• Journal of Applied Biological Chemistry
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• 제63권4호
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• pp.393-399
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• 2020

방풍(Saposhnikoviae Radix, SR) 과 식방풍(Peucedani Japonici Radix, PR)은 각각 다른 기원식물을 가지며 속과 종이 다르지만 한국, 중국, 및 일본에서 대표적인 전통 한약재로 오랫동안 혼용되어 사용되었다. 본 연구에서는 방풍과 식방풍의 판별 마커를 확인하기 위하여 UPLC-QTOF/MS를 이용한 대사체 프로파일링 및 다변량 통계분석을 진행하였다. 그 결과, 5-O-methylvisammioside와 peucedanol을 각각 방풍과 식방풍의 지표성분으로 선정하였으며, UPLC를 이용하여 분석법을 검증하였다. 제안된 방풍 및 식방풍의 지표성분에 대한 분석법 검증은 방풍과 식방풍의 분류와 품질 평가 및 성분 검증을 위한 효과적인 방법이 될 것으로 기대된다.

• 대한본초학회지
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• 제28권6호
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• pp.1-7
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• 2013

Objectives : The root of Peucedanum japonicum Thunberg (Peucedani Japonici Radix; PJR) has been traditionally used as an herbal medicine for the treatment of anti-headache, anti-paralysis, anti-cancer, vascular protection, and blood pressure regulation. In this study, we investigated the anti-allergic effect of PJR water extract on ovalbumin (OVA)-induced allergic asthma in mice. Methods : Mice were sensitized at days 1, 8 and 15 with OVA and airway challenged at days 22, 24, 26, 28, and 30 to induced allergic asthma. PJR-W extract at doses of 100 and 300 mg/kg/body weight (bw) was orally administered during OVA challenge once per a day. The levels of allergic mediators such as immunoglobulin (Ig) E, and Th1/Th2 cytokines (IFN-${\gamma}$ and IL-4) were measured in the sera of mice by ELISA. The histological change of lung tissue was observed with hematoxylin and eosin (H&E) staining. Results : The administration of PJR-W extract significantly decreased the serum levels of IgE, IL-4, and IFN-${\gamma}$ compared with those of OVA control group. In H&E staining, PJR-E extract inhibited OVA-induced airway inflammation and the inflammatory cells infiltration in the peribronchial regions of the lung. Conclusions : These results indicate that PJR-W extract has an anti-inflammatory and anti-allergic effect on allergic response through the down-regulation of allergic mediators, suggesting that this herb may be used as a useful source for the treatment of allergic inflammatory diseases such as asthma.

• 대한본초학회지
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• 제37권6호
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• pp.29-36
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• 2022

Objectives : The objective of this study was to investigate the possibility for the treatment of hypertension of herbal medicines belong to Umbelliferae family. Methods : Domestic and international articles about Herbology were investigated. A review was performed via the database (DB) search engines such as Pubmed, Korean studies Information Service System (KISS), KoreaScience, and Google Scholar. Hypertension-related terms including "vasorelaxation", "vasorelaxant", "vasodilation", "vasodilatory", "vasodilative", "hypotension", and "hypotensive" were performed as search terms. Results : A list was made about herbal medicines and origin plants belonging to the Umbelliferae family in Korean Pharmacopoeia 12 and Korean Herbal Pharmacopoeia. 14 herbal medicine and 22 origin plants were searched. Ostericum koreanum root and rhizome, Notopterygium incisum root and rhizome, N. forbesii root and rhizome, Ligusticum tenuissimum root and rhizome, L. jeholense root and rhizome, Angelica gigas root, A. dahurica root, A. dahurica var. formosana root, Bupleurum falcatum root, Peucedanum japonicum root, P. praeruptorum root, A. decursiva root, Cnidium officinale rhizome, L. chuanxiong rhizome, Foeniculum vulgare fruit, and Ferula assa-foetida resin and stem showed significant vasorelaxant or hypotensive effects. Conclusion : These review results showed that Osterici seu Notopterygii Radix et Rhizoma, Ligustici Tenuissimi Rhizoma et Radix, Angelicae Gigantis Radix, Angelicae Dahuricae Radix, Bupleuri Radix, Peucedani Japonici Radix, Peucedani Radix, Cnidii Rhizoma, Foeniculi Fructus, and Ferulae Resina had vasorelaxant or hypotensive effects. The results are expected as basic data in clinical trials and experimental researches for the treatment of hypertension of herbal medicines.

• 대한본초학회지
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• 제38권5호
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• pp.69-84
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• 2023

Objectives : Sik-bang-pung (植防風, Peucedani Japonici Radix), the root of Peucedanum japonicum Thunberg (Apiaceae), has often been used as a substitute for Bang-pung (防風, Saposhnikoviae Radix) in the past, but recently it is treated as a counterfeit of Bang-pung or a kind of 'Jeonho (Peucedani Radix)'. Hence, it is crucial to investigate the origin of herbal name to provide appropriate usage of Sik-bang-pung. Methods : The classic and contemporary literatures regarding to the herbal medicines and botanical nomenclature were searched to find the herbal and botanical origins of Bang-pung and Sik-bang-pung, respectively. Result : The botanical descriptions of Bang-pung (防風) were consistent throughout the classic literatures and its botanical species was determined as Saposhnikovia divaricata Schischkin (Apiaceae) in the compendium. In the literatures published in the Joseon Dynasty, 'Byeong-pung-na-mul' was recorded as the medicinal plant of Bang-pung, but its botanical species could not be confirmed. In Japanese literatures, Bang-gyu (防葵) was confirmed as Mok-dan-bang-pung (牡丹防風); botan-bōfū in Japanese), which was determined as the herbal name of the root of 'Gaet-girum-namul (P. japonicum)' in Korea during the period of Japanese rule. The roots of Gaet-girum-namul was medicinally named as Mok-dan-bang-pung (牡丹防風), Sik-bang-pung (植防風), or San-bang-pung (山防風) in the past decades in Korea. Among them, Sik-bang-pung might be chosen as the herbal name, but its nominal origin could not be found. Conclusions : The herbal name, Sik-bang-pung, was presumably affected by Japanese botanical nomenclature. Although its medicinal application is still controversial, Sik-bang-pung should be considered an independent herbal medicine.