• BMB Reports
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• v.37 no.3
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• pp.325-329
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• 2004

Oxidation of catecholamines may contribute to the pathogenesis of Parkinson's disease (PD). The effect of the oxidized products of catecholamines on the modification of Cu,Zn-superoxide dismutase (SOD) was investigated. When Cu,Zn-SOD was incubated with the oxidized 3,4-dihydroxyphenylalanine (DOPA) or dopamine, the protein was induced to be aggregated. The deoxyribose assay showed that hydroxyl radicals were generated during the oxidation of catecholamines in the presence of copper ion. Radical scavengers, azide, N-acetylcysteine, and catalase inhibited the oxidized catecholamine-mediated Cu,Zn-SOD aggregation. Therefore, the results indicate that free radicals may play a role in the aggregation of Cu,Zn-SOD. When Cu,Zn-SOD that had been exposed to catecholamines was subsequently analyzed by an amino acid analysis, the glycine and histidine residues were particularly sensitive. These results suggest that the modification of Cu,Zn-SOD by oxidized catecholamines might induce the perturbation of cellular antioxidant systems and led to a deleterious cell condition.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.6
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• pp.1016-1025
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• 2002

This paper deals with the measurement of the fluid viscosity by using the torsional vibration of a circular rod excited by a torsional vibrator at one end. The effect of an adjacent viscous fluid on the torsional vibration of the rod has been studied theoretically and expressed in terms of the mechanical impedance. The theoretically-obtained trend that the mechanical impedance is proportional to the square root of the viscosity times the density of the fluid has been confirmed by the impedance measurement. The paper demonstrates that a torsionally-vibrating rod can be used as a sensor to measure the viscosity of a fluid.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.8 no.1
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• pp.12-17
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• 1997

Measuring phonatory stability using MDVP(Multi-dimensional voice program, Kay Elemetrics Corp., NJ, USA) are becoming popular in many Korean clinics and laboratories, yet questions about standardization and reference values have remained. The purpose of present study was to examine the effects of frequency and intensity variation on the results of acoustic analysis related to phonatory stability. Twenty young adults(ten females and ten males) were asked to sustain vowel /a/ for more than 3 seconds under 9 different pitch and loudness conditions. Using MDVP, nine voice samples were analyzed, and jitter percent, fundamental frequency variation, shimmer percent, peak amplitude variation, noise to harmonic ratio, amplitude tremor intensity index, and degree of subharmonics were compared. The results showed that intensity changes can significantly affect various phonatory stability measures, and the lowest perturbation values can be obtained from slightly louder(10dB) phonatory condition than comfortable level phonation.

• Proceedings of the Korean Nuclear Society Conference
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• 1997.05a
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• pp.90-95
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• 1997

In this work, linear dynamics of a circulating fluid-fueled subcritical reactor system with temperature feedback and external neutron source was modeled and examined. In a circulating fluid-fuel system, the stable region is slightly moved by a circulation fluid effect. The effects of subcriticality and temperature feedback coefficient on the reactor stability were tested by calculating frequency response of neutron density originated from reactivity perturbation or external source oscillation of system. The amplitude transfer function has a different shape near subcritical region due to the exponential term in the transfer function. The results of the study show that at a slightly subcritical region, low frequency oscillation in accelerator current or reactivity can be amplified depending on the temperature feedback. However, as the subcriticality increases, the oscillation becomes negligible regardless of the magnitude of the temperature feedback coefficient.

• Journal of the Korean Magnetic Resonance Society
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• v.18 no.1
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• pp.10-14
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• 2014

Hsp90 is a good drug target molecule that is involved in regulating various signaling pathway in normal cell and the role of Hsp90 is highly emphasized especially in cancer cells. Thus, much efforts for discovery and development of Hsp90 inhibitor have been continued and a few Hsp90 inhibitors targeting the N-terminal ATP binding site are being tested in the clinical trials. There are no metabolic signature molecules that can be used to evaluate the effect of Hsp90 inhibition. We previously found a potential C-domain binder named PPC1 that is a synthetic small molecule. Here we report the metabolomics study to find signature metabolites upon treatment of PPC1 compound in lung cancer cell line, A549 and discuss the potentiality of metabolomic approach for evaluation of hit compounds.

• Journal of Electrical Engineering and Technology
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• v.10 no.2
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• pp.487-495
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• 2015

This paper proposes a new robust decentralized power oscillation dampers (POD) design of doubly-fed induction generator (DFIG) wind turbine for damping of low frequency electromechanical oscillations in an interconnected power system. The POD structure is based on the practical $2^{nd}$-order lead/lag compensator with single input. Without exact mathematical model, the inverse output multiplicative perturbation is applied to represent system uncertainties such as system parameters variation, various loading conditions etc. The parameters optimization of decentralized PODs is carried out so that the stabilizing performance and robust stability margin against system uncertainties are guaranteed. The improved firefly algorithm is applied to tune the optimal POD parameters automatically. Simulation study in two-area four-machine interconnected system shows that the proposed robust POD is much superior to the conventional POD in terms of stabilizing effect and robustness.

• Journal of KSNVE
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• v.6 no.5
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• pp.567-574
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• 1996

This paper concerns an articulated space robot with flexible links. The equations of its motion are derived by means of the Lagrangian mechanics. Assuming that magnitude of elastic motions are relatively small, the perturbation approach is taken to separate the original equations of motion into linear and nonlinear equations. Th effect the desired payload motion, open loop control inputs are first determined based on the nonlinear equations. One the other hand, in order to reduce the positional errors during the maneuver, vibration suppression is actively done with a feedforward control for disturbance cancellation to some extent. Additionally, for performance robustness against residual disturbance, an LQ control modified to have a prescribed degree of stability is applied based on the linear equations. Measurement equations are formulated to be used for the maximum likelihood estimator to reconstruct states from the original robot equations of motion. Finally, numerical simulations show effectiveness of the proposed control design scheme.

• Tribology and Lubricants
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• v.21 no.6
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• pp.283-288
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• 2005

This paper presents the theoretical model and analysis results to investigate the effect of Coulomb damping in the sub-structure of a foil bearing. Vertical and horizontal deflection of a bump is restricted by friction of the bump. Equivalent viscous damping of the bump foil is derived from the Coulomb friction. Dynamic equation of the bump is constituted by stiffness and damping terms. The air film is modeled by the compressible Reynolds equation. A perturbation approach and finite difference numerical method is used to determine the static and dynamic performance of the bearing from the coupled fluid-structural model. The analysis result shows that the static and dynamic performance is enhanced by the bump friction.

• Tribology and Lubricants
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• v.23 no.4
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• pp.162-169
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• 2007

This paper deals with friction effects on the performance of double-bumped AFBs. The stiffness and damping coefficients of the double bump vary depending on the external load and its friction coefficient. The double bump can be either in the single or double active region depending on vertical deflection. The equivalent stiffness and damping coefficients of the bump system are derived from the vertical and horizontal deflection of the bump, including the friction effect. A static and dynamic performance analysis is carried out by using the finite difference method and the perturbation technique. The results of the performance analysis for a double-bumped AFB are compared with those obtained for a single-bumped AFB. This paper successfully proves that a double bumped AFB has higher load capacity, stiffness, and damping than a single-bumped AFB in a heavily loaded condition.

• Journal of the Korean Vacuum Society
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• v.21 no.3
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• pp.130-135
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• 2012

The role of the electron diffusion on the stability of a Townsend discharge was investigated with the linear stability theory for the one-dimensional fluid equation with drift-diffusion approximation. It was proved that the discovered instability occurs as a result of the coupled action of electron diffusion and the perturbed electric field by space charge. The larger electron diffusion results in the faster growth rate at the regime of small perturbation of the electric field by space charges.