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EXPRESSION OF PLACENTA GROWTH FACTOR IN THE ORAL SQUAMOUS CELL CARCINOMA  

Lee, Sang-Gu (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University)
Kim, Chul-Hwan (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University)
Publication Information
Maxillofacial Plastic and Reconstructive Surgery / v.31, no.1, 2009 , pp. 27-34 More about this Journal
Abstract
Angiogenesis is essential for solid tumor growth and progression. Among the pro-angiogenetic factors, vascular endothelial growth factor(VEGF), also known as vascular permeability factor, is the most important as a mitogen for vascular endothelium. The VEGF family of molecules currently consists of six growth factors, VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and placenta growth factor(PlGF). Over-expression of PlGF is associated with angiogenesis under pathological conditions such as ischemia, inflammation, and cancer. Hence, the goal of this study is to identify the correlation of clinicopathlogical factors and the up-regulation of PlGF expression in oral squamous cell carcinoma. We studied the immunohistochemical staining of PlGF, PlGF gene expression and a real time quantitative RT-PCR in 20 specimens of 20 patients with oral squamous cell carcinoma. The results were as follows. 1. In the immunohistochemical study of poorly differentiated and invasive oral squamous cell carcinoma, the high level staining of PlGF was observed. And the correlation between immunohistopathological PlGF expression and histological differentiation of specimens was significant (Pearson correlation analysis, significance [r] >0.6, P < .05). 2. In the PlGF gene RT-PCR analysis, PlGF expression was more in tumor tissue than in adjacent normal tissue. Paired-samples analysis determined the difference of PlGF mRNA expression level between the cancer tissue and the normal tissue (Student's t - test, P < .05) These findings suggest that up-regulation of the PlGF gene may play a role in progression and local metastasis in invasive oral squamous cell carcinoma.
Keywords
Placenta growth factor; Squamous cell carcinoma; Vascular endothelial growth factor;
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1 Folkman J : Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1: 27-31, 1995   DOI   PUBMED   ScienceOn
2 Olofsson B, Pajusola K, Kaipainen A et al: Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc Natl Acad Sci USA 93: 2576-2581,1996   DOI   ScienceOn
3 Maglione D, Guerriero V, Viglietto G et al: Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci USA 88 : 9267-71, 1991   DOI   ScienceOn
4 Dvorak HF, Brown LF, Detmar M et al: Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146: 1029-1039, 1995
5 Benjamin LE, Golijanin D, Itin A et al: Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 103: 159-165, 1999   DOI   ScienceOn
6 Park JE, Chen HH, Winer J et al: Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vivo and in vitro, and high anity binding to Flt-1 but not to Flk-1/KDR. J Biol Chem 269: 25646-25654, 1994
7 Tournier C, Hess P, Yang DD et al: Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science. 288: 870-874, 2000   DOI   PUBMED   ScienceOn
8 Ferrara N, Leung DW, Cachianes G: Vascular endothelial growth factor is a secreted antiogenic mitogen. Science 246:1306-1309, 1989   DOI   PUBMED
9 Maglione D, Guerriero V, Viglietto G et al: Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14. Oncogene 8: 925-931, 1993
10 Park JE, Chen HH, Winer J et al: Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J Biol Chem 269: 25646-54, 1994
11 Jaye M, Howk R, Burgess W et al: Human endothelial cell growth factor : cloning, nucleotide sequence, and chromosome localization. Science 233:541-545, 1986   DOI   PUBMED
12 Gospodarowicz D, Ferrara N, Schweigerer L et al: Structural characterization and biological functions of fibroblast growth factor. Endocr Rev 8: 95-114, 1987   DOI   ScienceOn
13 Maglione D, Guerriero V, Viglietto G et al: Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci USA 88: 9267-9271, 1991   DOI   ScienceOn
14 Carmeliet P, Moons L, Luttun A et al: Synergism between vascular endothelial growth factor and placenta growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 7: 575-583, 2001   DOI   ScienceOn
15 Hauser S, Weich HA: A heparin-binding form of placenta growth factor(PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta. Growth Factors. 9: 259-68, 1993   DOI   ScienceOn
16 Ferrara N: Vascular endothelial growth factor as a target for anticancer therapy. Oncologist 9 (Suppl 1): 2-10, 2004
17 Takahashi A, Sasaki H, Kim SJ et al: Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res 54:4233-7, 1994
18 Vaisman N, Gospodarowicz D, Neufeld G et al: Characterization of the receptors for vascular endothelial growth factor. J Biol Chem 265: 19461-19466, 1990
19 Jain RK: Molecular regulation of vessel maturation. Nat Med 9: 685-693, 2003   DOI   PUBMED   ScienceOn
20 Carmeliet P, Moons L, Luttun A et al: Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 7: 575-83, 2001   DOI   ScienceOn
21 Ferrara N, Henzel WJ: Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161: 851-858, 1989   DOI   ScienceOn
22 Folkman J, Merler E, Abernathy C et al: Isolation of a tumor factor responsible for angiogenesis. J Exp Med 133:275-288, 1971   DOI   ScienceOn
23 Dvorak HF, Brown LF, Detmar M et al: Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146: 1029-1039, 1995
24 S-C Wei, P-N Tsao, S-C Yu et al: Placenta growth factor expression is correlated with survival of patients with colorectal cancer. Gut54: 666-672, 2005   DOI   ScienceOn
25 Plouet J, Moukadiri HJ: Characterization of the receptors for vasculotropin on bovine adrenal cortex-derived capillary endothelial cells. J Biol Chem 265: 22071-22075, 1990
26 Maeda T, Matsumura S, Hiranuma H et al: Expression of vascular endothelial growth factor in human oral squamous cell carcinoma: its association with tumour progression and p53 gene status. J Clin Path 51: 771-775, 1998   DOI   ScienceOn
27 Adini A, Kornaga T, Firoozbakht F et al: Placental growth factor is a survival factor for tumor endothelial cells and macrophages. Cancer Res 62: 2749-52, 2002
28 Folkman J, Klagsbrun M: Angiogenic factors. Science 235:442-447, 1987   DOI   PUBMED
29 Cao Y, Linden P, Shima D et al : In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. J Clin Invest 98: 2507-11, 1996   DOI   ScienceOn
30 Cao Y, Ji WR, Qi P et al: Placenta growth factor: identification and characterization of a nove isoform generated by RNA alternative splicing. Biochem Biophys Res Commun, 235: 493-498, 1997   DOI   ScienceOn
31 Lijian Zhang1, Jinfeng Chen1, Yang Ke et al: Expression of placenta growth factor (PlGF) in non-Small cell Lung cancer (NSCLC) and the clinical and prognostic significance World Journal of Surgical Oncology, 3: 68, 2005   DOI   ScienceOn
32 Yancopoulos GD, Davis S, Gale NW et al: Vascular-specific growth factors and blood vessel formation. Nature 407 : 242-248, 2000   DOI   PUBMED   ScienceOn
33 Kodama J, Seki N, Tokumo K et al: Placenta growth factor is abundantly expressed in human cervical squamous cell carcinoma. Eur J Gynaecol Oncol. 18(6): 508-10, 1997
34 Donnini S, Machein MR, Plate KH et al: Expression and localization of placenta growth factor and PlGF receptors in human meningiomas. J Pathol 189: 66-71, 1999   DOI   ScienceOn
35 Jakeman LB, Winer J, Bennett GL et al : Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest 89: 244-253, 1992   DOI   PUBMED
36 Lee JC, Chow NH, Wang ST et al: Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. Eur J Cancer 36: 748-53, 2000   DOI   ScienceOn
37 Tanigawa N, Amaya H, Matsumura M: Extent of tumour vascularization correlates with prognosis and haematogenous metastasis in gastric carcinomas. Cancer Res 56: 2671-2676, 1996