• 대한화학회지
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• 제56권1호
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• pp.82-91
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• 2012

Novel azopyrazolin-5-one dyes 4a-f were synthesized by the regioselective reaction of phenylhydrazine with 2,3,4-chromantrione-3-arylhydrazones 2a-f. The acid dissociation constants $pK_a$ for the series prepared were determined and correlated by the Hammett equation. The results of such correlation together with the spectral data indicated that the studied compounds exist predominantly in the hydrazone keto structure, (D) as the Z-configuration. The dyes were applied to polyester fabrics, affording orange-yellow shades and assessments of their dyeing performance are considered. Further, the compounds 4a-f were screened for their antimicrobial activity against various microorganisms.

• 생약학회지
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• 제19권2호
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• pp.111-119
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• 1988

Melanterite(Green vitriol) is a kind of mineral crude drug which has been used for a hemostatic and hematic, and it contained iron, zinc, magnesium, copper, calcium and manganese etc., and the contents of those matals were 14.34%, 1.21%, 0.91%, 0.41%, 0.37% and 0.15%, respectively. In the acute toxicity in mice its $LD_{50}$ was over 3,000 mg/kg and 2,000 mg/kg by the oral and subcutaneous administration, respectively, but the $LD_50$ by the intraperitoneal administration was 1,810 mg/kg. On the experimental anemia induced by the free bleeding in rabbits and by the phenylhydrazine in rats the reduced RBC, hemoglobin and hematocrit were rapidly recovered.

• Archives of Pharmacal Research
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• 제13권2호
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• pp.142-146
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• 1990

Reaction of ethyl 4-chloro-2-phenylpyrimidine-4-carboxylate (4) with 5-chloro-2-methylthiophenol or 3-aryl-4-phenyl-1, 2, 4-triazole-5 thiol yielded the corresponding thioethers (5) and (8a, b), respectively. Careful alkaline hydrolysis of (5) yielded the corresponding carboxylic acid (6). Reaction of (4) with p-aminoacetophenone yielded compound (10) which was reacted with certain aromatic aldehyde to afford the$\alpha,\beta$-unsaturated ketones (11a-d). Condensation of (11a-d) with malononitrile or phenylhydrazine yielded the 2-amino-3-cyanopyridines (12a-f) or the 2-pyrazolines (13a, b) respectively. Seven representative compounds were tested for their in vitro antimicrobial activity against some pathogenic micro-organisms, some of them were proved to be active.

• Archives of Pharmacal Research
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• 제13권2호
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• pp.198-200
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• 1990

3, 4-Diphenyl-5-cyanopyridazin-6-one 3 was prepared from the reaction of cyano acetamide 2 with benzihydrazone in dry pyridine. A series of its derivatives was prepard. Tolyl and benene sulphonyl derivatives 6a and 6b are also prepared. 3, 4-Diphenyl-5-cyanopyridazin-6-thione 5 was obtained from 3 by the action of $P_2S_5$ while 3, 4 diphenyl-5-cyano 6-chloropyridazine 4 was obtained from 3 by the action POCl$_3$. The reaction of 4 with hydrazine hydrate directly afforded the pyrazolopyridazine derivative 7. Compound 4 also reacted with phenylhydrazine, aniline, thiophenol and anthranilic acid to yield pyridazine derivatives 8, 9, 10 and 11, respectively. On treatment of compound 11 with acetic anhydride it cyclised to afford pyridazino pyrimidine derivatives 12.

• Bulletin of the Korean Chemical Society
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• 제34권11호
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• pp.3415-3419
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• 2013

The reaction of 1,3,5-triketones and arylhydrazines provided indolylpyrazole derivatives in a one-pot reaction in good to moderate yields. Both the pyrazole and indole rings were constructed simultaneously with phenylhydrazine, $RCOCH_2CO$- moiety for the pyrazole and the remaining -$CH_2COR$ part for the indole ring.

• 한국재료학회지
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• 제13권8호
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• pp.514-518
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• 2003

As a fundamental study on organic electroluminescence(EL), blue emitting materials were synthesized and characterized. Individual blue colored hydrazone derivatives were synthesized from the reaction of aldehydes (phthalaldehyde, isophthalaldehyde) with the corresponding amnios (1-methyl -1-phenylhydrazine, 1,1-diphenylhydrazine hydrochloride). Recrystallization of hydrazones from chloroform revealed the melting temperature within $142∼156^{\circ}C$. Photoluminescence(PL) analysis on each hydrazone showed that emission range were blue(458∼478 nm). The structure of obtained hydrazones were elucidated by FT-IR, $^1$H-NMR and C, H, N elemental analyzer.

• Journal of Photoscience
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• 제6권3호
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• pp.145-151
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• 1999

The use of O-carbamoyloximes as photobase generators was investigated. $\alpha$-Meth-ylbenzilydeneamino phenylcarbamate(2a) and $\alpha$-methyl benzilydeneamino cyclohexylcarbamate(2b) were prepared by the reaction of phenyl or cyclohexyl isocyanates with acetophenone oxime , respectively. Aniline, phenylhydrazine and N, N'-diphenylhydrazine were detected in thephotolysis of 2a and cyclohexylamine and cyclohexylhydrazine in the photolysis of 2b. A monomer having pendant carbamoyloxyimino groups (BGM) was prepared by the reaction fo methancryloyloxyethyl iocyanate with acetophenone oxime, and copolymerized with styrene. The BGM copolymer films turned insoluble on UV irradiation, and the degree of insolubilizationwas increased by post-baking. The photocrosslinking was thought to be due to coupling of resulting pendant aminyl radicals, and the thermal crosslinking was due to association of resulting amino and hydrazino groups by hydrogen bonding. The introduction of epoxy groups into polymer increased the degree of thermal crosslinking by post-baking.

• Archives of Pharmacal Research
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• 제13권3호
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• pp.274-277
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• 1990

It has been found that $\alpha, \beta$-unsaturated nitrile derivatives 1-3 reached with S- methylisothiourea to give the prpone derivatives 4-6 respectively. Cyclisation of 4-6 using ethanolic hydrochloric acid afforded the pyridine derivatives 7-9 in good yields. On the other hand, the reactions of hydrazine hydrate and of phenylhydrazine with each of 7-9 gave the corresponding pyrazolopyridine derivatives 10-15. The structures of the newly synthesised derivatives were assigned on the basis of elemental analyses, IR and $^1H$-NMR spectral data studies.

• 한국어병학회지
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• 제18권3호
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• pp.259-268
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• 2005

나일 틸라피아에 실험적 출혈성 빈혈 (EHA)과 용혈성 빈혈 (ELA)을 제작하여 빈혈 과정과 회복 과정에서의 병리학적 차이를 알기 위해서 본 실험을 수행하였다. EHA는 어체중의 약 1%에 해당하는 혈액을 반복 채혈하여 유도하였다. ELA는 1% phenylhydrazine을 2회 복강 주사하여 유도하였다. 회복 과정은 16일째부터 49일째까지로 하였다. 빈혈 및 회복 기간 동안 아가미의 빈혈성 퇴색 외 특기할 임상 소견은 관찰되지 않았다. 두 빈혈 경우 모두, 12일째에 세포질 염색성이 없는 적혈구들이 출현하기 시작하였으며 EHA의 경우 49일째까지, ELA의 경우 20일째까지 출현하였다. 빈혈 유형은 빈혈 유도 기간에는 EHA의 경우 정구성 저혈색소성이었고 ELA의 경우 대구성 정혈색소성이었으며, 회복 기간에는 두 경우 모두 정구성 저혈색소성이었다. 간장에서 EHA의 경우에 12일째에서 38일째까지 중심정맥 중심성 지방변성이 확인되었고, ELA의 경우에 12일에서 26일째까지 중심정맥 중심성 초자 변성이 확인되었다. EHA의 경우 12일째부터 26일째까지 두신에서 조혈활성 소견이 확인되었으며, ELA의 경우에서는 2일째부터 12일째까지 관찰되었다. 두신에서 적혈구 탐식 대식세포들이 EHA의 경우 16일째부터 38일째까지, ELA의 경우에서는 2일째부터 12일째까지 관찰되었다. 비장 협조직의 비후 소견이 EHA의 경우 12일째부터 26일째까지, ELA의 경우에서는 2일째부터 20일째까지 확인되었다. ELA의 경우 2일째에서 49일째까지 두신과 비장에서 hemosiderin 축적이 현저하였다. 49일째에 두 빈혈 경우 모두 Ht는 회복되었지만 Hb는 완전한 회복을 보이지 않았다.

• 대한화학회지
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• 제38권5호
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• pp.351-358
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• 1994

셀렌이 촉매작용을 하는 반응을 이용한 수용액중 흔적량 셀렌의 분광광도법 정량에 관하여 검토하였다. 즉, 산성의 수용액 매질에서 셀렌에 의한 페닐히드라진의 촉매반응은 H-acid(8-아미노-1-나프톨-3,6-이슬폰산의 이나트륨염)과 반응하여 붉은 색의 아조 염료로 변하는 벤젠디아조뮴이온을 생성한다. 이 반응에 대해, 시약들의 가하는 양과 용액의 pH등과 같은 실험조건들을 최적화시켰다. 시료용액 15ml를 0.1 M EDTA용액으로 처리하여 철 등을 제거한 다음에 0.06 M 페닐히드라진 염산 1 ml, 0.02 M H-acid 1 ml, 및 0.3 M-$KClO_4$ 3 ml를 용액에 순서대로 가하였다. 염산으로 용액의 pH를 1.4로 조정하였다. 끓는 물중탕에서 30분간 가열한 다음, 식혀서 탈염수로 25.00ml되게 묽혔다. 흡광도 측정을 위한 바탕용액은 탈염수로 만들었다. 527nm에서 흡광도를 측정하였다. 위의 실험과정으로 표준검정곡선법에 의해 수도물, 강물, 및 저수지물 등의 물시료중 흔적량 셀렌을 정량하고, 시료들에 가해진 일정량의 셀렌을 정량하여 회수율을 구하였다. 이렇게 얻은 104 내지 111%의 회수율로부터 이 방법이 자연수중 ng/ml수준의 셀렌 분석에 정량적으로 응용될수 있음을 알 수 있었다.