pp.299-303
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• 2004

A systematic investigation for the reactivity and solvent effect was studied on the reaction of optical resolving agents with the optically active assistant compounds. The reaction rate constants of the nucleophillic substitution reactions were determined by means of conductometric method The linear solvent energy relationship based on the solvent parameters and the thermodynamic parameters was discussed on the reactions of various physiological active compounds and optical resolving agents The reaction mechanism was discussed from the kinetic results compared with the optical purity.

• Nutritional Sciences
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• v.5 no.4
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• pp.228-233
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• 2002

The low molecular weight zinc-binding protein metallothionein(MT) contains 32% cysteine and has been shown to efficiently scavenge hydroxyl radicals in vitro. MT expression is induced by oxidative stress and an antioxidant role for this protein has therefore been proposed. This review mainly focuses on the evidence for this role arising from studies using genetically modified animals and cells which either over- or under-express MT. Despite some considerable disparity of results in the literature, reported studies do generally support an antioxidant role. Nevertheless, oxidant stress at non-physiological treatment levels has been the preferred experimental model and there is little information about the role of MT in physiological oxidative stress. Although it is presumed that the mechanism by which MT has an antioxidant effect involves oxidation of cysteinal thiols, it is possible that zinc release from MT is in itself an important signalling factor.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2000.04a
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• pp.99-103
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• 2000

There are two approaches in the study of emotion in the physiological psychology. The first is to clarify the brain mechanism of emotion, and the second is to evaluate objectively emotions using physiological responses along with our feeling experience. The method presented here belongs to the second one. Our method is based on the "level-crossing point detection" method. which involves the analysis of frequency fluctuations of EEG and is characterized by estimation of emotionality using coefficients of slopes in the log-power spectra of frequency fluctuation in alpha waves on both the left and right frontal lobe. In this paper we introduce a new theory of estimation on an individual's emotional state by using our non-invasive and easy measurement apparatus.

• The Journal of Korea Robotics Society
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• v.4 no.4
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• pp.327-333
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• 2009

This paper describe the riding robot system named by "RideBot" which is a riding robot like as a horse. In order to simulate the riding motions, we develope the saddle mechanism which can generate 3 DOF motions including pitch, roll, and bounce movement, and also we controlled the riding motions and the intention of horseman. To generate the riding motions with the bodily sensation, we developed Novel Washout Filter and the algorithms for motion control. And also, we developed some health care service for the health care of horseman. A body state index was proposed that evaluates the personal health state from both the measured physiological variables and the surveyed questions. The physiological variables such as weight, blood pressure, heart rate variability (HRV), accelerated state photoplethysmograph(APG), body fat, and happiness index were measured by the specially designed bio-handle system and survey questions. The efficiency of the proposed ride robot is evaluated in the experiments.

• Proceedings of the Korean Nutrition Society Conference
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• 2002.11b
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• pp.1171-1177
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• 2002

The low molecular weight zinc-binding protein metallothionein (MT) contains 32% cysteine and has been shown to efficiently scavenge hydroxyl radicals in vitro. MT expression is induced by oxidative stress and an antioxidant role for this protein has therefore been proposed. This review mainly focuses on the evidence for this role arising from studies using genetically modified animals and cells which either over-or under-express MT. Despite some considerable disparity of results in the literature, reported studies do generally support an antioxidant role. Nevertheless, oxidant stress at non-physiological treatment levels has been the preferred experimental model and there is little information about the role of MT in physiological oxidative stress Although it is presumed that the mechanism by which MT has an antioxidant effect involves oxidation of cysteinal thiols, it is possible that zinc release from MT is in itself an important signalling factor.