• Journal of Korea Technology Innovation Society
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• v.10 no.3
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• pp.406-430
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• 2007

Most pharmaceutical licensing deals are made in the early stage of drug development. While this development process is not unique for complicated technology, a special feature of drug development is that it is highly regulated and a well-defined process. Its statistics in terms of costs and chances of technical success have been researched extensively. This enables relatively detailed calculations as benchmarks for actual deals to be made. Based on such calculations and on the analysis of licensing terms in published agreements, various companies offer quite expensive information, databases, software programs and consultation services to help establish what might be reasonable economic terms in a licensing deal. Over the years, pharmaceutical royalties have been the subject of various articles in journals. Most specific on this subject was the article on determining pharmaceutical royalties. Many other articles are about a more general nature deal with determining reasonable royalty rates, evaluating and underpinning the empirical value and usefulness of the 25% rule. The object of this article is to provide a relatively simple analytical approach based on the major economic terms underlying pharmaceutical licensing deals. The aim is to enhance the understanding of the relations between the major factors involved. Details are disregarded, as generally, where the terms of licensing deals depend on predictions over a considerable length of time, the value of detail is limited. Some specific issues addressed by the approach are the impact on profits of large investments, high risks and long development times characteristic of drug development, the consequent strong impact that the ultimate sales levels and operating margins may have on what might be considered a reasonable royalty rate, and the relationship between upfront payments and milestone payments to be paid during pharmaceutical development and the royalties due once the drug enters the market.

• Physical Therapy Rehabilitation Science
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• v.11 no.4
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• pp.414-420
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• 2022

Objective: In this study, the test-retest reliability and validity were presented to evaluate the usability of isokinetic rehabilitation equipment for the knee joint. Design: Cross-sectional design, reliability & validity study. Methods: Thirty healthy adults participated in the study. A CSMI dynamometer was used as a standardized measuring device to present the validity of the equipment. It was measured based on the dominant leg. The average peak torque value was selected as the measurement variable. After the measurement, a questionnaire was conducted on safety, satisfaction, and performance through the usability evaluation questionnaire. Results: The knee joint isokinetic rehabilitation equipment showed high reliability with Intraclass Correlations Coefficients (ICC) =0.883~0.956. In order to check the validity of the equipment, the 95% confidence interval of the mean difference limit was confirmed by the Bland & Altman plot. As a result, all three angular velocities showed a smaller confidence interval in the flexion than in extension. There were less than 10 plots that were not included in 2 Standard Deviation (SD) between all measurements. As a result of the usability evaluation questionnaire, the average of the safety domain(4.9±0.4), satisfaction domain(4.1±0.8), performance domain(4.3±0.8). Conclusions: If the product is improved by supplementing the items identified in the usability evaluation process, it is judged that it can be used as a useful device in various knee joint rehabilitation fields.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.4
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• pp.735-740
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• 2021

The purpose of this study is to assess how accounting conservatism is practiced in the Jordanian pharmaceuticals and medical industry. It assesses the association between accounting conservatism and intellectual capital (IC) in this industry. This study measures IC performance using the market price per share less book value. Accounting conservatism is measured using the book-to-price ratio, and the data was collected from company annual reports and the Amman Stock Exchange (ASE) website. The data was collected for the period of six years (2014 to 2019). The sample was made up of four companies in the industry listed in the ASE. The data was analyzed using the SPSS program though the ordinary least squares regression model to assess how accounting conservatism is associated with IC. The findings indicate a negative association with companies having higher IC performance and reporting lower accounting conservatism. IC is applied more in these companies, although it might be lower than in other companies in other sectors. This study provides empirical evidence on how IC is applied in the industry and how it might be negatively associated with accounting conservatism. Findings indicate the need for more effective policies to promote recognition of intangible assets in the sector.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.22 no.52
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• pp.9-20
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• 1999

The standard deviation is constant in the progress of Powder Injection Filling, The setting value of the filling amount can modify the numerical rate. Since high level of the numerical rate can get the effect of reducing the material cost, it improves the productivity by permitting the possibility of the economical production. Consequently, this thesis analyzed and suggests the numerical model which consider the economical factors of the Powder Injection Shaping progress, and I try to reinforce the competitive powder of the domestic medicine manufacture industry which face the wave of globalism and evolutionism.

• Proceedings of the Membrane Society of Korea Conference
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• 1996.03a
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• pp.69-90
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• 1996

In the chemical industry, in the pharmaceutical industry, and in a number of other industries separation processes are necessary to separate and purify products and raw materials [1,2]. Separation processes are also widely used in other applications such as in recycling valuable materials from waste streams. Unit operations for separation processes can be classified in phase separation techniques and component separation techniques based on the nature of the feed mixtures to be separated. The former techniques are used for the separation of heterogeneous mixtures, in which the feed is already present in two or more separated phases on a micro-scale. The latter are suitable for the separation of homogeneous mixtures such as gaseous mixtures and mixtures of completely miscible liquids. tn these cases the separation into individual components is generally achieved by utilizing the differences in physico-chemical properties of components, and is much more difficult compared to phase separation techniques. Separation processes such as distillation, evaporation, liquid-liquid extraction, and crystallization belong to this class.

• Korean Journal of Clinical Pharmacy
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• v.26 no.3
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• pp.238-244
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• 2016

Background: Mupirocin, a topical antimicrobial agent has been used for patients with methicillin-resistant Staphylococcus aureus and recently mupirocin resistance was issued in some studies. The objective of this study was to analyze prescription patterns of topical mupirocin, to evaluate appropriateness of prescriptions in the ambulatory setting, and to compare frequency of mupirocin usage in South Korea with that in United States. Methods: Topical mupirocin prescription patterns (the number of prescription and a prescription period), and appropriateness of prescription (including a prescription rate over 10 days, a repeat prescription rate within 30 days and a prescription rate within labeled indications) were analyzed using the 2012 Health Insurance and Review and Assessment service-National Patient Sample dataset of South Korea. The National Ambulatory Medical Care Survey dataset was used to quantify topical mupirocin prescription in United States for comparison. Results: In South Korea, the prescriptions rate for use over 10 days was 3%, the repeat prescription rate within 30 days was 8.87% and the prescription proportion within labeled indications was 33.84%. The most frequent diagnostic code was nonbacterial infection. The prescription rate per 1000 population of topical mupirocin in South Korea was calculated to be 46.07, whereas in United States was calculated to be 13.10. Conclusion: Topical mupirocin has been used frequently and inappropriately, so further studies are required to investigate the rationale behind such prescribing mupirocin patterns.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.174.2-174.2
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• 2003

Quorum sensing, a gene expression in response to population density, is regulated by chemical signals, most of which are acylated homoserine lactones (AHLs). The AHL derivatives have been reported to regulate bioluminescence, virulence factors and / or swarming motility in bacteria. It is hypothesized that higher organisms may have evolved specific means to interfere with bacterial communication as exemplified in the AHL-antagonistic activity of halogenated furanones isolated from the Australian macroalga Delisea pulchra. (omitted)

• Archives of Pharmacal Research
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• v.4 no.2
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• pp.141-153
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• 1981

In Japan, rapid development of economy during the 1960s caused the problems of environmental pollution, and hazards occurred in many places of Japan, water pollution had increased in those days, and water used for drinking, agriculture, fishing, industry nd recreation were demaged. By water-born diseases like as Minamata and Itai-Itai diseases, many patients suffered as you know well. In 1967, Japanese Government set up Basic Law for Environmental Pollution Control and in 1970 Water Pollution Control and in 1970 Water Pollution Control Law.

• Proceedings of the PSK Conference
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• 2003.10a
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• pp.21-21
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• 2003

BT(Biotechnology) is transition stage from study and technology to mass production and one of most promising part in leading industry. After early completion of genome project, many countries keep trying their best to preoccupy in this field. Korean government support BT more than 10 years. Because their eco-compatibility and cleanness, BT is very promising part. But the big issue is the morals of genetic manipulation. (omitted)

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.04a
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• pp.117-117
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• 2019

Kirengeshoma koreana Nakai (K. koreana)was Saxifragaceae and rare plants in Korea, which is classified as an Critically Endangered (CR) species in Korea. Therefore, most of the studies on it were ecological and taxonomic, and there are no studies on biological activity. In this study, we evaluated the whitening activity of K. koreana extract (KKE). Melanogenesis Inhibitory effects were demonstrated by western-bot and RT-PCR for the effects of KKE on MITF, tyrosinase, TRP-1 and TRP-2 in IBMX-treated B16F10 melanoma cells. IBMX were reported as melanin synthesis enhancers. It could increase intracellular melanin synthesis by activation of the microphthalmia-associated transcription factor (MITF) signaling pathway. KKE showed no cytotoxicity at B16F10. In addition, KKE effectively inhibited the protein and mRNA levels of MITF, tyrosinase, TRP-1 and TRP-2. In conclusion, KKE inhibited melanin synthesis by inhibiting the expression of MITF and its downstream pathways tyrosinase, TRP-1 and TRP-2. Therefore, it was confirmed that K. koreana is a valuable resource for functional cosmetic and biomaterials.