• 제목/요약/키워드: Pharmaceutical Society of Korea

검색결과 10,548건 처리시간 0.043초

Synthesis of N,N',N"-Trisubstituted Thiourea Derivatives and their Antagonistic Effect on the Vanilloid Receptor

  • Park, Hyeung-Geun;Park, Mi-Kyung;Choi, Ji-Yeon;Choi, Sea-Hoon;Lee, Ji-Hye;Suh, Young-Ger;Cho, Ha-Won;Oh, Uh-Taek;Lee, Jee-Woo
    • 대한약학회:학술대회논문집
    • /
    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
    • /
    • pp.253.1-253.1
    • /
    • 2003
  • Twenty-seven N,N',N"-trisubstituted thiourea derivatives were prepared. Among them, 1- [3-(4'-hydroxy-3'-methoxy-phenyl)-propyl] -1,3-diphenethyl-thiourea (81, IC$\sub$50/= 0,32 $\mu\textrm{m}$), showed 2-fold higher antagonistic activity than that of capsazepine (3, IC$\sub$50/= 0,65 $\mu\textrm{m}$) against the vanilloid receptor in a Ca$\^$2+/ -influx assay.

  • PDF

Analysis of DA-6034. a New Flavonoid Derivative in Biological Fluids by Fluorescence Detector

  • Jang, Ji-Myun;Park, Kyung-Jin;Lee, Jong-Jin;Kim, Dong-Goo;Shim, Hyun-Joo;Son, Mi-Won;Kim, Dong-Sung;Kim, Soon-Hoe;Yoo, Moo-Hi
    • 대한약학회:학술대회논문집
    • /
    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
    • /
    • pp.403.2-403.2
    • /
    • 2002
  • A high performance liquid chromatographic method was developed for the determination of DA-6034 in biological fluids using fluorescence detector. The method involved deproteinization of biological sample with the same volume of acetonitrile, 0.2M zinc sulphate. and 0.15M barium hydroxide. The aliquot of supernatant was injected onto Nova-pak C18 column and detected by fluorescence detector. Emission and excitation wavelength of detector were 336nm and 440nm. (omitted)

  • PDF

첨가제의 배합목적 재정비와 제형에 따른 첨가제의 범위 (Reconstruction on Application Category of Pharmaceutical Additives and Boundaries of Pharmaceutical Additives according to the Dosage Forms)

  • 조정원;김승수;조원경;박효민;박인숙;정주연;정상전;이선희;황성주
    • Journal of Pharmaceutical Investigation
    • /
    • 제37권6호
    • /
    • pp.403-411
    • /
    • 2007
  • The importance of pharmaceutical additives is increasing and the sorts and application categories are being classified in detail. International pharmaceutical council based on IPEC-America, IPEC-Europe and JPEC was established for specifications, safety and efficacy, approval regulations of pharmaceutical additives in 1992. Therefore, scrutinized examination of pharmaceutical additives used for already approved domestic drug was performed under the supervision of KFDA and nomenclature on application categories of pharmaceutical additives was summarized and endowed their glossary. Additionally, the boundaries of pharmaceutical additives according to the dosage forms based on the principle of the dosage forms of Korean pharmacopoeia were classified. These informations could be available for standards & experimental methods, approval, evaluation, audit of drug and contribution for national welfare.

An Ellagic Acid Rhamnoside from the Roots of Potentilla discolor with Protein Glycation and Rat Lens Aldose Reductase Inhibitory Activity

  • Jang, Dae-Sik;Yoo, Nam-Hee;Kim, Jong-Min;Lee, Yun-Mi;Yoo, Jeong-Lim;Kim, Young-Sook;Kim, Jin-Sook
    • Natural Product Sciences
    • /
    • 제13권2호
    • /
    • pp.160-163
    • /
    • 2007
  • Four glycosides, rosamultin (1), tetracentronside B (2), 4-O-methylellagic acid 3-O-${\alpha}$-$_L$-rhamnopyranoside (3), and vanillic acid 4-O-${\beta}$-$_L$-glucopyranoside (4), isolated from the roots extract of Potentilla discolor, were subjected to in vitro bioassays to evaluate the inhibitory activity on advanced glycation end products (AGEs) formation and rat lens aldose reductase (RLAR). Compound 3 exhibited a significant inhibitory activity against both AGEs formation and RLAR with IC$_{50}$ values of 79.5 and 8.03 ${\mu}$M, respectively. All the compounds (1-4) were isolated for the first time from this plant.