• Korean Medical Education Review
• /
• v.16 no.3
• /
• pp.141-146
• /
• 2014

This study focused on investigating the future medicine and health care industry paradigm shift and suggesting the right direction for the medical education system in order for students to be better prepared in the near future. Here, I will discuss four issues related to the future of medicine: Health 2.0, digital health, personalized medicine, and innovations of the public healthcare system. Every issue has lessons for medical education and teaching for students who major in health professions. However, it is obvious that the present is an important period of time as, currently, we are at an early stage in the future health care environment. Recently, there have been rapid transformations in various fields of medicine. Therefore, if we fail to lead medical education in the right direction, medical students will suffer from major problems in coping with these changes.

• Tuberculosis and Respiratory Diseases
• /
• v.82 no.3
• /
• pp.179-189
• /
• 2019

Although recent advances in molecular targeted therapy and immuno-oncology have revolutionized the landscape of lung cancer therapeutics, cytotoxic chemotherapy remains an essential component of lung cancer treatment. Extensive evidence has demonstrated the clinical benefit of chemotherapy, either alone or in combination with other treatment modalities, on survival and quality of life of patients with early and advanced lung cancer. Combinational approaches with other classes of anti-neoplastic agents and new drug-delivery systems have revealed promising data and are areas of active investigation. Chemotherapy is recommended as a standard of care in patients that have progressed after tyrosine kinase inhibitors or immune checkpoint inhibitors. Chemotherapy remains the fundamental means of lung cancer management and keeps expanding its clinical implication. This review will discuss the current position and future role of chemotherapy, and specific consideration for its clinical application in the era of precision medicine.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.9
• /
• pp.4549-4553
• /
• 2012

This study was designed to investigate the frequency of CYP2D6 polymorphisms and evaluate the association between genetic polymorphisms of CYP2D6 and tamoxifen therapeutic outcome in Thai breast cancer patients. We recruited 48 breast cancer patients who received adjuvant tamoxifen for evaluating CYP2D6 genetic polymorphisms using microarray-based technology. Associations between genotypes-phenotypes and disease free survival were analyzed. Median follow up time was 5.6 years. The mean age of the subjects was 50 years. The 3 common allelic frequencies were 43.8% ($^*10$), 36.5 ($^*1$) and 10.4% ($^*2$) which are related to extensive metabolizer (EM) and intermediate metabolizer (IM) with 70.8% and 29.2 %, respectively. No association between CYP2D6 genotypes and DFS was demonstrated. Nevertheless, exploratory analysis showed statistically significant shorter DFS in the IM group of post-menopause patients (HR, 6.85; 95%CI, 1.48-31.69; P=0.005). Furthermore, we observed statistically significant shorter DFS of homozygous $CYP2D6^*10$ when compared with heterozygous CYP2D6*10 and other genotypes (P=0.005). $CYP2D6^*10$ was the most common genotype in our subjects. Post-menopause patients with homozygous $CYP2D6^*10$ and IM have shorter DFS. To confirm this relationship, larger samples and comprehensively designed trials in Thailand are required.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.5
• /
• pp.1909-1912
• /
• 2014

It is becoming progressively more understandable that between transcription and translation there lies another versatile regulator that quantitatively controls the expression of mRNAs. Identification of miRNAs as key regulators of wide ranging signaling cascades and modulators of different cell-type and context dependent activities attracted basic and clinical scientists to study modes and mechanisms in details. In line with this approach overwhelmingly increasing in vivo and in vitro studies are deepening our understanding regarding miR-421, mir-155 and miR-650 mediated regulation of cellular activities. We also attempt to provide an overview of long non coding RNAs.

• Journal of Korean Neurosurgical Society
• /
• v.62 no.5
• /
• pp.493-501
• /
• 2019

The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of essential platforms for targeted drug development. iPSCs retain the genome of the donor, may regenerate indefinitely, and undergo differentiation into virtually any cell type of interest using a range of published protocols. There has been enormous interest among researchers regarding the application of iPSC technology to regenerative medicine and human disease modeling, in particular, modeling of neurologic diseases using patient-specific iPSCs. For instance, Parkinson's disease, Alzheimer's disease, and spinal cord injuries may be treated with iPSC therapy or replacement tissues obtained from iPSCs. In this review, we discuss the work so far on generation and characterization of iPSCs and focus on recent advances in the use of human iPSCs in clinical setting.

• Journal of Preventive Medicine and Public Health
• /
• v.52 no.5
• /
• pp.277-280
• /
• 2019

The Ministry of Food and Drug Safety of Korea made an official announcement in March 2018 that the total number of inoculations of Hantaan virus vaccine ($Hantavax^{(R)}$) would change from 3 to 4. Some aspects of this decision remain controversial. Based on the characteristics of Hantaan virus (HTNV) and its role in the pathogenesis of hemorrhagic fever with renal syndrome, it might be difficult to develop an effective and safe HTNV vaccine through the isolate-inactivate-inject paradigm. With the development of high-through-put 'omics' technologies in the 21st century, vaccinomics has been introduced. While the goal of vaccinomics is to develop equations to describe and predict the immune response, it could also serve as a tool for developing new vaccine candidates and individualized approaches to vaccinology. Thus, the possibility of applying the innovative field of vaccinomics to develop a more effective and safer HTNV vaccine should be considered.

• Advances in nano research
• /
• v.15 no.2
• /
• pp.129-139
• /
• 2023

Emerge of nanotechnology has affected many aspects of our life and also triggers research studies in many fields. Nano-medicine are proven to be effective in encountering diseases. In the present study, aspects of the applications and effectiveness of nano-medicine in pediatrics patients are studied. In this regard, using experimental data of previous published researches, combination and dose of nano-medicines are optimized using response surface method and neural-fuzzy inference network. The input parameters of the selected multiple nano-medicines are dose and type and the output is the effectiveness of the combinations using IC50 parameter. A detailed parameter study is presented to observe effects of each inputs on the IC50. The results indicate that personalized scaling of nano-medicine is required in therapy of pediatric diseases such as cancers.

• Korean Journal of Oriental Medicine
• /
• v.16 no.1
• /
• pp.101-109
• /
• 2010

The medical and healthy paradigm is changing by various reasons such as improving of life quality, the limit of western medicine, demographic changes and so on. And the demand, interest and market size of traditional medicine(TM) and complementary and alternative medicine(CAM) are increasing continuously and there is a good traditional medicine called TKM(Traditional Korean Medicine) in Korea. TKM have differentiated characteristics like nature-friendly, systematic, preventive and personalized medicine from western medicine. TKM with these characteristics have possibility to increase national competitiveness and contribute to growth of economy. At this time, it is necessary to select key area of TKM R&D to increase competitiveness of TKM and to create new growth engine. In this paper, we suggest key area of TKM R&D through SWOT analysis, the analysis of world traditional medicine and expert's counsel. As a result, 3 key area and 10 specific fields of TKM R&D was selected, which they are 'the standardization for TKM technology and technique', 'the development of generic technology based on TKM' and 'the establishment of infrastructure for TKM information and material'. This study may contribute to make plan for TKM research and policy such as TKM middle and long term plan and TKM promotion plan.

• The Journal of Korean Medicine
• /
• v.41 no.4
• /
• pp.112-119
• /
• 2020

Objectives: The present study reports a case of chronic anemia patient who was significantly improved after taking Nokyongdaebo-tang (NYDBT) Methods: A 48-year-old male patient diagnosed with iron deficiency anemia (IDA) visited the Daejeon Korean medicine Hospital of Daejeon University on June 2018. The patient was treated with Korean medicine for 23 months including acupuncture, herbal medicine and Sasang constitutional medicine prescription. Improvement of anemia was assessed by changes of Hemoglobin value. Laboratory analysis was used to evaluate the safety of treatment. Results: Chronic anemia has significantly improved since taking NYDBT on 9 days (2019.12.09-2019.12.17). The Hb value has been maintained in the normal range since it first entered the normal range on January 18, 2020. The patient had become transfusion-free and this condition persisted for 6 months after stopping the transfusion. Conclusion: This case demonstrates the therapeutic potential of Sasang constitutional medicine for chronic anemia as a personalized medicine.

• Tuberculosis and Respiratory Diseases
• /
• v.69 no.3
• /
• pp.153-162
• /
• 2010

Smoking is the most important risk factor of many pulmonary diseases, including chronic obstructive pulmonary disease and lung cancer, cardiovascular disorders and other malignancies. Therefore, smoking cessation is a practical way to prevent and treat smoking-related diseases. Also, the clinicians who care the patients with smoking-related disease should pay attention to it. This article reviews briefly recent publications focused on the influence of smoking cessation in some smoking-related diseases and strategies to improve smoking cessation such as pharmacotherapy or systemic behavioral approach programs. In addition, it reviews personalized therapy based on gene typing for smoking cessation.