• 한국응용과학기술학회지
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• 제31권4호
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• pp.642-652
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• 2014

The synthesis of octenyl succinyl ${\beta}$-gucan (OSA-${\beta}$-glucan) was carried out and its interfacial properties at the oil-water interface and in emulsion systems were investigated. An aqueous ethanol system as a reaction media was used to facilitate the synthesis process; 10% (w/w) ethanol found to be the best as it showed a maximum degree of substitution (DS: 0.0132). FT-IR showed a characteristic absorption spectrum at $1736cm^{-1}$, indicating the esterification of octenyl succinyl groups to ${\beta}$-glucan backbone. As for interfacial tension measurements, it was decreased with increasing concentration of OSA-${\beta}$-glucan in the aqueous phase and when NaCl was added to aqueous OSA-${\beta}$-glucan solution in the range of 0.01 M to 0.1 M and also when pH was raised (pH 3 ~ pH 9). In systems of emulsion stabilized with OSA-${\beta}$-glucan, fat globule size found to decrease with increasing concentration of OSA-${\beta}$-glucan, showing a critical value of about $0.32{\mu}m$ at 0.5 wt%. When the OSA-${\beta}$-glucan emulsions were stored, it was found that fat globule size was increased with storage time and particularly pronounced increase was observed in emulsion with 1% OSA-${\beta}$-glucan, possibly due to depletion flocculation. Results of creaming stability evaluated by light scattering technique showed that it was more stable in emulsions containing smaller fat globule size. Surface load of OSA-${\beta}$-glucan in emulsions increased with increasing concentration of OSA-${\beta}$-glucan, suggesting a multilayer adsorption.

• 대한기계학회논문집B
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• 제37권6호
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• pp.583-590
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• 2013

가변 방사율 라디에이터는 우주환경에서 작동하는 장비의 온도가 낮을 때는 방사율이 낮아져 시스템의 외부로의 열 손실을 줄이고, 반대로 온도가 높은 때는 방사율이 높아져 장비의 열을 외부로 방출할 수 있어 효율적인 열제어가 가능하게 한다. 가변 방사율 소재로 보편적으로 이용하고 있는 것 중 하나인 감온변색 장치(thermochromics device)는 추가적인 장비 필요 없이 열제어가 가능하기 때문에 효율적이고 고장이 발생하지 않는 장점을 가지고 있다. 본 연구는 이와 같은 이유로 감온변색 장치의 소재 중 하나인 LSMO($La_{1-x}Sr_xMnO_3$)채택하여 졸-겔(sol-gel)방법을 이용하여 제작하고, 제작된 샘플의 가변방사 성능을 실험적으로 규명하였다. 또한, 진공환경과 극저온 환경에 반복 노출시켜 시편이 극심한 환경 변화 이후에도 방사율 값이 일정함을 확인하여 우주적합성을 판단하였다.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2009년도 학술논문요약집
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• pp.84-85
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• 2009

New approaches for detecting, preventing and remedying environmental damage are important for protection of the environment. Procedures must be developed and implemented to reduce the amount of waste produced in chemical processes, to detect the presence and/or concentration of contaminants and decontaminate fouled environments. Contamination can be classified into three general types: airborne, surface and structural. The most dangerous type is airborne contamination, because of the opportunity for inhalation and ingestion. The second most dangerous type is surface contamination. Surface contamination can be transferred to workers by casual contact and if disturbed can easily be made airborne. The decontamination of the surface in the nuclear facilities has been widely studied with particular emphasis on small and large surfaces. The amount of wastes being produced during decommissioning of nuclear facilities is much higher than the total wastes cumulated during operation. And, the process of decommissioning has a strong possibility of personal's exposure and emission to environment of the radioactive contaminants, requiring through monitoring and estimation of radiation and radioactivity. So, it is important to monitor the radioactive contamination level of the nuclear facilities for the determination of the decontamination method, the establishment of the decommissioning planning, and the worker's safety. But it is very difficult to measure the surface contamination of the floor and wall in the highly contaminated facilities. In this study, the poly(styrene-ethyl acrylate) [poly(St-EA)] core-shell composite polymer for measurement of the radioactive contamination was synthesized by the method of emulsion polymerization. The morphology of the poly(St-EA) composite emulsion particle was core-shell structure, with polystyrene (PS)as the core and poly(ethyl acrylate) (PEA) as the shell. Core-shell polymers of styrene (St)/ethyl acrylate (EA) pair were prepared by sequential emulsion polymerization in the presence of sodium dodecyl sulfate (SOS) as an emulsifier using ammonium persulfate (APS) as an initiator. The polymer was made by impregnating organic scintillators, 2,5-diphenyloxazole (PPO) and 1,4-bis[5-phenyl-2-oxazol]benzene (POPOP). Related tests and analysis confirmed the success in synthesis of composite polymer. The products are characterized by IT-IR spectroscopy, TGA that were used, respectively, to show the structure, the thermal stability of the prepared polymer. Two-phase particles with a core-shell structure were obtained in experiments where the estimated glass transition temperature and the morphologies of emulsion particles. Radiation pollution level the detection about under using examined the beta rays. The morphology of the poly(St-EA) composite polymer synthesized by the method of emulsion polymerization was a core-shell structure, as shown in Fig. 1. Core-shell materials consist of a core structural domain covered by a shell domain. Clearly, the entire surface of PS core was covered by PEA. The inner region was a PS core and the outer region was a PEA shell. The particle size distribution showed similar in the range 350-360 nm.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2006년도 추계학술대회
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• pp.65-74
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• 2006

Modem drug discovery requires rapid pharmacokinetic evaluation of chemically diverse compounds for early candidate selection. This demands the development of analytical methods that offer high-throughput of samples. Naturally, liquid chromatography / tandem mass spectrometry (LC-MS/MS) is choice of the analytical method because of its superior sensitivity and selectivity. As a result of the short analysis time(typically 3-5min) by LC-MS/MS, sample preparation has become the rate- determining step in the whole analytical cycle. Consequently tremendous efforts are being made to speed up and automate this step. In a typical automated 96-well SPE(solid-phase extraction) procedure, plasma samples are transferred to the 96-well SPE plate, internal standard and aqueous buffer solutions are added and then vacuum is applied using the robotic liquid handling system. It takes only 20-90 min to process 96 samples by automated SPE and the analyst is physically occupied for only approximately 10 min. Recently, the ultra-high flow rate liquid chromatography (turbulent-flow chromatography)has sparked a huge interest for rapid and direct quantitation of drugs in plasma. There is no sample preparation except for sample aliquotting, internal standard addition and centrifugation. This type of analysis is achieved by using a small diameter column with a large particle size(30-5O ${\mu}$m) and a high flow rate, typically between 3-5 ml/min. Silica-based monolithic HPLC columns contain a novel chromatographic support in which the traditional particulate packing has been replaced with a single, continuous network (monolith) of pcrous silica. The main advantage of such a network is decreased backpressure due to macropores (2 ${\mu}$m) throughout the network. This allows high flow rates, and hence fast analyses that are unattainable with traditional particulate columns. The reduction of particle diameter in HPLC results in increased column efficiency. use of small particles (<2 urn), however, requires p.essu.es beyond the traditional 6,000 psi of conventional pumping devices. Instrumental development in recent years has resulted in pumping devices capable of handling the requirements of columns packed with small particles. The staggered parallel HPLC system consists of four fully independent binary HPLC pumps, a modified auto sampler, and a series of switching and selector valves all controlled by a single computer program. The system improves sample throughput without sacrificing chromatographic separation or data quality. Sample throughput can be increased nearly four-fold without requiring significant changes in current analytical procedures. The process of Bioanalytical Method Validation is required by the FDA to assess and verify the performance of a chronlatographic method prior to its application in sample analysis. The validation should address the selectivity, linearity, accuracy, precision and stability of the method. This presentation will provide all overview of the work required to accomplish a full validation and show how a chromatographic method is suitable for toxirokinetic sample analysis. A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method developed to quantitate drug levels in dog plasma will be used as an example of tile process.

• Biomolecules & Therapeutics
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• 제20권6호
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• pp.538-543
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• 2012

The Maillard Reaction Products (MRPs) are chemical compounds which have been known to be effective in chemoprevention. Death receptors (DR) play a central role in directing apoptosis in several cancer cells. In our previous study, we demonstrated that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal, a MRP product, inhibited human colon cancer cell growth by inducing apoptosis via nuclear factor-${\kappa}B$ (NF-${\kappa}B$) inactivation and $G_2$/M phase cell cycle arrest. In this study, (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate, a new (E)-2,4-bis(p-hydroxyphenyl)-2-butenal derivative, was synthesized to improve their solubility and stability in water and then evaluated against NCI-H460 and A549 human lung cancer cells. (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate reduced the viability in both cell lines in a time and dose-dependent manner. We also found that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate increased apoptotic cell death through the upregulation of the expression of death receptor (DR)-3 and DR6 in both lung cancer cell lines. In addition to this, the transfection of DR3 siRNA diminished the growth inhibitory and apoptosis inducing effect of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate on lung cancer cells, however these effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate was not changed by DR6 siRNA. These results indicated that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate inhibits human lung cancer cell growth via increasing apoptotic cell death by upregulation of the expression of DR3.

• 한국구조물진단유지관리공학회 논문집
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• 제22권1호
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• pp.72-80
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• 2018

초고층 및 장경간 등 대형 구조물에 대한 시공시 부재의 품질이 저하될 정도로 과다한 철근이 배근되고 있다는 문제점이 제기되고 있으며, 최근 건축되고 있는 초고층 건축물에서는 건물의 안정성과 내구성 등을 감안하여 사용 재료의 강도도 점차 증가하고 있다. 초고층 및 장경간 구조물의 시공에서 고강도 철근을 사용할 경우 기존의 일반 강도 철근에 비해 배근량 감소로 인하여 부재에서 배근 간격에도 여유를 줄 수 있어 시공성 향상, 공기단축, 접합부 상세가 간소화 되는 장점이 있다. 이 연구에서는 SD500, SD600 철근을 국내에서 설계되었거나 시공되어진 라멘 구조 형식의 지하주차장 건축물에 적용하여 각 부재별로 철근의 강도에 따른 순수 철근량에 대한 정착 및 이음 철근량 증감을 비교 분석한 결과 다음과 같은 결론을 얻었다. 계산된 철근의 정착 및 이음 물량은 사용철근의 강도가 증가함에 따른 정착 및 이음길이의 증가량과 순수 물량의 감소비율, 사용철근의 직경이 줄였을 때의 단면적 감소 등의 요인들에 의해 정착 및 이음 물량이 결정되었으며, 전체적으로 순수 물량에 대한 정착 및 이음 물량의 비율이 SD400대비 SD500의 경우는 증가하였지만 SD500대비 SD600의 경우는 감소하였다. 이는 보의 정착 및 이음 물량이 전체 정착 및 이음 물량에 미치는 영향이 크기 때문으로 판단된다. 한편 순수 물량에 대한 정착 및 이음 물량의 비율에서 SD400과 SD500의 차이와 SD400과 SD600의 차이가 미미하여 철근의 정착 및 이음 물량이 강도 증가에 따른 전체 철근 물량의 증감에는 큰 영향을 주지 않는 것으로 파악되었다.

• 한국세라믹학회지
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• 제38권9호
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• pp.839-845
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• 2001

원자력발전소에서 발생하는 폐수지, 잡고체, 붕산폐액을 유리화 하기 위하여 폐기물별 조성을 바탕으로 유리조성 연구를 수행하였다. 폐수지, 잡고체를 각각 유리화 할 수 있는 두 개 의 후보유리 RG-1과 DG-1 그리고 폐수지, 잡고체, 붕산폐액을 혼합하여 처리할 수 있는 후보유리 MG-1을 개발하였다. 각 후보유리에 대해 운전변수, 고화체 품질, 가용 효과를 평가하였으며 일부 특성들은 실험실적으로 확인하였다. 운전 변수 가운데 유리의 점도와 전기 전도도는 세 후보유리 모두 적정운전 범위값 내에 만족하였으며 밀도, 화학적 견고성, 상안정성 등 고화체의 품질 또한 우수하였다. 개발한 유리 조성 연구를 바탕으로 폐수지, 잡고체, 혼합폐기물을 유리화 할 경우 감용비는 각각 21, 89, 75로 평가되었다.

• 지구물리와물리탐사
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• 제22권4호
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• pp.210-224
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• 2019

표면파 탐사는 매우 작은 규모의 초음파 분석부터 지질공학 규모의 분석까지 다양한 분야에서 활용하고 있으며, 특히 천부 지질의 지반 안정성을 평가하는 데 활발히 이용되고 있다. 표면파 탐사는 기본적으로 지표면을 따라 전파하는 표면파의 분산 특성에 기초하여 매질의 전단 속도 분포를 파악하는 탐사법이다. 즉, 지하 구조가 1차원 구조라는 가정 하에 탐사를 수행하는 표면파 탐사는, 진동수와 전파 속도의 관계인 분산곡선을 분석하고 1차원적 역산을 통해 층서구조 속도를 계산하게 된다. 이 논문에서는 천부 지질 조사를 위한 표면파 탐사법의 기초적인 이론부터 전반적인 자료처리 과정을 기술보고를 통해 설명하고자 한다. 먼저, 표면파에 대한 개략적인 설명과 가장 큰 특징 중 하나인 분산 특성에 대하여 설명한 후 일반적인 표면파 자료처리 순서에 대하여 설명하였다. 표면파 탐사법은 인공적인 송신원의 유무에 따라 능동 표면파 탐사법과 수동 표면파 탐사법으로 나눌 수 있으나 이 논문에서는 능동 표면파 탐사법인 CSW, SASW, MASW에 대하여 집중적으로 기술하였다. 수동 표면파 탐사법에 대해서는 다음 기술보고에서 다루고자 한다.

• 한국자기학회지
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• 제22권3호
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• pp.79-84
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• 2012

나노크기의 물질이 가지는 새로운 특성을 응용하는 연구가 매우 활발하게 진행되어 지고 있다. 본 연구에서는 PAD법으로 제조한 ${\alpha}$-Fe 나노분말을 이용하여 높은 포화자화와 기계적인 경도, 화학적 안정성, 작은 입자로 인한 tape noise의 감소 등의 특성을 지니고 있는 질화철인 $Fe_4N$을 합성하고, 이를 환원/확산법과 $N_2$가스 질화법으로 합성한 $Fe_{17}Sm_2N_x$ 자성분말과 자성 특성을 비교하였다. $NH_3+H_2$(부피비 3 : 1) 혼합가스를 이용하였을 경우 $Fe_4N$의 생성 온도와 반응시간 등의 조건 변수를 통해 $400^{\circ}C$에서 4시간 동안 열처리함으로서 단일상의 $Fe_4N$이 생성되는 것을 관찰 할 수 있었으며, 나노크기의 $Fe_4N$ 분말과 마이크론 크기의 $Fe_{17}Sm_2N_x$ 분말의 포화자화의 값은 각각 149, 117 emu/g의 값을 나타내었다.

• Journal of Pharmaceutical Investigation
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• 제30권3호
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• pp.167-172
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• 2000

The purpose of this study is to develop a transurethral liquid suppository containing prostaglandin $E_1\;(PGE_1)-loaded$ microemulsion, which undergoes a phase transition to gels at body temperature. The effects of oils, ethanol as solvent and HCl as pH-controlling agent on the physicochemical properties of liquid suppositories composed of poloxamer P 407, P 188 and carbopol was investigated. The stability of $PGE_1$ and release of $PGE_1$ from liquid suppository were evaluated. Oils such as Neobee and soybean oil significantly decreased the gelation temperature but increased the gel strength of liquid suppository due to their strongly binding with the components of liquid suppository base. However, ethanol slightly did the opposite. The pH of liquid suppositories hardly affected the gelation temperature and gel strength due to addition of very small HCl (0.005-0.01%). A liquid suppository [$PGE_1/P$ 407/P 188/carbopol/Neobee/ethanol/HCl (0.2/14/14/0.4/7/2/0.005%)], which had the gelation temperature $(34.2{\pm}0.6^{\circ}C)$ and gel strength $(31.35{\pm}4.37\;sec)$ suitable for liquid suppository system, was easily administered and not leak out from the body. About 60% of $PGE_1$ was released out within 2 h from this formulation. It was shown that the release of $PGE_1$ was proportional to the square root of time, indicating that $PGE_1$ might be released from the suppository by Fickian diffusion. It was stable at $4^{\circ}C$ for at least 2 months. The results suggest that transurethral liquid suppository containing prostaglandin $E_1-loaded$ microemulsion is thought to be a convenient, safe and effective dosage form for $PGE_1$. However, it should be further developed as a more convenient and stable dosage form for $PGE_1$.