• Title/Summary/Keyword: Phenylhydrazine

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Synthesis, Tautomeric Structure, Dyeing Characteristics, and Antimicrobial Activity of Novel 4-(2-Arylazophenyl)-3-(2-hydroxyphenyl)-1-phenyl-2-pyrazolin-5-ones

  • Metwally, M.A.;Bondock, S.A.;El-Desouky, S.I.;Abdou, M.M.
    • Journal of the Korean Chemical Society
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    • v.56 no.1
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    • pp.82-91
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    • 2012
  • Novel azopyrazolin-5-one dyes 4a-f were synthesized by the regioselective reaction of phenylhydrazine with 2,3,4-chromantrione-3-arylhydrazones 2a-f. The acid dissociation constants $pK_a$ for the series prepared were determined and correlated by the Hammett equation. The results of such correlation together with the spectral data indicated that the studied compounds exist predominantly in the hydrazone keto structure, (D) as the Z-configuration. The dyes were applied to polyester fabrics, affording orange-yellow shades and assessments of their dyeing performance are considered. Further, the compounds 4a-f were screened for their antimicrobial activity against various microorganisms.

Studies on the Anti-anemic Action of Melanterite (녹반(綠礬)의 항빈혈작용(抗貧血作用)에 관한 연구(硏究))

  • Cho, Bo-Sun;Rho, Young-Soo;Hong, Nam-Doo;Kim, Shin-Kyu
    • Korean Journal of Pharmacognosy
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    • v.19 no.2
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    • pp.111-119
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    • 1988
  • Melanterite(Green vitriol) is a kind of mineral crude drug which has been used for a hemostatic and hematic, and it contained iron, zinc, magnesium, copper, calcium and manganese etc., and the contents of those matals were 14.34%, 1.21%, 0.91%, 0.41%, 0.37% and 0.15%, respectively. In the acute toxicity in mice its $LD_{50}$ was over 3,000 mg/kg and 2,000 mg/kg by the oral and subcutaneous administration, respectively, but the $LD_50$ by the intraperitoneal administration was 1,810 mg/kg. On the experimental anemia induced by the free bleeding in rabbits and by the phenylhydrazine in rats the reduced RBC, hemoglobin and hematocrit were rapidly recovered.

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Synthesis of Certain Mercapto and Aminopyrimidine Derivatives as Potential Antimicrobial Agents

  • El-Kerdawy, M.M.;Eisa, H.M.;El-Emam, A.A.;Massoud, M.A.;Nasr, M.N.
    • Archives of Pharmacal Research
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    • v.13 no.2
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    • pp.142-146
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    • 1990
  • Reaction of ethyl 4-chloro-2-phenylpyrimidine-4-carboxylate (4) with 5-chloro-2-methylthiophenol or 3-aryl-4-phenyl-1, 2, 4-triazole-5 thiol yielded the corresponding thioethers (5) and (8a, b), respectively. Careful alkaline hydrolysis of (5) yielded the corresponding carboxylic acid (6). Reaction of (4) with p-aminoacetophenone yielded compound (10) which was reacted with certain aromatic aldehyde to afford the$\alpha,\beta$-unsaturated ketones (11a-d). Condensation of (11a-d) with malononitrile or phenylhydrazine yielded the 2-amino-3-cyanopyridines (12a-f) or the 2-pyrazolines (13a, b) respectively. Seven representative compounds were tested for their in vitro antimicrobial activity against some pathogenic micro-organisms, some of them were proved to be active.

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Synthesis and Reactions of Some Pyridazine Derivatives

  • A, Khalifa-Fathy
    • Archives of Pharmacal Research
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    • v.13 no.2
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    • pp.198-200
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    • 1990
  • 3, 4-Diphenyl-5-cyanopyridazin-6-one 3 was prepared from the reaction of cyano acetamide 2 with benzihydrazone in dry pyridine. A series of its derivatives was prepard. Tolyl and benene sulphonyl derivatives 6a and 6b are also prepared. 3, 4-Diphenyl-5-cyanopyridazin-6-thione 5 was obtained from 3 by the action of $P_2S_5$ while 3, 4 diphenyl-5-cyano 6-chloropyridazine 4 was obtained from 3 by the action POCl$_3$. The reaction of 4 with hydrazine hydrate directly afforded the pyrazolopyridazine derivative 7. Compound 4 also reacted with phenylhydrazine, aniline, thiophenol and anthranilic acid to yield pyridazine derivatives 8, 9, 10 and 11, respectively. On treatment of compound 11 with acetic anhydride it cyclised to afford pyridazino pyrimidine derivatives 12.

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Synthesis of 1H-Indol-3-ylpyrazole Derivatives from 1,3,5-Triketones and Arylhydrazines: One-Pot Construction of Pyrazole and Indole Rings

  • Kim, Sung Hwan;Lee, Sangku;Kim, Se Hee;Kim, Ko Hoon;Kim, Jae Nyoung
    • Bulletin of the Korean Chemical Society
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    • v.34 no.11
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    • pp.3415-3419
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    • 2013
  • The reaction of 1,3,5-triketones and arylhydrazines provided indolylpyrazole derivatives in a one-pot reaction in good to moderate yields. Both the pyrazole and indole rings were constructed simultaneously with phenylhydrazine, $RCOCH_2CO$- moiety for the pyrazole and the remaining -$CH_2COR$ part for the indole ring.

Synthesis of Blue Emission Hydrazone Derivatives for Organic Electroluminescence (유기 EL용 청색 발광 히드라존 유도체의 합성)

  • Chung, Pyung-Jin;Lim, Hoi-Deuk
    • Korean Journal of Materials Research
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    • v.13 no.8
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    • pp.514-518
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    • 2003
  • As a fundamental study on organic electroluminescence(EL), blue emitting materials were synthesized and characterized. Individual blue colored hydrazone derivatives were synthesized from the reaction of aldehydes (phthalaldehyde, isophthalaldehyde) with the corresponding amnios (1-methyl -1-phenylhydrazine, 1,1-diphenylhydrazine hydrochloride). Recrystallization of hydrazones from chloroform revealed the melting temperature within $142∼156^{\circ}C$. Photoluminescence(PL) analysis on each hydrazone showed that emission range were blue(458∼478 nm). The structure of obtained hydrazones were elucidated by FT-IR, $^1$H-NMR and C, H, N elemental analyzer.

Synthesis of Photobase Generators and Their Use for Design of Polymeric Photosensitive System

  • Tsunooka, Masahiro;Tachi, Hideki;Asakino, Kaori;Suyama, Kanji
    • Journal of Photoscience
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    • v.6 no.3
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    • pp.145-151
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    • 1999
  • The use of O-carbamoyloximes as photobase generators was investigated. $\alpha$-Meth-ylbenzilydeneamino phenylcarbamate(2a) and $\alpha$-methyl benzilydeneamino cyclohexylcarbamate(2b) were prepared by the reaction of phenyl or cyclohexyl isocyanates with acetophenone oxime , respectively. Aniline, phenylhydrazine and N, N'-diphenylhydrazine were detected in thephotolysis of 2a and cyclohexylamine and cyclohexylhydrazine in the photolysis of 2b. A monomer having pendant carbamoyloxyimino groups (BGM) was prepared by the reaction fo methancryloyloxyethyl iocyanate with acetophenone oxime, and copolymerized with styrene. The BGM copolymer films turned insoluble on UV irradiation, and the degree of insolubilizationwas increased by post-baking. The photocrosslinking was thought to be due to coupling of resulting pendant aminyl radicals, and the thermal crosslinking was due to association of resulting amino and hydrazino groups by hydrogen bonding. The introduction of epoxy groups into polymer increased the degree of thermal crosslinking by post-baking.

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Reactions with Activated Nitriles : A new route for the synthesis of new pyridine and pyrazolopyridine derivatives

  • Attaby, Fawzy-A.;Eldin, Sanaa-M.
    • Archives of Pharmacal Research
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    • v.13 no.3
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    • pp.274-277
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    • 1990
  • It has been found that $\alpha, \beta$-unsaturated nitrile derivatives 1-3 reached with S- methylisothiourea to give the prpone derivatives 4-6 respectively. Cyclisation of 4-6 using ethanolic hydrochloric acid afforded the pyridine derivatives 7-9 in good yields. On the other hand, the reactions of hydrazine hydrate and of phenylhydrazine with each of 7-9 gave the corresponding pyrazolopyridine derivatives 10-15. The structures of the newly synthesised derivatives were assigned on the basis of elemental analyses, IR and $^1H$-NMR spectral data studies.

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Pathological study on experimental hemorrhagic and hemolytic anemia in Nile tilapia, Oreochromis niloticus (나일틸라피아(Oreochromis niloticus)의 실험적 출혈성과 용혈성 빈혈의 병리학적 연구)

  • Song, Na-Young;Choi, Hye-Jeong;Lee, Mu-Kun;Huh, Min-Do
    • Journal of fish pathology
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    • v.18 no.3
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    • pp.259-268
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    • 2005
  • This study was conducted to know the differences in pathology between artificially induced hemorrhagic anemia (EHA) and hemolytic anemia (ELA) during the anemic and recovery course, using Nile tilapia (Oreochromis niloticus). EHA were induced by repeated bleedings with a volume of about 1% of body weight through caudal vein. ELA were induced by intraperitoneal injections of 1% phenylhydrazine for 2 times. A period of 16 to 49th day was arbitrarily taken as a recovery phase. There were no prominent clinical signs and gross findings except for pale gills during the anemic state of both. Characteristic erythrocytes with a weekly stained cytoplasm started appearing on the 12th day in both and were still noted on the 49 and 20th day respectively in EHA and ELA. EHA and ELA were normocytic hypochromic and macrocytic normochromic in type respectively, although both were normocytic hypochromic during the recovery phase. In liver, fatty degeneration around central vein on the 12-38th day in EHA and hyaline degeneration around central vein on the 12-26th day in ELA were found. In head kidney, increased hemopoiesis was observed on the 12-26th day in EHA and on the 2-12th day in ELA, and macrophages engulfing erythrocytes were observed on the 16-38th day in EHA and on the 2-12th days in ELA. In spleen, activated ellipsoids on the 12-26th day in EHA. and on the 2-20th day in ELA. In ELA, severe accumulation of hemosiderin in both spleen and head kidney were constantly noted from the 2-49th day. On the 49th, Ht was recovered but Hb was still lower than that of control in both anemia.

Spectrophotometric Determination of Trace Selenium in Aqueous Solutions by Catalytic Reaction (촉매반응을 이용한 수용액중 흔적량 셀렌의 분광광도법 정량)

  • Lee, Seung Hwa;Choe, Jong Mun;Choe, Hui Seon;Kim, Yeong Sang
    • Journal of the Korean Chemical Society
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    • v.38 no.5
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    • pp.351-358
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    • 1994
  • The spectrophotometric determination of trace selenium(Ⅳ) using its catalytic reaction has been studied in aqueous solutions. The catalytic reaction of phenylhydrazine hydrochloride with selenium(Ⅳ) in an acidic aqueous medium produces benzenediazonium ion which will be converted into a red-coloured azo dye by coupling with H-acid(8-amino-1-naphtol-3,6-disulfonic acid disodium salt). For the reaction, the experimental conditions such as amounts of the reagents and pH of the sample solutions were optimized. After 15 ml of the sample solution was treated with 1 ml of 0.1 M EDTA solution to mask $Fe^{3+}$, etc., 1 ml of 0.06 M phenylhydrazine hydrochloride, 1 ml of 0.02 M H-acid, and 3 ml of 0.3 M-$KClO_3$ were added into the solution, sequentially. The solution was adjusted to pH 1.4 with HCl. After it was heated in a steam bath for 30 minutes, the solution was cooled down to a room temperature and then diluted to 25 ml with deionized distilled water. A blank solution for the absorbance measurement was prepared from the deionized water. The absorbance was measured at 527 nm. Using the above procedure, the trace amount of selenium was determined in natural waters such as tap, river and pond waters by a standard curve method and recoveries of Se spiked to samples were also obtained. From the recoveries of 104 to 111%, it could be concluded that this method was applicable to the quantitative determination of ng/ml level of selenium in natural waters.

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