• Medical Lasers
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• 제10권1호
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• pp.7-14
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• 2021

In cancer therapy, it is often desirable to use precision medicine that involves treatments of high specificity. One such treatment is the use of photo-triggered theranostic nanoparticles. These nanoparticles make it possible to visualize and treat tumors specifically in a controlled manner with a single injection. Several novel and powerful photo-triggered theranostic nanoparticles have been developed. These range from small organic dyes, semiconducting and biopolymers, to inorganic nanomaterials such as iron-oxide or gold nanoparticles, carbon nanotubes, and upconversion nanoparticles. Using photo-triggered theranostic nanoparticles and localized irradiation, complete tumor ablation can be achieved without causing significant toxicity to normal tissue. Given the great advances and promising future of theranostic nanoparticles, this review highlights the progress that has been made in the past couple of years, the current challenges faced and offers a future perspective.

• 대한임상검사과학회지
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• 제56권1호
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• pp.52-58
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• 2024

광역학 요법(photodynamic therapy)은 특정 파장의 빛에 의해 활성화되는 광민감제(photosensitizer)를 사용하여 세포 내 산소를 활성화시키는 치료 방법으로, 항생제 내성균에 의한 상처 감염의 치료에 유망한 접근 방법이다. 일반적으로 건강한 사람에게 비병원성인 녹농균(Pseudomonas aeruginosa, P. aeruginosa)은 특정 병원성 징후를 보이지 않지만, 피부 손상이나 면역력이 저하된 사람들에서는 패혈증과 같은 심각한 질병을 유발할 수 있다. 항생제는 P. aeruginosa 감염에 대한 전통적인 치료법이나 약물 오용으로 인한 항생제 내성의 증가는 이러한 감염을 관리하는 데 큰 어려움을 준다. 본 연구에서는 P. aeruginosa의 억제제로서 광민감제(PhotoMed, Methyl pheophorbide A, Radachlorin^®)와 다이오드 레이저를 이용한 광역학 치료 효과를 조사하는 것을 목표로 했다. P. aeruginosa 현탁액과 광민감제(PhotoMed, Methyl pheophorbide A, Radachlorin^®)를 페트리 접시에 접종하여 30분 후 다이오드 레이저를 사용하여 3 J/cm²의 에너지 밀도로 조사했다. 그 결과, P. aeruginosa는 PhotoMed에서 79.65%, Methyl pheophorbide A에서 47.36%, Radachlorin^®에서 40.91%의 사멸률을 보였다. 이번 연구는 P. aeruginosa를 억제하기 위한 가장 효과적인 접근법이 PhotoMed와 다이오드 레이저를 이용한 광역학 치료임을 보여준다.

• The Journal of Korean Physical Therapy
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• 제11권2호
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• pp.5-9
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• 1999

The electromagnetic agent used in physical therapy rely far their effects on tissue heating and photo reaction of the body, Infrared has a thermal and analgesic effect, Ultra violet produces direct photo chemical reaction when it interacts with the body. Laser has broad effect on medicine, Ten ding Diancibo Pu (TDP) is in the infrared ray. The wave range is 20,000-250,000, as a far infrared. The effects of the TDP are number of white and red blued cell, capacity of animal immunization activity of enzyme in the organ and blood sugar density.

• 한국컴퓨터그래픽스학회논문지
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• 제22권3호
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• pp.75-87
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• 2016

사진 기반의 가상 현실 노출 치료 요법(Virtual Reality Exposure Therapy)은 다양한 정신 질환의 평가 및 치료 연구에 사용되어 왔다. 그러나 최근에 보급되기 시작한 스마트폰 기반의 헤드 마운트 디스플레이(Head-mounted display, HMD)를 활용한 가상 현실 노출 치료 연구는 거의 없었다. 본 연구에서는 스마트폰 기반의 가상현실 기기를 활용하여 환경 촬영부터 노출까지 누구나 쉽게 사용할 수 있는 실제 사진 기반의 가상 현실(Photo-realistic VR) 노출 시스템을 제안하고, 32명의 정상군을 대상으로 시험적으로 적용하고자 한다. 본 연구 결과에 따르면 개발된 스마트폰 기반의 시스템은 실내/실외, 친숙한/친숙하지 않은 환경들에서 피험자의 감정 변화를 이끌어내었다. 이에 대한 의의와 모바일 기반의 가상현실 노출 치료 시스템의 장점에 대하여 본 연구에서 논의하였다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2022년도 춘계학술대회
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• pp.55-57
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• 2022

본 연구에서는 체내심부 광테라피를 위한 맞춤형 반수동 RFID 수신 모듈 시스템을 구현한다. 생체 내부는 피부, 지방, 근육, 골격 및 수분으로 구성되어 체내 심부까지 RF신호 전송에는 한계가 있기 때문에 새로운 전송 방법 연구가 필요하다. 최근 소개된 RFID기반 CIB 빔포밍 기술은 체내와 같이 채널추정이 힘든 환경에서 높은 신뢰도로 무선전송이 가능한 기술이다. 제안하는 RFID기반 미니어처 광캡슐은 소형컨트롤러, 초소형 LED Array, 무선통신용 RFID 칩으로 구성된다. 표준 RFID 프로토콜(ISO-16000-8c)을 기반으로 UHF대역 RFID 안테나를 통해 외부리더기와 무선접속이 가능하며, 사용자 USER BANK 접근을 통해 제어신호 전송이 가능하다. 입력된 제어신호에 따라 캡슐의 테라피용 LED를 멀티레벨 디밍제어, 시간제어 가능하다. 제작된 RFID 광테라피 캡슐의 통신 접속 과정을 분석하고 신뢰도를 평가하였다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
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• pp.420.2-420.2
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• 2016

Various fields have been paid attention to upconversion nanoparticles (UCNPs) because of its unique optical properties. Moreover, to use the UC luminescent techniques through cell images for identified apoptosis/necrosis of cancer cells have been performed. They have been studied for a versatile biomedical application such as a biosensing tool, or delivery of active forms of medicines inside living cells. UCNPs have distinctive characteristics such as photoluminescence, special emission, low background fluorescence signal and good colloidal stability, which have many advantages compared with the organic dyes and quantum dots. UCNPs have not only a great potential for imaging (UC luminescence) but also therapies (photo-thermal therapy, PTT and photo-dynamic therapy, PDT) in cancer diagnostics. Therefore, we report the enhancement of upconversion red emission in NaYF4:Yb3+,Er3+ nanoparticles, synthesized via solid-state method with the thermal decomposition of trifluoroacetate as precursors and organic solvent at a high boiling point. The UCNPs have an emission in the field of near infrared wavelength, cubic shape and nano-size in length. In this study, we will further investigate it for cancer therapy with NIR optical detection onto the solid substrate.

• 통합자연과학논문집
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• 제17권3호
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• pp.67-73
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• 2024

Hydrophilic contact lens was prepared by dispersing MXene material in a hydrogel mixture, and the purpose of this study was to evaluate its properties as an ophthalmic material. The MXene used in the experiment was manufactured through an etching process using titanium aluminum carbide 312 [Ti3AlC2] and hydrofluoric acid [HF]. For the preparation of hydrophilic contact lenses, 2-hydroxyethyl methacrylate [HEMA], a photoinitiator 2-hydroxy-2-methylpropiophenone [2H2M], and a cross-linker Ethylene glycol dimethacrylate [EGDMA] were used, and UV-rays was irradiated for 50 seconds for photopolymerization. Optical transmittance, refractive index, water content, contact angle, electromagnetic wave shielding ability, and photo-thermal conversion effect were measured to evaluate the physical properties of the manufactured contact lens. Compared to MXene materials, MXene mixed with Dimethyl sulfoxide [DMSO] had superior dispersion ability in organic solvents, and the transparency of the prepared hydrophilic contact lenses was high. MXene did not significantly affect the refractive index and water content, and improved the wettability of the contact lens. In addition, the MXene material used as an additive showed electromagnetic wave shielding ability and photo-thermal conversion effect based on its excellent electrical conductivity. It is judged that the mixture using MXene as an additive can be used as a functional contact lens material for electromagnetic wave shielding and ocular photo-thermal therapy.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 추계학술대회
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• pp.646-648
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• 2021

The syntheses and properties of polynuclear metal complexes have been reported to develop the easy syntheses and noble photo-characteristics of those complexes for photodynamic diagnosis (PDD) or photodynamic therapy (PDT). We have been focused on the design and synthesis of polynuclear lanthanide dendritic molecule due to long life time of fluorescence. Therefore, we will be presented on the design of home (Eu or Gd) or hetero (Tb or Lu) polynuclear lanthanide dendritic molecule.

• Journal of Photoscience
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• 제8권2호
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• pp.71-71
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• 2001

• 한방안이비인후피부과학회지
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• 제17권1호
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• pp.16-33
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• 2004

In Oriental medicine, aging is just a natural process like change of seasons. Ancient Oriental people accepted it as a natural thing to be growing older and to die at last. The science of aging has advanced dramatically. In the last 2 decades, advances in genetics and molecular biology have led to extraordinary new understandings in how cells age, how apoptosis programs cells to die, and how neuroendocrinology plays a role in the lifespan of organisms. Today, the matter of primary concern about aging is a cellular and mitochondrial damage of human body induced by reactive oxygen species(ROS). The skin aging can be divided into two areas, intrinsic(chronologic)-aging and photo-aging. There are lots of photo damage about skin aging. The skin is increasingly exposed to ultraviolet(UV) irradiation in life. Therefore, the risk of photo-oxidative damage of the skin induced by reactive oxygen species(ROS) has increased substantially. Nowadays, many people believe that they can stop or at least delay the process of aging. There are lots of treatments that promise to slow the process of aging and the associated ailments. Many of these treatments, for example, exercise, Vit E, Vit C therapy, hormone therapy, restrict diet, are gradually being subjected to clinical trials. But in spite of all efforts, researches and investigations, there is no single method or treatment which is revealed to be truly effective for delaying progress of aging. Every methods insisted on effect for delaying aging process, has its dark side. All we can do is just keeping ourself healthy until the time of death.