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An Ellagic Acid Rhamnoside from the Roots of Potentilla discolor with Protein Glycation and Rat Lens Aldose Reductase Inhibitory Activity  

Jang, Dae-Sik (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Yoo, Nam-Hee (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Jong-Min (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Lee, Yun-Mi (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Yoo, Jeong-Lim (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Young-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Jin-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Publication Information
Natural Product Sciences / v.13, no.2, 2007 , pp. 160-163 More about this Journal
Abstract
Four glycosides, rosamultin (1), tetracentronside B (2), 4-O-methylellagic acid 3-O-${\alpha}$-$_L$-rhamnopyranoside (3), and vanillic acid 4-O-${\beta}$-$_L$-glucopyranoside (4), isolated from the roots extract of Potentilla discolor, were subjected to in vitro bioassays to evaluate the inhibitory activity on advanced glycation end products (AGEs) formation and rat lens aldose reductase (RLAR). Compound 3 exhibited a significant inhibitory activity against both AGEs formation and RLAR with IC$_{50}$ values of 79.5 and 8.03 ${\mu}$M, respectively. All the compounds (1-4) were isolated for the first time from this plant.
Keywords
Potentilla discolor; Rosaceae; diabetic complications; AGEs; aldose reductase;
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Times Cited By SCOPUS : 2
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