• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.2A
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• pp.171-179
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• 2009

The porosity in porous media like concrete can be considered as a durability index since it may be a routine for the intrusion of harmful ions and room for the keeping moisture. Recently, modeling and analysis techniques for deterioration are provided based on the pore structure with the significance of durability and the relationship between porosity and durability characteristics is an important issue. In this paper, a series of mortar samples with five water to cement ratios are prepared and tests for durability performance are carried out including porosity measurement. The durability test covers those for compressive strength, air permeability, chloride diffusion coefficient, absorption, and moisture diffusion coefficient. They are compared with water to cement ratios and porosity. From the normalized data, when porosity increases to 1.45 times, air permeability, chloride diffusion coefficient, absorption, and moisture diffusion coefficient decrease to 2.3 times, 2.1 times, 5.5 times and 3.7 times, respectively, while compressive strength decreases to 0.6 times. It was evaluated that these are linearly changed with porosity showing high corelation factors. Additionally, intended durability performances are established from the test results and literature studies and a porosity for durable concrete is proposed based on them.

• The Journal of Engineering Geology
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• v.27 no.2
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• pp.153-164
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• 2017

The geological factors for causing ground subsidence are very diverse. It can be affected by any geological or extrinsic influences, and even within the same geological factor, the soil depression impact factor can be determined by different physical properties. As a result of reviewing a large number of papers and case histories, it can be seen that there are seven categories of ground subsidence factors. The depth and thickness of the overburden can affect the subsidence depending on the existence of the cavity, whereas the depth and orientation of the boundary between soil and rock are dominant factors in the ground composed of soil and rock. In case of soil layers, more various influencing factors exist such as type of soil, shear strength, relative density and degree of compaction, dry unit weight, water content, and liquid limit. The type of rock, distance from the main fracture and RQD can be influential factors in the bedrock. When approaching from the hydrogeological point of view, the rainfall intensity, the distance and the depth from the main channel, the coefficient of permeability and fluctuation of ground water level can influence to ground subsidence. It is also possible that the ground subsidence can be affected by external factors such as the depth of excavation and distance from the earth retaining wall, groundwater treatment methods at excavation work, and existence of artificial facilities such as sewer pipes. It is estimated that to evaluate the ground subsidence factor during the construction of underground structures in urban areas will be essential. It is expected that ground subsidence factors examined in this study will contribute for the reliable evaluation of the ground subsidence risk.

• Journal of the Korean Geotechnical Society
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• v.33 no.12
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• pp.35-44
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• 2017

A large amount of recycled aggregates was produced and crushed from old buildings and pavements. In this study, when these aggregates are re-used in subbase or subgrade materials in near construction sites, their engineering characteristics caused by crushing are investigated in terms of permeability and shear strength. Three different sizes of aggregates (31.5-45.0 mm, 19.0-31.5 mm, 9.5-19.0 mm) and their mixtures, a total of 7 types of aggregates were used in compaction tests (modified D and B methods). After compaction tests, aggregates were sieved and analyzed with four different breakage factors ($B_{15}$, $C_c$, $B_{10}$, $B_r$). The D compaction method gave 2.0-8.0 times more crushable than B compaction method. The breakage factors for the largest size aggregate was 1.4-3.0 times higher than those of the smallest size aggregate. For aggregates with 5.6-9.5 mm sizes, the samples were prepared with $B_{15}$ of 1, 3, 10, 20, 30, 50, 60, and 70 for permeability and direct shear tests. As $B_{15}$ increased, the hydraulic conductivity decreased up to 1/22 for $B_{15}=50$. As $B_{15}$ increased from 1 to 50, the peak friction angle increased from $46.1^{\circ}$ to $54.5^{\circ}$. On the other hand, the friction angle decreased after $B_{15}=60$.

• Journal of Life Science
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• v.34 no.2
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• pp.128-137
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• 2024

This review discusses the pivotal role of vascular endothelial growth factors (VEGF) in angiogenesis and lymphangiogenesis, vital processes influencing vascular permeability, endothelial cell recruitment, and the maintenance of tumor-associated blood and lymphatic vessels. VEGF exerts its effects through tyrosine-kinase receptors, VEGFR-1, VEGFR-2, and VEGFR-3. This VEGF-VEGFR system is central not only to cancer but also to diseases arising from abnormal blood vessel and lymphatic vessel formation. In the context of cancer, VEGF and its receptors are essential for the development of tumor-associated vessels, making them attractive targets for therapeutic intervention. Various approaches, such as anti-VEGF antibodies, receptor antagonists, and VEGF receptor function inhibitors, are being explored to interfere with tumor growth. However, the clinical efficacy of anti-angiogenic agents remains uncertain and necessitates further refinement. The article also highlights the physiological role of VEGFs, emphasizing their involvement in endothelial cell functions, survival, and vascular permeability. The identification of five distinct VEGFs in humans (VEGF-A, VEGF-B, VEGF-C, VEGF-D, and PLGF) is discussed, along with the classification of VEGFRs as typical receptor tyrosine kinases with distinct signaling systems. The family includes VEGFR-1 and VEGFR-2, crucial in tumor biology and angiogenesis, and VEGFR-3, specifically involved in lymphangiogenesis. Overall, this review has provided a comprehensive overview of VEGF and VEGFR, detailing their roles in various diseases, including cancer. This is expected to further facilitate the utilization of VEGF and VEGFR as therapeutic targets.

• Journal of Korean Neurosurgical Society
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• v.29 no.9
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• pp.1222-1227
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• 2000

Objective : Vascular endothelial growth factor(VEGF), an endothelial cell specific cytokine, is a potent angiogenic growth factor implicated in the tumor angiogenesis and increases vascular permeability dramatically. Peritumoral brain edema(PTBE) occurs in 40-60% of meningiomas. Many causative factors have been investigated, but the mechanism of PTBE associate with meningioma is unclear. VEGF has been implicated as one of the causative factors of PTBE. This study was designed to determine whether the extent of VEGF expression is correlated with degree of PTBE in meningiomas. Methods : Meningioma tissue samples from 40 patients(7 men and 33 women, mean age $53{\pm}13years$) who underwent surgery were examined retrospectively for the expression of VEGF immunohistochemically. The extent of PTBE was estimated by using preoperative CT or MRI as an edema index(EI). In addition to VEGF, several causative factors including tumor size, location, histologic type, microvasculature(CD31) were compared with EI. Results : Twenty-six meningiomas demonstrated PTBE, and the other 14 did not. Of the 40 patients of meningiomas, 28 were positive(17 were 1+ and 11 were 2+) for VEGF. The EI increased significantly just as VEGF was strongly expressed(p=0.006). Microvascular proliferation was also closely correlated with the extent of peritumoral brain edema(p<0.05). Conclusion : These data suggest that VEGF expression and microvascular proliferation are closely correlated with PTBE in meningioma.

• Fashion & Textile Research Journal
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• v.16 no.4
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• pp.645-652
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• 2014

This study identifies consumer needs and a pattern sensory evaluation of jacquard fabrics for raincoats using quick-drying-absorbing polyester. We investigate the consumer's consciousness and raincoat improvements. Twelve kinds of jacquard fabrics were developed for use in this study. Developed jacquard fabrics were assessed subjectively by 152 university students using a 7-point scale of 26 consumer needs and 31 pattern image sensory descriptors. Data were analyzed by SPSS. The major results were: There was a need for consumers to improve the front fastener type, cuff fastener, mesh patch position, and raincoat pocket position. The most important parameter to choose raincoat fabric was waterproof and the other parameters were vapor-porous/water repellent, design, color, fashionability, air-permeability and easy-put on/off. The pattern image sensibility of jacquard fabrics was explained by seven factors: gorgeous, simple, cute, futuristic, ethnic, feminine, and cool. A higher pattern preference was found in the jacquard fabrics of unique, sporty, natural, luxurious, and trendy images. The pattern preference was predicted at 45.3% with gorgeous, simple, pure, cute, futuristic factors. The correlation coefficient between the pattern image sensibility factor 1 (gorgeous) and pattern preference was 0.674 and with factor 3 (cute) was 0.416, and with factor 6 (cool) was 0.209. The 4 factors (gorgeous, simple, cute, futuristic) were selected as a significant pattern image sensibility that influenced preference.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.31 no.1
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• pp.27-34
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• 2009

Angiogenesis is essential for solid tumor growth and progression. Among the pro-angiogenetic factors, vascular endothelial growth factor(VEGF), also known as vascular permeability factor, is the most important as a mitogen for vascular endothelium. The VEGF family of molecules currently consists of six growth factors, VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and placenta growth factor(PlGF). Over-expression of PlGF is associated with angiogenesis under pathological conditions such as ischemia, inflammation, and cancer. Hence, the goal of this study is to identify the correlation of clinicopathlogical factors and the up-regulation of PlGF expression in oral squamous cell carcinoma. We studied the immunohistochemical staining of PlGF, PlGF gene expression and a real time quantitative RT-PCR in 20 specimens of 20 patients with oral squamous cell carcinoma. The results were as follows. 1. In the immunohistochemical study of poorly differentiated and invasive oral squamous cell carcinoma, the high level staining of PlGF was observed. And the correlation between immunohistopathological PlGF expression and histological differentiation of specimens was significant (Pearson correlation analysis, significance [r] >0.6, P < .05). 2. In the PlGF gene RT-PCR analysis, PlGF expression was more in tumor tissue than in adjacent normal tissue. Paired-samples analysis determined the difference of PlGF mRNA expression level between the cancer tissue and the normal tissue (Student's t - test, P < .05) These findings suggest that up-regulation of the PlGF gene may play a role in progression and local metastasis in invasive oral squamous cell carcinoma.

• Journal of Korean Society of Water and Wastewater
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• v.34 no.6
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• pp.503-512
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• 2020

Identifying the water circulation status is one of the indispensable processes for watershed management in an urban area. Recently, various water circulation models have been developed to simulate the water circulation, but it takes a lot of time and cost to make a water circulation model that could adapt the characteristics of the watershed. This paper aims to develop a water circulation state estimation model that could easily calculate the status of water circulation in an urban watershed by using multiple linear regression analysis. The study watershed is a watershed in Seoul that applied the impermeable area ratio in 1962 and 2000. And, It was divided into 73 watersheds in order to consider changes in water circulation status according to the urban characteristic factors. The input data of the SHER(Similar Hydrologic Element Response) model, a water circulation model, were used as data for the urban characteristic factors of each watershed. A total of seven factors were considered as urban characteristic factors. Those factors included annual precipitation, watershed area, average land-surface slope, impervious surface ratio, coefficient of saturated permeability, hydraulic gradient of groundwater surface, and length of contact line with downstream block. With significance probabilities (or p-values) of 0.05 and below, all five models showed significant results in estimating the water circulation status such as the surface runoff rate and the evapotranspiration rate. The model that was applied all seven urban characteristics factors, can calculate the most similar results such as the existing water circulation model. The water circulation estimation model developed in this study is not only useful to simply estimate the water circulation status of ungauged watersheds but can also provide data for parameter calibration and validation.

• Economic and Environmental Geology
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• v.57 no.4
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• pp.397-416
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• 2024

This study assessed the hydrogeological properties of the deep geological environment to develop safety criteria for the natural barriers used in the deep geological disposal of high-level radioactive waste in Korea. The assessment focused on the distribution and trends of hydraulic conductivity and permeability properties appropriate for the domestic geological environment, using various in-situ hydraulic test data collected for groundwater development and management. To develop a depth-hydrogeological property relationship model suitable for domestic conditions, the study reviewed various international research examples and applied a representative model that explains the trends of hydraulic conductivity and permeability with depth. The development of the model suitable for Korea involved applying ensemble regression analysis to account for the uncertainty of various factors in the collected data. The results confirmed that existing international depth-hydrogeological property relationship models adequately describe the characteristics of the domestic geological environment. Considering the preferred hydrogeological criteria suggested by countries like Sweden, Germany, and Canada, there is a high likelihood that a suitable geological environment exists in Korea. Additionally, the application of hydrogeological criteria indicative of low-permeability environments showed that suitable conditions for disposal construction increase at depths greater than 300 m, where the influence of fractures on groundwater flow might be minimal at depths exceeding 500 m. This research can serve as foundational information for establishing hydrogeological safety standards for natural barriers in Korea according to international regulatory guidelines.

• Geomechanics and Engineering
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• v.10 no.4
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• pp.527-546
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• 2016

This paper discusses improvements of compressibility, permeability, static and liquefaction strengths of in-situ soils by grouting. Both field testing and laboratory evaluation of the on-site samples were conducted. The improvement of soils was influenced by two main factors, i.e., the grout materials and the injection mechanisms introduced by the field grouting. On-site grout mapping revealed the major mechanism was fracturing accompanied with some permeation at deeper zones of sandy soils, where long-gel time suspension grout and solution grout were applied. The study found the compressibility and swelling potential of CL soils at a 0.5 m distance to grout hole could be reduced by 25% and 50%, respectively, due to the grouting. The effect on hydraulic conductivity of the CL soils appeared insignificant. The grouting slightly improved the cohesion of the CL soils by 10~15 kPa, and the friction angle appeared unaffected. The grouting had also improved the cohesion of the on-site SM soils by 10~90 kPa, while influences on the friction angle of soils were uncertain. Liquefaction resistances could be enhanced for the sandy soils within a 2~3 m extent to the grout hole. Average improvements of 40% and 20% on the liquefaction resistance were achievable for the sandy soils for earthquake magnitudes of 6 and ${\geq}7.5$, respectively, by the grouting.