Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
권호 표지

Prescription Patterns and Appropriateness of Topical Mupirocin in Ambulatory Care using the Korean National Health Insurance Claims Database

건강보험심사평가원 환자 표본 자료를 활용한 mupirocin 외래처방 패턴 분석 및 처방적절성 평가

  • Suh, Jinuk (The Graduate School of Pharmaceutical Industry Management, Chung-Ang University) ;
  • Jeong, Kyeong Hye (College of Pharmacy, Chung-Ang University) ;
  • Kim, Eunyoung (The Graduate School of Pharmaceutical Industry Management, Chung-Ang University)
  • 서진욱 (중앙대학교 제약산업특성화대학원) ;
  • 정경혜 (중앙대학교 약학대학) ;
  • 김은영 (중앙대학교 제약산업특성화대학원)
  • Received : 2016.08.04
  • Accepted : 2016.09.26
  • Published : 2016.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Mupirocin, a topical antimicrobial agent has been used for patients with methicillin-resistant Staphylococcus aureus and recently mupirocin resistance was issued in some studies. The objective of this study was to analyze prescription patterns of topical mupirocin, to evaluate appropriateness of prescriptions in the ambulatory setting, and to compare frequency of mupirocin usage in South Korea with that in United States. Methods: Topical mupirocin prescription patterns (the number of prescription and a prescription period), and appropriateness of prescription (including a prescription rate over 10 days, a repeat prescription rate within 30 days and a prescription rate within labeled indications) were analyzed using the 2012 Health Insurance and Review and Assessment service-National Patient Sample dataset of South Korea. The National Ambulatory Medical Care Survey dataset was used to quantify topical mupirocin prescription in United States for comparison. Results: In South Korea, the prescriptions rate for use over 10 days was 3%, the repeat prescription rate within 30 days was 8.87% and the prescription proportion within labeled indications was 33.84%. The most frequent diagnostic code was nonbacterial infection. The prescription rate per 1000 population of topical mupirocin in South Korea was calculated to be 46.07, whereas in United States was calculated to be 13.10. Conclusion: Topical mupirocin has been used frequently and inappropriately, so further studies are required to investigate the rationale behind such prescribing mupirocin patterns.

Keywords

References

  1. World Health Organization. Antimicrobial resistance global report on surveillance: 2014 summary. 2014.
  2. Espersen F. Resistance to antibiotics used in dermatological practice. Br J Dermatol 1998;139 Suppl 53: 4-8. https://doi.org/10.1046/j.1365-2133.1998.1390s3004.x
  3. Liu C, Bayer A, Cosgrove SE, Daum RS, et al. Clinical practice guidelines by the infectious diseases society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis 2011;52: e18-55. https://doi.org/10.1093/cid/ciq146
  4. U.S. Food and Drug Administration. Available from http://www.accessdata.fda.gov/scripts/cder/ob/default.cfm. Accessed September 13, 2016.
  5. Ministry of Food and Drug safety. Available from https://ezdrug.mfds.go.kr/#!CCBAA03F020. Accessed July 07, 2016.
  6. Yoo JI, Shin ES, Cha JO, et al. Clonal dissemination and mupA gene polymorphism of mupirocin-resistant Staphylococcus aureus isolates from long-term-care facilities in South Korea. Antimicrob Agents Chemother 2006;50: 365-7. https://doi.org/10.1128/AAC.50.1.365-367.2006
  7. Park SY, Kim SM, Park SD. The prevalence, genotype and antimicrobial susceptibility of high-and low-level mupirocin resistant methicillin-resistant Staphylococcus aureus. Ann Dermatol 2012;24: 32-8. https://doi.org/10.5021/ad.2012.24.1.32
  8. Youn SH, Lee SS, Kim S, et al. Drug utilization review of mupirocin ointment in a Korean university-affiliated hospital. Korean J Intern Med 2015;30: 515-20. https://doi.org/10.3904/kjim.2015.30.4.515
  9. Park SH, Kim SY, Lee JH, et al. Community-genotype strains of methicillin-resistant Staphylococcus aureus with high-level mupirocin resistance in a neonatal intensive care unit. Early Hum Dev 2013;89: 661-5. https://doi.org/10.1016/j.earlhumdev.2013.04.014
  10. Health Insurance and Review and Assessment service. Available from http://www.hira.or.kr/rf/medicine/getIngredientList.do?pgmid=HIRAA030035030000. Accessed September 13, 2016.
  11. Thomas V R, Christine FC, Rodney A B, et al. Mupirocin-resistant methicillin-resistat staphylococcus aureus in Western Australia. Med J Aust 1994;161:397-8
  12. Kim LY, Sakong J, Kim Y, et al. Developing the inpatient sample for the national health insurance claims data. Health Policy and Management 2013;23:152-61. https://doi.org/10.4332/KJHPA.2013.23.2.152
  13. Klein RJ, Proctor SE, Boudreault MA, et al. Healthy people 2010 criteria for data suppression. Healthy People 2010 Stat Notes 2002:1-12.
  14. Centers for Disease Control and Prevention. Available from http://www2.cdc.gov/drugs/druglist_applicationNav1.asp. Accessed September 13, 2016.
  15. Centers for Disease Control and Prevention. Available from http://www.cdc.gov/nchs/data/ahcd/namcs_summary/2012_namcs_web_tables.pdf. Accessed August 02, 2016.
  16. Central Intelligence Agency. Available from https://www.cia.gov/library/publications/download/download-2012/. Accessed September 06, 2016.
  17. Kim L, Kim JA, Kim S. A guide for the utilization of health insurance review and assessment service national patient samples. Epidemiol Health 2014;36: e2014008.
  18. Ruxton GD. The unequal variance t-test is an underused alternative to Student's t-test and the Mann-Whitney U test. Behavioral Ecology 2006;17:688-90. https://doi.org/10.1093/beheco/ark016
  19. Korean Health Industry statistics System. Available from https://www.khiss.go.kr/khidi/importantstat/listImportantStatNew.jsp?list_id=358_E&txt_code=. Accessed September 13, 2016.
  20. Upton A, Land S, Heffernan H. Mupirocin and Staphylococcus aureus:a recent paradigm of emerging antibiotic resistance. J Antimicrob Chemother 2003;51:613-7. https://doi.org/10.1093/jac/dkg127
  21. McNeil JC, Hulten KG, Kaplan SL, et al. Decreased susceptibilities to retapamulin, mupirocin, and chlorhexidine among Staphylococcus aureus isolates causing skin and soft tissue infections in otherwise healthy children. Antimicrob Agents Chemother 2014;58:2878-83. https://doi.org/10.1128/AAC.02707-13
  22. dos Santos KRN, de Souza Fonseca L, Gontijo Filho PP. Emergence of high-level mupirocin resistance in methicillin-resistant Staphylococcus aureus isolated from Brazilian university hospitals. Infection Control & Hospital Epidemiology 1996;17:813-6. https://doi.org/10.2307/30141177
  23. Biedenbach DJ, Bouchillon SK, Johnson SA, et al. Susceptibility of Staphylococcus aureus to topical agents in the United States: a sentinel study. Clin Ther 2014;36:953-60. https://doi.org/10.1016/j.clinthera.2014.04.003