• The Journal of Korean Physical Therapy
• /
• v.19 no.2
• /
• pp.41-55
• /
• 2007

Purpose: This study aimed to compare the effect on nerve regeneration of ultrasound irradiation in rats with peripheral nerve injury. Methods: To investigate alterations of the NCAM immunoreactivity in non-crushed part and crushed part of the spinal cord, the unilateral sciatic nerve of the rats were crushed. The expression of NCAM was used as the marked of peripheral nerve regeneration, and also plays an important role in developing nerve system. Experimental animals were sacrificed by perfusion fixation at post-injury 1, 3, 7, 14 days after ultrasound irradiation. The pulsed US was applied at a frequency of 1MHz and a spatial average-temporal average Intensity of 0.5W/of (20% pulse ratio) for 1 mins. The Luxol fast blue-cresyl violet stain were also done to observe the morphological changes. Results: Alteration of NCAM immunoreactivity in the crushed part and the non-crushed part of lower lumbar spinal cord were observed. NCAM-immunoreactivity cells were some increased in the dorsal horn lamina I, III and cell ventral horn at 1 day after unilateral sciatic nerve injury. However, there was not significant difference in the relationship between crushed part and non-crushed part. NCAM-inmmunoreactivity was remarkably increased at 3 days after unilateral sciatic nerve injuryin the gray matter and white matter. NCAM-immunoreactivity was increased in the ventral horn and post horn of experimental crushed part. Also, NCAM-immunoreactivity in large motor neurons in ventral horns lamina VIII, IX were increased at 7 days after unilateral sciatic nerve injury. At 14 days after sciatic nerve crushed injury, there was no significant difference. All group were decreased for 14 days. In the time course of NCAM expression, all groups showed a significant difference at 3day groups(p<0.05). Whereas, CC group was noted a significant difference between 3day and 7 day group respectively. In NCAM expression, there were significantly increased in all group. In the relationship between CNC group and ENC group, significant difference was detected among 3, 7, 14 day group(p<0.05). The difference between CC group and ENC group were noted in all groups(p<0.05). Conclusion: It is consequently suggested that the effects of the ultrasound irradiation may increase the NCAM immunoreactive neurons and glial cell in the spinal cord after unilateral sciatic nerve crushed injury. Therefore, the increased NCAM immunoreactivity in the spinal cord may reflect the neuronal damage and healing process induced by a ultrasound irradiation after peripheral nerve injury in rat.

• The Journal of Korean Physical Therapy
• /
• v.14 no.3
• /
• pp.74-91
• /
• 2002

This studies to investigate the effects of ultrasound and swimming on the changes of the serum creatine kinase, latate dehydrogenase, aspatate aminotransferase, alanine aminotransferase, alkaline phosphatase, in peripheral nerve and muscle injury rats. The forty Sprague-Dawley adult male rats were assigned to the 4 groups: the experimental groups(3), and the peripheral nerve and muscle injury control group(1). There was made artificial injured by ischial nerve and muscle of each rats the each experimental ultrasound group and swimming group were treated from 3 days after being injuried for the 5 minutes and 10 minutes every day during the 10 days and 16 days respectively. The results were as follows: 1. The activities of creatine kinase, lactate dehydrogenase were significantly decreased on of the ultrasound and swimming groups for 10 days. All experimental group were significantly decreased for 16 days. there were significantly decreased the swimming group and ultrasound group were to the 10 days group. 2. The activities of asparatate aminotransferase, alalnine aminotransferase on the ultrasound group were significantly increased to the injured control group, there were significantly decreased the ultrasound group for 16 days group were to the 10 days group and there were significantly increased the swimming group for 16 days group were to the 10 days group. 3. The activities of alkaline phosphatase changes were no difference all experimental groups, there were significantly increased for 16 days group to the 10 days group. From these results it may be concluded that the effects of the ultrasound and swimming, the changes of the serum activities creatine kinase , lactate dehydrogenase of (; the objective indicates) to the muscle regeneration process of the nerve and muscle injured rats.

• Restorative Dentistry and Endodontics
• /
• v.41 no.4
• /
• pp.296-303
• /
• 2016

Objectives: The purpose of the present study was to evaluate the effects of proanthocyanidin (PAC), a crosslinking agent, on the physical properties of a collagen hydrogel and the behavior of human periodontal ligament cells (hPDLCs) cultured in the scaffold. Materials and Methods: Viability of hPDLCs treated with PAC was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The physical properties of PAC treated collagen hydrogel scaffold were evaluated by the measurement of setting time, surface roughness, and differential scanning calorimetry (DSC). The behavior of the hPDLCs in the collagen scaffold was evaluated by cell morphology observation and cell numbers counting. Results: The setting time of the collagen scaffold was shortened in the presence of PAC (p < 0.05). The surface roughness of the PAC-treated collagen was higher compared to the untreated control group (p < 0.05). The thermogram of the crosslinked collagen exhibited a higher endothermic peak compared to the uncrosslinked one. Cells in the PAC-treated collagen were observed to attach in closer proximity to one another with more cytoplasmic extensions compared to cells in the untreated control group. The number of cells cultured in the PAC-treated collagen scaffolds was significantly increased compared to the untreated control (p < 0.05). Conclusions: Our results showed that PAC enhanced the physical properties of the collagen scaffold. Furthermore, the proliferation of hPDLCs cultured in the collagen scaffold crosslinked with PAC was facilitated. Conclusively, the application of PAC to the collagen scaffold may be beneficial for engineering-based periodontal ligament regeneration in delayed replantation.

• ETRI Journal
• /
• v.34 no.3
• /
• pp.352-360
• /
• 2012

This paper proposes a low-cost, low-power, and high-capacity optical-electrical-optical-type reach extender that can provide 3R frame regeneration and remote management to increase the reach and split ratio with no change to a legacy time division multiple access passive optical network. To provide remote management, the extender gathers information regarding optical transceivers and link status per port and then transmits to a service provider using a simple network management protocol agent. The extender can also apply to an Ethernet passive optical network (E-PON) or a gigabit-capable PON (G-PON) by remote control. In a G-PON, in particular, it can provide burst mode signal retiming and burst-to-continuous mode conversion at the upstream path through a G-PON transmission convergence frame adaptor. Our proposed reach extender is based on the quad-port architecture for cost-effective design and can accommodate both the physical reach of 60 km and the 512 split ratios in a G-PON and the physical reach of 80 km and the 256 split ratios in an E-PON.

• International Journal of Advanced Culture Technology
• /
• v.9 no.3
• /
• pp.243-252
• /
• 2021

The Gwangju Daein Art Market, once declared as a declined market, was regarded as a success after an inflow of artists. However, the number of resident artists decreased from 100 at the end of 2015 to 39, to 9 in 2018, and to 6 in 2021. The project site showed signs of decline toward the completion of the project, leading to a Longitudinal study on the project's sustainability. The purpose of this study is to investigate the causes of outflow of artists and the network characteristics of the remaining artists from a sustainability perspective and thereby draw policy implications. As an analysis method, in-depth interviews and surveys were conducted. After that, we checked the remaining artists in 2018 and 2021 and identified the network characteristics. Based on the interview results, the causes of outflow were classified into programmatic, physical, and other factors. The results of a comparison showed that the levels of understanding, satisfaction, and frequency of exchange decreased. The study also provides policy implications. First, a sustainable, long-term program for the artists must involve the improvement of physical space. Second, participation in the market should be encouraged by working with artists on program composition or business progress. Third, programs for supporting exchange among artists should be further strengthened.

• Proceeding of Spring/Autumn Annual Conference of KHA
• /
• 2011.04a
• /
• pp.135-140
• /
• 2011

Recently, people aim for a healthy environment which enhances quality of life, and also there are communication in green space like therapy garden and weekend farm growing. Meanwhile, in Korea, administrative organizations have leaded to plan and proceed in reference to physical regeneration in local areas, and this had caused social and maintenance problems. The purpose of this study was to introduce a concept of community garden which is regarded as green and community space and to insist on a way of residents participation on plan for community garden and its necessity. For that, there were five ways of residents participation on plan for community garden based on literatured and theoretical contemplation and case studies, and these were subject to construction project of community garden in deteriorated area in Jeonju city. This study can provide improvement guidelines for the initial stage of plan for residents participation community garden.

• Biomolecules & Therapeutics
• /
• v.18 no.4
• /
• pp.351-362
• /
• 2010

Nitric oxide (NO), synthesized from L-arginine by three isoforms of NO synthase (NOS), is a gaseous signaling molecule with an astonishingly wide range of biological and pathophysiological activities, including vasorelaxation, angiogenesis, anti-inflammation, and anti-apoptosis in mammalian cells. Recent studies have shown that NO donors and inhaled NO convert to biologically active NO under biological conditions and act as a signaling molecule in pathophysiological conditions. This review will discuss the roles of NO and its potential therapeutic implication in various human diseases, such as tumor, vascular regeneration, hypertension, wound healing, and ischemia-reperfusion injury.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.15 no.2
• /
• pp.28-34
• /
• 2007

In design stage of vehicles, the application of virtual durability analysis techniques enables us to cut down the necessary time and cost to carry out various physical experiments. In this study, computer simulations of vehicle suspensions were carried out with DADS program including component flexibility, and the durability analysis of vehicle components was executed with MSC/Fatigue program using the load history obtained from vehicle dynamic simulation. Driving test of a vehicle was also carried out to obtain precise input data for the durability analysis, and the results of virtual durability analysis were compared to those of experiments.

• Proceeding of Spring/Autumn Annual Conference of KHA
• /
• 2008.11a
• /
• pp.231-234
• /
• 2008

Urban redevelopment make a short term effects without consideration about resident‘s lives. so, there are many problems and planners solve the problems to improve urban redevelopment based on resident leaded direction. The purpose of this research is to find inherent district which is character by residents. Most of them could be explained in relation to life, religious leadership, traditional cultural heritage and democratic movement. Group interviews at a field site were carried as the main methodology by people who have an intimate knowledge of the place facts. This research has implication on a cognitive and emotional community map of residents compared to the just physical and geographical map. The places and place recognition activities and movement can be a basic foundation for residents participation in improving their housing neighborhood environment.

• Biotechnology and Bioprocess Engineering:BBE
• /
• v.6 no.5
• /
• pp.311-325
• /
• 2001

Tissue engineering scaffolds play a critical role in regulating the reconstructed human tissue development. Various types of scaffolds have been developed in recent years, including fibrous matrix and foam-like scaffolds. The design of scaffold materials has been investigated extensively. However, the design of physical structure of the scaffold, especially fibrous matrices, has not received much attention. This paper compares the different characteristics of fibrous and foam-like scaffolds, and reviews regulatory roles of important scaffold properties, including surface geometry, scaffold configuration, pore structure, mechanical property and bioactivity. Tissue regeneration, cell organization, proliferation and differentiation under different microstructures were evaluated. The importance of proper scaffold selection and design is further discussed with the examples of bone tissue engineering and stem cell tissue engineering. This review addresses the importance of scaffold microstructure and provides insights in designing appropriate scaffold structure for different applications of tissue engineering.