• Journal of Korean Neurosurgical Society
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• 제37권2호
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• pp.101-104
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• 2005

Objective: A persistent trigeminal artery (PTA) may be found incidentally on conventional cerebral angiography and magnetic resonance(MR) angiography. Our goal is to examine the course and relationships of the vessel to the surrounding structures. Methods: Cerebral angiography was performed in 494 patients and MRA in 880; the patients had or were suspected to have cerebrovascular disease. In the images, the incidence, origin, course, and relationships of the PTA were evaluated. Results: A PTA was found in two (0.4%) of the patients undergoing cerebral angiography and three (0.34%) receiving an MR angiography. In four patients, the PTA arose from the lateral part of the cavernous segment of the internal carotid artery, then passed caudally and around the base of the dorsum sellae. In the other patient, the PTA arose from the medial aspect of the siphon, and ascended sharply to pierce the dorsum sellae and join the basilar artery. In four cases, there was hypoplasia of a proximal basilar artery below the abnormal communication; the vessel was of increased diameter above the communication. Conclusion: Identification of a PTA with a trans-sellar course is crucial if trans-sphenoidal surgery is planned. Hypoplasia of a proximal basilar artery should not be mistaken for an acquired narrowing.

• Molecular & Cellular Toxicology
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• 제5권3호
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• pp.179-186
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• 2009

Hexachlorobenzene (HCB) is a bioaccumulative, persistent, and toxic pollutant. HCB is one of the 12 priority of Persistent Organic Pollutants (POPs) intended for global action by the United Nations Environment Program (UNEP) Governing Council. POPs are organic compounds that are resistant to environmental degradation through chemical, biological, and photolytic processes. Some of HCB is ubiquitous in air, water, soil, and biological matrices, as well as in major environmental compartments. HCB has effects on various organs such as thyroid, bone, skin, kidneys and blood cells and especially, revealed strong toxicity to liver. In this study, we identified genes related to hepatotoxiciy induced by HCB in human hepatocellular carcinoma (HepG2) cells using microarray and gene ontology (GO) analysis. Through microarray analysis, we identified 96 up- and 617 down-regulated genes changed by more than 1.5-fold by HCB. And after GO analysis, we determined several key pathways which known as related to hepatotoxicity such as metabolism of xenobiotics by cytochrome P450, complement and coagulation cascades, and tight junction. Thus, our present study suggests that genes expressed by HCB may provide a clue for hepatotoxic mechanism of HCB and gene expression profiling by toxicogenomic analysis also affords promising opportunities to reveal potential new mechanistic markers of toxicity.

• Tuberculosis and Respiratory Diseases
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• 제82권3호
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• pp.190-193
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• 2019

Inhaled corticosteroids (ICSs) have been widely used as a key medication for asthma control. However, ICSs have been known to cause respiratory infections, such as pneumonia and pulmonary tuberculosis. Consequently, a dilemma exists regarding recommendation of persistent lifetime use of ICSs to mild asthma patients. Short-acting ${\beta}$-agonists (SABAs) have also been widely used for symptom relief. However, SABAs have been reported to increase the risk of asthma-related death, though incidences have been very rare. Consequently, a dilemma exists regarding recommendation of a SABA alone without an ICS or a controller to asthma patients even with very mild disease. In the real world, asthma patients tend to intermittently use ICS and more likely to be dependent on SABA since many patients want immediate relief of their symptoms. Consequently, a dilemma exists regarding the underuse of ICSs but the overuse of SABAs. One strategy for solving the presented dilemma would be identification of patients with asthma who require persistent use of asthma controllers. Such patients, who may be referred to as "persistent controller users," should continuously receive ICSs, even under controlled states of asthma. Another strategy would be a patient-adjusted, symptom-driven, intermittent-to-regular treatment combining low-dose ICS/rapid-onset long-acting ${\beta}$-agonists instead of using a SABA alone or with low-dose ICS for the asthma patients with mild disease. Both of these two strategies could avoid the risky treatment of a SABA alone without an ICS and could reduce the dose of ICS with the maintenance of asthma control.

• 한국지반공학회논문집
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• 제19권2호
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• pp.39-48
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• 2003

블럭이론에서는 불연속면의 유한한 연속성을 무시하여 불연속면이 암반내에서 무한이 연속되어진다고 가정하였다. 본 논문에서는 터널시공의 안정성 평가기법으로 불연속면의 유한한 연속성을 고려한 키블럭 해석기법을 제안하고, 실제의 현장에 적용했다. 불연속면 원반 모델을 이용하여 불연속면의 연속성을 고려한 3차원 암반블럭의 생성을 판정하였다. 이 판정기 법은 블럭의 형상에 관계없이 모든 형상의 블럭이 인식가능하여 복잡한 굴착면의 문제에 적용가능 하다. 판정된 암반블럭에 대해서 거동성 및 안정성을 해석하였다. 실제 건설중에 있는 대단면 터널현장에 적용하여 해석결과를 비교 검토하므로써, 본 논문에서 개발한 수치해석기법의 타당성과 적용성에 대한 검증을 하였다.

• 한방안이비인후피부과학회지
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• 제27권4호
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• pp.110-120
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• 2014

Objectives : We performed a clinical study to investigate autonomic conditions in persistent allergic rhinitis depending on various pattern identifications and the availability of heart rate variability (HRV) as a pattern identification diagnostic tool. Methods : 32 patients with persistent allergic rhinitis were asked to interview with doctor of Korean Medicine and perform the four pattern questionnaires (Cold-Heat Pattern, Phlegm Pattern, Yin Deficiency pattern, bloodstasis pattern). Then, they were examined their autonomic conditions with heart rate variability test. Results : Patients were classified as three pattern groups (Lung-stomach heat, Lung qi deficiency cold, Lung-spleen qi deficiency) by doctor. In the Lung qi deficiency cold group, Total power of the HRV (TP) and the power of the low frequency component (LF) significantly higher than in the Lung-stomach heat or Lung-spleen qi deficiency group (P < 0.05). Also, Patients were classified as 8 pattern groups (Cold/Heat, Phlegm/Non-phlegm, Yin deficiency/Non-yin deficiency, Bloodstasis/Non-bloodstasis) by four pattern questionnaires. Only in the Yin deficiency group, the power of the low frequency component (LF) significantly lower than in the Non-yin deficiency group (P < 0.05). There were not any significant differences in the rest groups. Conclusions : The result may provide that HRV doesn't reflect well the differences in the various pattern groups, and the HRV's availability is low. Continuous studies are needed to develop the objective and standardized pattern identification diagnostic tool for allergic rhinitis.

• 대한환경공학회지
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• 제37권2호
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• pp.113-119
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• 2015

본 연구에서는 대표적 난분해성 유기화합물인 PCBs (Polychlorinated Biphenyls) 및 기타 난분해성 물질 오염토양을 정화하기 위하여 고온고압의 물을 이용하였다. 먼저, PCBs 오염토 적용시 반응온도에 따른 영향에서는 아임계수 조건에서 온도가 증가함에 따라 처리효율이 선형적으로 증가하였고 반응시간의 증가에 따라서도 처리효율은 증가함을 보였다. 처리입경별 실험에서는 미세토의 경우가 처리효율이 약간 낮았다. 아임계수와 영가철에 의한 PCBs 분해 기작을 예측하기 위해 Ion chromatography 및 GC-MS 분석을 한 결과 탈염화 반응산물이 생성되었으며 헤드스페이스 실험결과 PCBs분해기작은 대부분 산화이며, 일부만이 탈염화에 의한 것임을 확인하였다. TPH, BTEX, TCE/PCE, 클로르피리포스 등의 난분해성 물질 오염토처리를 위해 $300^{\circ}C$ 아임계수 조건을 적용한 결과 모두 90% 이상의 처리효율을 나타냈으며, 처리효율과 반응부산물 등의 검토를 통해 PCBs 오염토 외에 다른 난분해성 물질 오염토 처리분야에도 적용가능함을 확인하였다.

• 동의신경정신과학회지
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• 제30권1호
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• pp.1-11
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• 2019

Objectives: Attention-Deficit/Hyperactivity Disorder (ADHD) is characterized by a persistent pattern of inattention and/or hyperactivity impulsivity that interferes with function or development in children. In traditional Korean medicine (TKM) and traditional Chinese medicine (TCM), ADHD is classified by several patterns based on symptoms and signs. However, currently, there is no objective diagnostic tool for ADHD in traditional medicine. The objective of this study was to develop the Pattern Identification Questionnaire for ADHD (parents-survey style) to be used in Korean medicine, through a literature review and consultation with groups of experts. Methods: The types of pattern identifications of ADHD mentioned in 13 pieces of Korean and Chinese literatures and their symptoms and signs were analyzed. The advisory committee (15 Neuropsychiatrist and 11 Pediatrist in Korean Medicine) assessed the appropriateness of the literature selection and the types of pattern identification selection and their symptoms and signs, and weighed the significance of the symptoms and signs. The Pattern Identification Questionnaire for ADHD was developed using the calculated weights by evaluated significance. The translation of symptoms and signs to the Korean language was achieved through consultation with expert translators. Results: 1. Four pattern identification types and their symptoms and signs were selected according to frequency of appearance in the Korean and Chinese literatures, and were reviewed by the advisory committee: Kidney yin deficiency and liver yang ascendant hyperactivity (腎虛肝亢), Dual deficiencies in the heart and spleen (心脾兩虛), Phlegm-fire harassing the heart (痰火擾心), and Spleen weakness and liver energy preponderance (脾虛肝旺). 2. The weights of all the symptoms and signs in the four patterns were calculated using the means and standard deviations of the symptoms and signs' importance that were obtained from specialists' significance weighting. 3. The Pattern Identification Questionnaire for ADHD (parents-survey style) in Korean medicine composed of 38 questions was suggested. Conclusions: Using a review of the literature and expert advice, Pattern Identification Questionnaire for ADHD (parents-survey style) in Korean medicine was developed. Further clinical study is required to develop a final version of the questionnaire through the evaluation of reliability and validity.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1997년도 하계학술대회 논문집 F
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• pp.2088-2090
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• 1997

This paper consists of the speed sensorless vector control of induction motors with the estimation of rotor resistance. In the application of variable-speed induction motor drives, if an inaccurate rotor resistance is used because the rotor resistance can change due to skin effects and temperature variables, it is difficult to achieve a collect field orientation. In this paper, to overcome these difficulties adaptive algorithm is designed for rotor resistance identification. The proposed adaptive algorithm for rotor resistance estimation in the synchronous reference frame is applied by sliding mode current controller satisfing persistent excitation(PE) condition. Adaptive flux observer is here used for the purpose of estimating rotor flux and speed in the speed sensorless scheme. Computer simulations are carried out to verify the validity of the proposed algorithm.

• 한국환경성돌연변이발암원학회지
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• 제16권2호
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• pp.88-96
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• 1996

Fluorescence in situ hybridization (FISH) with the DNA probe for human chromosome 4 was used to analyse in vitro radiation induced chromosome rearrangement in peripheral lymphocyte. Translocations, dicentrics, acentrics and color junctions involving the painted chromosome were scored according to the Protocol for Aberration Identification and Nomenclature Terminology (PAINT) system. The frequency of chromosome rearrangements including reciprocal translocation, dicentric, acentric fragment and color junction increased with radiation dose. The frequency of dicentric chromosome reduced by the fixation time following irradiation, whereas that of translocation was relatively persistent. The applicability of FISH for scoring stable translocation for biological dosimetry was demonstrated.

• 대한기계학회논문집
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• 제14권2호
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• pp.331-338
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• 1990

In adaptive control, the lack of persistent and rich excitation causes the estimated parameters to drift, which degrade the performance of the system and may introduces instability to the system in a stochastic environment. To solve the problem of the parameter drift, the concept of single parameter adaptation is presented. For the parameter identification, a priori error is directly used for adaptation error. The structure of the controller is based upon the minimum variance control technique. The stability and robustness analysis is carried out by the sector stability theorem for the second order system. The computer simulation is performed to justify the theoretical analysis for the various cases.