• BMB Reports
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• v.42 no.6
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• pp.315-323
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• 2009

In order to elucidate ultimate biological function of the genome, the model animal system carrying mutations is indispensable. Recently, large-scale mutagenesis projects have been launched in various species. Especially, the mouse is considered to be an ideal model to human because it is a mammalian species accompanied with well-established genetic as well as embryonic technologies. In 1990', large-scale mouse mutagenesis projects firstly initiated with a potent chemical mutagen, N-ethyl-N-nitrosourea (ENU) by the phenotype-driven approach or forward genetics. The knockout mouse mutagenesis projects with trapping/conditional mutagenesis have then followed as Phase II since 2006 by the gene-driven approach or reverse genetics. Recently, the next-generation gene targeting system has also become available to the research community, which allows us to establish and analyze mutant mice carrying an allelic series of base substitutions in target genes as another reverse genetics. Overall trends in the large-scale mouse mutagenesis will be reviewed in this article particularly focusing on the new advancement of the next-generation gene targeting system. The drastic expansion of the mutant mouse resources altogether will enhance the systematic understanding of the life. The construction of the mutant mouse resources developed by the forward and reverse genetic mutagenesis is just the beginning of the annotation of mammalian genome. They provide basic infrastructure to understand the molecular mechanism of the gene and genome and will contribute to not only basic researches but also applied sciences such as human disease modelling, genomic medicine and personalized medicine.

• Genomics & Informatics
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• v.6 no.2
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• pp.91-94
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• 2008

Single nucleotide polymorphisms (SNPs) are the most abundant form of human genetic variation and are a resource for mapping complex genetic traits. A genome is covered by millions of these markers, and researchers are able to compare which SNPs predominate in people who have a certain disease. The International HapMap Project, launched in October, 2002, motivated us to start the Korean HapMap Project in order to support Korean HapMap infrastructure development and to accelerate the finding of genes that affect health, disease, and individual responses to medications and environmental factors. A Korean SNP and haplotype database system was developed through the Korean HapMap Project to provide Korean researchers with useful data-mining information about disease-associated biomarkers for studies on complex diseases, such as diabetes, cancer, and stroke. Also, we have developed a series of software programs for association studies as well as the comparison and analysis of Korean HapMap data with other populations, such as European, Chinese, Japanese, and African populations. The developed software includes HapMapSNPAnalyzer, SNPflank, HWE Test, FESD, D2GSNP, SNP@Domain, KMSD, KFOD, KFRG, and SNP@WEB. We developed a disease-related SNP retrieval system, in which OMIM, GeneCards, and MeSH information were integrated and analyzed for medical research scientists. The kHapMap Browser system that we developed and integrated provides haplotype retrieval and comparative study tools of human ethnicities for comprehensive disease association studies (http://www.khapmap.org). It is expected that researchers may be able to retrieve useful information from the kHapMap Browser to find useful biomarkers and genes in complex disease association studies and use these biomarkers and genes to study and develop new drugs for personalized medicine.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.8
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• pp.1494-1502
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• 2016

With the increasing availability of medical sensors and Internet of Things(IoT) devices for personal use, considering the interaction with users, it is planned to add intelligent function design to the fashionable jewelry, and develop composite multi-function intelligent jewelry through sensors identification. By means of IoT technology, while possessing communication function of intelligent jewelry, the function of intelligent jewelry can be expanded to the linkage network. In order to rapidly manage the mass data produced by intelligent jewelry sensors based on IoT, an intelligent jewelry system for health management is designed and an ontology model of intelligent jewelry system based on IoT is worked out. After the state of the services through the smart phone application is shown. The application provides a personalized service to the user and to determine the risk to show the guide lines according to the disease.

• Journal of Internet Computing and Services
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• v.18 no.6
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• pp.75-84
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• 2017

As there has been growing interests in PHR-based personalized health management project, various institutions recently explore safe methods of recording personal medical and health information. In particular, innovative medical solution can be realized when medical researchers and medical service institutes can generally get access to patient data. As EMR data is extremely sensitive, there has been no progress in clinical information exchange. Moreover, patients cannot get access to their own health data and exchange it with researchers or service institutions. It can be operated in terms of technology, yet policy environment are affected by state laws as well as Privacy and Security Policy. Blockchain technology-independent, in transaction, and under test-is introduced in the medical industry in order to settle these problems. In other words, medical organizations can grant preliminary approval on patient information exchange by using the safely encrypted and distributed Blockchain ledger and can be managed independently and completely by individuals. More apparently, medical researchers can gain access to information, thereby contributing to the scientific advance in rare diseases or minor groups in the world. In this paper, we focused on how to manage personal medical information and its protective use and proposes medical treatment exchange system for patients based on a permissioned Blockchain network for the safe PHR operation. Trusted Model for Sharing Medical Data (TMSMD), that is proposed model, is based on exchanging information as patients rely on hospitals as well as among hospitals. And introduce medical treatment exchange system for patients based on a permissioned Blockchain network. This system is a model that encrypts and records patients' medical information by using this permissioned Blockchain and further enhances the security due to its restricted counterfeit. This provides service to share medical information uploaded on the permissioned Blockchain to approved users through role-based access control. In addition, this paper presents methods with smart contracts if medical institutions request patient information complying with domestic laws by using the distributed Blockchain ledger and eventually granting preliminary approval for sharing information. This service will provide an independent information transaction and the Blockchain technology under test will be adopted in the medical industry.

• Journal of Digital Convergence
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• v.11 no.3
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• pp.389-395
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• 2013

More sales of food and beverage coupons have been made using SNS on social commerce recently. If one buys coupons on social commerce, he/she can enjoy products at a lower price; however, there are drawbacks that one must consider such as location, service hours, and discount rate. Thus, this paper suggests a system that recommends food and beverage coupons on social commerce for users that considers a user's personal context of location, time, and purchase history. In order to reflect a user's context awareness and continuous preference, this paper suggests a method based on the Bayesian network. In order to reflect personalized weighting on the standard of coupon selection to match a user's preference, a measurement and classification of weighting preferences is performed on the basis of AHP. 20 experiments in one month involving 12 students were carried out to verify the effectiveness of the system, resulting in an 80% satisfaction level.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.05a
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• pp.603-604
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• 2016

Due to the recent popularization and commercialization of smart devices the change in the IoT(Internet of Things) environment continues. Thus a personalized service to the individual characteristics it is required by the user increases. However, existing systems are provided, there is a problem that only generalized service to the user, because the operation is manually carried out according to the rules set by the developer. In this paper, we design a custom operation management system to solve this problem. User to prioritize each of the sensors through the application Accordingly manages the sensor. This allows the user to perform an action is thought to be for the individual characteristics and can expect a more efficient productivity.

• Journal of Convergence for Information Technology
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• v.10 no.1
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• pp.195-202
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• 2020

This study is to investigate the effect of lower extremity strength exercise using biofeedback system on community-based elderly. Ten community-based elderly were exercised using the biofeedback system (with functional electrical stimulation) three times a week for six weeks. Data analysis was performed using Wilcoxon signed rank test. Physical function improved significantly, but there was no significant difference in muscle strength and muscle mass. Although elderly people were able to confirm that community-based ICT home biofeedback training could be possible and could lead to improvements in the lower extremity function, further research is needed to demonstrate a clearer effect by expanding the target population, distinguishing the sexes, and providing a personalized training method.

• Convergence Security Journal
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• v.15 no.5
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• pp.47-52
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• 2015

The aim of this study is to suggest the effective protocol to manage the obese children using the data based on PAPS(Physical Activity Promotion System). In the school, there are a lot of efforts for the management of increasing obese children through the data obtained from PAPS which is conducted annually includes the assessment of obesity. But the follow-up of obese children was not effective due to the workload of teachers and the lack of available manpower. For more active and systematic management, the combination of a smart device transfer in the existing ways for facilitating access to the information is more effective. The information of obese children such as fitness, health, and obesity automatically will be sent in web-PAPS, And when personalized exercise prescription, proper nutrition education for obesity are shared with their parent, it will be more effective in weight management.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.31 no.1
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• pp.311-335
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• 2020

This study was conducted to suggest the ways of improving legislative information services in the National Assembly Library based on the information needs of the legislative support organization arising from the legislation process done by the National Assembly Members. For the purpose, 20 users of legislative support organizations were interviewed in depth. Based on the analysis of the results, the study suggested the improvement proposals in the areas of services and system. Service improvement reflected the information needs of overseas legislative cases, the need for supplementing policy information, and the areas that need to be promoted Second, in the area of system improvement, it was proposed to raise the service awareness of the legal information system centered on foreign legal information and to operate personalized service that can provide differentiated information services for each legislative support organization.

• Journal of Broadcast Engineering
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• v.23 no.2
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• pp.253-260
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• 2018

Personalized media broadcasting services can produce their own broadcasting contents with a variety of creative themes if they have just a transmission platform and devices that can obtain videos and voices of producers without the existing expensive equipment. In this paper, we develop and implement a new broadcasting system by applying this service framework to events such as seminars or academic conferences. The devices can be installed at each conference rooms and the integrated system transmitted to users. They can watch via their multi-resolution screen, such as smart-phones, laptops, and tablet PCs. It has the advantage of being able to receive real-time streaming and VOD services as well as additional information related to the conference. It is expected to provide convenience by allowing attendees to access the information via their devices, thereby creating an impact on participation and the underlying technology for the future research.