• The Journal of Industrial Distribution & Business
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• v.12 no.5
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• pp.27-36
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• 2021

Purpose: This study empirically investigates the effect of collaborative communication and information sharing on the supply chain performance of South Korean pharmaceutical companies. Specifically, it understands the importance collaborative communication and suggests a method for investigating communication in academic research on the pharmaceutical industry. Investigating this sector is crucial because the importance of the pharmaceutical industry is increasing globally against the background of the Covid-19 pandemic. Research design, data, and methodology: A questionnaire was administered to employees of South Korean pharmaceutical companies and 244 valid responses were used for the statistical analysis. Additionally, structural equation modeling was used to measure the relationships between the observed and latent variables. Results: Collaborative communication has a positive effect on information sharing. However, information sharing, unlike collaborative communication, does not exhibit a significant positive relationship with supply chain performance. These results indicate that it is important to communicate effectively in the supply chain rather than strive for the right type of information sharing. Conclusions: Consumers and retailers within the supply chain should continue to strive for candid communication. This study is meaningful, as it empirically tests the relationships between collaborative communication, information sharing, and supply chain performance in the South Korean pharmaceutical industry.

• Korean Journal of Clinical Pharmacy
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• v.20 no.2
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• pp.128-137
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• 2010

This review summarizes gender differences in pharmacokinetics, pharmacodynamics, and adverse drug reactions. Gender differences in pharmacokinetics are categorized by four major factors: absorption/bioavailability, distribution, metabolism, and elimination. There are sex-based differences in gastric emptying time, gastric alcohol dehydrogenase activity, apparent volume of distribution, ${\alpha}1$-acid glycoprotein level, phase I (CYP) and phase II metabolizing enzymes, glomerular filtration rate, and drug transporters. This review also reports gender differences in pharmacokinetics and pharmacodynamics of cardiovascular agents, central nervous system acting agents and antiviral agents. In addition, it has been reported that females experience more adverse reactions such as coughing, tachycardia, nausea, vomiting, rash, hypersensitivity, hepatotoxicity, and metabolic disorder after taking cardiovascular, central nervous system acting and antiviral agents. Therefore, in order to provide optimal drug dosage regimens both in male and female, gender differences in pharmacokinetics, pharmacodynamics, and adverse drug reactions must be considered.

• Archives of Pharmacal Research
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• v.3 no.2
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• pp.65-74
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• 1980

Analysis of particle size distribution of a sample of fine aluminum hydroxide powder was carried out by four different methods, i. e., conductivity, air permeability, gas-adsorption and sedimentation. Each method was reproducible. The results obtained by Coulter counter and sedimentation balance were similar, and the data obtained by Lea and Nurse permeameter and Stroehlein areameter were also similar. But the results differ considerabley between the former and the latter. The advantages and disavantages of each method were discussed briefly and a means of comparing the results with those obtianed by surface area measurements was shown.

• YAKHAK HOEJI
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• v.46 no.2
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• pp.102-107
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• 2002

The particle size of medicinal materials is an important physical property which affects the pharmaceutical behaviors such as dissolution, chemical stability, compressibility and bioavailability of solid dosage forms. The size reduction of raw pharmaceutical powder is needed to formulize insoluble drugs or slightly soluble drugs and to improve the pharmaceutical properties such as the solubility, the pharmaceutical mixing and the dispersion. The objective of the present study is to evaluate the grinding characteristics of ursodeoxycholic acid(UDCA) as a model of insoluble drugs. The effects of the grinding time and the amount of additive on particle size distribution of ground UDCA were investigated. Grinding of insoluble drug, UDCA and a series of dry co-grinding experiments of UDCA with sodium lauryl sulfate(SLS) as an additive were carried out using a planetary ball mill. It was measured that the median diameter and the particle size distribution of ground products with grinding UDCA and additive SLS by Mastersizer. As a result of co-grinding of UDCA and SLS, the particle size of co-grinding products was decreased more than single grinding one. However, it was observed that co-grinding products were reaggregated to larger particles after 120 min.

• Journal of Pharmaceutical Investigation
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• v.17 no.1
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• pp.41-46
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• 1987

Oil in water microemulsion containing soybean oil and egg phosphatide was prepared by vacuum high shear mixing and high pressure homogenizing. The laser particle sizer, Coulter counter and photomicroscope were used to determine the particle size distribution at each cycle of homogenizing. Particularly, the laser particle sizer(dynamic light scattering method) was applied to the study of particle size distribution behavior below $1\;{\mu}m$. It was found that the particle size distribution below $1\;{\mu}m$ was shifted to lower size range as the number of passing cycle was increased. Beyond the 7th cycle, however, the particle size distribution was not varied.

• YAKHAK HOEJI
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• v.18 no.3
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• pp.183-189
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• 1974

Distribution coefficients between nitrobanzene solution and deionized water, show a straight line when the number of alkyl radicals against the logarithm of distribution coefficient of the salts was plotted. After extracting salts of the indicator and the cationic surfactants with organic solvents, and employing the colorimetric method was used. A calculation method of distribution coefficients of the salts in the organic solvent has been suggested and it could be used for the extraction equilibrium of the primary amine, $CH_{3}(CH_2)_{n}NH_3^+$ secondary amine, $CH_{3}(CH_2)_{n}NH_{2}(CH_3)^+$, tertiary amine $CH_{3}(CH_2)_{n}NH(CH_3)_2^+$ and quaternary ammonium, $CH_{3}(CH_2)_{n}N(CH_3)_3^+$MO$^-$salts, (n=3,5,7,11).

• Journal of Pharmaceutical Investigation
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• v.17 no.2
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• pp.89-93
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• 1987

Effects of Ssang Wha Tang (SWT), a blended Chinese traditional medicine, on the pharmacokinetics of sulfobromophthalein (BSP) were studied in the rats. BSP was administered via portal vein to the control and the SWT-treated rats. The in vitro distribution of BSP to blood cells and the hemato-physiological conditions, liver weight, GOT. GPT activity were also examined. The systemic clearance $(CL_s)$ of BSP was increased with the administration of SWT, but no significant differences were observed in the liver weight and in vitro distribution of BSP to blood cells. These results suggest that the intrinsic clearance of free BSP of the liver is increased with the administration of SWT in the rats.

• YAKHAK HOEJI
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• v.18 no.4
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• pp.236-242
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• 1974

Extrusion-spheronization processing combination was used to produce spherical granules with experimental formulations which contain microcrystalline cellulose as a diluent. The produced granules were compared on the basis of the following physical properties ; (a) bulk density, (e) porosity, (f) friabillity and (g) dissolution rate. With the specific experimental formulations used in this study, the increased plate rotational speeds of Marumerizer (400-1200rpm) produced continually more spherical material and also the obtained data indicated that the particle size distribution and dissolution rate depend upon the amount of microcrystalline cellulose used. As a result, the spherical granule preparation with microcrystalline cellulose has good properties in flow rate, packing propertyu and friability and offers a suitable method of granule preparation in pharmaceutical industry.

• YAKHAK HOEJI
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• v.41 no.3
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• pp.312-320
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• 1997

Pharmacokinetics and tissue distribution of DWP20349 and 20351, new quinolones, were examined in rats after a single intravenous and oral administration. Analyses of DWP20349 an d DWP20351 in plasma, tissue, and urine were determined by both HPLC and bioassay(microbiological assay). The plasma concentrations of the drugs declined biexponentially. The terminal half-lives ($t_{1/2\beta}$) of drugs were about 114 min (DWP20349) and 105 min (DWP20351) after intravenous dosing, and were 77 min (DWP20349) and 79 min (DWP20351) after oral dosing. The volume of distrbution at steady-state ($Vd_{ss}$) and total body clearances ($Cl_t$) of DWP20349 and DWP20351 were 760 ml/kg and 1126 ml/kg, and 5ml/min/kg and 10 ml/min/kg, respectively. The extents of bioavailability if DWP20349 and DWP20351 after oral administration were 29% and 28%, respectively. 24 h urinary recoveries measured by bioassay were 1.8% (DWP20349) and 1.3% (DWP20351) after oral dosing, and 2.4% (DWP20349) and 1.9% (DWP20351) after intravenous dosing. Plasma protein binding ratios ranged from 87%-90% (DWP20349) and 61%-68% (DWP20351). These drugs were highly distrbuted by the order of lung, kidney, liver and plasma (DWP20394), and lung, liver, kidney and plasma (DWP20351) after 1 hour orally administered.

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.120-120
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• 2003

Synthesis and distribution of extracellular matrix (ECM) components are dynamically altered in response to the pathophysiological processes including infection, inflammation and apoptosis. In particular, the levels of hyaluronan (HA) change with concomitant increases in the levels of collagen (e.g. type I collagen) and fibronectin in chronic liver diseases.(omitted)