• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2004년도 The 3rd Annual Conference for The Korean Society for Bioinformatics Association of Asian Societies for Bioinformatics 2004 Symposium
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• pp.210-218
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• 2004

Poly(ADP-ribose)polymerase-1 (PARP-1) is a nuclear enzyme involved in various physical functions related to genomic repair, and PARP inhibitors have therapeutic application in a variety of neurological diseases. Docking and the QSAR (quantitative structure-activity relationships) studies for 52 PARP-1 inhibitors were conducted using FlexX algorithm, comparative molecular field analysis (CoMFA), and hologram quantitative structure-activity relationship analysis (HQSAR). The resultant FlexX model showed a reasonable correlation (r$^{2}$ = 0.701) between predicted activity and observed activity. Partial least squares analysis produced statistically significant models with q$^{2}$ values of 0.795 (SDEP=0.690, r$^{2}$=0.940, s=0.367) and 0.796 (SDEP=0.678, r$^{2}$ = 0.919, s=0.427) for CoMFA and HQSAR, respectively. The models for the entire inhibitor set were validated by prediction test and scrambling in both QSAR methods. In this work, combination of docking, CoMFA with 3D descriptors and HQSAR based on molecular fragments provided an improved understanding in the interaction between the inhibitors and the PARP. This can be utilized for virtual screening to design novel PARP-1 inhibitors.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2823-2828
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• 2013

Background: This study was performed to evaluate relationships between different demographic variables and hopelessness and depression in end of life Turkish cancer patients. This study was a descriptive survey with repeated measures conducted a university hospital in the city of Erzurum, in the eastern part of Turkey. The study enrolled 216 patients undergoing palliative treatment at the hospital. Materials and Methods: Data were collected using questionnaires (demographic questionnaire, Beck Hopelessness Scale (BHS), Beck Depression Scale (BDS) and analyzed for demographic and disease-related variable effects on hopelessness and depression. Results: Th hopelessness score was significantly high in female, illiterate, married, and living in rural areas cancer patients. Both hopelessness and depression scores were significantly higher with longer disease duration, receiving radiotherapy treatment, and having metastatic disease. Conclusions: These findings demonstrate the coexistence of the physical, psychological, and cognitive problems faced by patients with cancer. Nurses can conduct brief screening assessments to identify patients with probable distress and and psychosocial support, as well as referrals to support services.

• 대한간호학회지
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• 제40권6호
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• pp.820-830
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• 2010

Purpose: The purpose was to develop a preliminary scale to measure Korean adolescents' health behaviors through a qualitative approach, to evaluate the scale psychometrically, and to develop a final scale. Methods: Participants were 61 adolescents for qualitative interviews and 1,687 adolescents for the psychometric evaluation. Procedure included content analysis of interviews to identify health behavior categories for Korean adolescents, pre-test to confirm that preliminary scale items were understandable, content validity by an expert panel, development of the web-based computer-assisted survey (CAS), and psychometric analysis to determine reliability and validity of the final scale. Results: A final scale was developed for both paper-and-pencil and CAS. It consisted of 14 health behaviors (72 items), including stress and mental health (10), sleep habits (5), dietary habits (12), weight control (4), physical activity (4), hygiene habits (5), tobacco use (5), substance use (2), alcohol consumption (4), safety (4), sexual behavior (9), computer use (3), health screening (4), and posture (1). Conclusion: The scale's strong points are: 1) Two thirds of the final scale items are Likert scale items, enabling calculation of a health behavior score. 2) The scale is appropriate to Korean culture. 3) The scale focuses on concrete health behaviors, not abstract concepts.

• 한국직업건강간호학회지
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• 제22권4호
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• pp.343-351
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• 2013

Purpose: This study was to identify factors affecting mammography screening behavior in job women by attitude, social influence and self-efficacy model. Methods: The data were obtained from 171 job women in one residency area by structural questionnaire from March to June 2013 and analysed by using $x^2$-test, ANOVA, Spearman's correlation and logistic regression analysis. Results: The each performance rate was 45.1% in mammography, 44.9% in breast self examination and 48.5% in physical examination. The mammography performance rate in job women showed higher significance in the groups of 1) older age, urban residency, marital status or high economic state, 2) shorter office hours or higher job position, 3) childbirth experience or menopause and 4) preferring soy bean food, practicing regular exercise, suffering chronic disease or receiving radiation therapy. Attitude, social influences and self-efficacy made significant differences in mammography performance. Logistic regression analysis showed that 50 years or older, urban residency, social influences towards mammography and high self-efficacy were significant relationship. Conclusion: In order to increase the mammography performance rate, the intervention strategies are needed to increase positive social influences or self-efficacy and to offer public information to younger age.

• 가정∙방문간호학회지
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• 제25권2호
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• pp.209-218
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• 2018

Purpose: This study is to identify the health promoting behaviors, health belief, and self-efficacy of visiting nurses working for the Health Visiting Project in Seoul and to determine the predictors of influencing health promoting behaviors. Methods: Data were collected from an online survey of 496 visiting nurses form 25 districts in Seoul. Using SPSS ver. 24, the study performed descriptive statistics, t-test, one-way ANOVA, correlations, and stepwise multiple regression. Results: The mean scores for health promoting behaviors and self-efficacy were slightly higher than that of the median, whereas health belief showed in the median. The factors influencing health promoting behavior were perceived barriers, perceived sensitivity, self-efficacy, and age. These variables explained 36.0% of health promoting behaviors(F=60.62, p<.05). Conclusion: To prevent illness and to promote the health of the population, the visiting nurse mainly performs health screening, health education and counseling. To fulfill these responsibilities, the visiting nurse should be healthy and perform health promoting behaviors well, effectively serving as a model for their clients. Most of the visiting nurses were middle-aged, thus, it is necessary to strengthen health promotion activities that manage physical and psychological health at the individual level.

• 보건행정학회지
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• 제31권3호
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• pp.374-383
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• 2021

Background: The purpose of this study is to identify the factors affecting the depressive mood experience in university students by gender. Methods: This study is a descriptive survey that conducted a secondary analysis using data from the 2020 Community Health Survey, which is conducted annually in Korea. The study targets 8,928 college students, 4,682 male students and 4,246 female students. Data analysis was conducted after creating a composite sample plan file that reflected layering variables, colony variables, and weights. Results: Factors affecting the depressive mood experience of both males and females were household income, smoking, subjective stress levels, changes in drinking and smoking, and the number of encounters caused by coronavirus disease 2019 (COVID-19). Factors influencing the depressive mood experience of females were the presence of breakfast, changes in physical activity due to COVID-19, and the presence of helpers in self-quarantine due to COVID-19 (p<0.05). Conclusion: Psychological counseling programs should be promoted to actively utilize mental health in those in their 20s and 30s. Universities also need to detect depressed students early through screening and perform timely and appropriate interventions.

• 대한정형외과 초음파학회지
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• 제7권2호
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• pp.89-97
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• 2014

목적: 중학교 야구 선수의 단체 검진에서 확인된 주관절 초음파 검사의 이상 소견에 대해 알아보고자 한다. 대상 및 방법: 4개의 중학교 야구부를 방문하여 주관절 통증 유무에 상관없이 총 93명의 선수(나이: 12~15세, 평균: 13.5세)에게 양측 주관절 초음파 검사를 시행하였다. 초음파 검사는 양측 주관절의 내측과 전외측을 검사하여 각각 내상과 골단의 분리나 분절, 소두 박리성 골연골염의 유무를 확인하였다. 주관절 통증 유무, 이학적 검사 소견과 초음파 이상 소견의 관계 및 투수와 일반 야수들의 초음파 소견의 차이를 알아보았다. 결과: 총 93명의 선수 중 36명(39%)에서 우세수의 초음파 이상 소견이 관찰되었으며 내상과 골단 분리 또는 분절이 30명, 주두 박리성 골연골염은 2명, 두 병변 모두가 동반된 경우가 4명 이었다. 주관절 통증이 있는 37명 중 29명(78%)에서 초음파 이상 소견이 관찰되었다. 이학적 검사 상 내상과 골단 이상은 내측부 압통(59%), 외반 부하검사(52%)에서 양성을 보였으며 박리성 골연골염을 보이는 6명 중 5명(83%)에서 $5^{\circ}$이상의 주관절 굴곡 구축이 있었다. 내상과 골단 이상은 투수와 야수에서 진단 빈도의 의미있는 차이는 없었으나 박리성 골연골염은 투수에 많았다(p<0.05). 결론: 주관절 초음파 검사는 현장에서 시행할 수 있는 유용한 선별 검사이며 청소년 야구 주관절 통증의 주 원인이 되는 주관절 내상과 골단의 이상이나 박리성 골연골염을 조기 발견하는데 효과적인 방법으로 생각된다.

• 한국산학기술학회논문지
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• 제17권7호
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• pp.656-665
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• 2016

연구목적: 이 연구는 한국의 재림교인과 일반 인구집단간의 생활습관 및 건강행동 비교 분석 연구를 통하여 특성과 관련요인들을 도출하고자 실시하였다. 연구방법: 수도권 지역 만 20세 이상 재림교인 878명과 제4기 2차년도 국민건강영양 조사자료 중에서 수도권 지역 만 20세 이상 3,000명을 대상으로 건강행태와 관련된 건강검진, 흡연, 음주, 신체활동, 주관적 스트레스, 체중관리, 구강건강 관련 항목의 비교는 카이제곱 검정을 사용하였으며, 건강행동에 기여요인을 확인하기 위해 로지스틱회귀분석을 실시하였다. 연구결과: 건강검진율은 재림교인이 일반 인구집단보다 높게 나타났으며(p<0.001), 재림교인은 연령이 낮은 20-30대에서 검진율이 낮게 나타났다(p<0.001). 평생 흡연 경험율 및 현재 흡연율에서 재림교인이 일반 인구집단보다 현저하게 낮게 나타났으며(p<0.001), 재림교인 중 과거 흡연자의 금연 성공율은 매우 높게 나타났다. 음주율에서는 재림교인이 일반 인구집단보다 현저하게 낮게 나타났으며, 재림교인은 신앙기간이 짧을수록 음주를 많이 하는 것으로 나타났으며(p<0.001), 남자가 여자보다 음주율이 높은 것으로 나타났다(p<0.001). 중등도 신체활동 및 걷기 운동에서 재림교인은 일반 인구집단보다 실천율이 높게 나타났으며, 재림교인들의 남자가 여자보다 중등도 신체활동은 높은 것으로 나타났다(p<0.001). 결론: 이상에서 나타난 재림교인들의 건강생활습관에서 흡연 및 음주 등에서는 일반 인구집단에 보다 탁월하게 건강생활을 실천하고 있어 추후 보다 심층적인 추적관찰 연구 등이 필요해 보인다.

• 농촌의학ㆍ지역보건
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• 제25권2호
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• pp.327-341
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• 2000

농촌 사회는 60세 이상의 노령인구가 점차 증가하고 있고, 연령이 증가할수록 본인이 느끼는 건강 상태를 나쁘게 인식하고 있는 것으로 나타나 이에 대한 대책이 필요할 것이다. 남성에서는 연령 이 증가할수록 건강증진 행태 점수가 높게 조사되었으며, 30~40대 연령층에서 건강증진 행태 점수가 가장 낮으면서 본인의 건강을 과신하는 것으로 조사되었다. 여성에서는 연령이 증가할수록 본인의 건강이 나쁘다고 인식하고 있었으며, 건강증진 행태 점수도 낮게 조사되었다. 농촌 지역 남성을 대상으로 한 건강증진 노력은 젊은 연령층을 중점적으로 올바른 건강행태 교육을 통해 지속적인 건강증진에 주력해야 할 것이다. 특히 30대~40대 연령층을 중점적으로 금연 운동에 노력해야 할 것이며, 40대~50대 연령층에게는 적절한 체중관리를 위한 프로그램 개발에 노력해야 할 것이다. 여성에서는 고연령층을 대상으로 건강증진에 노력해야 할 것이며, 특히 60대~70대 고령의 노인들이 할 수 있는 운동 프로그램 개발 노력과 40대~50대 연령층의 체중관리에도 노력해야 할 것이다.

• Safety and Health at Work
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• 제8권1호
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• pp.36-41
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• 2017

Background: Police work is generally sedentary although there may be situations that require physical endurance and strength, such as foot chases and arresting suspects. Factors such as excessive body fat can impede an officer's physical ability to deal with such occurrences. Our objective was to examine associations between officers' body fat percentage (BF%) and performance on a standardized fitness protocol. Methods: Data were obtained from fitness screening among 1,826 male and 115 female officers in a large US police agency. The screening consisted of a 2.4-km run, push-ups, sit-ups, and sit-and-reach test. Sex-specific body fat percentages were estimated from skinfold thickness measured using calipers. Linear regression models were used to examine unadjusted and adjusted mean scores of fitness tests across BF% tertiles. Results: The prevalence of overall fitness was 4.3 times greater in male officers and 3.6 times greater in female officers having the lowest BF% tertile compared with the highest tertile (30.3% vs 7.1% and 46.0% vs 12.8%, respectively). BF% was linearly and positively associated with the time of 2.4-km run (p < 0.001), and linearly and inversely associated with the number of push-ups (p < 0.001), sit-ups (p < 0.001), and the distance of sit-and-reach (p < 0.001) in men. Similar associations were observed in women with the exception of sit-and-reach (p = 0.122). Associations were independent of age, race/ethnicity, rank, and duty station. Conclusion: Overall, BF% was inversely associated with fitness levels in male and female officers. Future longitudinal studies should be initiated to explore the potentially causal relationship between BF% and fitness in law enforcement officers.