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http://dx.doi.org/10.7314/APJCP.2014.15.5.1909

miR-421, miR-155 and miR-650: Emerging Trends of Regulation of Cancer and Apoptosis  

Farooqi, Ammad Ahmad (Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College)
Qureshi, Muhammad Zahid (Biochemistry Lab, Department of Chemistry, GC University)
Coskunpinar, Ender (Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University)
Naqvi, Syed Kamran-Ul-Hassan (COMSATS Institute of Information Technology)
Yaylim, Ilhan (Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University)
Ismail, Muhammad (Institute of Biomedical and Genetic Engineering)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.5, 2014 , pp. 1909-1912 More about this Journal
Abstract
It is becoming progressively more understandable that between transcription and translation there lies another versatile regulator that quantitatively controls the expression of mRNAs. Identification of miRNAs as key regulators of wide ranging signaling cascades and modulators of different cell-type and context dependent activities attracted basic and clinical scientists to study modes and mechanisms in details. In line with this approach overwhelmingly increasing in vivo and in vitro studies are deepening our understanding regarding miR-421, mir-155 and miR-650 mediated regulation of cellular activities. We also attempt to provide an overview of long non coding RNAs.
Keywords
miRNA; cancer; apoptosis; signaling;
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