• Structural Engineering and Mechanics
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• v.50 no.2
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• pp.151-161
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• 2014

In this paper, fuel tank of the locomotive ER 24 has been studied. Firstly the behavior of fuel and air during the braking time has been investigated by using a two-phase model. Then, the distribution of pressure on the surface of baffles caused by sloshing has been extracted. Also, the fuel tank has been modeled and analyzed using Finite Element Method (FEM) considering loading conditions suggested by the DIN EN 12663 standard and real boundary conditions. In each loading condition, high stressed areas have been identified. By comparing the distribution of pressure caused by sloshing phenomena and suggested loading conditions, optimization of the tank has been taken into consideration. Moreover, internal baffles have been investigated and by modifying their geometric properties, search of the design space has been done to reach the optimal tank. Then, in order to reduce the mass and manufacturing cost of the fuel tank, Non-dominated Sorting Genetic Algorithm (NSGA-II) and Artificial Neural Networks (ANNs) have been employed. It is shown that compared to the primary design, the optimized fuel tank not only provides the safety conditions, but also reduces mass and manufacturing cost by %39 and %73, respectively.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.2
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• pp.37-45
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• 2016

Control chart is representative tools of statistical process control (SPC). It is a graph that plotting the characteristic values from the process. It has two steps (or Phase). First step is a procedure for finding a process parameters. It is called Phase I. This step is to find the process parameters by using data obtained from in-controlled process. It is a step that the standard value was not determined. Another step is monitoring process by already known process parameters from Phase I. It is called Phase II. These control chart is the process quality characteristic value for management, which is plotted dot whether the existence within the control limit or not. But, this is not given information about the economic loss that occurs when a product characteristic value does not match the target value. In order to meet the customer needs, company not only consider stability of the process variation but also produce the product that is meet the target value. Taguchi's quadratic loss function is include information about economic loss that occurred by the mismatch the target value. However, Taguchi's quadratic loss function is very simple quadratic curve. It is difficult to realistically reflect the increased amount of loss that due to a deviation from the target value. Also, it can be well explained by only on condition that the normal process. Spiring proposed an alternative loss function that called reflected normal loss function (RNLF). In this paper, we design a new control chart for overcome these disadvantage by using the Spiring's RNLF. And we demonstrate effectiveness of new control chart by comparing its average run length (ARL) with ${\bar{x}}-R$ control chart and expected loss control chart (ELCC).

• Biomolecules & Therapeutics
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• v.21 no.5
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• pp.323-331
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• 2013

TGF-${\beta}$ pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-${\beta}$ (TGF-${\beta}$) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-${\beta}$ related functional contexts. This review discusses the molecular mechanism of the TGF-${\beta}$ pathway and describes the different ways of tumor suppression and promotion by TGF-${\beta}$. In the last part of the review, the data on targeting TGF-${\beta}$ pathway for cancer treatment is assessed. The TGF-${\beta}$ inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.93-97
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• 2005

This paper proposes a design of stepper motor control in microstep driven mode using FPGA (Field Programmable Gate Array) for hardware implementation. The methods to drive stepper motor in microstep excitation mode are to control of the controlling currents in each phase windings of stepper motor with reference signals. These reference signals are used for controlling the current levels, the required variation of current levels with rotor position can be obtained from the ideal linear or sinusoidal approximations to the static torque-displacement ($T-{\theta}$) characteristic curve. In addition, the hardware implementation of stepper motor controller can be designed uses VHDL (Very high speed integrated circuits Hardware Description Language) and synthesis using an Altera FPGA, FLEX10K family, EPF10K20RC240-4 device as target technology and use MAX+PlusII program for overall development. A multi-stack variable-reluctance stepper motor of Sanyo Denki is used in the experiments.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.7
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• pp.4041-4047
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• 2013

Cancer vaccine development is in the process of becoming reality in future, due to successful phase II/III clinical trials. However, there are still problems due to the specificity of tumor antigens and weakness of tumor associated antigens in eliciting an effective immune response. Computational models to assess the vaccine efficacy have helped to improve and understand what is necessary for personalized treatment. Further research is needed to elucidate the mechanisms of activation of antigen specific cytotoxic T lymphocytes, decreased TREG number functionality and antigen cascade, so that overall improvement in vaccine efficacy and disease free survival can be attained. T cell epitomic based in sillico approaches might be very effective for the design and development of novel cancer vaccines.

• Proceedings of the KIPE Conference
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• 2002.07a
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• pp.485-488
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• 2002

DC-DC converter for KOMPSAT 2 has been designed to satisfy input current, and output voltage ripples constraints, in this paper. The converter has been simulated to analyze small signal characteristics. The resulted phase margin of the converter is above $60^{\circ}$. The DC-DC converter has been experimented for 93kHz, 90W output load.

• Korean Institute of Interior Design Journal
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• v.21 no.1
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• pp.95-102
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• 2012

This study analyzed the observation characteristics with the subject of observation data through defining the change of the observation degree as attention /conscious observation /visual understanding. Furthermore, by obtaining the formular with which to estimate the subjects' observation amount, this study suggests a potential method for easier analysis of observation characteristics. The conclusions from the study are as the followings. First, the observation frequency was being generated with wide deviation among subjects while there was a flow-on characteristics depending on the degree of observation. These characteristics enabled the study to obtain the formular with which to estimate the observation amount. Second, the study could establish the area frequency by grade from the entire observation data. The area I was at most 4% for the area frequency but accounted for 18.2% of the entire effective observation time, and the area II 16% and 38.7% respectively. Accordingly, only considering the observation area distribution of the area I or the areas I and II shows which position of the space the subjects were observing. Third, with the subject of the relatively higher observation time at at the subject's observation characteristics, as the observation phase was getting higher, the observation time decreased more. Forth, by obtaining the formular to estimate the observation amount for observation data according to the change of observation degree, the study could find the estimating observation characteristics of additional subjects. The formular shortens the analysis time and facilitates the analysis process.

• Journal of the Korean Wood Science and Technology
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• v.19 no.3
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• pp.62-71
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• 1991

An evaluation of bending test of composite I and Box beams for determining the ultimate strength limit design criteria was presented. Maxium loads of composite I beams were found in beams composed of thicker upper flanges and/or vertical LVL flanges. These loads of plywood web beams were greater than those of PB web beams. Maximum loads of unsymmetrical box beams were less than those of symmetrical box beams. Thus, it took on different phase in box type beams. Ultimate loads of composite beams were greater than those of solid. The failure of composite beams were abrupt and failure mode was classified into following categories; Edgewise shear failure in web, delamination in flange-web joint, tension failure and tearing in LVL flanges, and web delamination. These failures of composite beams were appeared at the mixed mode. The influence factor affecting the performance of tested composite beams was shear strength of PB-web composite beams and compressive strength in plywood-web composite beams. It was also assumed that the influence factors on structural performance on composite beams were flange quality, web material and geometry of cross section. As one of the design methods resisting to compressive stress that was required in the case of small span to depth ratio and deep beams. composite I-beams composed of thicker upper flanges comparing to lower flanges were very effective in structural performance.

• Journal of the Korean Society of Costume
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• v.56 no.9 s.109
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• pp.66-82
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• 2006

Clothes and human body are inseparably related. Aesthetic consciousness of the body determines the form of clothing, reflecting the time and culture as well as the individual and society. Clothes can even reorganize the meaning of the body, while transcending their instrumental functions of protecting, expanding and deforming the body. Using 'body' to analyze the clothing form, my study develops a framework by which to classify the representation of the body in fashion focusing on the representation of physicality. In order to inquire the formative style and aesthetic values expressed in representing body in fashion, my study examines subjects from the 14th century European costumes to fashion collections of the 20th century. In fashion, representation of the body is visually analogous to the ideal boily shape and structure, including a realistic presentation of the body as well as reflection of aesthetic ideals. Manipulation of physicality entails the reconstruction of the ideal body image through the clothes that modify physicality into unnatural body. Ruff collar, gigot sleeve, crinoline, bustle, stomacher, and corset were all used to materialize the fictitious curves symbolizing femininity, authority, healthiness, maternity, virginity, socioeconomic status, and fertility. Accentuating specific clothing parts represents emphasizing the symbolism of the correspondent body parts. Consequently, in this phase signifiant is $signifi\'{e}$. Aesthetic ideal of the body is visualized in the firm of a dress. Fashion continues to explore forms and images that transcend the traditional representations of the clothed body. As a type of intimate architecture, fashion always mediates the dialogue between clothes and body, or fashion and figure. My study suggests a framework to analyze bodily representation in fashion, focusing on the relationship between the clothes and body.

• Korean Journal of Construction Engineering and Management
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• v.8 no.6
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• pp.178-187
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• 2007

As the government has enforced recently the policies on the distribution of the housing, the construction cost of multi-family housing projects has increasingly become very sensitive and political issue. However, it is difficult to predict the construction cost in planning and design phase of the project because the Bill of Quantity of the multi-family housing projects was composed of breakdown structure based on each work package. To predict the construction cost in planning and design phase for multi-family housing projects in more effective and reasonable way, this study developed the cost breakdown structure based on spaces using Delphi method. The Cost Breakdown Structure (CBS) based on spaces for multi-family housing projects basically consists of three parts: (i) Building part; (ii) Non-building part; and (iii) Additional part. The characteristics of spaces in multi-family housing projects are fully taken into consideration. Then these three parts were subdivided into work packages in terms of work tasks. Additionally, the usefulness and effectiveness of Space CBS in this paper were validated by analyzing the BOQs of several collected sample projects and matching with Space CBS afterwards.