• International Journal of Automotive Technology
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• v.8 no.1
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• pp.33-38
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• 2007

Since it is difficult to analytically express the Melnikov function when a dynamic system possesses multiple saddle fixed points with homoclinic and/or heteroclinic orbits, this paper investigates a vehicle model with nonlinear suspension spring and hysteretic damping element, which exhibits multiple heteroclinic orbits in the unperturbed system. First, an algorithm for Melnikov integrals is developed based on the Melnikov method. And then the amplitude threshold of road excitation at the onset of chaos is determined. By numerical simulation, the existence of chaos in the present system is verified via time history curves, phase portrait plots and $Poincar{\acute{e}}$ maps. Finally, in order to further identify the chaotic motion of the nonlinear system, the maximal Lyapunov exponent is also adopted. The results indicate that the numerical method of estimating chaotic threshold is an effective one to complicated vehicle systems.

• Biomolecules & Therapeutics
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• v.13 no.2
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• pp.90-94
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• 2005

Prazosin hydrochloride is an antihypertensive drug with selective ${\alpha}_1$-adrenoreceptor blocking effects. A simple high performance liquid chromatographic method has been developed and validated for the quantitative determination of prazosin in human plasma. A reversed-phase C18 column was used for the separation of prazosin and terazosin (internal standard) with a mobile phase composed of water, acetonitrile and triethylamine(75:25:0.1, V/V;pH5.0) at a flow rate of 1.5 ml/min. the fluorescence detector was set at excitation and emissionwavelengths of 250 and 370 nm, respectively. Intra-and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification of 0.5 ng/ml. Good recovery (>80%) was seen in plasma. Prazosin was stable in human plasma under various storage conditions. This method was used successfully for a pharmacokinetic study in plasma after oral administration of a single 2-mg dose as prazosin base to 16 healthy volunteers. The maximum plasma concentration of prazosin was 23.1 ${\pm}$ 16.5 ng/ml at 2.1 h, and the mean area under the curve and elimination half-life were calculated to be 108.4 ${\pm}$ 74.2 ng ${\cdot}$hr/ml and 2.5 ${\pm}$ 0.6 h, respectively.

• Biomolecules & Therapeutics
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• v.14 no.1
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• pp.40-44
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• 2006

Mirtazapine is an antidepressant agent with dual action on both the noradrenergic and serotonergic neurotransmitter systems. A simple high performance liquid chromatographic method has been developed and validated for the quantitative determination of mirtazapine in human plasma. A reversed-phase Cl8 column was used for the determination of mirtazapine with a mobile phase composed of 0.01M ammonium acetate solution (pH 4.2) and acetonitrile (75:25, v/v%) at a flow rate of 1.2 mL/min. Terazosin hydrochloride was used as an internal standard. The fluorescence detector was set at excitation and emission wavelengths of 290 and 350 nm, respectively. Intra- and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification of 3 ng/mL. Mirtazapine was stable in human plasma under various storage conditions. This method was used successfully for a pharmacokinetic study using plasma samples after oral administration of a single 30 mg dose as mirtazapine base to 8 healthy volunteers. The maximum plasma concentration of mirtazapine was $64.1{\pm}28.0ng/mL$ at 1.8 h, and the area under the curve and elimination half-life were calculated to be $674.1{\pm}218.5ng\;h/mL\;and\;23.4{\pm}3.8h$, respectively.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2006.06a
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• pp.489-490
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• 2006

The Ce-doped YAG(Yttrium Aluminum Garnet, $Y_3Al_5O_{12}$) phosphor powders were synthesized by Sol-gel method. The luminescence, formation process and structure of phosphor powders were investigated by means of XRD, SEM and PL. The XRD patterns show that YAG phase can form through sintering at $1000^{\circ}C$ for 2h. This temperature is much lower than that required to synthesize YAG phase via the conventional solid state reaction method. There were no intermediate phases such as YAP(Yttrium Aluminum Perovskite, $YAlO_3$) and YAM(Yttrium Aluminum Monoclinic, $Y_4Al_2O_9$) observed in the sintering process. The powders absorbed excitation energy in the range 410~510nm. Also, the crystalline YAG:Ce showed broad emission peaks in the range 480~600nm and had maximum intensity at 528nm.

• The Journal of the Korea institute of electronic communication sciences
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• v.17 no.1
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• pp.23-30
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• 2022

The active phased array antenna system performs beam steering, multi-beam formation and adaptive beam forming by controlling the amplitude and phase of signals fed to each radiating element. In order to obtain the desired radiation characteristics using an active phased array antenna system, the accurate amplitude and phase of the signal must be fed to each radiating element; however, due to various causes, the signal errors occurs in each radiating element. In this paper, a signal error estimation method of each radiating element is proposed. The proposed method simplifies the process of signal error estimation, and can quickly and accurately calculate the signal error.

• Proceedings of the Acoustical Society of Korea Conference
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• 1995.06a
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• pp.123-126
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• 1995

The waveform coding are concerned with simply preserving the wave shape of speech signal through a redundancy reduction process. In the case of speech synthesis, the wave form coding with high quality are mainly used to the synthesis by analysis. However, because the parameters of this coding are not classified as either excitation and vocal tract parameters, it is difficult to applying the waveform coding to the synthesis by rule. In this paper, we proposed a new pitch alteration method that can change the pitch period in waveform coding by using scaling the time-axis and compensating the spectrum. This is a time-frequency domain method that is preserved in the phase components of the waveform and that has a little spectrum distortion with 2.5% and less for 50% pitch change.

• Journal of Information Processing Systems
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• v.20 no.3
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• pp.399-408
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• 2024

The moisture content of crude oil notably affects various aspects of oil production, storage, transportation, and exploration. However, accurately measuring this moisture content is challenging because of numerous influencing factors, leading to a lack of precision in existing detection methods. This inadequacy hinders the progress of China's petroleum industry. To overcome these challenges, this paper proposes a conductivity-based method for measuring crude oil moisture content. By employing an embedded system, we designed a sensor comprising five electrodes. Additionally, we developed signal excitation and signal processing circuits. Moreover, a software program was designed to analyze and compute the output signal using fast Fourier transform operations. This facilitated the identification of flow patterns, computation of relevant flow rates, and establishment of correlation rates based on frequency spectral characteristics. Based on experimental results, we established a functional relationship between measurement parameters and crude oil moisture content. This study enhanced the precision of moisture content measurement, thereby addressing existing limitations and fostering the advancement of China's petroleum industry.

• Bulletin of the Korean Chemical Society
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• v.15 no.8
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• pp.663-669
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• 1994

Decay kinetics of Ga(5s), Ga(5p) and Ga(4d) atoms in Ar were studied by laser induced fluorescence technique. Theground state gallium atoms in the gas phase were generated by pulsed dc discharge of trimethyl gallium and argon mixtures. Both pulsed discharge and YAG-DYE laser system were controlled by a dual channel pulse generator and the delay time between the end of discharge and laser pulses was set 3.0-6.0 ms. The Ga(5s) and Ga(4d) atoms were generated by single photon excitation from the ground state Ga atoms and radiative lifetimes as well as the total quenching rate constants in Ar were obtained from the pressure dependence of the fluorescence decay rates. The Ga(5p) atoms were populated by a two-photon excitation method and the cascade fluorescence from Ga(5s) atoms were analyzed to extract quenching rate constant of Ga(5p) atoms by Ar in addition to radiative lifetimes of Ga(5p) state. The magnitudes of the quenching rate constants by Ar for the low-lying excited states of Ga atoms are 1.6-3$ {\times}10^{-11}cm^3$ molecul$e^{-1}s^{-1}$, which are much larger than those for alkali, alkaline earth and Group 12 metals. Based on the measured rate constants, kinetic simulations were done to assign state-to-state rate constants.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.9 no.1
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• pp.35-41
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• 2023

Photodynamic therapy (PDT), in which a photosensitizer (PS), light, and molecular oxygen are essential components, is a non-invasive and highly effective cancer therapeutic method. However, PDT suffers from the penetration limit of light caused by attenuation and scattering of light through tissues constraining its use to skin and endoscopically accessible cancers. Cerenkov luminescence (CL) is defined as the light illuminated when charged particles move in a dielectric medium at a velocity greater than the phase velocity of light. It is known that medical radioisotopes in preclinical and clinical settings have enough energy to generate CL, and lately, CL has been exploited as an excitation source for PDT without external light illumination. This review introduces state of the art studies of radioisotope-based PDT for cancer, in which radioisotopes are utilized as a light source.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 2007.11a
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• pp.337-340
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• 2007

In the dissertation, a power conversion system for fuel cell is composed of a PWM inverter with LC filter in order to convert fuel cell voltage to a single phase 220[V], In addition, new insulated DC-DC converters are proposed in order that fuel cell voltage is boosted to 380[V]. In this paper, it requires smaller components than existing converters, which makes easy control. The proposed DC-DC converter controls output power by the adjustment of phase-shift width using switch S5 and S6 in the secondary switch, which provides 93-97[%] efficiency in the wide range of output voltage. Fuel cell simulator is implemented to show similar output characteristics to actual fuel cell. Appropriate dead time td enables soft switching to the range where the peak value of excitation current in a high frequency transformer is in accordance with current in the primary circuit. Moreover, appropriate setting to serial inductance La reduces communication loss arisen at light-load generator and serge voltage arisen at a secondary switch and serial diode. Finally, TMS320C31 board and EPLD using PWM switching technique to act a single phase full-bridge inverter which is planed to make alternating current suitable for household.